Mechanism of action and toxicities of purgatives used for colonoscopy preparation

Bibliography

• Jemal A, Center MM, Desantis C, Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 2010;19(8):1893-907
   PubMed Web of Science ®Google Scholar
• Seeff LC, Nadel MR, Klabunde CN, Patterns and predictors of colorectal cancer test use in the adult U.S. population. Cancer 2004;100(10):2093-103
   PubMed Web of Science ®Google Scholar
• Froehlich F, Wietlisbach V, Gonvers JJ, Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc 2005;61(3):378-84
   PubMed Web of Science ®Google Scholar
• Harewood GC, Sharma VK, de Garmo P. Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc 2003;58(1):76-9
   PubMed Web of Science ®Google Scholar
• Binder HJ. Mechanisms underlying the absorption of water and ions. Int Rev Physiol 1977;12:285-304
   PubMedGoogle Scholar
• Kunzelmann K, Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol Rev 2002;82(1):245-89
   PubMed Web of Science ®Google Scholar
• Kockerling A, Fromm M. Origin of cAMP-dependent Cl- secretion from both crypts and surface epithelia of rat intestine. Am J Physiol 1993;264(5 Pt 1):C1294-301
   PubMed Web of Science ®Google Scholar
• Chang WW, Leblond CP. Renewal of the epithelium in the descending colon of the mouse. I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin. Am J Anat 1971;131(1):73-99
   PubMedGoogle Scholar
• Dorge A, Beck FX, Rechkemmer G. Cellular site of active K absorption in the guinea-pig distal colonic epithelium. Pflugers Arch 1998;436(2):280-8
   PubMed Web of Science ®Google Scholar
• Luciano L, Reale E, Rechkemmer G, Structure of zonulae occludentes and the permeability of the epithelium to short-chain fatty acids in the proximal and the distal colon of guinea pig. J Membr Biol 1984;82(2):145-56
   PubMed Web of Science ®Google Scholar
• Dawson DC. Ion channels and colonic salt transport. Annu Rev Physiol 1991;53:321-39
   PubMed Web of Science ®Google Scholar
• Feldman GM. HCO3- secretion by rat distal colon: effects of inhibitors and extracellular Na+. Gastroenterology 1994;107(2):329-38
   PubMed Web of Science ®Google Scholar
• Halm DR, Halm ST. Secretagogue response of goblet cells and columnar cells in human colonic crypts. Am J Physiol Cell Physiol 2000;278(1):C212-33
   PubMed Web of Science ®Google Scholar
• Spring KR. Routes and mechanism of fluid transport by epithelia. Annu Rev Physiol 1998;60:105-19
   PubMedGoogle Scholar
• Koyama Y, Yamamoto T, Tani T, Expression and localization of aquaporins in rat gastrointestinal tract. Am J Physiol 1999;276(3 Pt 1):C621-7
   PubMed Web of Science ®Google Scholar
• Beck DE, Harford FJ, DiPalma JA. Comparison of cleansing methods in preparation for colonic surgery. Dis Colon Rectum 1985;28(7):491-5
   PubMed Web of Science ®Google Scholar
• Brown AR, DiPalma JA. Bowel preparation for gastrointestinal procedures. Curr Gastroenterol Rep 2004;6(5):395-401
   PubMedGoogle Scholar
• Johnson WC. Oral elemental diet: a new bowel preparation. Arch Surg 1974;108(1):32-4
   PubMed Web of Science ®Google Scholar
• Lever EL, Walter MH, Condon SC, Addition of enemas to oral lavage preparation for colonoscopy is not necessary. Gastrointest Endosc 1992;38(3):369-72
   PubMed Web of Science ®Google Scholar
• DiPalma JA, Brady CE III. Colon cleansing for diagnostic and surgical procedures: polyethylene glycol-electrolyte lavage solution. Am J Gastroenterol 1989;84(9):1008-16
   PubMed Web of Science ®Google Scholar
• Donovan IA, Arabi Y, Keighley MR, Modification of the physiological disturbances produced by whole gut irrigation by preliminary mannitol administration. Br J Surg 1980;67(2):138-9
   PubMed Web of Science ®Google Scholar
• Shawki S, Wexner SD. Oral colorectal cleansing preparations in adults. Drugs 2008;68(4):417-37
   PubMed Web of Science ®Google Scholar
• Taylor EW, Bentley S, Youngs D, Bowel preparation and the safety of colonoscopic polypectomy. Gastroenterology 1981;81(1):1-4
   PubMed Web of Science ®Google Scholar
• Davis GR, Santa Ana CA, Morawski SG, Development of a lavage solution associated with minimal water and electrolyte absorption or secretion. Gastroenterology 1980;78(5 Pt 1):991-5
   PubMed Web of Science ®Google Scholar
• Tooson JD, Gates LK. Bowel preparation before colonoscopy. Choosing the best lavage regimen. Postgrad Med 1996;100(2): 203,4, 207-12, 214.
   PubMed Web of Science ®Google Scholar
• Fordtran JS, Santa Ana CA, Cleveland M. A low-sodium solution for gastrointestinal lavage. Gastroenterology 1990;98(1):11-16
   PubMed Web of Science ®Google Scholar
• Vanner SJ, MacDonald PH, Paterson WG, A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution [Golytely] in the preparation of patients for colonoscopy. Am J Gastroenterol 1990;85(4):422-7
   PubMed Web of Science ®Google Scholar
• Aronchick CA, Lipshutz WH, Wright SH, A novel tableted purgative for colonoscopic preparation: efficacy and safety comparisons with Colyte and Fleet Phospho-Soda. Gastrointest Endosc. 2000;52(3):346-52
   PubMed Web of Science ®Google Scholar
• Markowitz GS, Stokes MB, Radhakrishnan J, Acute phosphate nephropathy following oral sodium phosphate bowel purgative: an underrecognized cause of chronic renal failure. J Am Soc Nephrol 2005;16(11):3389-96
   PubMed Web of Science ®Google Scholar
• Golub RW, Kerner BA, Wise WE, Colonoscopic bowel preparations – which one? A blinded, prospective, randomized trial. Dis Colon Rectum 1995;38(6):594-9
   PubMed Web of Science ®Google Scholar
• Marshall JB, Pineda JJ, Barthel JS, Prospective, randomized trial comparing sodium phosphate solution with polyethylene glycol-electrolyte lavage for colonoscopy preparation. Gastrointest Endosc 1993;39(5):631-4
   PubMed Web of Science ®Google Scholar
• Tan JJ, Tjandra JJ. Which is the optimal bowel preparation for colonoscopy – a meta-analysis. Colorectal Dis 2006;8(4):247-58
   PubMed Web of Science ®Google Scholar
• Parente F, Marino B, DeVecchi N, Faecal occult blood test-based screening programme with high compliance for colonoscopy has a strong clinical impact on colorectal cancer. Br J Surg 2009;96(5):533-40
   PubMed Web of Science ®Google Scholar
• Clark LE, Dipalma JA. Safety issues regarding colonic cleansing for diagnostic and surgical procedures. Drug Saf 2004;27(15):1235-42
   PubMed Web of Science ®Google Scholar
• DiPalma JA, Marshall JB. Comparison of a new sulfate-free polyethylene glycol electrolyte lavage solution versus a standard solution for colonoscopy cleansing. Gastrointest Endosc 1990;36(3):285-9
   PubMed Web of Science ®Google Scholar
• Tomlinson TL, DiPalma JA, Mangano FA. Comparison of a new colon lavage solution [Golytely-RSS] with a standard preparation for air-contrast barium enema. AJR Am J Roentgenol 1988;151(5):947-50
   PubMed Web of Science ®Google Scholar
• Froehlich F, Fried M, Schnegg JF, Palatability of a new solution compared with standard polyethylene glycol solution for gastrointestinal lavage. Gastrointest Endosc 1991;37(3):325-8
   PubMed Web of Science ®Google Scholar
• Raymond JM, Beyssac R, Capdenat E, Tolerance, effectiveness, and acceptability of sulfate-free electrolyte lavage solution for colon cleaning before colonoscopy. Endoscopy 1996;28(7):555-8
   PubMed Web of Science ®Google Scholar
• Matter SE, Rice PS, Campbell DR. Colonic lavage solutions: plain versus flavored. Am J Gastroenterol 1993;88(1):49-52
   PubMed Web of Science ®Google Scholar
• Pashankar DS, Uc A, Bishop WP. Polyethylene glycol 3350 without electrolytes: a new safe, effective, and palatable bowel preparation for colonoscopy in children. J Pediatr 2004;144(3):358-62
   PubMed Web of Science ®Google Scholar
• ASGE Technology Committee, Mamula P, Adler DG, Colonoscopy preparation. Gastrointest Endosc 2009;69(7):1201-9
   PubMed Web of Science ®Google Scholar
• Aoun E, Abdul-Baki H, Azar C, A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation. Gastrointest Endosc 2005;62(2):213-18
   PubMed Web of Science ®Google Scholar
• Rosch T, Classen M. Fractional cleansing of the large bowel with “Golytely” for colonoscopic preparation: a controlled trial. Endoscopy 1987;19(5):198-200
   PubMed Web of Science ®Google Scholar
• Church JM. Effectiveness of polyethylene glycol antegrade gut lavage bowel preparation for colonoscopy – timing is the key! Dis Colon Rectum 1998;41(10):1223-5
   PubMed Web of Science ®Google Scholar
• Rex DK, Johnson DA, Anderson JC, American College of Gastroenterology guidelines for colorectal cancer screening 2008 [corrected]. Am J Gastroenterol 2009;104(3):739-50
   PubMed Web of Science ®Google Scholar
• Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ 2001;164(3):353-5
   PubMed Web of Science ®Google Scholar
• Cohen LB, Sanyal SM, von Althann C, Clinical trial: 2-L polyethylene glycol-based lavage solutions for colonoscopy preparation – a randomized, single-blind study of two formulations. Aliment Pharmacol Ther 2010;32(5):637-44
   PubMed Web of Science ®Google Scholar
• Corporaal S, Kleibeuker JH, Koornstra JJ. Low-volume PEG plus ascorbic acid versus high-volume PEG as bowel preparation for colonoscopy. Scand J Gastroenterol 2010;45(11):1380-6
   PubMed Web of Science ®Google Scholar
• Worthington J, Thyssen M, Chapman G, A randomised controlled trial of a new 2 litre polyethylene glycol solution versus sodium picosulphate + magnesium citrate solution for bowel cleansing prior to colonoscopy. Curr Med Res Opin 2008;24(2):481-8
   PubMed Web of Science ®Google Scholar
• Martinek J, Hess J, Delarive J, Cisapride does not improve precolonoscopy bowel preparation with either sodium phosphate or polyethylene glycol electrolyte lavage. Gastrointest Endosc 2001;54(2):180-5
   PubMed Web of Science ®Google Scholar
• Abdul-Baki H, Hashash JG, Elhajj II, A randomized, controlled, double-blind trial of the adjunct use of tegaserod in whole-dose or split-dose polyethylene glycol electrolyte solution for colonoscopy preparation. Gastrointest Endosc 2008;68(2): 294,300; quiz 334, 336
   PubMed Web of Science ®Google Scholar
• Sanaka MR, Super DM, Mullen KD, Use of tegaserod along with polyethylene glycol electrolyte solution for colonoscopy bowel preparation: a prospective, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2006;23(5):669-74
   PubMed Web of Science ®Google Scholar
• Sharma VK, Chockalingham SK, Ugheoke EA, Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation. Gastrointest Endosc 1998;47(2):167-71
   PubMed Web of Science ®Google Scholar
• Adams WJ, Meagher AP, Lubowski DZ, Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation. Dis Colon Rectum 1994;37(3): 229,33; discussion 233-4
   PubMed Web of Science ®Google Scholar
• DiPalma JA, Wolff BG, Meagher A, Comparison of reduced volume versus four liters sulfate-free electrolyte lavage solutions for colonoscopy colon cleansing. Am J Gastroenterol 2003;98(10):2187-91
   PubMed Web of Science ®Google Scholar
• DiPalma JA, McGowan J, Cleveland MV. Clinical trial: an efficacy evaluation of reduced bisacodyl given as part of a polyethylene glycol electrolyte solution preparation prior to colonoscopy. Aliment Pharmacol Ther 2007;26(8):1113-19
   PubMed Web of Science ®Google Scholar
• Baudet JS, Castro V, Redondo I. Recurrent ischemic colitis induced by colonoscopy bowel lavage. Am J Gastroenterol 2010;105(3):700-1
   PubMed Web of Science ®Google Scholar
• Trautwein AL, Vinitski LA, Peck SN. Bowel preparation before colonoscopy in the pediatric patient: a randomized study. Gastroenterol Nurs 1996;19(4):137-9
   PubMedGoogle Scholar
• Iida Y, Miura S, Asada Y, Bowel preparation for the total colonoscopy by 2,000 ml of balanced lavage solution [Golytely] and sennoside. Gastroenterol Jpn 1992;27(6):728-33
   PubMedGoogle Scholar
• Radaelli F, Meucci G, Imperiali G, High-dose senna compared with conventional PEG-ES lavage as bowel preparation for elective colonoscopy: a prospective, randomized, investigator-blinded trial. Am J Gastroenterol 2005;100(12):2674-80
   PubMed Web of Science ®Google Scholar
• Amato A, Radaelli F, Paggi S, Half doses of PEG-ES and senna vs. high-dose senna for bowel cleansing before colonoscopy: a randomized, investigator-blinded trial. Am J Gastroenterol 2010;105(3):675-81
   PubMed Web of Science ®Google Scholar
• Belsey J, Epstein O, Heresbach D. Systematic review: adverse event reports for oral sodium phosphate and polyethylene glycol. Aliment Pharmacol Ther 2009;29(1):15-28
   PubMed Web of Science ®Google Scholar
• Hookey LC, Depew WT, Vanner S. The safety profile of oral sodium phosphate for colonic cleansing before colonoscopy in adults. Gastrointest Endosc 2002;56(6):895-902
   PubMed Web of Science ®Google Scholar
• Rex DK. Dosing considerations in the use of sodium phosphate bowel preparations for colonoscopy. Ann Pharmacother 2007;41(9):1466-75
   PubMed Web of Science ®Google Scholar
• Kim DH, Hyun SH, Shim SB, The role of intestinal bacteria in the transformation of sodium picosulfate. Jpn J Pharmacol 1992;59(1):1-5
   PubMedGoogle Scholar
• Wexner SD, Beck DE, Baron TH, A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons [ASCRS], the American Society for Gastrointestinal Endoscopy [ASGE], and the Society of American Gastrointestinal and Endoscopic Surgeons [SAGES]. Gastrointest Endosc 2006;63(7):894-909
   PubMed Web of Science ®Google Scholar
• Nelson DB, Barkun AN, Block KP, Technology Status Evaluation report. Colonoscopy preparations. May 2001. Gastrointest Endosc 2001;54(6):829-32
   PubMed Web of Science ®Google Scholar
• Hamilton D, Mulcahy D, Walsh D, Sodium picosulphate compared with polyethylene glycol solution for large bowel lavage: a prospective randomised trial. Br J Clin Pract 1996;50(2):73-5
   PubMedGoogle Scholar
• Yoshioka K, Connolly AB, Ogunbiyi OA, Randomized trial of oral sodium phosphate compared with oral sodium picosulphate [Picolax] for elective colorectal surgery and colonoscopy. Dig Surg 2000;17(1):66-70
   PubMed Web of Science ®Google Scholar
• Di Palma JA, Rodriguez R, McGowan J, A randomized clinical study evaluating the safety and efficacy of a new, reduced-volume, oral sulfate colon-cleansing preparation for colonoscopy. Am J Gastroenterol 2009;104(9):2275-84
   PubMed Web of Science ®Google Scholar
• Ness RM, Manam R, Hoen H, Predictors of inadequate bowel preparation for colonoscopy. Am J Gastroenterol 2001;96(6):1797-802
   PubMed Web of Science ®Google Scholar
• Chung YW, Han DS, Park KH, Patient factors predictive of inadequate bowel preparation using polyethylene glycol: a prospective study in Korea. J Clin Gastroenterol 2009;43(5):448-52
   PubMed Web of Science ®Google Scholar
• Lebwohl B, Wang TC, Neugut AI. Socioeconomic and other predictors of colonoscopy preparation quality. Dig Dis Sci 2010;55(7):2014-20
   PubMed Web of Science ®Google Scholar
• Froehlich F, Wietlisbach V, Gonvers JJ, Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European Panel of Appropriateness of Gastrointestinal Endoscopy European multicenter study. Gastrointest Endosc 2005;61(3):378-84
   PubMed Web of Science ®Google Scholar
• Borg BB, Gupta NK, Zuckerman GR, Impact of obesity on bowel preparation for colonoscopy. Clin Gastroenterol Hepatol 2009;7(6):670-5
   PubMed Web of Science ®Google Scholar
• Lichtenstein G. Bowel preparations for colonoscopy: a review. Am J Health Syst Pharm 2009;66(1):27-37
   PubMed Web of Science ®Google Scholar
• Cohen CD, Keuneke C, Schiemann U, Hyponatraemia as a complication of colonoscopy. Lancet 2001;357(9252):282-3
   PubMed Web of Science ®Google Scholar
• Marschall HU, Bartels F. Life-threatening complications of nasogastric administration of polyethylene glycol-electrolyte solutions [Golytely] for bowel cleansing. Gastrointest Endosc 1998;47(5):408-10
   PubMed Web of Science ®Google Scholar
• Ayus JC, Levine R, Arieff AI. Fatal dysnatraemia caused by elective colonoscopy. BMJ 2003;326(7385):382-4
   PubMed Web of Science ®Google Scholar
• Nagler J, Poppers D, Turetz M. Severe hyponatremia and seizure following a polyethylene glycol-based bowel preparation for colonoscopy. J Clin Gastroenterol 2006;40(6):558-9
   PubMed Web of Science ®Google Scholar
• Schroppel B, Segerer S, Keuneke C, Hyponatremic encephalopathy after preparation for colonoscopy. Gastrointest Endosc 2001;53(4):527-9
   PubMed Web of Science ®Google Scholar
• Pockros PJ, Foroozan P. Golytely lavage versus a standard colonoscopy preparation. Effect on normal colonic mucosal histology. Gastroenterology 1985;88(2):545-8
   PubMed Web of Science ®Google Scholar
• Brinberg DE, Stein J. Mallory-Weiss tear with colonic lavage. Ann Intern Med 1986;104(6):894-5
   PubMed Web of Science ®Google Scholar
• Eisen GM, Jowell PS. Esophageal perforation after ingestion of colon lavage solution. Am J Gastroenterol 1995;90(11):2074
   PubMed Web of Science ®Google Scholar
• Hroncich ME. Colonoscopy preparation complicated by Mallory-Weiss tear. South Med J 1992;85(3):328
   PubMed Web of Science ®Google Scholar
• McBride MA, Vanagunas A. Esophageal perforation associated with polyethylene glycol electrolyte lavage solution. Gastrointest Endosc 1993;39(6):856-7
   PubMed Web of Science ®Google Scholar
• Pham T, Porter T, Carroll G. A case report of Boerhaave's syndrome following colonoscopy preparation. Med J Aust 1993;159(10):708
   PubMed Web of Science ®Google Scholar
• Raymond PL. Mallory-Weiss tear associated with polyethylene glycol electrolyte lavage solution. Gastrointest Endosc 1991;37(3):410-11
   PubMed Web of Science ®Google Scholar
• Santoro MJ, Chen YK, Collen MJ. Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tears. Am J Gastroenterol 1993;88(8):1292-3
   PubMed Web of Science ®Google Scholar
• Langdon DE. Colonic perforation with volume laxatives. Am J Gastroenterol 1996;91(3):622-3
   PubMed Web of Science ®Google Scholar
• Granberry MC, White LM, Gardner SF. Exacerbation of congestive heart failure after administration of polyethylene glycol-electrolyte lavage solution. Ann Pharmacother 1995;29(12):1232-5
   PubMed Web of Science ®Google Scholar
• Barkun A, Chiba N, Enns R, Commonly used preparations for colonoscopy: efficacy, tolerability, and safety – a Canadian Association of Gastroenterology position paper. Can J Gastroenterol 2006;20(11):699-710
   PubMed Web of Science ®Google Scholar
• Ainley EJ, Winwood PJ, Begley JP. Measurement of serum electrolytes and phosphate after sodium phosphate colonoscopy bowel preparation: an evaluation. Dig Dis Sci. 2005;50(7):1319-23
   PubMed Web of Science ®Google Scholar
• DiPalma JA, Buckley SE, Warner BA, Biochemical effects of oral sodium phosphate. Dig Dis Sci 1996;41(4):749-53
   PubMed Web of Science ®Google Scholar
• Tan HL, Liew QY, Loo S, Severe hyperphosphataemia and associated electrolyte and metabolic derangement following the administration of sodium phosphate for bowel preparation. Anaesthesia 2002;57(5):478-83
   PubMed Web of Science ®Google Scholar
• Fass R, Do S, Hixson LJ. Fatal hyperphosphatemia following Fleet Phospo-Soda in a patient with colonic ileus. Am J Gastroenterol 1993;88(6):929-32
   PubMed Web of Science ®Google Scholar
• Beloosesky Y, Grinblat J, Weiss A, Electrolyte disorders following oral sodium phosphate administration for bowel cleansing in elderly patients. Arch Intern Med 2003;163(7):803-8
   PubMed Web of Science ®Google Scholar
• Ahmed M, Raval P, Buganza G. Oral sodium phosphate catharsis and acute renal failure. Am J Gastroenterol 1996;91(6):1261-2
   PubMed Web of Science ®Google Scholar
• Frizelle FA, Colls BM. Hyponatremia and seizures after bowel preparation: report of three cases. Dis Colon Rectum 2005;48(2):393-6
   PubMed Web of Science ®Google Scholar
• Lien YH. Is bowel preparation before colonoscopy a risky business for the kidney? Nat Clin Pract Nephrol 2008;4(11):606-14
   PubMedGoogle Scholar
• Caswell M, Thompson WO, Kanapka JA, The time course and effect on serum electrolytes of oral sodium phosphates solution in healthy male and female volunteers. Can J Clin Pharmacol 2007;14(3):e260-74
   PubMedGoogle Scholar
• Clarkston WK, Tsen TN, Dies DF, Oral sodium phosphate versus sulfate-free polyethylene glycol electrolyte lavage solution in outpatient preparation for colonoscopy: a prospective comparison. Gastrointest Endosc 1996;43(1):42-8
   PubMed Web of Science ®Google Scholar
• Hixson LJ. Colorectal ulcers associated with sodium phosphate catharsis. Gastrointest Endosc 1995;42(1):101-2
   PubMed Web of Science ®Google Scholar
• Zwas FR, Cirillo NW, el-Serag HB, Colonic mucosal abnormalities associated with oral sodium phosphate solution. Gastrointest Endosc 1996;43(5):463-6
   PubMed Web of Science ®Google Scholar
• Kontani M, Hara A, Ohta S, Ikeda T. Hypermagnesemia induced by massive cathartic ingestion in an elderly woman without pre-existing renal dysfunction. Intern Med 2005;44(5):448-52
   PubMed Web of Science ®Google Scholar
• Schelling JR. Fatal hypermagnesemia. Clin Nephrol 2000;53(1):61-5
   PubMed Web of Science ®Google Scholar
• Gremse DA, Sacks AI, Raines S. Comparison of oral sodium phosphate to polyethylene glycol-based solution for bowel preparation for colonoscopy in children. J Pediatr Gastroenterol Nutr 1996;23(5):586-90
   PubMed Web of Science ®Google Scholar