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Expert Opinion on Drug Discovery Volume 10, 2015 - Issue 11
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Appropriate models for novel osteoporosis drug discovery and future perspectives

Luigi GennariUniversity of Siena, Department of Medicine, Surgery and Neurosciences, Policlinico Santa Maria alle Scotte, Viale Bracci, 53100-Siena, Italy+39 05 77 58 53 64; +39 05 77 23 34 46; [email protected]
, MD PhD,
Stefano RotatoriUniversity of Siena, Department of Medicine, Surgery and Neurosciences, Policlinico Santa Maria alle Scotte, Viale Bracci, 53100-Siena, Italy+39 05 77 58 53 64; +39 05 77 23 34 46; [email protected]
, MD,
Simone BianciardiUniversity of Siena, Department of Medicine, Surgery and Neurosciences, Policlinico Santa Maria alle Scotte, Viale Bracci, 53100-Siena, Italy+39 05 77 58 53 64; +39 05 77 23 34 46; [email protected]
, PhD,
Stefano GonnelliUniversity of Siena, Department of Medicine, Surgery and Neurosciences, Policlinico Santa Maria alle Scotte, Viale Bracci, 53100-Siena, Italy+39 05 77 58 53 64; +39 05 77 23 34 46; [email protected]
, MD,
Ranuccio NutiUniversity of Siena, Department of Medicine, Surgery and Neurosciences, Policlinico Santa Maria alle Scotte, Viale Bracci, 53100-Siena, Italy+39 05 77 58 53 64; +39 05 77 23 34 46; [email protected]
, MD &
Daniela MerlottiUniversity of Siena, Department of Medicine, Surgery and Neurosciences, Policlinico Santa Maria alle Scotte, Viale Bracci, 53100-Siena, Italy+39 05 77 58 53 64; +39 05 77 23 34 46; [email protected];San Raffaele Hospital, Division of Genetics and Cell Biology, Via Olgettina 60, 20132- Milan, Italy
, MD PhD
Pages 1201-1216 | Published online: 19 Aug 2015

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Read on this site (4)

Luigi Gennari, Daniela Merlotti, Alberto Falchetti, Cristina Eller Vainicher, Roberta Cosso & Iacopo Chiodini. (2020) Emerging therapeutic targets for osteoporosis. Expert Opinion on Therapeutic Targets 24:2, pages 115-130.
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D. Merlotti, M. Materozzi, T. Picchioni, S. Bianciardi, M. Alessandri, R. Nuti & L. Gennari. (2018) Recent advances in models for screening potential osteoporosis drugs. Expert Opinion on Drug Discovery 13:8, pages 741-752.
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Luigi Gennari & John P. Bilezikian. (2018) New and developing pharmacotherapy for osteoporosis in men. Expert Opinion on Pharmacotherapy 19:3, pages 253-264.
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Luigi Gennari, Stefano Rotatori, Simone Bianciardi, Ranuccio Nuti & Daniela Merlotti. (2016) Treatment needs and current options for postmenopausal osteoporosis. Expert Opinion on Pharmacotherapy 17:8, pages 1141-1152.
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Articles from other publishers (16)

Renpeng PengYimin DongHonglei KangQian GuoMeipeng ZhuFeng Li. (2022) Identification of Genes with Altered Methylation in Osteoclast Differentiation and Its Roles in Osteoporosis. DNA and Cell Biology 41:6, pages 575-589.
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Vishu Upmanyu, Leena Sapra & Rupesh K. Srivastava. 2022. Bioactive Natural Products. Bioactive Natural Products 161 241 .
Xue Feng, Suisui Jiang, Fan Zhang, Runfang Wang, Tietao Zhang, Yuanhui Zhao & Mingyong Zeng. (2021) Extraction and characterization of matrix protein from pacific oyster ( Crassostrea gigs ) shell and its anti-osteoporosis properties in vitro and in vivo . Food & Function 12:19, pages 9066-9076.
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Kaudjhis Patrick Ulrich N’deh, Han-Seok Yoo, Kang-Hyun Chung, Kwon-Jai Lee, Dong-Hee Kim, Jin A Yoon & Jeung Hee An. (2020) Collagen Extract Derived from Yeonsan Ogye Chicken Increases Bone Microarchitecture by Suppressing the RANKL/OPG Ratio via the JNK Signaling Pathway. Nutrients 12:7, pages 1967.
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Alexander Sieberath, Elena Della Bella, Ana Marina Ferreira, Piergiorgio Gentile, David Eglin & Kenny Dalgarno. (2020) A Comparison of Osteoblast and Osteoclast In Vitro Co-Culture Models and Their Translation for Preclinical Drug Testing Applications. International Journal of Molecular Sciences 21:3, pages 912.
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Taruneet Kaur, Rajeev Kapila & Suman Kapila. 2020. Bone Regeneration [Working Title]. Bone Regeneration [Working Title].
Lingyu Zhu, Yingying Xie, Boting Wen, Mengliang Ye, Yusi Liu, Khandaker Md Sharif Uddin Imam, Huimei Cai, Chunhui Zhang, Fengzhong Wang & Fengjiao Xin. (2020) Porcine bone collagen peptides promote osteoblast proliferation and differentiation by activating the PI3K/Akt signaling pathway. Journal of Functional Foods 64, pages 103697.
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Yasmin Mohamed Hassan, Leonardo Massa, Claudia Caviglia & Stephan Sylvest Keller. (2019) Electrochemical Monitoring of Saos-2 Cell Differentiation on Pyrolytic Carbon Electrodes. Electroanalysis 31:2, pages 256-266.
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Emily G. Armitage, Joanna Godzien, Imanol Peña, Ángeles López-Gonzálvez, Santiago Angulo, Ana Gradillas, Vanesa Alonso-Herranz, Julio Martín, Jose M. Fiandor, Michael P. Barrett, Raquel Gabarro & Coral Barbas. (2018) Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis. ACS Chemical Biology 13:5, pages 1361-1369.
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Maria Materozzi, Daniela Merlotti, Luigi Gennari & Simone Bianciardi. (2018) The Potential Role of miRNAs as New Biomarkers for Osteoporosis. International Journal of Endocrinology 2018, pages 1-10.
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Ozra Tabatabaei-Malazy, Pooneh Salari, Patricia Khashayar & Bagher Larijani. (2017) New horizons in treatment of osteoporosis. DARU Journal of Pharmaceutical Sciences 25:1.
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Jessika Bertacchini, Marta Benincasa, Marta Checchi, Francesco Cavani, Alberto Smargiassi, Marzia Ferretti & Carla Palumbo. (2017) Expression and functional proteomic analyses of osteocytes from Xenopus laevis tested under mechanical stress conditions: preliminary observations on an appropriate new animal model . Journal of Anatomy 231:6, pages 823-834.
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Do Kim, Ji Lee, Kyung Shim, Jin Cho, Ho Lee, Seong Park & Mun Chang. (2016) Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells. Molecular Medicine Reports.
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Huanhuan Lv, Feng Jiang, Daogang Guan, Cheng Lu, Baosheng Guo, Chileung Chan, Songlin Peng, Baoqin Liu, Wenwei Guo, Hailong Zhu, Xuegong Xu, Aiping Lu & Ge Zhang. (2016) Metabolomics and Its Application in the Development of Discovering Biomarkers for Osteoporosis Research. International Journal of Molecular Sciences 17:12, pages 2018.
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Sina Pan, Ali Chen, Zhihui Han, Yaling Wang, Xin Lu & Yongxia Yang. (2016) 1H NMR-based metabonomic study on the effects of Epimedium on glucocorticoid-induced osteoporosis. Journal of Chromatography B 1038, pages 118-126.
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Zachary Wolff & Charles J. Malemud. 2016. Mesenchymal Stem Cells and Immunomodulation. Mesenchymal Stem Cells and Immunomodulation 75 82 .

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