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In silico models for drug-induced liver injury – current status

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Pages 201-217 | Published online: 17 Jan 2012

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Daniel E. Di Zeo-Sánchez, Antonio Segovia-Zafra, Gonzalo Matilla-Cabello, José M. Pinazo-Bandera, Raúl J. Andrade, M. Isabel Lucena & Marina Villanueva-Paz. (2022) Modeling drug-induced liver injury: current status and future prospects. Expert Opinion on Drug Metabolism & Toxicology 18:9, pages 555-573.
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Julia Pletz, Steven J. Enoch, Diviya M. Jais, Claire L. Mellor, Gopal Pawar, James W. Firman, Judith C. Madden, Steven D. Webb, Carlos A. Tagliati & Mark T. D. Cronin. (2018) A critical review of adverse effects to the kidney: mechanisms, data sources, and in silico tools to assist prediction. Expert Opinion on Drug Metabolism & Toxicology 14:12, pages 1225-1253.
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Pan Zhao, Bin Liu & Chunya Wang. (2017) Hepatotoxicity evaluation of traditional Chinese medicines using a computational molecular model. Clinical Toxicology 55:9, pages 996-1000.
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Isoude A. Kuijper, Huan Yang, Bob Van De Water & Joost B. Beltman. (2017) Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling. Expert Opinion on Drug Metabolism & Toxicology 13:1, pages 5-17.
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X.-W. Zhu, Y.-J. Xin & Q.-H. Chen. (2016) Chemical and in vitro biological information to predict mouse liver toxicity using recursive random forests. SAR and QSAR in Environmental Research 27:7, pages 559-572.
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Qiuping Guo, Wei Yang, Baiquan Xiao, Hong Zhang, Xialing Lei, Huiyu Ou, Renan Qin & Ruomin Jin. (2015) Study on early biomarkers of zebrafish liver injury induced by acetaminophen. Toxin Reviews 34:1, pages 28-36.
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M. Hewitt, S. J. Enoch, J. C. Madden, K. R. Przybylak & M. T. D. Cronin. (2013) Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action. Critical Reviews in Toxicology 43:7, pages 537-558.
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Maiyen Tran Hawkins & James H Lewis. (2012) Latest advances in predicting DILI in human subjects: focus on biomarkers. Expert Opinion on Drug Metabolism & Toxicology 8:12, pages 1521-1530.
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Wang, Xiao, Chen & Wang. (2019) In Silico Prediction of Drug-Induced Liver Injury Based on Ensemble Classifier Method. International Journal of Molecular Sciences 20:17, pages 4106.
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