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In vitro cell culture models for the assessment of pulmonary drug disposition

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Pages 333-345 | Published online: 23 Apr 2008

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Felix R. Jimenez, Josh B. Lewis, Samuel T. Belgique, Dallin C. Milner, Adam L. Lewis, Todd M. Dunaway, Kaleb M. Egbert, Duane R. Winden, Juan A. Arroyo & Paul R. Reynolds. (2016) Cigarette smoke and decreased oxygen tension inhibit pulmonary claudin-6 expression. Experimental Lung Research 42:8-10, pages 440-452.
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Sabrina Nickel, Caoimhe G. Clerkin, Mohammed Ali Selo & Carsten Ehrhardt. (2016) Transport mechanisms at the pulmonary mucosa: implications for drug delivery. Expert Opinion on Drug Delivery 13:5, pages 667-690.
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Mikihisa Takano, Masashi Kawami, Ayako Aoki & Ryoko Yumoto. (2015) Receptor-mediated endocytosis of macromolecules and strategy to enhance their transport in alveolar epithelial cells. Expert Opinion on Drug Delivery 12:5, pages 813-825.
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Xin Liu, Lu Jin, John W Upham & Michael S Roberts. (2013) The development of models for the evaluation of pulmonary drug disposition. Expert Opinion on Drug Metabolism & Toxicology 9:4, pages 487-505.
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Chris MacDonald, Di Shao, Angus Oli & Remigius U. Agu. (2013) Characterization of Calu-3 cell monolayers as a model of bronchial epithelial transport: organic cation interaction studies. Journal of Drug Targeting 21:1, pages 97-106.
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Simona Mura, Herve Hillaireau, Julien Nicolas, Benjamin Le Droumaguet, Claire Gueutin, Sandrine Zanna, Nicolas Tsapis & Elias Fattal. (2011) Influence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cells. International Journal of Nanomedicine 6, pages 2591-2605.
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Remigius U Agu & Michael I Ugwoke. (2011) In vitro and in vivo testing methods for respiratory drug delivery. Expert Opinion on Drug Delivery 8:1, pages 57-69.
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Felix R Jimenez, Joshua B Lewis, Samuel T Belgique, Tyler T Wood & Paul R Reynolds. (2014) Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2. Respiratory Research 15:1.
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A. HibbittsA.M. O'MahonyE. FordeL. NolanJ. OgierS. DesgrangesR. DarcyR. MacLoughlinC.M. O'DriscollS.A. Cryan. (2014) Early-Stage Development of Novel Cyclodextrin-siRNA Nanocomplexes Allows for Successful Postnebulization Transfection of Bronchial Epithelial Cells. Journal of Aerosol Medicine and Pulmonary Drug Delivery 27:6, pages 466-477.
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Cristiane de Souza Carvalho, Nicole Daum & Claus-Michael Lehr. (2014) Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery. Advanced Drug Delivery Reviews 75, pages 129-140.
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Chibueze Ihekwereme, Charles Esimone, Di Shao & Remigius Agu. (2014) Preliminary Studies on Validation of Calu-3 Cell Line as a Model for Screening Respiratory Mucosa Irritation and Toxicity. Pharmaceutics 6:2, pages 268-280.
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Johanna J. Salomon, Viktoria E. Muchitsch, Julia C. Gausterer, Elena Schwagerus, Hanno Huwer, Nicole Daum, Claus-Michael Lehr & Carsten Ehrhardt. (2014) The Cell Line NCl-H441 Is a Useful in Vitro Model for Transport Studies of Human Distal Lung Epithelial Barrier . Molecular Pharmaceutics 11:3, pages 995-1006.
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Victoria Hutter, David Y.S. Chau, Constanze Hilgendorf, Alan Brown, Anne Cooper, Vanessa Zann, David I. Pritchard & Cynthia Bosquillon. (2014) Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1. European Journal of Pharmaceutics and Biopharmaceutics 86:1, pages 74-82.
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V. Hutter, C. Hilgendorf, A. Cooper, V. Zann, D.I. Pritchard & C. Bosquillon. (2012) Evaluation of layers of the rat airway epithelial cell line RL-65 for permeability screening of inhaled drug candidates. European Journal of Pharmaceutical Sciences 47:2, pages 481-489.
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Johanna Jessica Salomon & Carsten Ehrhardt. (2012) Organic cation transporters in the blood–air barrier: expression and implications for pulmonary drug delivery. Therapeutic Delivery 3:6, pages 735-747.
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Johanna J. Salomon, Sibylle Endter, Gaëlle Tachon, Françoise Falson, Stephen T. Buckley & Carsten Ehrhardt. (2012) Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells. European Journal of Pharmaceutics and Biopharmaceutics 81:2, pages 351-359.
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Manali Mukherjee, D.I. Pritchard & C. Bosquillon. (2012) Evaluation of air-interfaced Calu-3 cell layers for investigation of inhaled drug interactions with organic cation transporters in vitro. International Journal of Pharmaceutics 426:1-2, pages 7-14.
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Leonie Baginski, Frederic Tewes, Stephen T. Buckley, Anne Marie Healy, Udo Bakowsky & Carsten Ehrhardt. (2011) Investigations into the Fate of Inhaled Salmon Calcitonin at the Respiratory Epithelial Barrier. Pharmaceutical Research 29:1, pages 332-341.
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