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Expert Opinion on Drug Discovery Volume 3, 2008 - Issue 9

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Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases

Claire Bonfils MethylGene, Inc., 7220 Frederick-Banting, Montreal, Quebec H4S 2A1, Canada

Donald R Walkinshaw McGill University Health Centre, Molecular Oncology Group, Department of Medicine, Montréal, Québec, Canada; McGill University, McGill Cancer Center, Montréal, Québec, Canada

Jeffrey M Besterman MethylGene, Inc., 7220 Frederick-Banting, Montreal, Quebec H4S 2A1, Canada

Xiang-Jiao Yang McGill University Health Centre, Molecular Oncology Group, Department of Medicine, Montréal, Québec, Canada; McGill University, McGill Cancer Center, Montréal, Québec, Canada

Zuomei Li Executive Director, Molecular Biology MethylGene, Inc., 7220 Frederick-Banting, Montreal, Quebec H4S 2A1, Canada +1 514 337 3333, ext. 245;+1 514 337 0550; [email protected]

, PhD

Pages 1041-1065 | Published online: 21 Aug 2008

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https://doi.org/10.1517/17460441.3.9.1041

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Gülsevinç AKSOY, Ümit LÜLEYAP, Gülşah EVYAPAN, Perçin PAZARCI, Davut ALPTEKİN, Ayfer PAZARBAŞI & Mehmet Bertan YILMAZ. (2021) Sh-Sy5y hücre hattında sodyum bütiratın bazı alternatif kırpılma genleri ve BACE1 izoformları üzeindeki etkisiEffect of sodium butyrate on some alternative splicing genes and BACE1 isoforms in Sh-Sy5y cell line. Cukurova Medical Journal 46:2, pages 764-771.
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Xinli An, Zekun Wei, Botian Ran, Hao Tian, Hongyu Gu, Yan Liu, Hongjuan Cui & Shunqin Zhu. (2020) Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells. Anti-Cancer Agents in Medicinal Chemistry 20:17, pages 2114-2124.
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Fuqiang Yuan, Xiaopan Chen, Jie Liu, Wenke Feng, Lu Cai, Xiaoyang Wu & Shao-yu Chen. (2018) Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos. Experimental Neurology 300, pages 60-66.
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JUNFEN MA, XIAOBING GUO, SHIJIE ZHANG, HONGCHUN LIU, JING LU, ZIMING DONG, KANGDONG LIU & LIANG MING. (2015) Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. Molecular Medicine Reports 11:6, pages 4525-4531.
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Vivek Vaish, Tripti Khare, Mukesh Verma & Sharad Khare. 2015. Cancer Epigenetics. Cancer Epigenetics 771 782 .

Joey L. Methot, Dawn Mampreian Hoffman, David J. Witter, Matthew G. Stanton, Paul Harrington, Christopher Hamblett, Phieng Siliphaivanh, Kevin Wilson, Jed Hubbs, Richard Heidebrecht, Astrid M. Kral, Nicole Ozerova, Judith C. Fleming, Hongmei Wang, Alexander A. Szewczak, Richard E. Middleton, Bethany Hughes, Jonathan C. Cruz, Brian B. Haines, Melissa Chenard, Candia M. Kenific, Andreas Harsch, J. Paul Secrist & Thomas A. Miller. (2014) Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. ACS Medicinal Chemistry Letters 5:4, pages 340-345.
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Wei-Jian Sun, Xiang Zhou, Ji-Hang Zheng, Ming-Dong Lu, Jian-Yun Nie, Xiang-Jiao Yang & Zhi-Qiang Zheng. (2012) Histone acetyltransferases and deacetylases: molecular and clinical implications to gastrointestinal carcinogenesis. Acta Biochimica et Biophysica Sinica 44:1, pages 80-91.
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Stéphane Raeppel, Nancy Zhou, Frédéric Gaudette, Silvana Leit, Isabelle Paquin, Guillaume Larouche, Oscar Moradei, Sylvie Fréchette, Ljubomir Isakovic, Daniel Delorme, Marielle Fournel, Ann Kalita, Aihua Lu, Marie-Claude Trachy-Bourget, Pu Theresa Yan, Jianhong Liu, Jubrail Rahil, James Wang, Jeffrey M. Besterman, Koji Murakami, Zuomei Li & Arkadii Vaisburg. (2009) SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103). Bioorganic & Medicinal Chemistry Letters 19:3, pages 644-649.
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Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases

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