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Review

Advances in phage display technology for drug discovery

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Pages 651-669 | Received 28 Dec 2014, Accepted 01 Apr 2015, Published online: 24 Apr 2015

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Karolina Pierzynowska, Joanna Morcinek-Orłowska, Lidia Gaffke, Weronika Jaroszewicz, Piotr M. Skowron & Grzegorz Węgrzyn. (2023) Applications of the phage display technology in molecular biology, biotechnology and medicine. Critical Reviews in Microbiology 0:0, pages 1-41.
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Lihong Qin, Mao Huiwen, Jianguo Wang, Yuanyaun Wang, Salman A. Khan, Ying Zhang, Hong Qiu, Longwei Jiang, Lingfeng He, Yan Zhang & Shaochang Jia. (2022) A novel polymerase β inhibitor from phage displayed peptide library augments the anti-tumour effects of temozolomide on colorectal cancer. Journal of Chemotherapy 34:6, pages 391-400.
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Ningning Song, Lingzhou Zhao, Meilin Zhu & Jinhua Zhao. (2019) Recent progress in LyP-1-based strategies for targeted imaging and therapy. Drug Delivery 26:1, pages 363-375.
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Leila Rahbarnia, Safar Farajnia, Hossein Babaei, Jafar Majidi, Kamal Veisi, Vahideh Ahmadzadeh & Bahman Akbari. (2017) Evolution of phage display technology: from discovery to application. Journal of Drug Targeting 25:3, pages 216-224.
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Donald J. AbrahamNicholas J. Klus, Lester A. Mitscher & Jeffrey Aubé. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 47 .
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Zsolt Keresztessy, Edina Erdos, Lilla Ozgyin, János Kádas, József Horváth, Gábor Zahuczky & Balint L. Balint. (2019) Development of an antibody control system using phage display. Journal of Biotechnology 300, pages 63-69.
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Daniela S. Mattes, Nicole Jung, Laura K. Weber, Stefan Bräse & Frank Breitling. (2019) Miniaturized and Automated Synthesis of Biomolecules—Overview and Perspectives. Advanced Materials 31:26, pages 1806656.
Crossref
Andy Chi-Lung Lee, Janelle Louise Harris, Kum Kum Khanna & Ji-Hong Hong. (2019) A Comprehensive Review on Current Advances in Peptide Drug Development and Design. International Journal of Molecular Sciences 20:10, pages 2383.
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Marlon S. Zambrano-Mila, Karen Elizabeth Sánchez Blacio & Nelson Santiago Vispo. (2019) Peptide Phage Display: Molecular Principles and Biomedical Applications. Therapeutic Innovation & Regulatory Science, pages 216847901983762.
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Chunbao Liu, Jun Zhou, Xiaojie Cheng, Liang Xia, Junfen Zhou, Shufang Xu, Yichun Wang, Yongxue Zhang & Diyu Lu. (2019) Single-Chain Variable Fragment Antibody of Vascular Cell Adhesion Molecule 1 as a Molecular Imaging Probe for Colitis Model Rabbit Investigation. Contrast Media & Molecular Imaging 2019, pages 1-8.
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Tatiana Q. Aguiar, Sílvio B. Santos, Ivone M. Martins, Lucília Domingues & Carla Oliveira. 2019. Proteins: Sustainable Source, Processing and Applications. Proteins: Sustainable Source, Processing and Applications 259 293 .
Erick Giang, Fernando Aleman & Mansun Law. 2019. Hepatitis C Virus Protocols. Hepatitis C Virus Protocols 381 393 .
Kalishwaralal Kalimuthu, Bat-Chen Lubin, Andrii Bazylevich, Gary Gellerman, Ofer Shpilberg, Galia Luboshits & Michael A. Firer. (2018) Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells. Journal of Nanobiotechnology 16:1.
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Crossref
Pilar Domingo-Calap & Jennifer Delgado-Martínez. (2018) Bacteriophages: Protagonists of a Post-Antibiotic Era. Antibiotics 7:3, pages 66.
Crossref
Marcus Rebouças Santos, Viviane Sisdelli Assao, Fabiana de Almeida Araújo Santos, Rafael Locatelli Salgado, Ana Paula Carneiro, Juliana Lopes Rangel Fietto, Gustavo Costa Bressan, Márcia Rogéria de Almeida, Zelia Inês Portela Lobato, Carlos Ueira-Veira, Luíz Ricardo Goulart & Abelardo Silva-Júnior. (2018) Utilization of phage display to identify antigenic regions in the PCV2 capsid protein for the evaluation of serological responses in mice and pigs. Archives of Virology 163:7, pages 1877-1887.
Crossref
Antoine Henninot, James C. Collins & John M. Nuss. (2017) The Current State of Peptide Drug Discovery: Back to the Future?. Journal of Medicinal Chemistry 61:4, pages 1382-1414.
Crossref
Christopher D. Spicer, Coline Jumeaux, Bakul Gupta & Molly M. Stevens. (2018) Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications. Chemical Society Reviews 47:10, pages 3574-3620.
Crossref
Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc & Kursad Genc. 2018. Therapeutic Proteins and Peptides. Therapeutic Proteins and Peptides 309 357 .
Paul Hyman & Jenna Denyes. 2018. Bacteriophages. Bacteriophages 1 31 .
Lianhua Zhu, Yanli Guo, Luofu Wang, Xiaozhou Fan, Xingyu Xiong, Kejing Fang & Dan Xu. (2017) Construction of ultrasonic nanobubbles carrying CAIX polypeptides to target carcinoma cells derived from various organs. Journal of Nanobiotechnology 15:1.
Crossref
Michael Garton, Maryam Sayadi & Philip M. Kim. (2017) A computational approach for designing D-proteins with non-canonical amino acid optimised binding affinity. PLOS ONE 12:11, pages e0187524.
Crossref
O. Bashari, B. Redko, A. Cohen, G. Luboshits, G. Gellerman & M.A. Firer. (2017) Discovery of peptide drug carrier candidates for targeted multi-drug delivery into prostate cancer cells. Cancer Letters 408, pages 164-173.
Crossref
Mohamed Alfaleh, Martina Jones, Christopher Howard & Stephen Mahler. (2017) Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning. Antibodies 6:3, pages 10.
Crossref
Antti Kulmala, Tuomas Huovinen & Urpo Lamminmäki. (2017) Effect of DNA sequence of Fab fragment on yield characteristics and cell growth of E. coli. Scientific Reports 7:1.
Crossref
Anna D Cunningham, Nir Qvit & Daria Mochly-Rosen. (2017) Peptides and peptidomimetics as regulators of protein–protein interactions. Current Opinion in Structural Biology 44, pages 59-66.
Crossref
Seolhee Park, Hyeon-Jun Shin, Masaud Shah, Hey-Young Cho, Muhammad Ayaz Anwar, Asma Achek, Hyuk-Kwon Kwon, Byugsung Lee, Tae Hyeon Yoo & Sangdun Choi. (2017) TLR4/MD2 specific peptides stalled in vivo LPS-induced immune exacerbation. Biomaterials 126, pages 49-60.
Crossref
Lina Y. Hu, Kimberly A. Kelly & Julie L. Sutcliffe. (2016) High-Throughput Approaches to the Development of Molecular Imaging Agents. Molecular Imaging and Biology 19:2, pages 163-182.
Crossref
Aleksandra Ellert-Miklaszewska, Katarzyna Poleszak & Bozena Kaminska. (2017) Short peptides interfering with signaling pathways as new therapeutic tools for cancer treatment. Future Medicinal Chemistry 9:2, pages 199-221.
Crossref
Julius Grzeschik, Steffen C. Hinz, Doreen Könning, Thomas Pirzer, Stefan Becker, Stefan Zielonka & Harald Kolmar. (2017) A simplified procedure for antibody engineering by yeast surface display: Coupling display levels and target binding by ribosomal skipping. Biotechnology Journal 12:2, pages 1600454.
Crossref
Carles Corbi-VergeMichael GartonSatra NimPhilip M. Kim. (2017) Strategies to Develop Inhibitors of Motif-Mediated Protein-Protein Interactions as Drug Leads. Annual Review of Pharmacology and Toxicology 57:1, pages 39-60.
Crossref
Caitlin M. Quinn & Tatyana Polenova. (2017) Structural biology of supramolecular assemblies by magic-angle spinning NMR spectroscopy. Quarterly Reviews of Biophysics 50.
Crossref
Mark L Chiu & Gary L Gilliland. (2016) Engineering antibody therapeutics. Current Opinion in Structural Biology 38, pages 163-173.
Crossref
John J. Rhoden, Gregory L. Dyas & Victor J. Wroblewski. (2016) A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets. Journal of Biological Chemistry 291:21, pages 11337-11347.
Crossref
Gloria Ruiz-Gómez, John C. Hawkins, Jenny Philipp, Georg Künze, Robert Wodtke, Reik Löser, Karim Fahmy & M. Teresa Pisabarro. (2016) Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics. PLOS ONE 11:4, pages e0154046.
Crossref
Arwa Kurabi, Kwang K. Pak, Marlen Bernhardt, Andrew Baird & Allen F. Ryan. (2016) Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear. Scientific Reports 6:1.
Crossref
Elaine Spain, Sarah Gilgunn, Shikha Sharma, Kellie Adamson, Eadaoin Carthy, Richard O’Kennedy & Robert J. Forster. (2016) Detection of prostate specific antigen based on electrocatalytic platinum nanoparticles conjugated to a recombinant scFv antibody. Biosensors and Bioelectronics 77, pages 759-766.
Crossref
Lisa O'Sullivan, Colin Buttimer, Olivia McAuliffe, Declan Bolton & Aidan Coffey. (2016) Bacteriophage-based tools: recent advances and novel applications. F1000Research 5, pages 2782.
Crossref
Simon Ng & Ratmir Derda. (2016) Phage-displayed macrocyclic glycopeptide libraries. Organic & Biomolecular Chemistry 14:24, pages 5539-5545.
Crossref
Antonia P. Sagona, Aurelija M. Grigonyte, Paul R. MacDonald & Alfonso Jaramillo. (2016) Genetically modified bacteriophages. Integrative Biology 8:4, pages 465-474.
Crossref

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