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The clinical relevance of circulating, exosomal miRNAs as biomarkers for cancer

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Letícia F Ramos, Caio M Silva, Camila C Pansa & Karen C M Moraes. (2021) Non-alcoholic fatty liver disease: molecular and cellular interplays of the lipid metabolism in a steatotic liver. Expert Review of Gastroenterology & Hepatology 15:1, pages 25-40.
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Magdalena Grunt, Antonio Virgilio Failla, Ines Stevic, Timo Hillebrand & Heidi Schwarzenbach. (2020) A novel assay for exosomal and cell-free miRNA isolation and quantification. RNA Biology 17:4, pages 425-440.
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Yuzhu Ma, Daolu Yuwen, Jingwei Chen, Bingfeng Zheng, Jian Gao, Minmin Fan, Wenwen Xue, Yixuan Wang, Wuhao Li, Yongqian Shu, Qiang Xu & Yan Shen. (2019) Exosomal Transfer Of Cisplatin-Induced miR-425-3p Confers Cisplatin Resistance In NSCLC Through Activating Autophagy. International Journal of Nanomedicine 14, pages 8121-8132.
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Margaritis Avgeris, Konstantina Panoutsopoulou, Maria-Alexandra Papadimitriou & Andreas Scorilas. (2019) Circulating exosomal miRNAs: clinical significance in human cancers. Expert Review of Molecular Diagnostics 19:11, pages 979-995.
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Wanli Yang, Yu Han, Xinhui Zhao, Lili Duan, Wei Zhou, Xiaoqian Wang, Gaokai Shi, Yinggang Che, Yujie Zhang, Jinqiang Liu, Hongwei Zhang, Qingchuan Zhao, Liu Hong & Daiming Fan. (2019) Advances in prognostic biomarkers for esophageal cancer. Expert Review of Molecular Diagnostics 19:2, pages 109-119.
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Articles from other publishers (63)

Li Luo, Weirun Li & Zhenhua Li. 2024. Biomedical Applications of Extracellular Vesicles. Biomedical Applications of Extracellular Vesicles 147 179 .
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Atonu Chakrabortty, Daniel J. Patton, Bruce F. Smith & Payal Agarwal. (2023) miRNAs: Potential as Biomarkers and Therapeutic Targets for Cancer. Genes 14:7, pages 1375.
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Panagiotis Skouras, Antonios N. Gargalionis & Christina Piperi. (2023) Exosomes as Novel Diagnostic Biomarkers and Therapeutic Tools in Gliomas. International Journal of Molecular Sciences 24:12, pages 10162.
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Kayla C. LaRue & Martin E. Fernandez-Zapico. (2023) EGFR Reloaded: Finding New Ways to Shape Pancreatic Cancer Epigenome. Cellular and Molecular Gastroenterology and Hepatology 15:5, pages 1253-1254.
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Oana Baldasici, Loredana Balacescu, Daniel Cruceriu, Andrei Roman, Carmen Lisencu, Bogdan Fetica, Simona Visan, Andrei Cismaru, Ancuta Jurj, Lucian Barbu-Tudoran, Valentina Pileczki, Laurian Vlase, Oana Tudoran & Ovidiu Balacescu. (2022) Circulating Small EVs miRNAs as Predictors of Pathological Response to Neo-Adjuvant Therapy in Breast Cancer Patients. International Journal of Molecular Sciences 23:20, pages 12625.
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Nan Miao, Wenjie Cai, Sijia Ding, Yajuan Liu, Wanhua Chen & Tao Sun. (2022) Characterization of plasma exosomal microRNAs in responding to radiotherapy of human esophageal squamous cell carcinoma. Molecular Medicine Reports 26:3.
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Valentina K. Todorova, Stephanie D. Byrum, Allen J. Gies, Cade Haynie, Hunter Smith, Nathan S. Reyna & Issam Makhoul. (2022) Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer. Current Oncology 29:2, pages 613-630.
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Payal Agarwal, Melissa P. Crepps, Natalie A. Stahr, Will P. Kretzschmar, Hannah C. Harris, Nripesh Prasad, Shawn E. Levy & Bruce F. Smith. (2021) Identification of canine circulating miRNAs as tumor biospecific markers using Next-Generation Sequencing and Q-RT-PCR. Biochemistry and Biophysics Reports 28, pages 101106.
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Jiulue Hu, Jelena Stojanović, Saman Yasamineh, Pooneh Yasamineh, Sathish Kumar Karuppannan, Mohammed Junaid Hussain Dowlath & Hamed Serati-Nouri. (2021) The potential use of microRNAs as a therapeutic strategy for SARS-CoV-2 infection. Archives of Virology 166:10, pages 2649-2672.
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Maria I. Mosquera-Heredia, Luis C. Morales, Oscar M. Vidal, Ernesto Barceló, Carlos Silvera-Redondo, Jorge I. Vélez & Pilar Garavito-Galofre. (2021) Exosomes: Potential Disease Biomarkers and New Therapeutic Targets. Biomedicines 9:8, pages 1061.
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Camila D.M. Campos, Katie Childers, Sachindra S.T. Gamage, Harshani Wijerathne, Zheng Zhao & Steven A. Soper. (2021) Analytical Technologies for Liquid Biopsy of Subcellular Materials. Annual Review of Analytical Chemistry 14:1, pages 207-229.
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Yun Chen, Ling-Yan Zhai, Li-Min Zhang, Xiao-Shan Ma, Zheng Liu, Min-Min Li, Jin-Xiang Chen & Wen-Jun Duan. (2021) Breast cancer plasma biopsy by in situ determination of exosomal microRNA-1246 with a molecular beacon . The Analyst 146:7, pages 2264-2276.
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Eline J. C. A. Kamp, Winand N. M. Dinjens, Michail Doukas, Marco J. Bruno, Pieter Jan F. de Jonge, Maikel P. Peppelenbosch & Annemarie C. de Vries. (2021) Optimal tissue sampling during ERCP and emerging molecular techniques for the differentiation of benign and malignant biliary strictures. Therapeutic Advances in Gastroenterology 14, pages 175628482110020.
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Shilpa Kusampudi & Nagarjun Konduru. 2021. Early Detection and Treatment of Head & Neck Cancers. Early Detection and Treatment of Head & Neck Cancers 149 166 .
Patrick J. Hunt, Katherine E. Kabotyanski, George A. Calin, Tongxin Xie, Jeffrey N. Myers & Moran Amit. (2020) Interrupting Neuron—Tumor Interactions to Overcome Treatment Resistance. Cancers 12:12, pages 3741.
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Qunqun Guo, Yongqi Yu, Hui Zhang, Chenxin Cai & Qingming Shen. (2020) Electrochemical Sensing of Exosomal MicroRNA Based on Hybridization Chain Reaction Signal Amplification with Reduced False-Positive Signals. Analytical Chemistry 92:7, pages 5302-5310.
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Lukas Valihrach, Peter Androvic & Mikael Kubista. (2020) Circulating miRNA analysis for cancer diagnostics and therapy. Molecular Aspects of Medicine 72, pages 100825.
Crossref
Xinbao Yin, Xueping Zheng, Ming Liu, Dong Wang, Hui Sun, Yue Qiu, Jun Chen & Benkang Shi. (2020) Exosomal miR‐663b targets Ets2‐repressor factor to promote proliferation and the epithelial–mesenchymal transition of bladder cancer cells. Cell Biology International 44:4, pages 958-965.
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Faisal J. Alibhai, Fievel Lim, Azadeh Yeganeh, Peter V. DiStefano, Tina Binesh‐Marvasti, Alyssa Belfiore, Lukasz Wlodarek, Dakota Gustafson, Sean Millar, Shu‐Hong Li, Richard D. Weisel, Jason E. Fish & Ren‐Ke Li. (2020) Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function. Aging Cell 19:3.
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Huating Wu, Dawei Xie, Yingxia Yang, Qing Yang, Xiajun Shi & Rong Yang. (2020) Ultrasound-Targeted Microbubble Destruction-Mediated miR-206 Overexpression Promotes Apoptosis and Inhibits Metastasis of Hepatocellular Carcinoma Cells Via Targeting PPIB. Technology in Cancer Research & Treatment 19, pages 153303382095935.
Crossref
Ju-Seop Kang. 2020. Exosomes. Exosomes 467 486 .
Óscar Rapado-González, Rafael López-López, José Luis López-Cedrún, Gabriel Triana-Martínez, Laura Muinelo-Romay & María Mercedes Suárez-Cunqueiro. (2019) Cell-Free microRNAs as Potential Oral Cancer Biomarkers: From Diagnosis to Therapy. Cells 8:12, pages 1653.
Crossref
Francesco Ingenito, Giuseppina Roscigno, Alessandra Affinito, Silvia Nuzzo, Iolanda Scognamiglio, Cristina Quintavalle & Gerolama Condorelli. (2019) The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications. International Journal of Molecular Sciences 20:19, pages 4687.
Crossref
Theresa Link, Jan Dominik Kuhlmann, Dennis Kobelt, Pia Herrmann, Yana D. Vassileva, Michael Kramer, Kerstin Frank, Maren Göckenjan, Pauline Wimberger & Ulrike Stein. (2019) Clinical relevance of circulating MACC 1 and S100A4 transcripts for ovarian cancer . Molecular Oncology 13:5, pages 1268-1279.
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Volkmar Müller, Leticia Oliveira‐Ferrer, Bettina Steinbach, Klaus Pantel & Heidi Schwarzenbach. (2019) Interplay of lncRNA H19/miR‐675 and lncRNA NEAT1/miR‐204 in breast cancer. Molecular Oncology 13:5, pages 1137-1149.
Crossref
Liqiong Xu, Wei Chen, Min Ma, Anfang Chen, Chengyue Tang, Chengwei Zhang & Lin Cai. (2018) Microarray profiling analysis identifies the mechanism of miR‐200b‐3p/mRNA‐CD36 affecting diabetic cardiomyopathy via peroxisome proliferator activated receptor‐γ signaling pathway. Journal of Cellular Biochemistry 120:4, pages 5193-5206.
Crossref
Zhen Zhao, Jia Fan, Yen-Michael S. Hsu, Christopher J. Lyon, Bo Ning & Tony Y. Hu. (2019) Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application. Lab on a Chip 19:7, pages 1114-1140.
Crossref
Heidi Schwarzenbach & Peter Gahan. (2019) MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer. Non-Coding RNA 5:1, pages 28.
Crossref
Li Jun, Gu Yang & Liu Zhisu. (2019) The utility of serum exosomal microRNAs in hepatocellular carcinoma. Biomedicine & Pharmacotherapy 111, pages 1221-1227.
Crossref
Daolu Yuwen, Yuzhu Ma, Deqiang Wang, Jian Gao, Xin Li, Wenwen Xue, Minmin Fan, Qiang Xu, Yan Shen & Yongqian Shu. (2019) Prognostic Role of Circulating Exosomal miR-425-3p for the Response of NSCLC to Platinum-Based Chemotherapy. Cancer Epidemiology, Biomarkers & Prevention 28:1, pages 163-173.
Crossref
Lygia Therese Budnik, Balazs Adam, Maria Albin, Barbara Banelli, Xaver Baur, Fiorella Belpoggi, Claudia Bolognesi, Karin Broberg, Per Gustavsson, Thomas Göen, Axel Fischer, Dorota Jarosinska, Fabiana Manservisi, Richard O’Kennedy, Johan Øvrevik, Elizabet Paunovic, Beate Ritz, Paul T. J. Scheepers, Vivi Schlünssen, Heidi Schwarzenbach, Per E. Schwarze, Orla Sheils, Torben Sigsgaard, Karel Van Damme & Ludwine Casteleyn. (2018) Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health. Journal of Occupational Medicine and Toxicology 13:1.
Crossref
Milica Popovic, Elisa Mazzega, Barbara Toffoletto & Ario de Marco. (2018) Isolation of anti-extra-cellular vesicle single-domain antibodies by direct panning on vesicle-enriched fractions. Microbial Cell Factories 17:1.
Crossref
Ines Stevic, Volkmar Müller, Karsten Weber, Peter A. Fasching, Thomas Karn, Frederic Marmé, Christian Schem, Elmar Stickeler, Carsten Denkert, Marion van Mackelenbergh, Christoph Salat, Andreas Schneeweiss, Klaus Pantel, Sibylle Loibl, Michael Untch & Heidi Schwarzenbach. (2018) Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial. BMC Medicine 16:1.
Crossref
Ling-Yan Zhai, Min-Xiang Li, Wei-Lun Pan, Yun Chen, Min-Min Li, Jian-Xin Pang, Lei Zheng, Jin-Xiang Chen & Wen-Jun Duan. (2018) In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe. ACS Applied Materials & Interfaces 10:46, pages 39478-39486.
Crossref
Chi Pan, Ines Stevic, Volkmar Müller, Qingtao Ni, Leticia Oliveira‐Ferrer, Klaus Pantel & Heidi Schwarzenbach. (2018) Exosomal micro RNA s as tumor markers in epithelial ovarian cancer . Molecular Oncology 12:11, pages 1935-1948.
Crossref
Mahsa Salehi & Mohammadreza Sharifi. (2018) Exosomal miRNAs as novel cancer biomarkers: Challenges and opportunities. Journal of Cellular Physiology 233:9, pages 6370-6380.
Crossref
Qingtao Ni, Ines Stevic, Chi Pan, Volkmar Müller, Leticia Oliveira-Ferrer, Klaus Pantel & Heidi Schwarzenbach. (2018) Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients. Scientific Reports 8:1.
Crossref
Dingwen Qin, Haige Li & Honglin Xie. (2018) Ultrasound‑targeted microbubble destruction‑mediated miR‑205 enhances cisplatin cytotoxicity in prostate cancer cells. Molecular Medicine Reports.
Crossref
Jennifer Pérez-Boza, Michelle Lion & Ingrid Struman. (2018) Exploring the RNA landscape of endothelial exosomes. RNA 24:3, pages 423-435.
Crossref
Mansi Arora & Deepak KaulMansi Arora & Deepak Kaul. 2018. Cancer RNome: Nature & Evolution. Cancer RNome: Nature & Evolution 243 285 .
Armando Luis Garcia, Ke Jin, Ravi Doddapaneni, Catherine Jeeyun Choi, Maria Paula Fernandez, Sander Dubovy, David Tse, Daniel Pelaez & Wensi Tao. 2018. Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs 199 220 .
Guan Zhang & Ping Yang. (2018) A novel cell-cell communication mechanism in the nervous system: exosomes. Journal of Neuroscience Research 96:1, pages 45-52.
Crossref
Elmira Gheytanchi, Zahra Madjd, Leila Janani, Arezoo Rasti, Roya Ghods, Fatemeh Atyabi, Mohammad Hossein Asadi-Lari & Sadegh Babashah. (2017) Exosomal microRNAs as potential circulating biomarkers in gastrointestinal tract cancers: a systematic review protocol. Systematic Reviews 6:1.
Crossref
Zhan-Peng Sun, An-Qi Li, Wen-Huan Jia, Sen Ye, Grace Van Eps, Jian-Min Yu & Wei-Jun Yang. (2017) MicroRNA expression profiling in exosomes derived from gastric cancer stem-like cells. Oncotarget 8:55, pages 93839-93855.
Crossref
Guobin Zhang, Yunsheng Zhang, Sen Cheng, Zhen Wu, Fusheng Liu & Junting Zhang. (2017) CD133 positive U87 glioblastoma cells-derived exosomal microRNAs in hypoxia- versus normoxia-microenviroment. Journal of Neuro-Oncology 135:1, pages 37-46.
Crossref
Lucio Barile & Giuseppe Vassalli. (2017) Exosomes: Therapy delivery tools and biomarkers of diseases. Pharmacology & Therapeutics 174, pages 63-78.
Crossref
Olga A. Kossinova, Alexander V. Gopanenko, Svetlana N. Tamkovich, Olga A. Krasheninina, Alexey E. Tupikin, Elena Kiseleva, Darya D. Yanshina, Alexey A. Malygin, Alia G. Ven'yaminova, Marsel R. Kabilov & Galina G. Karpova. (2017) Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomes. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1865:6, pages 664-673.
Crossref
Qian Lin, Leina Ma, Zhantao Liu, Zhihong Yang, Jin Wang, Jia Liu & Guohui Jiang. (2016) Targeting microRNAs: a new action mechanism of natural compounds. Oncotarget 8:9, pages 15961-15970.
Crossref
Carmen Jerónimo & Rui Henrique. (2016) Is There a Role for Exosome-derived MicroRNAs in Detection of Renal Cell Tumors Using Urine Samples? Editorial to [European Urology Focus 2/2 (2016) 210–218]. European Urology Focus 2:6, pages 654-655.
Crossref
Heidi Schwarzenbach. (2016) Diagnostic relevance of circulating cell-free and exosomal microRNAs and long non-coding RNAs in blood of cancer patients. LaboratoriumsMedizin 40:5, pages 345-353.
Crossref
Siti A. Sulaiman, Nurul-Syakima Ab Mutalib & Rahman Jamal. (2016) miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. Frontiers in Pharmacology 7.
Crossref
Yang Li, Ze Yang, Xiaoya Wan, Jianguo Zhou, Yu Zhang, Hu Ma & Yuju Bai. (2016) Clinical Prognostic Value of Metastasis-Associated Lung Adenocarcinoma Transcript 1 in Various Human Cancers: An Updated Meta-Analysis. The International Journal of Biological Markers 31:2, pages 173-182.
Crossref
Xiaodan Meng, Volkmar Müller, Karin Milde-Langosch, Fabian Trillsch, Klaus Pantel & Heidi Schwarzenbach. (2016) Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer. Oncotarget 7:13, pages 16923-16935.
Crossref
Shentong Yu, Yifang Wei, Yuqiao Xu, Yuan Zhang, Jipeng Li & Jian Zhang. (2016) Extracellular vesicles in breast cancer drug resistance and their clinical application. Tumor Biology 37:3, pages 2849-2861.
Crossref
Alejandro Luarte, Luis Federico Bátiz, Ursula Wyneken & Carlos Lafourcade. (2016) Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche. Stem Cells International 2016, pages 1-16.
Crossref
Stefan Holdenrieder. 2016. Circulating Nucleic Acids in Serum and Plasma – CNAPS IX. Circulating Nucleic Acids in Serum and Plasma – CNAPS IX 53 60 .
A. V. Malek, R. B. Samsonov & A. . Chiesi. (2015) DEVELOPMENT OF CANCER DIAGNOSTICS AND MONITORING METHODS BASED ON ANALYSIS OF TUMOR-DERIVED EXOSOMES. Russian Journal of Biotherapy 14:4, pages 9-18.
Crossref

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