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Volume 7, Issue 3

Expert Opinion on Drug Metabolism & Toxicology

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Expert Opinion on Drug Metabolism & Toxicology, Volume 7, Issue 3 (2011)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 7, Issue 3 (2011)

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Reviews

Article

The effects of high physical activity on pharmacokinetic drug interactions

Thomas L Lenz (Associate Professor of Pharmacy Practice) PharmD MA PAPHS

Pages: 257-266

Published online: 19 Jan 2011

AbstractforThe effects of high physical activity on pharmacokinetic drug interactions | Full Text | References | PDF (219.5 KB)

595 Views
24 CrossRef citations
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Article

The effect of grapefruit juice on drug disposition

Michael J Hanley PharmD, Paul Cancalon PhD, Wilbur W Widmer PhD & David J Greenblatt MD

Pages: 267-286

Published online: 22 Jan 2011

AbstractforThe effect of grapefruit juice on drug disposition | Full Text | References | PDF (556.6 KB)

1095 Views
148 CrossRef citations
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Article

Quantitative knowledge-based analysis in compound safety assessment

Svetlana Bureeva & Yuri Nikolsky

Pages: 287-298

Published online: 22 Jan 2011

AbstractforQuantitative knowledge-based analysis in compound safety assessment | Full Text | References | PDF (327.6 KB)

143 Views
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Article

In silico site of metabolism prediction of cytochrome P450-mediated biotransformations

Ákos Tarcsay (Research Scientist) & György M Keserű (Head of Discovery Chemistry) PhD DSc

Pages: 299-312

Published online: 04 Feb 2011

AbstractforIn silico site of metabolism prediction of cytochrome P450-mediated biotransformations | Full Text | References | PDF (503.7 KB)

539 Views
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Article

Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality

Jing Sun, Jonathan M Miller, Avital Beig, Liat Rozen, Gordon L Amidon & Arik Dahan

Pages: 313-323

Published online: 14 Jan 2011

AbstractforMechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality | Full Text | References | PDF (438.7 KB)

262 Views
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Article

Genetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents

Erika K Pollex PhD & Janine R Hutson MSc

Pages: 325-339

Published online: 20 Jan 2011

AbstractforGenetic polymorphisms in placental transporters: implications for fetal drug exposure to oral antidiabetic agents | Full Text | References | PDF (307.5 KB)

175 Views
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Article

The role of cytokines in the regulation of drug disposition: extended functional pleiotropism?

Neill James Liptrott & Andrew Owen

Pages: 341-352

Published online: 08 Feb 2011

AbstractforThe role of cytokines in the regulation of drug disposition: extended functional pleiotropism? | Full Text | References | PDF (290.8 KB)

184 Views
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Article

Role of phosphatidylserine binding in tissue distribution of amine-containing basic compounds

Teruo Murakami & Ryoko Yumoto

Pages: 353-364

Published online: 19 Feb 2011

AbstractforRole of phosphatidylserine binding in tissue distribution of amine-containing basic compounds | Full Text | References | PDF (381.2 KB)

418 Views
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Drug Evaluations

Article

Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis

Jan Thöne MD & Ralf Gold MD

Pages: 365-370

Published online: 10 Feb 2011

AbstractforLaquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis | Full Text | References | PDF (226.3 KB)

262 Views
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Article

Pharmacokinetic evaluation of ambrisentan

Mitchell S Buckley PharmD BCPS FCCM, Laura M Wicks PharmD, Robin L Staib PharmD, Anna K Kirejczyk PharmD, Andrew S Varker PharmD, Jamie J Gibson PharmD & Jeremy P Feldman MD FCCP

Pages: 371-380

Published online: 08 Feb 2011

AbstractforPharmacokinetic evaluation of ambrisentan | Full Text | References | PDF (256.3 KB)

536 Views
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