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Review

Androgen receptor: role and novel therapeutic prospects in prostate cancer

Pages 1495-1508 | Published online: 10 Jan 2014

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Sachin A. Dhawale, Pallavi Bhosle, Sadhana Mahajan, Geetanjali Patil, Sachin Gawale, Mangesh Ghodke, Ganesh Tapadiya & Azim Ansari. (2023) Dual targeting in prostate cancer with phytoconstituents as a potent lead: a computational approach for novel drug discovery. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-14.
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Shinya Fujii & Hiroyuki Kagechika. (2019) Androgen receptor modulators: a review of recent patents and reports (2012-2018). Expert Opinion on Therapeutic Patents 29:6, pages 439-453.
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Shu-Pin Huang, Bo-Ying Bao, Ming-Tsang Wu, Toni K. Choueiri, William B. Goggins, Chia-Chu Liu, Chao-Yuan Huang, Yeong-Shiau Pu, Chia-Cheng Yu, Tony T. Wu, Chun-Nung Huang, Chun-Hsiung Huang & Wen-Jeng Wu. (2012) Significant associations of prostate-specific antigen nadir and time to prostate-specific antigen nadir with survival in prostate cancer patients treated with androgen-deprivation therapy. The Aging Male 15:1, pages 34-41.
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Daniel R. Ciocca, Mariel A. Fanelli, Fernando D. Cuello-Carrion & Gisela N. Castro. (2010) Heat shock proteins in prostate cancer: from tumorigenesis to the clinic. International Journal of Hyperthermia 26:8, pages 737-747.
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MURALIKRISHNA YARAGANI, PRASAD YADLAPALLI, SRIRAM RAGHAVAN, NIRAIKULAM AYYADURAI, SARAVANAN CHINNUSAMY, VENKATA BASAVESWARA RAO MANDAVA & RAJASEKHARA PRASAD KOTTAPALLI. (2020) Design and synthesis of novel tetrahydrofuran cyclic urea derivatives as androgen receptor antagonists. Journal of Chemical Sciences 132:1.
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Hitomi Koga, Mai Negishi, Marie Kinoshita, Shinya Fujii, Shuichi Mori, Mari Ishigami-Yuasa, Emiko Kawachi, Hiroyuki Kagechika & Aya Tanatani. (2020) Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore. International Journal of Molecular Sciences 21:15, pages 5584.
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Shih‐Yin Huang, Guan‐Jhong Huang, Po‐Fan Hsieh, Hsi‐Chin Wu & Wen‐Chin Huang. (2019) Osajin displays potential antiprostate cancer efficacy via impairment of fatty acid synthase and androgen receptor expression. The Prostate 79:13, pages 1543-1552.
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Jian Wang, Wei Yuan, Chuang Yue, Feng Dai, Shenglin Gao, Yuanyuan Mi, Yu Bai, Lifeng Zhang, Li Zuo, Xingyu Wu & Wei Zhang. (2019) RNASEL 1623A>C variant is associated with the risk of prostate cancer in African descendants. Journal of Cellular Biochemistry 120:7, pages 11955-11964.
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Sebastien J. Hotte, Kim N. Chi, Anthony M. Joshua, Donsheng Tu, Robyn J. Macfarlane, Rirchard W. Gregg, Joseph D. Ruether, Naveen S. Basappa, Daygen Finch, Muhammad Salim, Eric W. Winquist, Vamsee Torri, Scott North, Christian Kollmannsberger, Susan L. Ellard, Bernard J. Eigl, Anna Tinker, Alison L. Allan, Kevin Beja, Matti Annala, Jean Powers, Alexander W. Wyatt & Lesley Seymour. (2019) A Phase II Study of PX-866 in Patients With Recurrent or Metastatic Castration-resistant Prostate Cancer: Canadian Cancer Trials Group Study IND205. Clinical Genitourinary Cancer 17:3, pages 201-208.e1.
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Yuko Kazui, Shinya Fujii, Ayumi Yamada, Mari Ishigami-Yuasa, Hiroyuki Kagechika & Aya Tanatani. (2018) Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents. Bioorganic & Medicinal Chemistry 26:18, pages 5118-5127.
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Chao Zhao, You Hee Choi, Daulat Bikram Khadka, Yifeng Jin, Kwang-Youl Lee & Won-Jea Cho. (2016) Design and synthesis of novel androgen receptor antagonists via molecular modeling. Bioorganic & Medicinal Chemistry 24:4, pages 789-801.
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Khaled Lotfy. (2015) Molecular Modeling, Docking and ADMET of Dimethylthiohydantoin Derivatives for Prostate Cancer Treatment. Journal of Biophysical Chemistry 06:04, pages 91-117.
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P-C Kuo, C-W Huang, C-I Lee, H-W Chang, S-W Hsieh, Y-P Chung, M-S Lee, C-S Huang, L-P Tsao, Y-P Tsao & S-L Chen. (2014) BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability. British Journal of Cancer 112:2, pages 391-402.
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C. M. Nieto, L. C. Rider & S. D. Cramer. (2014) Influence of stromal-epithelial interactions on androgen action. Endocrine Related Cancer 21:4, pages T147-T160.
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Weiguo Liu, Jinming Zhou, Guoyan Geng, Rongtuan Lin & Jian Hui Wu. (2013) Synthesis and in vitro characterization of ionone-based compounds as dual inhibitors of the androgen receptor and NF-κB. Investigational New Drugs 32:2, pages 227-234.
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Ayumi Yamada, Shinya Fujii, Shuichi Mori & Hiroyuki Kagechika. (2013) Design and Synthesis of 4-(4-Benzoylaminophenoxy)phenol Derivatives As Androgen Receptor Antagonists. ACS Medicinal Chemistry Letters 4:10, pages 937-941.
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Shuping Li, Miaofen G. Hu, Yeqing Sun, Norie Yoshioka, Soichiro Ibaragi, Jinghao Sheng, Guangjie Sun, Koji Kishimoto & Guo-Fu Hu. (2013) Angiogenin Mediates Androgen-Stimulated Prostate Cancer Growth and Enables Castration Resistance. Molecular Cancer Research 11:10, pages 1203-1214.
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Natalie Sampson, Christoph Zenzmaier, Martin Heitz, Martin Hermann, Eugen Plas, Georg Schäfer, Helmut Klocker & Peter Berger. (2013) Stromal Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) Is Elevated in the Diseased Human Prostate and Promotes ex Vivo Fibroblast-to-Myofibroblast Differentiation. Endocrinology 154:8, pages 2586-2599.
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Robert H. Bradbury, Neil J. Hales, Alfred A. Rabow, Graeme E. Walker, David G. Acton, David M. Andrews, Peter Ballard, Nigel A.N. Brooks, Nicola Colclough, Alan Girdwood, Urs J. Hancox, Owen Jones, David Jude, Sarah A. Loddick & Andrew A. Mortlock. (2011) Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer. Bioorganic & Medicinal Chemistry Letters 21:18, pages 5442-5445.
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