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Expert Opinion on Drug Metabolism & Toxicology Volume 8, 2012 - Issue 8
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The early estimation of circulating drug metabolites in humans

Debra Luffer-AtlasDepartment of Drug Disposition, Lilly Research Laboratories, Indianapolis, IN 46285, USA+1 317 277 3851; +1 317 433 6432; [email protected]
, PhD
Pages 985-997 | Published online: 10 Jun 2012

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Read on this site (2)

Debra Luffer-Atlas & Aisar Atrakchi. (2017) A decade of drug metabolite safety testing: industry and regulatory shared learning. Expert Opinion on Drug Metabolism & Toxicology 13:9, pages 897-900.
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Mario Pellegatti. (2014) The debate on animal ADME studies in drug development: an update. Expert Opinion on Drug Metabolism & Toxicology 10:12, pages 1615-1620.
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Articles from other publishers (8)

Debra Luffer-Atlas, R. Scott Obach & Dennis A. Smith. (2023) A MIST conception: what has been learned from twenty years of human metabolite safety assessment?. Medicinal Chemistry Research.
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Yong Gong, Jie Chen, Yifan Shi, Heng-Keang Lim, Naidong Weng & Rhys Salter. (2017) Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application. Analytical Chemistry 89:16, pages 8399-8404.
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Jingmin Shi, Cen Xie, Hongbing Liu, Kristopher W. Krausz, Carole A. Bewley, Suhui Zhang, Liming Tang, Zhijun Zhou & Frank J. Gonzalez. (2016) Metabolism and Bioactivation of Fluorochloridone, a Novel Selective Herbicide, in Vivo and in Vitro. Environmental Science & Technology 50:17, pages 9652-9660.
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I. J. Martin, S. E. Hill, J. A. Baker, S. V. Deshmukh & E. F. Mulrooney. (2016) A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose. Drug Metabolism and Disposition 44:8, pages 1435-1440.
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J. Iegre, M. A. Hayes, R. A. Thompson, L. Weidolf & E. M. Isin. (2016) Database Extraction of Metabolite Information of Drug Candidates: Analysis of 27 AstraZeneca Compounds with Human Absorption, Distribution, Metabolism, and Excretion Data. Drug Metabolism and Disposition 44:5, pages 732-740.
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Thomas A. Baillie. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 202 226 .
Ann Aurell Holmberg, Anja Ekdahl & Lars Weidolf. (2014) Systemic Exposure to the Metabolites of Lesogaberan in Humans and Animals: A Case Study of Metabolites in Safety Testing. Drug Metabolism and Disposition 42:6, pages 1016-1021.
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Johanna Haglund, Magnus M. Halldin, Åsa Brunnström, Göran Eklund, Antti Kautiainen, Anna Sandholm & Suzanne L. Iverson. (2014) Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase. Chemical Research in Toxicology 27:4, pages 601-610.
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