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Preclinical in vivo ADME studies in drug development: a critical review

(DMPK independent scientist)
Pages 161-172 | Published online: 17 Jan 2012

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Jay Tibbitts, David Canter, Ryan Graff, Alison Smith & Leslie A. Khawli. (2016) Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development. mAbs 8:2, pages 229-245.
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Mario Pellegatti. (2014) The debate on animal ADME studies in drug development: an update. Expert Opinion on Drug Metabolism & Toxicology 10:12, pages 1615-1620.
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Mario Pellegatti. (2013) Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1171-1180.
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