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Reconstructed skin models as emerging tools for drug absorption studies

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Pages 1255-1263 | Published online: 05 Jul 2013

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Eman Abd, Shereen A Yousef, Michael N Pastore, Krishna Telaprolu, Yousuf H Mohammed, Sarika Namjoshi, Jeffrey E Grice & Michael S Roberts. (2016) Skin models for the testing of transdermal drugs. Clinical Pharmacology: Advances and Applications 8, pages 163-176.
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Articles from other publishers (44)

He Zhao, Zhaozeng Chen, Xingchen Kang, Bo Yang, Peihua Luo, Hui Li & Qiaojun He. (2023) The frontline of alternatives to animal testing: novel in vitro skin model application in drug development and evaluation . Toxicological Sciences 196:2, pages 152-169.
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Katharina KaiserJens Ahm SørensenJonathan Brewer. (2023) Novel chip for applying mechanical forces on human skin models under dynamic culture conditions.. Tissue Engineering Part C: Methods.
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Hichem Kichou, Franck Bonnier, Yuri Dancik, Joudi Bakar, Rime Michael-Jubeli, Amanda C. Caritá, Xavier Perse, Martin Soucé, Laetitia Rapetti, Ali Tfayli, Igor Chourpa & Emilie Munnier. (2023) Strat-M® positioning for skin permeation studies: A comparative study including EpiSkin® RHE, and human skin. International Journal of Pharmaceutics 647, pages 123488.
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Ornella Urzì, Roberta Gasparro, Elisa Costanzo, Angela De Luca, Gianluca Giavaresi, Simona Fontana & Riccardo Alessandro. (2023) Three-Dimensional Cell Cultures: The Bridge between In Vitro and In Vivo Models. International Journal of Molecular Sciences 24:15, pages 12046.
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William Mason, Albert M. Levin, Katherine Buhl, Takahiro Ouchi, Bianca Parker, Jessica Tan, Nureddin Ashammakhi & Lamont R Jones. (2023) Translational Research Techniques for the Facial Plastic Surgeon: An Overview. Facial Plastic Surgery.
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Hichem Kichou, Amanda C. Caritá, Guillaume Gillet, Lahcen Bougassaa, Xavier Perse, Martin Soucé, Laurianne Gressin, Igor Chourpa, Franck Bonnier & Emilie Munnier. (2023) Efficiency of emulsifier‐free emulsions in delivering caffeine and α‐tocopherol to human skin. International Journal of Cosmetic Science 45:3, pages 329-344.
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Nicole Esposto Biondo, Débora Fretes Argenta & Thiago Caon. (2023) A Comparative Analysis of Biological and Synthetic Skin Models for Drug Transport Studies. Pharmaceutical Research 40:5, pages 1209-1221.
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Tsze Yin Tan, Hai Ning Wee, Lye Siang Lee, Hong Yu Han, Chee Tian Ong, M. Neela, Jeyakumar Masilamani, Thang T. Phan & Jianhong Ching. (2022) Sensitive ex vivo human skin transdermal assay testing method with mass spectrometric analysis for cosmetics application. Journal of Cosmetic Dermatology 21:11, pages 6124-6128.
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Jeanett Holzknecht, Sandrine Dubrac, Sarah Hedtrich, László Galgóczy & Florentine Marx. (2022) Small, Cationic Antifungal Proteins from Filamentous Fungi Inhibit Candida albicans Growth in 3D Skin Infection Models . Microbiology Spectrum 10:3.
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Ewa Olkowska & Goran Gržinić. (2022) Skin models for dermal exposure assessment of phthalates. Chemosphere 295, pages 133909.
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Hichem Kichou, Yuri Dancik, Christophe Eklouh‐Molinier, Nicolas Huang, Martin Soucé, Laurianne Gressin, Guillaume Gillet, Igor Chourpa, Emilie Munnier & Franck Bonnier. (2022) Highlighting the efficiency of ultrasound‐based emulsifier‐free emulsions to penetrate reconstructed human skin. International Journal of Cosmetic Science 44:2, pages 262-270.
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Fátima Pinto, Luis P. Fonseca & Dragana P. C. de Barros. 2022. Nanotoxicology in Safety Assessment of Nanomaterials. Nanotoxicology in Safety Assessment of Nanomaterials 83 114 .
Maddalena Sguizzato, Francesca Ferrara, Paolo Mariani, Alessia Pepe, Rita Cortesi, Nicolas Huang, Fanny Simelière, Paola Boldrini, Anna Baldisserotto, Giuseppe Valacchi & Elisabetta Esposito. (2021) “Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation. Pharmaceutics 13:8, pages 1124.
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Shibani Supe & Pooja Takudage. (2020) Methods for evaluating penetration of drug into the skin: A review. Skin Research and Technology 27:3, pages 299-308.
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Marcel Nani Leite, Juliana Santos Rosa Viegas, Fabíola Silva Garcia Praça, Natália Aparecida de Paula, Leandra Náira Zambelli Ramalho, Maria Vitória Lopes Badra Bentley & Marco Andrey Cipriani Frade. (2021) Ex vivo model of human skin (hOSEC) for assessing the dermatokinetics of the anti-melanoma drug Dacarbazine. European Journal of Pharmaceutical Sciences 160, pages 105769.
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Sani Sabo & Laura J. Waters. (2021) Poly(dimethylsiloxane): A Sustainable Human Skin Alternative for Transdermal Drug Delivery Prediction. Journal of Pharmaceutical Sciences 110:3, pages 1018-1024.
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Yuri Dancik, Hichem Kichou, Christophe Eklouh-Molinier, Martin Soucé, Emilie Munnier, Igor Chourpa & Franck Bonnier. (2020) Freezing Weakens the Barrier Function of Reconstructed Human Epidermis as Evidenced by Raman Spectroscopy and Percutaneous Permeation. Pharmaceutics 12:11, pages 1041.
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Rhiannon N. Hardwick, Catherine J. Betts, Jessica Whritenour, Radhakrishna Sura, Maike Thamsen, Elad H. Kaufman & Kristin Fabre. (2020) Drug-induced skin toxicity: gaps in preclinical testing cascade as opportunities for complex in vitro models and assays . Lab on a Chip 20:2, pages 199-214.
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Chihiro Naito, Tomoko Yamaguchi, Hidemasa Katsumi, Suyo Kimura, Sachi Kamei, Masaki Morishita, Toshiyasu Sakane, Kenji Kawabata & Akira Yamamoto. (2019) Utility of Three-Dimensional Skin From Human-Induced Pluripotent Stem Cells as a Tool to Evaluate Transdermal Drug Permeation. Journal of Pharmaceutical Sciences 108:11, pages 3524-3527.
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Alberto Passi & Davide Vigetti. (2019) Hyaluronan as tunable drug delivery system. Advanced Drug Delivery Reviews 146, pages 83-96.
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Hyeongmin Kim, Sukkyun Jung, Sooho Yeo, Dohyun Kim, Young Chae Na, Gyiae Yun & Jaehwi Lee. (2019) Characteristics of Skin Deposition of Itraconazole Solubilized in Cream Formulation. Pharmaceutics 11:4, pages 195.
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Alessandro Poma, Yiwen Pei, Lorena Ruiz‐Perez, Loris Rizzello & Giuseppe Battaglia. 2002. Encyclopedia of Polymer Science and Technology. Encyclopedia of Polymer Science and Technology 1 43 .
Hanna Niehues, Joke A. Bouwstra, Abdoelwaheb El Ghalbzouri, Johanna M. Brandner, Patrick L. J. M. Zeeuwen & Ellen H. van den Bogaard. (2018) 3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function. Experimental Dermatology 27:5, pages 501-511.
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Samad Ahadian, Robert Civitarese, Dawn Bannerman, Mohammad Hossein Mohammadi, Rick Lu, Erika Wang, Locke Davenport-Huyer, Ben Lai, Boyang Zhang, Yimu Zhao, Serena Mandla, Anastasia Korolj & Milica Radisic. (2018) Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies. Advanced Healthcare Materials 7:2, pages 1700506.
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Nadine Döge, Araks Avetisyan, Sabrina Hadam, Eva Katharina Barbosa Pfannes, Fiorenza Rancan, Ulrike Blume-Peytavi & Annika Vogt. (2017) Assessment of skin barrier function and biochemical changes of ex vivo human skin in response to physical and chemical barrier disruption. European Journal of Pharmaceutics and Biopharmaceutics 116, pages 138-148.
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Candice Csongradi, Jeanetta du Plessis, Marique Elizabeth Aucamp & Minja Gerber. (2017) Topical delivery of roxithromycin solid-state forms entrapped in vesicles. European Journal of Pharmaceutics and Biopharmaceutics 114, pages 96-107.
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Leonie Wallmeyer, Kristina Dietert, Michaela Sochorová, Achim D. Gruber, Burkhard Kleuser, Kateřina Vávrová & Sarah Hedtrich. (2017) TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents. Scientific Reports 7:1.
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Kay Strüver, Wolfgang Friess & Sarah Hedtrich. (2017) Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models. Skin Pharmacology and Physiology 30:4, pages 180-189.
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Viktoria Planz, Claus-Michael Lehr & Maike Windbergs. (2016) In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery. Journal of Controlled Release 242, pages 89-104.
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Ahmad Rezaei Kolahchi, Nima Khadem Mohtaram, Hassan Pezeshgi Modarres, Mohammad Mohammadi, Armin Geraili, Parya Jafari, Mohsen Akbari & Amir Sanati-Nezhad. (2016) Microfluidic-Based Multi-Organ Platforms for Drug Discovery. Micromachines 7:9, pages 162.
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C. Mathes, A. Melero, P. Conrad, T. Vogt, L. Rigo, D. Selzer, W.A. Prado, C. De Rossi, T.M. Garrigues, S. Hansen, S.S. Guterres, A.R. Pohlmann, R.C.R. Beck, C.-M. Lehr & U.F. Schaefer. (2016) Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects. Journal of Controlled Release 223, pages 207-214.
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Leonie Wallmeyer, Dominika Lehnen, Natascha Eger, Michaela Sochorová, Lukáš Opálka, Andrej Kováčik, Kateřina Vávrová & Sarah Hedtrich. (2015) Stimulation of PPARα normalizes the skin lipid ratio and improves the skin barrier of normal and filaggrin deficient reconstructed skin. Journal of Dermatological Science 80:2, pages 102-110.
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M. Khiao In, L. Wallmeyer, S. Hedtrich, K.C. Richardson, J. Plendl & S. Kaessmeyer. (2015) The effect of endothelialization on the epidermal differentiation in human three-dimensional skin constructs – A morphological study. Clinical Hemorheology and Microcirculation 61:2, pages 157-174.
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Bing Cai, Wei Xia, Susanne Bredenberg, Hao Li & Håkan Engqvist. (2015) Bioceramic microneedles with flexible and self-swelling substrate. European Journal of Pharmaceutics and Biopharmaceutics 94, pages 404-410.
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Madeleine Witting, Maria Molina, Katja Obst, Roswitha Plank, Katja Martina Eckl, Hans Christian Hennies, Marcelo Calderón, Wolfgang Frieß & Sarah Hedtrich. (2015) Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules. Nanomedicine: Nanotechnology, Biology and Medicine 11:5, pages 1179-1187.
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Coralie DumontPilar PrietoDavid AsturiolAndrew Worth. (2015) Review of the Availability of In Vitro and In Silico Methods for Assessing Dermal Bioavailability . Applied In Vitro Toxicology 1:2, pages 147-164.
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Madeleine Witting, Alexander Boreham, Robert Brodwolf, Kateřina Vávrová, Ulrike Alexiev, Wolfgang Friess & Sarah Hedtrich. (2015) Interactions of Hyaluronic Acid with the Skin and Implications for the Dermal Delivery of Biomacromolecules. Molecular Pharmaceutics 12:5, pages 1391-1401.
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Madeleine Witting, Katja Obst, Markus Pietzsch, Wolfgang Friess & Sarah Hedtrich. (2015) Feasibility study for intraepidermal delivery of proteins using a solid microneedle array. International Journal of Pharmaceutics 486:1-2, pages 52-58.
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C. Stiefel & W. Schwack. (2015) Photoprotection in changing times - UV filter efficacy and safety, sensitization processes and regulatory aspects. International Journal of Cosmetic Science 37:1, pages 2-30.
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Gary P. Moss, Darren R. Gullick & Simon C. WilkinsonGary P. Moss, Darren R. Gullick & Simon C. Wilkinson. 2015. Predictive Methods in Percutaneous Absorption. Predictive Methods in Percutaneous Absorption 91 102 .
S. Rosenberger, A. Dick, S. Latzko, I. Hausser, H.-J. Stark, M. Rauh, H. Schneider & P. Krieg. (2014) A mouse organotypic tissue culture model for autosomal recessive congenital ichthyosis. British Journal of Dermatology 171:6, pages 1347-1357.
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Ali Tfayli, Franck Bonnier, Zeineb Farhane, Danielle Libong, Hugh J. Byrne & Arlette Baillet‐Guffroy. (2014) Comparison of structure and organization of cutaneous lipids in a reconstructed skin model and human skin: spectroscopic imaging and chromatographic profiling. Experimental Dermatology 23:6, pages 441-443.
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Anastasia Petrova, Anna Celli, Laureen Jacquet, Dimitra Dafou, Debra Crumrine, Melanie Hupe, Matthew Arno, Carl Hobbs, Aleksandra Cvoro, Panagiotis Karagiannis, Liani Devito, Richard Sun, Lillian C. Adame, Robert Vaughan, John A. McGrath, Theodora M. Mauro & Dusko Ilic. (2014) 3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. Stem Cell Reports 2:5, pages 675-689.
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Atul Nayak, Diganta B. Das & Goran T. Vladisavljević. (2013) Microneedle-Assisted Permeation of Lidocaine Carboxymethylcellulose with Gelatine Co-polymer Hydrogel. Pharmaceutical Research 31:5, pages 1170-1184.
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