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Review

The next generation of HIV/AIDS drugs: novel and developmental antiHIV drugs and targets

Pages 97-128 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Martin Platten & Gerd Fätkenheuer. (2013) Lersivirine – a new drug for HIV infection therapy. Expert Opinion on Investigational Drugs 22:12, pages 1687-1694.
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George M Bahr. (2005) Immune deficiency in HIV-1 infection: novel therapeutic approaches targeting innate and adaptive responses. Expert Review of Clinical Immunology 1:4, pages 529-547.
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RobynM. Hyde, Keith Jensen, Jindrich Kopecek & ArthurD. Broom. (2005) Confocal-microscopy Studies of a Model Oligoribonucleotide HIV Inhibitor. Nucleosides, Nucleotides & Nucleic Acids 24:10-12, pages 1875-1884.
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Manoli Vourvahis, Michelle Gleave, Angus N. R. Nedderman, Ruth Hyland, Iain Gardner, Martin Howard, Sarah Kempshall, Claire Collins & Robert LaBadie. (2010) Excretion and Metabolism of Lersivirine (5-{[3,5-Diethyl-1-(2-hydroxyethyl)(3,5- 14 C 2 )-1 H -pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a Next-Generation Non-Nucleoside Reverse Transcriptase Inhibitor, after Administration of [ 14 C]Lersivirine to Healthy Volunteers . Drug Metabolism and Disposition 38:5, pages 789-800.
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Valérie GoldschmidtLisa M Miller Jenkins, Hugues de RocquignyJean-Luc Darlix & Yves Mély. (2010) The nucleocapsid protein of HIV-1 as a promising therapeutic target for antiviral drugs. HIV Therapy 4:2, pages 179-198.
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B. Romani, S. Engelbrecht & R. H. Glashoff. (2009) Functions of Tat: the versatile protein of human immunodeficiency virus type 1. Journal of General Virology 91:1, pages 1-12.
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Jeffrey D. Fisher, K. Rivet Amico, William A. Fisher & Jennifer J. Harman. (2008) The Information-Motivation-Behavioral Skills model of antiretroviral adherence and its applications. Current HIV/AIDS Reports 5:4, pages 193-203.
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Antonio MastrolorenzoAlfonso MarescaStefano RusconiClaudiu T Supuran. (2008) Update on the development of HIV entry inhibitors. Future HIV Therapy 2:5, pages 479-507.
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A.K. Dudani, A. MartyresH. Fliss. (2008) Short Communication: Rapid Preparation of Preventive and Therapeutic Whole-Killed Retroviral Vaccines Using the Microbicide Taurine Chloramine . AIDS Research and Human Retroviruses 24:4, pages 635-642.
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Jim A. Turpin, Marco L. Schito, Lisa M. Miller Jenkins, John K. Inman & Ettore Appella. 2008. HIV-1: Molecular Biology and Pathogenesis. HIV-1: Molecular Biology and Pathogenesis 229 256 .
B. Courcot, D. Firley, B. Fraisse, P. Becker, J.-M. Gillet, P. Pattison, D. Chernyshov, M. Sghaier, F. Zouhiri, D. Desmaële, J. d'Angelo, F. Bonhomme, S. Geiger & N. E. Ghermani. (2007) Crystal and Electronic Structures of Magnesium(II), Copper(II), and Mixed Magnesium(II)−Copper(II) Complexes of the Quinoline Half of Styrylquinoline-Type HIV-1 Integrase Inhibitors. The Journal of Physical Chemistry B 111:21, pages 6042-6050.
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Lian Yi Han, Chan Juan Zheng, Bin Xie, Jia Jia, Xiao Hua Ma, Feng Zhu, Hong Huang Lin, Xin Chen & Yu Zong Chen. (2007) Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness. Drug Discovery Today 12:7-8, pages 304-313.
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Carla J. Berg, Susan E. Michelson & Steven A. Safren. (2007) Behavioral Aspects of HIV Care: Adherence, Depression, Substance Use, and HIV-Transmission Behaviors. Infectious Disease Clinics of North America 21:1, pages 181-200.
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Longhu Zhou, Chandar S. Thakur, Ross J. Molinaro, Jayashree M. Paranjape, Rieuwert Hoppes, Kuan-Teh Jeang, Robert H. Silverman & Paul F. Torrence. (2006) Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat. Bioorganic & Medicinal Chemistry 14:23, pages 7862-7874.
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Masakazu Kamata, Raymond P. Wu, Dong Sung An, Jonathan P. Saxe, Robert Damoiseaux, Michael E. Phelps, Jing Huang & Irvin S.Y. Chen. (2006) Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death. Biochemical and Biophysical Research Communications 348:3, pages 1101-1106.
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Jeffrey D. Fisher, William A. Fisher, K. Rivet Amico & Jennifer J. Harman. (2006) An information-motivation-behavioral skills model of adherence to antiretroviral therapy.. Health Psychology 25:4, pages 462-473.
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Mario SechiAlessia BacchiMauro CarcelliCarlotta CompariElenia DuceEmilia FisicaroDominga RogolinoPaul GatesMarco DerudasLaith Q. Al-MawsawiNouri Neamati. (2006) From Ligand to Complexes:  Inhibition of Human Immunodeficiency Virus Type 1 Integrase by β-Diketo Acid Metal Complexes. Journal of Medicinal Chemistry 49:14, pages 4248-4260.
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Jinxia Deng, James A. Kelley, Joseph J. Barchi, Tino Sanchez, Raveendra Dayam, Yves Pommier & Nouri Neamati. (2006) Mining the NCI antiviral compounds for HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry 14:11, pages 3785-3792.
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C.A. Menezes de Pádua, C.C. César, P.F. Bonolo, F.A. Acurcio & M.D.C. Guimarães. (2006) High incidence of adverse reactions to initial antiretroviral therapy in Brazil. Brazilian Journal of Medical and Biological Research 39:4, pages 495-505.
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Axel T. Neffe, Matthias Bilang & Bernd Meyer. (2006) Synthesis and optimization of peptidomimetics as HIV entry inhibitors against the receptor protein CD4 using STD NMR and ligand docking. Organic & Biomolecular Chemistry 4:17, pages 3259.
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Meizi He, Dekai Yuan, Wei Lin, Ruifang Pang, Xiaolin Yu & Ming Yang. (2005) Synthesis and assay of isoquinoline derivatives as HIV-1 Tat–TAR interaction inhibitors. Bioorganic & Medicinal Chemistry Letters 15:17, pages 3978-3981.
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Hugues J.-P. Ryser & Rudolf Flückiger. (2005) Keynote review: Progress in targeting HIV-1 entry. Drug Discovery Today 10:16, pages 1085-1094.
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