Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 2 (2012)

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Expert Opinion on Drug Metabolism & Toxicology, Volume 8, Issue 2 (2012)

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Editorial

Editorial
Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy
Jeremy K Nicholson, Jeremy R Everett & John C Lindon
Pages: 135-139
Published online: 17 Jan 2012
AbstractforLongitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy | Full Text | References | PDF (288.5 KB)
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Reviews

Review Article
Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?
Rong Deng PhD, Feng Jin PhD, Saileta Prabhu PhD & Suhasini Iyer PhD
Pages: 141-160
Published online: 17 Jan 2012
AbstractforMonoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development? | Full Text | References | PDF (440.6 KB)
  • 3604 Views
  • 106 CrossRef citations
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Review Article
Preclinical in vivo ADME studies in drug development: a critical review
Mario Pellegatti (DMPK independent scientist)
Pages: 161-172
Published online: 17 Jan 2012
AbstractforPreclinical in vivo ADME studies in drug development: a critical review | Full Text | References | PDF (502 KB)
  • 1981 Views
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Review Article
Clinically–relevant anticancer-antidepressant drug interactions
Alexandre Chan PharmD MPH BCOP BCPS, Terence Rong De Ng BSc (Pharm) (Hons) & Kevin Yi-Lwern Yap PhD ARPharmS
Pages: 173-199
Published online: 23 Dec 2011
AbstractforClinically–relevant anticancer-antidepressant drug interactions | Full Text | References | PDF (357.3 KB)
  • 670 Views
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Review Article
In silico models for drug-induced liver injury – current status
Katarzyna R Przybylak & Mark TD Cronin
Pages: 201-217
Published online: 17 Jan 2012
AbstractforIn silico models for drug-induced liver injury – current status | Full Text | References | PDF (288.2 KB)
  • 775 Views
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Review Article
The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo
Claudia V Pereira, Sashi Nadanaciva, Paulo J Oliveira & Yvonne Will PhD
Pages: 219-237
Published online: 17 Jan 2012
AbstractforThe contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo | Full Text | References | PDF (404.5 KB)
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Review Article
Standardization of pluripotent stem cell cultures for toxicity testing
Francesca Pistollato, Susanne Bremer-Hoffmann, Lyn Healy, Lesley Young & Glyn Stacey
Pages: 239-257
Published online: 17 Jan 2012
AbstractforStandardization of pluripotent stem cell cultures for toxicity testing | Full Text | References | PDF (275.5 KB)
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Drug Evaluations

Article
Pharmacokinetic evaluation of axitinib
Brian Patson, Roger B Cohen (Director) & Anthony J. Olszanski (Director)
Pages: 259-270
Published online: 17 Jan 2012
AbstractforPharmacokinetic evaluation of axitinib | Full Text | References | PDF (382.7 KB)
  • 738 Views
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Article
Pharmacokinetics of alteplase in the treatment of ischaemic stroke
Paul Acheampong (Doctor in Clinical Pharmacology) MB ChB MSc MD MRCP & Gary A Ford (Professor, Jacobson Chair of Clinical Pharmacology) MD FRCP
Pages: 271-281
Published online: 17 Jan 2012
AbstractforPharmacokinetics of alteplase in the treatment of ischaemic stroke | Full Text | References | PDF (324.1 KB)
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