Advanced search
Publication Cover
Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 2
Submit an article Journal homepage
1,708
Views
31
CrossRef citations to date
0
Altmetric
Drug Evaluations

Pharmacokinetics of alteplase in the treatment of ischaemic stroke

Paul AcheampongAcute Stroke Service, Newcastle Upon Tyne Hospitals NHS Foundation Trust, England, UK
, MB ChB MSc MD MRCP (Doctor in Clinical Pharmacology) &
Gary A FordNewcastle University, Institute for Ageing and Health, Stroke Research Group, Level 6 Leazes Wing, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, England, UK+0191 222 7744; +0191 282 0064; [email protected]
, MD FRCP (Professor, Jacobson Chair of Clinical Pharmacology)
Pages 271-281 | Published online: 17 Jan 2012

Citations (31)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Charles I. Mosimah, Pamela J. Murray & James W. Simpkins. (2019) Not all clots are created equal: a review of deficient thrombolysis with tissue plasminogen activator (tPA) in patients with metabolic syndrome. International Journal of Neuroscience 129:6, pages 612-618.
Read now

Articles from other publishers (30)

Priya Bindal, Vishal Kumar, Lakshay Kapil, Charan Singh & Arti Singh. (2023) Therapeutic management of ischemic stroke. Naunyn-Schmiedeberg's Archives of Pharmacology.
Crossref
Antonio De Mase, Paolo Candelaresi, Emanuele Spina, Flavio Giordano, Stefano Barbato, Giovanna Servillo, Elio Prestipino, Alessandra Fasolino, Gianluigi Guarnieri, Giuseppe Leone, Massimo Muto, Mario Muto & Vincenzo Andreone. (2023) Intra-Arterial Thrombolysis to Improve Final Thrombolysis in Cerebral Infarction Score after Thrombectomy: A Case-Series Analysis. Neurointervention 18:2, pages 123-128.
Crossref
Shahideh Amini, Aysa Rezabakhsh, Javad Hashemi, Fatemeh Saghafi, Hossein Azizi, Antoni Sureda, Solomon Habtemariam, Hamid Reza Khayat Kashani, Zahra Hesari & Adeleh Sahebnasagh. (2022) Pharmacotherapy consideration of thrombolytic medications in COVID-19-associated ARDS. Journal of Intensive Care 10:1.
Crossref
Simone Savino, Tom Desmet & Jorick Franceus. (2022) Insertions and deletions in protein evolution and engineering. Biotechnology Advances 60, pages 108010.
Crossref
Bruno P. Meloni, David J. Blacker, Adam B. Edwards & Neville W. Knuckey. (2022) Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis. Journal of Thrombosis and Thrombolysis 54:1, pages 172-182.
Crossref
Dante Disharoon, Brian G. Trewyn, Paco S. Herson, David W.M. Marr & Keith B. Neeves. (2022) Breaking the fibrinolytic speed limit with microwheel co‐delivery of tissue plasminogen activator and plasminogen. Journal of Thrombosis and Haemostasis 20:2, pages 486-497.
Crossref
Dmitri Nikitin, Jan Mican, Martin Toul, David Bednar, Michaela Peskova, Patricia Kittova, Sandra Thalerova, Jan Vitecek, Jiri Damborsky, Robert Mikulik, Sarel J. Fleishman, Zbynek Prokop & Martin Marek. (2022) Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin. Computational and Structural Biotechnology Journal 20, pages 1366-1377.
Crossref
Sandra Thalerová, Michaela Pešková, Patrícia Kittová, Sumeet Gulati, Jan Víteček, Lukáš Kubala & Robert Mikulík. (2021) Effect of Apixaban Pretreatment on Alteplase-Induced Thrombolysis: An In Vitro Study. Frontiers in Pharmacology 12.
Crossref
Chayakrit Krittanawong, Joshua Hahn, Waleed Kayani & Hani Jneid. (2021) Fibrinolytic Therapy in Patients with Acute ST-elevation Myocardial Infarction. Interventional Cardiology Clinics 10:3, pages 381-390.
Crossref
M.J. Bakkum, V.L. Schouten, Y.M. Smulders, E.J. Nossent, M.A. van Agtmael & P.R. Tuinman. (2021) Accelerated treatment with rtPA for pulmonary embolism induced circulatory arrest. Thrombosis Research.
Crossref
Miguel Leal Rato, Maria José Diógenes & Ana Sebastião. 2021. Precision Medicine in Stroke. Precision Medicine in Stroke 41 69 .
Tamer Roushdy, Eman Hamid, Mai Fathy, Islam Bastawy, Hany Aref & Nevine El Nahas. (2020) Peripheral embolization following thrombolytic therapy for acute ischemic stroke—a case report. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery 56:1.
Crossref
Jade E. Kenna, Ryan S. Anderton, Neville W. Knuckey & Bruno P. Meloni. (2020) Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D. Neurochemical Research 45:5, pages 1215-1229.
Crossref
Robert Joseph Cruz Sarmiento, Jose Danilo Bengzon Diestro, Adrian Isidoro Espiritu & Maria Cristina Zarsadias San Jose. (2019) Safety and Efficacy of Repeated Thrombolysis with Alteplase in Early Recurrent Ischemic Stroke: A Systematic Review. Journal of Stroke and Cerebrovascular Diseases 28:10, pages 104290.
Crossref
Robert A. Hamilton, Mausaminben Hathidara, Syeda Dania Shujaat, Allison E. Strickland, Bradley N. Bohnstedt & Bappaditya Ray. (2019) Dasatinib Reinitiation After Poststroke Thrombolysis Associated with Symptomatic Intracerebral Hemorrhage. World Neurosurgery 125, pages 383-386.
Crossref
Boram Gu, Andris Piebalgs, Yu Huang, Colin Longstaff, Alun Hughes, Rongjun Chen, Simon Thom & Xiao Xu. (2019) Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time. Pharmaceutics 11:3, pages 111.
Crossref
Stéphane LoyauBenoit Ho-Tin-NoéMarie-Charlotte BourrienneYacine BoulaftaliMartine Jandrot-Perrus. (2018) Microfluidic Modeling of Thrombolysis. Arteriosclerosis, Thrombosis, and Vascular Biology 38:11, pages 2626-2637.
Crossref
D. Leenaerts, S. Loyau, J.C. Mertens, W. Boisseau, J.B. Michel, A.M. Lambeir, M. Jandrot‐Perrus & D. Hendriks. (2018) Carboxypeptidase U (CPU, carboxypeptidase B2, activated thrombin‐activatable fibrinolysis inhibitor) inhibition stimulates the fibrinolytic rate in different in vitro models. Journal of Thrombosis and Haemostasis 16:10, pages 2057-2069.
Crossref
Jan-Dirk Vermeij, Willeke F. Westendorp, Yvo B. Roos, Matthijs C. Brouwer, Diederik van de Beek & Paul J. Nederkoorn. (2016) Preventive Ceftriaxone in Patients with Stroke Treated with Intravenous Thrombolysis: Post Hoc Analysis of the Preventive Antibiotics in Stroke Study. Cerebrovascular Diseases 42:5-6, pages 361-369.
Crossref
Dinu Stanescu-Segall, Florian Balta & Timothy L. Jackson. (2016) Submacular hemorrhage in neovascular age-related macular degeneration: A synthesis of the literature. Survey of Ophthalmology 61:1, pages 18-32.
Crossref
Woosuk S. Hur, Nima Mazinani, X. J. David Lu, Heidi M. Britton, James R. Byrnes, Alisa S. Wolberg & Christian J. Kastrup. (2015) Coagulation factor XIIIa is inactivated by plasmin. Blood 126:20, pages 2329-2337.
Crossref
F Fabbian. (2015) Impact of Glomerular Filtration Rate on Intravenous Thrombolytic Therapy in Acute Ischemic Stroke: A Retrospective Study from a Single Italian Center. Archives of Clinical Nephrology, pages 001-006.
Crossref
Rick Gill, Elisabeth Donahey & Sean Ruland. (2015) Early Administration of Therapeutic Anticoagulation Following Intravenous Thrombolysis for Acute Cardiogenic Embolic Stroke Caused by Left Ventricular Thrombus: Case Report and Topic Review. Frontiers in Neurology 6.
Crossref
Manuel Cappellari, Giuseppe Moretto & Paolo Bovi. (2014) Repeated intravenous thrombolysis after recurrent stroke. A case series and review of the literature. Journal of the Neurological Sciences 345:1-2, pages 181-183.
Crossref
Sourabh Lahoti, Sankalp Gokhale, Louis Caplan, Patrik Michel, Yves Samson, Charlotte Rosso, Kaustubh Limaye, Archana Hinduja, Aneesh Singhal, Syed Ali, Luther Creed Pettigrew, Richard Kryscio, Nikita Dedhia, Shirish Hastak & David S. Liebeskind. (2014) Thrombolysis in Ischemic Stroke Without Arterial Occlusion at Presentation. Stroke 45:9, pages 2722-2727.
Crossref
Be'eri Niego & Robert L Medcalf. (2014) Plasmin-Dependent Modulation of the Blood–Brain Barrier: A Major Consideration during tPA-Induced Thrombolysis?. Journal of Cerebral Blood Flow & Metabolism 34:8, pages 1283-1296.
Crossref
Paul Acheampong, Margaret T. May, Gary A. Ford & Anand K. Dixit. (2014) Bolus-Infusion Delays of Alteplase during Thrombolysis in Acute Ischaemic Stroke and Functional Outcome at 3 Months. Stroke Research and Treatment 2014, pages 1-4.
Crossref
Ansaar T Rai, Jeffrey S Carpenter, Karthikram Raghuram, Thomas D Roberts, Daniel Rodgers & Gerald R Hobbs. (2013) Endovascular therapy yields significantly superior outcomes for large vessel occlusions compared with intravenous thrombolysis: is it time to randomize?. Journal of NeuroInterventional Surgery 5:5, pages 430-434.
Crossref
Han Soo YooYoung Dae KimHye Sun LeeDongbeom SongTae Jin SongByung Moon KimDong Joon KimDong Ik KimJi Hoe HeoHyo Suk Nam. (2013) Repeated Thrombolytic Therapy in Patients with Recurrent Acute Ischemic Stroke. Journal of Stroke 15:3, pages 182.
Crossref
Sohita Dhillon. (2012) Alteplase. CNS Drugs 26:10, pages 899-926.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.