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Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications

, , PharmD, PhD (Pediatric Research Fellow) , , PharmD & , PhD (Associate Professor, Director of Graduate Studies)
Pages 943-958 | Published online: 22 May 2012

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Reginald Halaby. (2015) Role of lysosomes in cancer therapy. Research and Reports in Biology 6, pages 147-155.
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Vernon LaLone, Doug Smith, Jennifer Diaz-Espinosa & Gus R. Rosania. (2023) Quantitative Raman chemical imaging of intracellular drug-membrane aggregates and small molecule drug precipitates in cytoplasmic organelles. Advanced Drug Delivery Reviews 202, pages 115107.
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Irena Loryan & Margareta Hammarlund-Udenaes. 2022. Drug Delivery to the Brain. Drug Delivery to the Brain 389 436 .
Alan Talevi & Carolina L. Bellera. 2022. The ADME Encyclopedia. The ADME Encyclopedia 326 333 .
Shu-Hui Wu, Chia-Chu Hsieh, Szu-Chun Hsu, Ming Yao, Jong-Kai Hsiao, Shih-Wei Wang, Chih-Peng Lin & Dong-Ming Huang. (2021) RBC-derived vesicles as a systemic delivery system of doxorubicin for lysosomal-mitochondrial axis-improved cancer therapy. Journal of Advanced Research 30, pages 185-196.
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Barbara Lenz, Andreas Brink, Michael J Mihatsch, Bernd Altmann, Urs Niederhauser, Bernd Steinhuber, Nicole Wyttenbach & Holger Fischer. (2021) Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt. Toxicological Sciences 180:2, pages 383-394.
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Alan Talevi & Carolina L. Bellera. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 9 .
Ulf Norinder, Astrud Tuck, Kalle Norgren & Vesna Munic Kos. (2020) Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19. Biomedicine & Pharmacotherapy 130, pages 110582.
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Susana Llanos, Diego Megias, Carmen Blanco-Aparicio, Elena Hernández-Encinas, Miguel Rovira, Federico Pietrocola & Manuel Serrano. (2019) Lysosomal trapping of palbociclib and its functional implications. Oncogene 38:20, pages 3886-3902.
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Anne M. Filppula, Rezvan Parvizi, André Mateus, Pawel Baranczewski & Per Artursson. (2019) Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations. Scientific Reports 9:1.
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Miguel Angel Merlos Rodrigo, Hana Buchtelova, Vivian de los Rios, José Ignacio Casal, Tomas Eckschlager, Jan Hrabeta, Marie Belhajova, Zbynek Heger & Vojtech Adam. (2018) Proteomic Signature of Neuroblastoma Cells UKF-NB-4 Reveals Key Role of Lysosomal Sequestration and the Proteasome Complex in Acquiring Chemoresistance to Cisplatin. Journal of Proteome Research 18:3, pages 1255-1263.
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Daniel de Klerk, Richard Honeywell, Gerrit Jansen & Godefridus Peters. (2018) Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance. Cancers 10:12, pages 503.
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Andrea Treyer, André Mateus, Jacek R Wiśniewski, Hinnerk Boriss, Pär Matsson & Per Artursson. (2018) Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids. Molecular Pharmaceutics 15:6, pages 2224-2233.
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B. Lenz, A. Braendli-Baiocco, J. Engelhardt, P. Fant, H. Fischer, S. Francke, R. Fukuda, S. Gröters, T. Harada, H. Harleman, W. Kaufmann, S. Kustermann, T. Nolte, X. Palazzi, G. Pohlmeyer-Esch, A. Popp, A. Romeike, A. Schulte, B. Silva Lima, L. Tomlinson, J. Willard, C. E. Wood & M. Yoshida. (2018) Characterizing Adversity of Lysosomal Accumulation in Nonclinical Toxicity Studies: Results from the 5th ESTP International Expert Workshop. Toxicologic Pathology 46:2, pages 224-246.
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António Matos, Filipa Mendes, Andreia Valente, Tânia Morais, Ana Isabel Tomaz, Philippe Zinck, Maria Helena Garcia, Manuel Bicho & Fernanda Marques. 2018. Ruthenium Complexes. Ruthenium Complexes 201 219 .
Tehetina Woldemichael & Gus R. Rosania. (2017) The physiological determinants of drug-induced lysosomal stress resistance. PLOS ONE 12:11, pages e0187627.
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Frauke Assmus, J. Brian Houston & Aleksandra Galetin. (2017) Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs. European Journal of Pharmaceutical Sciences 109, pages 419-430.
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Selvi C. Ersoy, Douglas M. Heithoff, Lucien BarnesVV, Geneva K. Tripp, John K. House, Jamey D. Marth, Jeffrey W. Smith & Michael J. Mahan. (2017) Correcting a Fundamental Flaw in the Paradigm for Antimicrobial Susceptibility Testing. EBioMedicine 20, pages 173-181.
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Ayşe UfukFrauke AssmusLaura FrancisJonathan PlumbValeriu Damian, Michael Gertz, J. Brian HoustonAleksandra Galetin. (2017) In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages . Molecular Pharmaceutics 14:4, pages 1033-1046.
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Tânia S Morais, Andreia Valente, Ana Isabel Tomaz, Fernanda Marques & Maria Helena Garcia. (2016) Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds. Future Medicinal Chemistry 8:5, pages 527-544.
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Benny Zhitomirsky & Yehuda G. Assaraf. (2016) Lysosomes as mediators of drug resistance in cancer. Drug Resistance Updates 24, pages 23-33.
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Ayşe Ufuk, Graham Somers, J. Brian Houston & Aleksandra Galetin. (2015) In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. Pharmaceutical Research 32:12, pages 3937-3951.
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Marlyn Laksitorini, Vivitri D Prasasty, Paul K Kiptoo & Teruna J Siahaan. (2014) Pathways and progress in improving drug delivery through the intestinal mucosa and blood–brain barriers. Therapeutic Delivery 5:10, pages 1143-1163.
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Irena Loryan, Vikash Sinha, Claire Mackie, Achiel Van Peer, Wilhelmus Drinkenburg, An Vermeulen, Denise Morrison, Mario Monshouwer, Donald Heald & Margareta Hammarlund-Udenaes. (2014) Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery. Pharmaceutical Research 31:8, pages 2203-2219.
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Irena Loryan & Margareta Hammarlund-Udenaes. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain 271 316 .
Leonor Côrte-Real, António P. Matos, Irina Alho, Tânia S. Morais, Ana Isabel Tomaz, Maria Helena Garcia, Isabel Santos, Manuel P. Bicho & Fernanda Marques. (2013) Cellular Uptake Mechanisms of an Antitumor Ruthenium Compound: The Endosomal/Lysosomal System as a Target for Anticancer Metal-Based Drugs. Microscopy and Microanalysis 19:5, pages 1122-1130.
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André Mateus, Pär Matsson & Per Artursson. (2013) Rapid Measurement of Intracellular Unbound Drug Concentrations. Molecular Pharmaceutics 10:6, pages 2467-2478.
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Faraz Kazmi, Tiffini Hensley, Chad Pope, Ryan S. Funk, Greg J. Loewen, David B. Buckley & Andrew Parkinson. (2013) Lysosomal Sequestration (Trapping) of Lipophilic Amine (Cationic Amphiphilic) Drugs in Immortalized Human Hepatocytes (Fa2N-4 Cells). Drug Metabolism and Disposition 41:4, pages 897-905.
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