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Expert Opinion on Drug Discovery Volume 4, 2009 - Issue 9
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Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part II: targeting cell cycle events, caspases, NF-κB and the proteasome

Donavon C Hiss Head, Molecular Oncology Research Programme, University of the Western Cape, Department of Medical BioSciences, Bellville, 7535, South Africa +27 21 959 2334; +27 959 1563; [email protected]
, MSc (Med) PhD (Med) &
Gary A Gabriels Chief Medical Scientific Officer, University of Cape Town, Observatory, Division of Clinical Pharmacology, Department of Medicine, 7925, South Africa
, MSc (Med)
Pages 907-921 | Published online: 25 Jun 2009

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Pooneh Mokarram, Mohammed Albokashy, Maryam Zarghooni, Mohammad Amin Moosavi, Zahra Sepehri, Qi Min Chen, Andrzej Hudecki, Aliyeh Sargazi, Javad Alizadeh, Adel Rezaei Moghadam, Mohammad Hashemi, Hesam Movassagh, Thomas Klonisch, Ali Akbar Owji, Marek J. Łos & Saeid Ghavami. (2017) New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets. Autophagy 13:5, pages 781-819.
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Ahsen Guler, Zuhal Hamurcu, Halil Ulutabanca, Venhar Cınar, Nursultan Nurdinov, Serife Erdem & Bulent Ozpolat. (2023) Flavopiridol Suppresses Cell Proliferation and Migration and Induces Apoptotic Cell Death by Inhibiting Oncogenic FOXM1 Signaling in IDH Wild-Type and IDH-Mutant GBM Cells. Molecular Neurobiology.
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Junyao Wang, Wenjing Peng, Aiying Yu, Mohamed Fokar & Yehia Mechref. (2022) Comparative Transcriptomics and Proteomics of Cancer Cell Lines Cultivated by Physiological and Commercial Media. Biomolecules 12:11, pages 1575.
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Yuting Li, Yuming Wang, Xiaoqun Wang, Lulu Jin, Lu Yang, Jinli Zhu, Hongwu Wang, Fang Zheng, Huantian Cui, Xiaojiang Li & Yingjie Jia. (2022) Evodiamine suppresses the progression of non-small cell lung carcinoma via endoplasmic reticulum stress-mediated apoptosis pathway in vivo and in vitro . International Journal of Immunopathology and Pharmacology 36, pages 039463202210860.
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Yi-Nan Liu, Yu-Dong Mu, Hui Wang, Meng Zhang, Ya-Wen Shi, Ge Mi, Lei-Xuan Peng & Jing-Hong Chen. (2021) Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis. Toxicology 464, pages 152989.
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Oleksandr H. Minchenko, Dariia O. Tsymbal, Olena O. Khita & Dmytro O. Minchenko. (2021) Inhibition of ERN1 Signaling is Important for the Suppression of Tumor Growth. Clinical Cancer Drugs 8:1, pages 27-38.
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Chia-Chen Hsu, Yu-Fu Su, Kuo-Yang Tsai, Feng-Chih Kuo, Chi-Fu Chiang, Chu-Yen Chien, Ying-Chen Chen, Chien-Hsing Lee, Yu-Chiao Wu, Kun Wang, Shyun-Yeu Liu & Yi-Shing Shieh. (2020) Gamma synuclein is a novel nicotine responsive protein in oral cancer malignancy. Cancer Cell International 20:1.
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Pierre-Jean Le Reste, Tony Avril, Véronique Quillien, Xavier Morandi & Eric Chevet. (2016) Reprint of: Signaling the Unfolded Protein Response in primary brain cancers. Brain Research 1648, pages 542-552.
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Pierre-Jean Le Reste, Tony Avril, Véronique Quillien, Xavier Morandi & Eric Chevet. (2016) Signaling the Unfolded Protein Response in primary brain cancers. Brain Research 1642, pages 59-69.
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Yingli Wang, Bo Wan, Dawei Li, Jun Zhou, Ruwei Li, Meirong Bai, Fang Chen & Long Yu. (2012) BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis. Biochemical and Biophysical Research Communications 423:4, pages 813-818.
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