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Expert Opinion on Drug Metabolism & Toxicology Volume 7, 2011 - Issue 3
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Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality

Jing Sun Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
,
Jonathan M Miller Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
,
Avital Beig Department of Clinical Pharmacology and School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel +972 8 6479483; +972 8 6479483; [email protected]
,
Liat Rozen Department of Clinical Pharmacology and School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel +972 8 6479483; +972 8 6479483; [email protected]
,
Gordon L Amidon Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
&
Arik Dahan Department of Clinical Pharmacology and School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel +972 8 6479483; +972 8 6479483; [email protected]
Pages 313-323 | Published online: 14 Jan 2011

Citations (14)

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Hasan M. Yildiz, Craig A. McKelvey, Patrick J. Marsac & Rebecca L. Carrier. (2015) Size selectivity of intestinal mucus to diffusing particulates is dependent on surface chemistry and exposure to lipids. Journal of Drug Targeting 23:7-8, pages 768-774.
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Muhammad Khawar Rauf, Imtiaz-ud-Din & Amin Badshah. (2014) Novel approaches to screening guanidine derivatives. Expert Opinion on Drug Discovery 9:1, pages 39-53.
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Franciszek Sączewski & Łukasz Balewski. (2013) Biological activities of guanidine compounds, 2008 – 2012 update. Expert Opinion on Therapeutic Patents 23:8, pages 965-995.
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Arik Dahan, Mustafa Khamis, Riad Agbaria & Rafik Karaman. (2012) Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach. Expert Opinion on Drug Delivery 9:8, pages 1001-1013.
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Articles from other publishers (10)

Milica Markovic, Shimon Ben‐Shabat & Arik Dahan. 2022. Targeted Drug Delivery. Targeted Drug Delivery 169 192 .
Milica Markovic, Suyash Deodhar, Jatin Machhi, Pravin Yeapuri, Maamoon Saleh, Benson J. Edagwa, Rodney Lee Mosley & Howard E. Gendelman. (2022) Prodrug Therapies for Infectious and Neurodegenerative Diseases. Pharmaceutics 14:3, pages 518.
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Arik Dahan, Daniel Porat, Milica Markovic, Moran Zur, Olga Kister & Peter Langguth. (2021) Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin. Pharmaceutics 13:11, pages 1873.
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Milica Markovic, Shimon Ben-Shabat & Arik Dahan. (2020) Prodrugs for Improved Drug Delivery: Lessons Learned from Recently Developed and Marketed Products. Pharmaceutics 12:11, pages 1031.
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Peng-Hao Hsu, Din-Chi Chiu, Kuan-Lin Wu, Pei-Shan Lee, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Keng-Chang Tsai, Ting-Jen Cheng & Jim-Min Fang. (2018) Acylguanidine derivatives of zanamivir and oseltamivir: Potential orally available prodrugs against influenza viruses. European Journal of Medicinal Chemistry 154, pages 314-323.
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Arik Dahan & Shimon Ben-Shabat. 2017. Drug Delivery. Drug Delivery 47 64 .
Arik Dahan, Ellen Zimmermann & Shimon Ben-Shabat. (2014) Modern Prodrug Design for Targeted Oral Drug Delivery. Molecules 19:10, pages 16489-16505.
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Ting-Jen R. Cheng, Steven Weinheimer, E. Bart Tarbet, Jia-Tsrong Jan, Yih-Shyun E. Cheng, Jiun-Jie Shie, Chun-Lin Chen, Chih-An Chen, Wei-Che Hsieh, Pei-Wei Huang, Wen-Hao Lin, Shi-Yun Wang, Jim-Min Fang, Oliver Yoa-Pu Hu & Chi-Huey Wong. (2012) Development of Oseltamivir Phosphonate Congeners as Anti-influenza Agents. Journal of Medicinal Chemistry 55:20, pages 8657-8670.
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Luca Casettari, Driton Vllasaliu, Jenny K.W. Lam, Mahmoud Soliman & Lisbeth Illum. (2012) Biomedical applications of amino acid-modified chitosans: A review. Biomaterials 33:30, pages 7565-7583.
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Caleb M. Bromba, Jeremy W. Mason, Michael G. Brant, Tracy Chan, Martine D. Lunke, Martin Petric, Martin J. Boulanger & Jeremy E. Wulff. (2011) The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase. Bioorganic & Medicinal Chemistry Letters 21:23, pages 7137-7141.
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