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Expert Opinion on Drug Metabolism & Toxicology Volume 7, 2011 - Issue 10
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The pharmacogenetics of antimalaria artemisinin combination therapy

Rita PiedadeKarolinska Institute, Division of Pharmacogenetics, Department of Physiology and Pharmacology, Stockholm, Sweden+46 0 8 52486826; +46 0 8 33 73 27; [email protected]; University of Algarve, Institute of Biotechnology and Bioengineering, Centre of Molecular and Structural Biomedicine, Faro, Portugal
&
José Pedro GilKarolinska Institute, Division of Pharmacogenetics, Department of Physiology and Pharmacology, Stockholm, Sweden+46 0 8 52486826; +46 0 8 33 73 27; [email protected]; University of Algarve, Institute of Biotechnology and Bioengineering, Centre of Molecular and Structural Biomedicine, Faro, Portugal; Binghamton University, Department of Anthropology, Laboratory of Molecular Anthropology and Health, Binghamton, NY, USA
Pages 1185-1200 | Published online: 08 Sep 2011

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Karol J Marwa, Anthony Kapesa, Erasmus Kamugisha & Göte Swedberg. (2023) The Influence of Cytochrome P450 Polymorphisms on Pharmacokinetic Profiles and Treatment Outcomes Among Malaria Patients in Sub-Saharan Africa: A Systematic Review. Pharmacogenomics and Personalized Medicine 16, pages 449-461.
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Leyre Pernaute-Lau, Mahamadou Camara, Taís Nóbrega de Sousa, Ulrika Morris, Marcelo Urbano Ferreira & José Pedro Gil. (2022) An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malaria. Expert Opinion on Drug Metabolism & Toxicology 18:1, pages 39-59.
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Articles from other publishers (19)

Karol J Marwa, Anthony C Liwa, Eveline T Konje, Stanley Mwita, Erasmus Kamugisha & Göte Swedberg. (2022) Lumefantrine plasma concentrations in uncontrolled conditions among patients treated with artemether-lumefantrine for uncomplicated plasmodium falciparum malaria in Mwanza, Tanzania. International Journal of Infectious Diseases 123, pages 192-199.
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Meng Chen, Shu-yi Zhou, Erlinda Fabriaga, Pian-hong Zhang & Quan Zhou. (2018) Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review. Journal of Food and Drug Analysis 26:2, pages S61-S71.
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Kinanga Kiaco, António Sebastião Rodrigues, Virgílio do Rosário, José Pedro Gil & Dinora Lopes. (2017) The drug transporter ABCB1 c.3435C>T SNP influences artemether–lumefantrine treatment outcome. Malaria Journal 16:1.
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Ritah F. Mutagonda, Appolinary A. R. Kamuhabwa, Omary M. S. Minzi, Siriel N. Massawe, Muhammad Asghar, Manijeh V. Homann, Anna F?rnert & Eleni Aklillu. (2017) Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women. Malaria Journal 16:1.
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Karin Vos, Carlotta Lo Sciuto, Rita Piedade, Michael Ashton, Anders Björkman, Billy Ngasala, Andreas Mårtensson & José Pedro Gil. (2017) MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy . Pharmacogenomics 18:10, pages 981-985.
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E. Elliot, T. Mahungu & A. Owen. 2017. Genetics and Evolution of Infectious Diseases. Genetics and Evolution of Infectious Diseases 435 457 .
. 2016. Molecular Microbiology. Molecular Microbiology 613 633 .
Patricia R. Slev & David R. Hillyard. 2016. Molecular Pathology in Clinical Practice. Molecular Pathology in Clinical Practice 291 300 .
Karol J Marwa, Theresa Schmidt, Maria Sjögren, Omary MS Minzi, Erasmus Kamugisha & Göte Swedberg. (2014) Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations. Malaria Journal 13:1.
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Ar Kar Aung, David W Haas, Todd Hulgan & Elizabeth J Phillips. (2014) Pharmacogenomics of antimicrobial agents. Pharmacogenomics 15:15, pages 1903-1930.
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Dominic Mosha, Monia Guidi, Felista Mwingira, Salim Abdulla, Thomas Mercier, Laurent Arthur Decosterd, Chantal Csajka & Blaise Genton. (2014) Population Pharmacokinetics and Clinical Response for Artemether-Lumefantrine in Pregnant and Nonpregnant Women with Uncomplicated Plasmodium falciparum Malaria in Tanzania. Antimicrobial Agents and Chemotherapy 58:8, pages 4583-4592.
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Thierry Rolling, Tsiri Agbenyega, Saadou Issifou, Ayola Akim Adegnika, Justice Sylverken, Dorothee Spahlinger, Daniel Ansong, Sascha J. Z. Löhr, Gerd D. Burchard, Jürgen May, Benjamin Mordmüller, Sanjeev Krishna, Peter G. Kremsner & Jakob P. Cramer. (2014) Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria—A Double-center Prospective Study. The Journal of Infectious Diseases 209:12, pages 1921-1928.
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Sanjeev Krishna & Peter Gottfried Kremsner. (2013) Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy. Trends in Parasitology 29:7, pages 313-317.
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Alba G. Blazquez, Manuel Fernandez-Dolon, Laura Sanchez-Vicente, Alba D. Maestre, Ana B. Gomez-San Miguel, Marcelino Alvarez, Maria A. Serrano, Herwig Jansen, Thomas Efferth, Jose J.G. Marin & Marta R. Romero. (2013) Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis. Bioorganic & Medicinal Chemistry 21:14, pages 4432-4441.
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JP Gil. (2013) Malaria pharmacogenomics: return to the future. Pharmacogenomics 14:7, pages 707-710.
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Eva Maria Staehli Hodel, Chantal Csajka, Frédéric Ariey, Monia Guidi, Abdunoor Mulokozi Kabanywanyi, Socheat Duong, Laurent Arthur Decosterd, Piero Olliaro, Hans-Peter Beck & Blaise Genton. (2013) Effect of Single Nucleotide Polymorphisms in Cytochrome P450 Isoenzyme and N -Acetyltransferase 2 Genes on the Metabolism of Artemisinin-Based Combination Therapies in Malaria Patients from Cambodia and Tanzania . Antimicrobial Agents and Chemotherapy 57:2, pages 950-958.
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Ripudaman K. Bains. (2013) African variation at Cytochrome P450 genes. Evolution, Medicine, and Public Health 2013:1, pages 118-134.
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P. Byakika-Kibwika, M. Lamorde, V. Okaba-Kayom, H. Mayanja-Kizza, E. Katabira, W. Hanpithakpong, N. Pakker, T. P. C. Dorlo, J. Tarning, N. Lindegardh, P. J. de Vries, D. Back, S. Khoo & C. Merry. (2012) Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults. Journal of Antimicrobial Chemotherapy 67:5, pages 1217-1223.
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Rita Piedade, Elke Schaeffeler, Stefan Winter, Sara Asimus, Matthias Schwab, Michael Ashton, Oliver Burk & José P. Gil. (2012) PXR Variants and Artemisinin Use in Vietnamese Subjects: Frequency Distribution and Impact on the Interindividual Variability of CYP3A Induction by Artemisinin . Antimicrobial Agents and Chemotherapy 56:4, pages 2153-2157.
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