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Editorial

Green tea polyphenols in drug discovery: a success or failure?

Pages 589-595 | Published online: 07 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Iúri Frias, Ana Rute Neves, Marina Pinheiro & Salette Reis. (2016) Design, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation. Drug Design, Development and Therapy 10, pages 3519-3528.
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Md. Mohabbulla Mohib, S.M. Fazla Rabby, Tasfiq Zaman Paran, Md. Mehedee Hasan, Iqbal Ahmed, Nahid Hasan, Md. Abu Taher Sagor & Sarif Mohiuddin. (2016) Protective role of green tea on diabetic nephropathy—A review. Cogent Biology 2:1.
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Articles from other publishers (29)

Emmanuelle V. LeBlanc & Che C. Colpitts. (2022) The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor. Scientific Reports 12:1.
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Gusti Ayu Sinta Deasy Andani, Ronny Lesmana & Yuni Susanti Pratiwi. (2022) The Role of Herbs Supplementation in Modulating Injury-induced Inflammatory Response in Skeletal Muscle: A Systematic Review. The Natural Products Journal 12:7.
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Barbara Brodziak-Dopierała & Agnieszka Fischer. (2022) Analysis of Mercury Content in Various Types of Tea (Camellia sinensis) and Yerba Mate (Ilex paraguariensis). International Journal of Environmental Research and Public Health 19:9, pages 5491.
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Gian Luca Araldi & Yu-Wen Hwang. (2022) Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis. Bioorganic & Medicinal Chemistry Letters 64, pages 128675.
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Iqra Sarfraz, Azhar Rasul, Şevki Adem, Ilknur Ucak, Ayesha Sarfraz, Shazia Anwer Bukhari & Abdo A. Elfiky. 2022. Coronavirus Drug Discovery. Coronavirus Drug Discovery 203 215 .
Mayank Kaashyap, Marc Cohen & Nitin Mantri. (2021) Microbial Diversity and Characteristics of Kombucha as Revealed by Metagenomic and Physicochemical Analysis. Nutrients 13:12, pages 4446.
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Reem Abdul-Latif, Ieva Stupans, Ayman Allahham, Benu Adhikari & Thilini Thrimawithana. (2021) Natural antioxidants in the management of Parkinson’s disease: Review of evidence from cell line and animal models. Journal of Integrative Medicine 19:4, pages 300-310.
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Vladimir L. Katanaev, Artem Blagodatski, Jiabin Xu, Yuri Khotimchenko & Alexey Koval. 2021. Pharmacology of the WNT Signaling System. Pharmacology of the WNT Signaling System 215 248 .
Adriana N. dos Santos, Tatiana R. de L. Nascimento, Brenna L. C. Gondim, Marilia M. A. C. Velo, Renaly I. de A. Rêgo, José R. do C. Neto, Juliana R. Machado, Marcos V. da Silva, Helvia W. C. de Araújo, Maria G. Fonseca & Lúcio R. C. Castellano. (2020) Catechins as Model Bioactive Compounds for Biomedical Applications. Current Pharmaceutical Design 26:33, pages 4032-4047.
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Charles R. Goodlett, Megan Stringer, Jonathan LaCombe, Roshni Patel, Joseph M. Wallace & Randall J. Roper. (2020) Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice. Scientific Reports 10:1.
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Amanda L. Tauber, Stephanie S. Schweiker & Stephan M. Levonis. (2020) From tea to treatment; epigallocatechin gallate and its potential involvement in minimizing the metabolic changes in cancer. Nutrition Research 74, pages 23-36.
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Fahimeh Haghighatdoost & Mitra Hariri. (2019) The effect of green tea on inflammatory mediators: A systematic review and meta‐analysis of randomized clinical trials. Phytotherapy Research 33:9, pages 2274-2287.
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Xiu-Hua Meng, Na Li, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang & Ying-Jun Zhang. (2018) Plant Resources, Chemical Constituents, and Bioactivities of Tea Plants from the Genus Camellia Section Thea . Journal of Agricultural and Food Chemistry 67:19, pages 5318-5349.
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Hong Q. Smith, Changhong Li, Charles A. Stanley & Thomas James Smith. (2017) Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point. Neurochemical Research 44:1, pages 117-132.
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Alexey Koval, Constant A. Pieme, Emerson Ferreira Queiroz, Simone Ragusa, Kamal Ahmed, Artem Blagodatski, Jean-Luc Wolfender, Tatiana V. Petrova & Vladimir L. Katanaev. (2018) Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts. Cancer Letters 435, pages 110-120.
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Xiao Li, Guang-Jing Liu, Wei Zhang, Yv-Long Zhou, Tie-Jun Ling, Xiao-Chun Wan & Guan-Hu Bao. (2018) Novel Flavoalkaloids from White Tea with Inhibitory Activity against the Formation of Advanced Glycation End Products. Journal of Agricultural and Food Chemistry 66:18, pages 4621-4629.
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Chartchai Khanongnuch, Kridsada Unban, Apinun Kanpiengjai & Chalermpong Saenjum. (2017) Recent research advances and ethno-botanical history of miang , a traditional fermented tea ( Camellia sinensis var. assamica ) of northern Thailand. Journal of Ethnic Foods 4:3, pages 135-144.
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Megan Stringer, Charles R. Goodlett & Randall J. Roper. (2017) Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits. Molecular Genetics & Genomic Medicine 5:5, pages 451-465.
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Liviuta Budisan, Diana Gulei, Oana Zanoaga, Alexandra Irimie, Sergiu Chira, Cornelia Braicu, Claudia Gherman & Ioana Berindan-Neagoe. (2017) Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer. International Journal of Molecular Sciences 18:6, pages 1178.
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Graziamaria Corbi, Valeria Conti, Sergio Davinelli, Giovanni Scapagnini, Amelia Filippelli & Nicola Ferrara. (2016) Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?. Frontiers in Pharmacology 7.
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Takuji Suzuki, Noriyuki Miyoshi, Sumio Hayakawa, Shinjiro Imai, Mamoru Isemura & Yoriyuki Nakamura. 2016. Beverage Impacts on Health and Nutrition. Beverage Impacts on Health and Nutrition 49 67 .
Rituparna Bhattacharjee, Arpita Devi & Seema Mishra. (2015) Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma. Journal of Molecular Modeling 21:10.
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Severina Pacifico, Simona Piccolella, Sabina Marciano, Silvia Galasso, Paola Nocera, Vincenzo Piscopo, Antonio Fiorentino & Pietro Monaco. (2014) LC-MS/MS Profiling of a Mastic Leaf Phenol Enriched Extract and Its Effects on H 2 O 2 and Aβ(25–35) Oxidative Injury in SK-B-NE(C)-2 Cells . Journal of Agricultural and Food Chemistry 62:49, pages 11957-11966.
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Che C. Colpitts & Luis M. Schang. (2014) A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans. Journal of Virology 88:14, pages 7806-7817.
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Ming Li, Changhong Li, Aron Allen, Charles A. Stanley & Thomas J. Smith. (2013) Glutamate Dehydrogenase: Structure, Allosteric Regulation, and Role in Insulin Homeostasis. Neurochemical Research 39:3, pages 433-445.
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Lucie Cahlíková, Kateřina Macáková, Nina Benešová, Jakub Chlebek, Anna Hošťálková & Lubomír Opletal. 2014. 153 194 .
Sandhya KhuranaMatthew PicheAmanda HollingsworthKrishnan VenkataramanT.C. Tai. (2013) Oxidative stress and cardiovascular health: therapeutic potential of polyphenols. Canadian Journal of Physiology and Pharmacology 91:3, pages 198-212.
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Ming Li, Changhong Li, Aron Allen, Charles A. Stanley & Thomas J. Smith. (2012) The structure and allosteric regulation of mammalian glutamate dehydrogenase. Archives of Biochemistry and Biophysics 519:2, pages 69-80.
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Changhong Li, Ming Li, Pan Chen, Srinivas Narayan, Franz M. Matschinsky, Michael J. Bennett, Charles A. Stanley & Thomas J. Smith. (2011) Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site. Journal of Biological Chemistry 286:39, pages 34164-34174.
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