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Review

Prospects for a vaccine against otitis media

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Pages 517-534 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Roman Prymula & Lode Schuerman. (2009) 10-valent pneumococcal nontypeable Haemophilus influenzae PD conjugate vaccine: Synflorix™. Expert Review of Vaccines 8:11, pages 1479-1500.
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Cristiana Maria Nascimento-Carvalho. (2009) Pneumococcal conjugate vaccination and otitis media: differences among high-risk and low-risk populations. Expert Review of Vaccines 8:6, pages 695-698.
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Fatme Mawas, Mei Mei Ho & Michael J Corbel. (2009) Current progress with Moraxella catarrhalis antigens as vaccine candidates. Expert Review of Vaccines 8:1, pages 77-90.
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Articles from other publishers (45)

Preeti Garai, John M. Atack, Brandon M. Wills, Michael P. Jennings, Lauren O. Bakaletz & Kenneth L. Brockman. (2023) Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions. Microbiology Spectrum 11:1.
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Seyed Davar Siadat, Azad Khaledi, Fereshteh Shahcheraghi, Somaye Rashki & Maryam Arfaatabar. (2020) Molecular diversity of hpd gene in clinical isolates of Haemophilus influenzae. Gene Reports 18, pages 100556.
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Philip F. Lavere, Jason F. Ohlstein, Steven P. Smith, Wasyl Szeremeta & Harold S. Pine. (2019) Preventing unnecessary tympanostomy tube placement in children. International Journal of Pediatric Otorhinolaryngology 122, pages 40-43.
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Arwa Kurabi, Daniel Schaerer & Allen F. Ryan. 2018. Inflammatory Mechanisms in Mediating Hearing Loss. Inflammatory Mechanisms in Mediating Hearing Loss 115 132 .
J Jervis-Bardy, A S Carney, R Duguid & A J Leach. (2017) Microbiology of otitis media in Indigenous Australian children: review. The Journal of Laryngology & Otology 131:S2, pages S2-S11.
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Felix Pumarola, Ignacio Salamanca de la Cueva, Alessandra Sistiaga-Hernando, Pilar García-Corbeira, Fernando A. Moraga-Llop, Sara Cardelús, Cynthia McCoig, Justo Ramón Gómez Martínez, Rosa Rosell Ferrer, Jesús Iniesta Turpin & Raghavendra Devadiga. (2016) Etiología bacteriana de la otitis media aguda en España en la era de la vacuna neumocócica conjugada. Anales de Pediatría 85:5, pages 224-231.
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Felix Pumarola, Ignacio Salamanca de la Cueva, Alessandra Sistiaga-Hernando, Pilar Garc?a-Corbeira, Fernando A. Moraga-Llop, Sara Cardel?s, Cynthia McCoig, Justo Ram?n G?mez Mart?nez, Rosa Rosell Ferrer, Jes?s Iniesta Turpin & Raghavendra Devadiga. (2016) Bacterial etiology of acute otitis media in Spain in the post-pneumococcal conjugate vaccine era. Anales de Pediatr?a (English Edition) 85:5, pages 224-231.
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Anne G. M. Schilder, Tasnee Chonmaitree, Allan W. Cripps, Richard M. Rosenfeld, Margaretha L. Casselbrant, Mark P. Haggard & Roderick P. Venekamp. (2016) Otitis media. Nature Reviews Disease Primers 2:1.
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Hong Min Ng, Lin Xin Kin, Stuart G. Dashper, Nada Slakeski, Catherine A. Butler & Eric C. Reynolds. (2016) Bacterial interactions in pathogenic subgingival plaque. Microbial Pathogenesis 94, pages 60-69.
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Chinh C. Ngo, Helen M. Massa, Ruth B. Thornton & Allan W. Cripps. (2016) Predominant Bacteria Detected from the Middle Ear Fluid of Children Experiencing Otitis Media: A Systematic Review. PLOS ONE 11:3, pages e0150949.
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Arwa Kurabi, Kwang Pak, Allen F. Ryan & Stephen I. Wasserman. (2016) Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media. Current Allergy and Asthma Reports 16:1.
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Helen M. Massa, David J. Lim, Yuichi Kurono & Allan W. Cripps. 2015. Mucosal Immunology. Mucosal Immunology 1923 1942 .
Johan Van Eldere, Mary P E Slack, Shamez Ladhani & Allan W Cripps. (2014) Non-typeable Haemophilus influenzae, an under-recognised pathogen. The Lancet Infectious Diseases 14:12, pages 1281-1292.
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Sharad K. Sharma & Michael E. Pichichero. (2013) Cellular Immune Response in Young Children Accounts for Recurrent Acute Otitis Media. Current Allergy and Asthma Reports 13:5, pages 495-500.
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Margarita Smidt, Patrick Bättig, Suzanne J. C. Verhaegh, Axel Niebisch, Markus Hanner, Sanja Selak, Wolfgang Schüler, Eva Morfeldt, Christel Hellberg, Eszter Nagy, Urban Lundberg, John P. Hays, Andreas Meinke & Birgitta Henriques-Normark. (2013) Comprehensive Antigen Screening Identifies Moraxella catarrhalis Proteins That Induce Protection in a Mouse Pulmonary Clearance Model. PLoS ONE 8:5, pages e64422.
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Sam Mehr & Nicholas Wood. (2012) Streptococcus pneumoniae – a review of carriage, infection, serotype replacement and vaccination. Paediatric Respiratory Reviews 13:4, pages 258-264.
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Yu-Ching Su, Birendra Singh & Kristian Riesbeck. (2012) Moraxella catarrhalis : from interactions with the host immune system to vaccine development . Future Microbiology 7:9, pages 1073-1100.
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M. Nadeem Khan, Ravinder Kaur & Michael E. Pichichero. (2012) Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children . FEMS Immunology & Medical Microbiology 65:3, pages 439-447.
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S. Taylor, P. Marchisio, A. Vergison, J. Harriague, W. P. Hausdorff & M. Haggard. (2012) Impact of Pneumococcal Conjugate Vaccination on Otitis Media: A Systematic Review. Clinical Infectious Diseases 54:12, pages 1765-1773.
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Matthew J. Bottomley, Davide Serruto, Marco Aurélio Palazzi Sáfadi & Keith P. Klugman. (2012) Future challenges in the elimination of bacterial meningitis. Vaccine 30, pages B78-B86.
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Diana Barthel, Birendra Singh, Kristian Riesbeck & Peter F. Zipfel. (2012) Haemophilus influenzae Uses the Surface Protein E To Acquire Human Plasminogen and To Evade Innate Immunity . The Journal of Immunology 188:1, pages 379-385.
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Brian M. Peters, Mary Ann Jabra-Rizk, Graeme A. O'May, J. William Costerton & Mark E. Shirtliff. (2012) Polymicrobial Interactions: Impact on Pathogenesis and Human Disease. Clinical Microbiology Reviews 25:1, pages 193-213.
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F. Ramos Puerto. 2012. Manual de Otorrinolaringología Infantil. Manual de Otorrinolaringología Infantil 88 100 .
Michael J Binks, Allen C Cheng, Heidi Smith-Vaughan, Theo Sloots, Michael Nissen, David Whiley, Joseph McDonnell & Amanda J Leach. (2011) Viral-bacterial co-infection in Australian Indigenous children with acute otitis media. BMC Infectious Diseases 11:1.
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Melinda M. Pettigrew, Janneane F. Gent, Richard B. Pyles, Aaron L. Miller, Johanna Nokso-Koivisto & Tasnee Chonmaitree. (2011) Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection. Journal of Clinical Microbiology 49:11, pages 3750-3755.
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Michael E. Pichichero, Ravinder Kaur, Janet R. Casey, Albert Sabirov, M. Nadeem Khan & Anthony Almudevar. (2010) Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine 28:44, pages 7184-7192.
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Wenzhou Hong, Daxin Peng, Maritza Rivera & Xin-Xing Gu. (2010) Protection against nontypeable Haemophilus influenzae challenges by mucosal vaccination with a detoxified lipooligosaccharide conjugate in two chinchilla models. Microbes and Infection 12:1, pages 11-18.
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Larry E. Davis. 2010. Cummings Otolaryngology - Head and Neck Surgery. Cummings Otolaryngology - Head and Neck Surgery 2153 2163 .
Helen M MassaAllan W CrippsDeborah Lehmann. (2009) Otitis media: viruses, bacteria, biofilms and vaccines. Medical Journal of Australia 191:S9.
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Paola Marchisio, Susanna Esposito, Sonia Bianchini, Elisa Dusi, Michela Fusi, Erica Nazzari, Raffaella Picchi, Carlotta Galeone & Nicola Principi. (2009) Efficacy of Injectable Trivalent Virosomal-Adjuvanted Inactivated Influenza Vaccine in Preventing Acute Otitis Media in Children With Recurrent Complicated or Noncomplicated Acute Otitis Media. Pediatric Infectious Disease Journal 28:10, pages 855-859.
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Satomi Moriyama, Muneki Hotomi, Jun Shimada, Dewan S. Billal, Keiji Fujihara & Noboru Yamanaka. (2009) Formation of biofilm by Haemophilus influenzae isolated from pediatric intractable otitis media. Auris Nasus Larynx 36:5, pages 525-531.
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Teresia Hallström, Anna M. Blom, Peter F. Zipfel & Kristian Riesbeck. (2009) Nontypeable Haemophilus influenzae Protein E Binds Vitronectin and Is Important for Serum Resistance . The Journal of Immunology 183:4, pages 2593-2601.
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Simon Urschel, Lale Kayikci, Uwe Wintergerst, Gundula Notheis, Annette Jansson & Bernd H. Belohradsky. (2009) Common Variable Immunodeficiency Disorders in Children: Delayed Diagnosis Despite Typical Clinical Presentation. The Journal of Pediatrics 154:6, pages 888-894.
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Elena Ronander, Marta Brant, Emily Eriksson, Matthias Mörgelin, Oskar Hallgren, Gunilla Westergren‐Thorsson, Arne Forsgren & Kristian Riesbeck. (2009) Nontypeable Haemophilus influenzae Adhesin Protein E: Characterization and Biological Activity . The Journal of Infectious Diseases 199:4, pages 522-531.
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Sarah W. Satola, Brooke Napier & Monica M. Farley. (2008) Association of IS 1016 with the hia Adhesin Gene and Biotypes V and I in Invasive Nontypeable Haemophilus influenzae . Infection and Immunity 76:11, pages 5221-5227.
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Allan W Cripps, Philip Sutton, Ken Beagley, Sarah Robertson & Margaret Dunkley. (2008) Mucosal immunology down under: Special Interest Group in Mucosal Immunology workshop, Australasian Society for Immunology, Sydney, Australia, 2 December 2007. Immunology & Cell Biology 86:7, pages 557-561.
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Fernando Baquero-Artigao & Fernando del Castillo. (2008) La otitis media aguda en la era de la vacunación antineumocócica. Enfermedades Infecciosas y Microbiología Clínica 26:8, pages 505-509.
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Shengqing Yu, Hang Xie, Anup Datta, Natasha Naidu & Xin-Xing Gu. (2008) Galactose Residues on the Lipooligosaccharide of Moraxella catarrhalis 26404 Form the Epitope Recognized by the Bactericidal Antiserum from Conjugate Vaccination . Infection and Immunity 76:9, pages 4251-4258.
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J. Marès Bermúdez & F.A. Moraga Llop. (2008) Vacunas para la prevención de la otitis media aguda en el niño. Vacunas 9:2, pages 70-79.
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Laura A. Novotny, Santiago Partida-Sánchez, Robert S. MunsonJr.Jr. & Lauren O. Bakaletz. (2008) Differential Uptake and Processing of a Haemophilus influenzae P5-Derived Immunogen by Chinchilla Dendritic Cells. Infection and Immunity 76:3, pages 967-977.
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Alice L. Erwin, Sara A. Sandstedt, Paul J. Bonthuis, Jennifer L. Geelhood, Kevin L. Nelson, William C. T. Unrath, Mathew A. Diggle, Mary J. Theodore, Cynthia R. Pleatman, Elizabeth A. Mothershed, Claudio T. Sacchi, Leonard W. Mayer, Janet R. Gilsdorf & Arnold L. Smith. (2008) Analysis of Genetic Relatedness of Haemophilus influenzae Isolates by Multilocus Sequence Typing . Journal of Bacteriology 190:4, pages 1473-1483.
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Terhi Kilpi & Lode Schuerman. 2008. Pneumococcal Vaccines. Pneumococcal Vaccines 301 315 .
Elena Ronander, Marta Brant, Håkan Janson, Joanna Sheldon, Arne Forsgren & Kristian Riesbeck. (2008) Identification of a novel Haemophilus influenzae protein important for adhesion to epithelial cells. Microbes and Infection 10:1, pages 87-96.
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Shengqing Yu & Xin-Xing Gu. (2007) Biological and Immunological Characteristics of Lipooligosaccharide-Based Conjugate Vaccines for Serotype C Moraxella catarrhalis . Infection and Immunity 75:6, pages 2974-2980.
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Dianne C. Webb, Diana C. Otczyk & Allan W. Cripps. (2007) Investigation of the potential of a 48kDa protein as a vaccine candidate for infection against nontypable Haemophilus influenzae. Vaccine 25:20, pages 4012-4019.
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