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Expert Opinion on Drug Metabolism & Toxicology Volume 11, 2015 - Issue 5
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Review

Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters

Candido G Da SilvaVU University Medical Center, Department of Medical Oncology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
,
Richard J HoneywellVU University Medical Center, Department of Medical Oncology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
,
Henk DekkerVU University Medical Center, Department of Medical Oncology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
&
Godefridus J PetersVU University Medical Center, Department of Medical Oncology, PO Box 7057, 1007 MB Amsterdam, The Netherlands+31 20 4442633; +31 20 4443844; [email protected]
, PhD (Professor)
Pages 703-717 | Published online: 29 Jan 2015

Citations (15)

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Read on this site (2)

Ittai B Muller, Adrianus J De Langen, Richard J Honeywell, Elisa Giovannetti & Godefridus J Peters. (2016) Overcoming crizotinib resistance in ALK-rearranged NSCLC with the second-generation ALK-inhibitor ceritinib. Expert Review of Anticancer Therapy 16:2, pages 147-157.
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Godefridus J Peters & Richard J Honeywell. (2015) Drug transport and metabolism of novel anticancer drugs. Expert Opinion on Drug Metabolism & Toxicology 11:5, pages 661-663.
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Articles from other publishers (13)

Fangrui Xiu, Magdalena Rausch, Zhibo Gai, Shanshan Su, Shijun Wang & Michele Visentin. (2023) The Role of Organic Cation Transporters in the Pharmacokinetics, Pharmacodynamics and Drug–Drug Interactions of Tyrosine Kinase Inhibitors. International Journal of Molecular Sciences 24:3, pages 2101.
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David Malnoë, Olivier Fardel & Pascal Le Corre. (2022) Involvement of Transporters in Intestinal Drug–Drug Interactions of Oral Targeted Anticancer Drugs Assessed by Changes in Drug Absorption Time. Pharmaceutics 14:11, pages 2493.
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Richard J. Honeywell, Ietje Kathmann, Elisa Giovannetti, Carmelo Tibaldi, Egbert F. Smit, Maria N. Rovithi, Henk M.W. Verheul & Godefridus J. Peters. (2020) Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance. Cancers 12:11, pages 3322.
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Nele Van Der Steen, Kaylee Keller, Henk Dekker, Letizia Porcelli, Richard J. Honeywell, Johan Van Meerloo, René J. P. Musters, Ietje Kathmann, Adam E. Frampton, Daniel S. K. Liu, Rob Ruijtenbeek, Christian Rolfo, Patrick Pauwels, Elisa Giovannetti & Godefridus J. Peters. (2020) Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function. Journal of Cellular Physiology 235:11, pages 8085-8097.
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Dominique A. Garrison, Zahra Talebi, Eric D. Eisenmann, Alex Sparreboom & Sharyn D. Baker. (2020) Role of OATP1B1 and OATP1B3 in Drug-Drug Interactions Mediated by Tyrosine Kinase Inhibitors. Pharmaceutics 12:9, pages 856.
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Cordula Stillhart, Katarina Vučićević, Patrick Augustijns, Abdul W. Basit, Hannah Batchelor, Talia R. Flanagan, Ina Gesquiere, Rick Greupink, Daniel Keszthelyi, Mikko Koskinen, Christine M. Madla, Christophe Matthys, Goran Miljuš, Miriam G. Mooij, Neil Parrott, Anna-Lena Ungell, Saskia N. de Wildt, Mine Orlu, Sandra Klein & Anette Müllertz. (2020) Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review. European Journal of Pharmaceutical Sciences 147, pages 105280.
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Murányi, Varga, Gyulavári, Pénzes, Németh, Csala, Pethő, Csámpai, Halmos, Peták & Vályi-Nagy. (2019) Novel Crizotinib–GnRH conjugates revealed the significance of lysosomal trapping in GnRH-based drug delivery systems. International Journal of Molecular Sciences 20:22, pages 5590.
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Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Batoul Farran, Saikrishna Lakkakula, Sujatha Peela, Nagendra Sastry Yarla, Pallaval Veera Bramhachari, Mohammad Amjad Kamal, Madhu Sudhana Saddala & Ganji Purnachandra Nagaraju. (2019) Small molecule tyrosine kinase inhibitors and pancreatic cancer—Trials and troubles. Seminars in Cancer Biology 56, pages 149-167.
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Daniel de Klerk, Richard Honeywell, Gerrit Jansen & Godefridus Peters. (2018) Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance. Cancers 10:12, pages 503.
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Paola Perego, Georg Hempel, Stig Linder, Tracey D. Bradshaw, Annette K. Larsen, Godefridus J. Peters & Roger M. Phillips. (2017) Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group. Cancer Chemotherapy and Pharmacology 81:3, pages 427-441.
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C. G. Da Silva, Godefridus J. Peters, Ferry Ossendorp & Luis J. Cruz. (2017) The potential of multi-compound nanoparticles to bypass drug resistance in cancer. Cancer Chemotherapy and Pharmacology 80:5, pages 881-894.
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Zhiyong Yan, Zonghua Wang, Zhuang Miao & Yang Liu. (2015) Dye-Sensitized and Localized Surface Plasmon Resonance Enhanced Visible-Light Photoelectrochemical Biosensors for Highly Sensitive Analysis of Protein Kinase Activity. Analytical Chemistry 88:1, pages 922-929.
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Suneet Shukla, Atish Patel & Suresh V. Ambudkar. 2016. ABC Transporters - 40 Years on. ABC Transporters - 40 Years on 227 272 .

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