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Review

Physiologically based pharmacokinetic and pharmacodynamic modeling in cancer drug development: status, potential and gaps

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Letizia Carrara, Silvia Maria Lavezzi, Elisa Borella, Giuseppe De Nicolao, Paolo Magni & Italo Poggesi. (2017) Current mathematical models for cancer drug discovery. Expert Opinion on Drug Discovery 12:8, pages 785-799.
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Fatih M. Uckun & Sanjive Qazi. 2020. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 343 360 .
Nathalie Rioux, Sherri Smith, Manav Korpal, Morgan O’Shea, Sudeep Prajapati, Guo Zhu Zheng, Markus Warmuth & Peter G. Smith. (2018) Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA). Cancer Chemotherapy and Pharmacology 83:1, pages 151-160.
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Fatih M. Uckun & Sanjive Qazi. 2018. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 1 18 .
Teerachat Saeheng, Kesara Na-Bangchang & Juntra Karbwang. (2018) Utility of physiologically based pharmacokinetic (PBPK) modeling in oncology drug development and its accuracy: a systematic review. European Journal of Clinical Pharmacology 74:11, pages 1365-1376.
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Panteleimon D. Mavroudis, Helen E. Hermes, Donato Teutonico, Thomas G. Preuss & Sebastian Schneckener. (2018) Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits. PLOS ONE 13:3, pages e0194294.
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Arthur Volovetsky, Vladimir Sukhov, Irina Balalaeva, Varvara Dudenkova, Natalia Shilyagina, Аlexey Feofanov, Anastasija Efremenko, Mikhail Grin, Andrey Mironov, Igor Sivaev, Vladimir Bregadze & Anna Maslennikova. (2017) Pharmacokinetics of Chlorin e6-Cobalt Bis(Dicarbollide) Conjugate in Balb/c Mice with Engrafted Carcinoma. International Journal of Molecular Sciences 18:12, pages 2556.
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L Kuepfer, C Niederalt, T Wendl, J‐F Schlender, S Willmann, J Lippert, M Block, T Eissing & D Teutonico. (2016) Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model. CPT: Pharmacometrics & Systems Pharmacology 5:10, pages 516-531.
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N. Rioux & N. J. Waters. (2016) Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development. Drug Metabolism and Disposition 44:7, pages 934-943.
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Anne M. Comi, Mustafa Sahin, Adrienne Hammill, Emma H. Kaplan, Csaba Juhász, Paula North, Karen L. Ball, Alex V. Levin, Bernard Cohen, Jill Morris, Warren Lo, E. Steve Roach, Nicolas Abreu, Maria Acosta, Karen L. Ball, Audina Berrocal, Joyce Bischoff, James Brodie, Craig Burkhart, Bernard Cohen, Anne M. Comi, Gosia Dymerska, David Eckstein, Mabel Enriquez-Algeciras, Joshua Ewen, Brian Fisher, Sharon Freedman, Emily Germain-Lee, Roy Geronemus, Michael Gold, Rashmi Gopal-Srivastava, Adrienne Hammill, Adelaide Hebert, Lan Huang, Henry Jampel, Csaba Juhász, Emma H. Kaplan, Matsanga Kaseka, Yasmine Kirkorian, Eric Kossoff, Alex V. Levin, Doris Lin, Warren Lo, Jeffrey Loeb, Kalyani Marathe, Doug Marchuk, Alice Mead, Scott Mellis, Jill Morris, Timothy Murray, Paula North, Thuy Phung, Anna Pinto, Kate Puttgen, Nancy Ratner, Jennifer Reeve, Steve Roach, Mustafa Sahin, Charles Swindell, Hung Tseng, Miriya Tune, Sarah Wetzel-Strong, Monica White & Vicky Whittemore. (2016) Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research. Pediatric Neurology 58, pages 12-24.
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IOANNIS S. VIZIRIANAKIS, GEORGE A. MYSTRIDIS, KONSTANTINOS AVGOUSTAKIS, DIMITRIOS G. FATOUROS & MARIOS SPANAKIS. (2016) Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review). Oncology Reports 35:4, pages 1891-1904.
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Christoph Thiel, Ute Hofmann, Ahmed Ghallab, Rolf Gebhardt, Jan G. Hengstler & Lars Kuepfer. (2016) Towards knowledge-driven cross-species extrapolation. Drug Discovery Today: Disease Models 22, pages 21-26.
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