Advanced search
Publication Cover
Expert Review of Anti-infective Therapy Volume 11, 2013 - Issue 9
Submit an article Journal homepage
264
Views
41
CrossRef citations to date
0
Altmetric
Reviews

Evaluating Chagas disease progression and cure through blood-derived biomarkers: a systematic review

Ana Requena-MéndezBarcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), C/Rosello’ 132 4°,08036; Barcelona, Spain;COHEMI project, Coordination center at IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Public Health. Via Giuseppe La Masa 19, 20156 Milan, ItalyCorrespondence[email protected]
,
Manuel Carlos LópezInstituto de Parasitología y Biomedicina López Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada, Spain
,
Andrea AnghebenCOHEMI project, Coordination center at IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Public Health. Via Giuseppe La Masa 19, 20156 Milan, Italy;Centre for Tropical Diseases (CTD), Sacro Cuore Hospital, Verona, Italy
,
Luis IzquierdoBarcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), C/Rosello’ 132 4°,08036; Barcelona, Spain
,
Isabela RibeiroBarcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), C/Rosello’ 132 4°,08036; Barcelona, Spain
,
Maria-Jesús PinazoBarcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), C/Rosello’ 132 4°,08036; Barcelona, Spain
,
Joaquim GasconDrugs for Neglected Diseases Initiative, 15 Ch. Louis-Dunant 1202 Geneva, Switzerland;COHEMI project, Coordination center at IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Public Health. Via Giuseppe La Masa 19, 20156 Milan, Italy
&
José MuñozBarcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), C/Rosello’ 132 4°,08036; Barcelona, Spain;Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), C/Rosello’ 132 4°,08036; Barcelona, Spain
 show all
Pages 957-976 | Published online: 10 Jan 2014

Citations (41)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Alane Beatriz Vermelho, Giseli Capaci Rodrigues & Claudiu T. Supuran. (2020) Why hasn’t there been more progress in new Chagas disease drug discovery?. Expert Opinion on Drug Discovery 15:2, pages 145-158.
Read now
Cristina Alonso-Vega, Irene Losada-Galván, María-Jesus Pinazo, Javier Sancho Mas, Joaquim Gascón Brustenga & Julio Alonso-Padilla. (2019) The senseless orphanage of Chagas disease. Expert Opinion on Orphan Drugs 7:12, pages 535-545.
Read now
Maria-Jesus Pinazo & Joaquim Gascon. (2015) Chagas disease: from Latin America to the world. Reports in Parasitology 4, pages 7-14.
Read now
Eric Chatelain & Nandini Konar. (2015) Translational challenges of animal models in Chagas disease drug development: a review. Drug Design, Development and Therapy 9, pages 4807-4823.
Read now

Articles from other publishers (37)

Ratish R. Nair, Jong Min An, Jaehoon Kim & Dokyoung Kim. (2023) Review: Recent progress in fluorescent molecular systems for the detection of disease-related biomarkers in biofluids. Coordination Chemistry Reviews 494, pages 215336.
Crossref
G Cesar, M A Natale, M C Albareda, M G Alvarez, B Lococo, A M De Rissio, M Fernandez, M D Castro Eiro, G Bertocchi, B E White, F Zabaleta, R Viotti, R L Tarleton & S A Laucella. (2023) B-Cell Responses in Chronic Chagas Disease: Waning of Trypanosoma cruzi –Specific Antibody-Secreting Cells Following Successful Etiological Treatment . The Journal of Infectious Diseases 227:11, pages 1322-1332.
Crossref
Marcelle Almeida Caminha, Ana Luiza Barbosa Godart Cavalcante & Rubem Figueiredo Sadok Menna-Barreto. 2023. Rapid Antigen Testing [Working Title]. Rapid Antigen Testing [Working Title].
Rafael P. Madeira, Paula Meneghetti, Lucas A. de Barros, Paula de Cassia Buck, Charles Mady, Barbara M. Ianni, Carmen Fernandez‐Becerra & Ana C. Torrecilhas. (2022) Isolation and molecular characterization of circulating extracellular vesicles from blood of chronic Chagas disease patients. Cell Biology International 46:6, pages 883-894.
Crossref
Fernanda Lascano, Facundo García Bournissen & Jaime Altcheh. (2021) Review of pharmacological options for the treatment of Chagas disease. British Journal of Clinical Pharmacology 88:2, pages 383-402.
Crossref
Inmaculada Gómez, M. Carmen Thomas, Génesis Palacios, Adriana Egui, Bartolomé Carrilero, Marina Simón, Basilio Valladares, Manuel Segovia, Emma Carmelo & Manuel Carlos López. (2021) Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Lígia Camera Pierrotti & Karim Yaqub Ibrahim. 2021. Emerging Transplant Infections. Emerging Transplant Infections 1293 1339 .
Ethel Sequeira-Aymar, Ximena diLollo, Yolanda Osorio-Lopez, Alessandra Queiroga Gonçalves, Carme Subirà & Ana Requena-Méndez. (2020) Recomendaciones para el cribado de enfermedad infecciosa, salud mental y mutilación genital femenina en pacientes inmigrantes atendidos en Atención Primaria. Atención Primaria 52:3, pages 193-205.
Crossref
Lígia Camera Pierrotti & Karim Yaqub Ibrahim. 2020. Emerging Transplant Infections. Emerging Transplant Infections 1 47 .
Yoav Y. Broza, Xi Zhou, Miaomiao Yuan, Danyao Qu, Youbing Zheng, Rotem Vishinkin, Muhammad Khatib, Weiwei Wu & Hossam Haick. (2019) Disease Detection with Molecular Biomarkers: From Chemistry of Body Fluids to Nature-Inspired Chemical Sensors. Chemical Reviews 119:22, pages 11761-11817.
Crossref
Adriana Egui, M. Carmen Thomas, Ana Fernández-Villegas, Elena Pérez-Antón, Inmaculada Gómez, Bartolomé Carrilero, Ángel del Pozo, Maialen Ceballos, Eduardo Andrés-León, Miguel Ángel López-Ruz, Eusebio Gainza, Enrique Oquiñena, Manuel Segovia & Manuel Carlos López. (2019) A Parasite Biomarker Set for Evaluating Benznidazole Treatment Efficacy in Patients with Chronic Asymptomatic Trypanosoma cruzi Infection. Antimicrobial Agents and Chemotherapy 63:10.
Crossref
Colin Forsyth, Sheba Meymandi, Ilan Moss, Jason Cone, Rachel Cohen & Carolina Batista. (2019) Proposed multidimensional framework for understanding Chagas disease healthcare barriers in the United States. PLOS Neglected Tropical Diseases 13:9, pages e0007447.
Crossref
Deninson Alejandro Vargas, Miguel Dario Prieto, Alvaro José Martínez-Valencia, Alexandra Cossio, Karl E. V. Burgess, Richard J.S. Burchmore & María Adelaida Gómez. (2019) Pharmacometabolomics of Meglumine Antimoniate in Patients With Cutaneous Leishmaniasis. Frontiers in Pharmacology 10.
Crossref
Marcelle A. Caminha, Virginia Maria B. de Lorena, Wilson de Oliveira Júnior, Jonas Perales, Paulo C. Carvalho, Diogo B. Lima, Maria da Glória A.M. Cavalcanti, Sílvia M. Martins, Richard H. Valente & Rubem F.S. Menna-Barreto. (2019) Trypanosoma cruzi immunoproteome: Calpain-like CAP5.5 differentially detected throughout distinct stages of human Chagas disease cardiomyopathy. Journal of Proteomics 194, pages 179-190.
Crossref
Elizabeth Ruiz-Lancheros, Eric Chatelain & Momar Ndao. 2019. Chagas Disease. Chagas Disease 323 349 .
Maria Carmo Pereira Nunes, Andrea Beaton, Harry Acquatella, Caryn Bern, Ann F. Bolger, Luis E. Echeverría, Walderez O. Dutra, Joaquim Gascon, Carlos A. Morillo, Jamary Oliveira-Filho, Antonio Luiz Pinho Ribeiro & Jose Antonio Marin-Neto. (2018) Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association. Circulation 138:12.
Crossref
Sheba Meymandi, Salvador Hernandez, Sandy Park, Daniel R. Sanchez & Colin Forsyth. (2018) Treatment of Chagas Disease in the United States. Current Treatment Options in Infectious Diseases 10:3, pages 373-388.
Crossref
Bianca L. Ferreira, Éden R. Ferreira, Marlon V. de Brito, Bruno R. Salu, Maria L. V. Oliva, Renato A. Mortara & Cristina M. Orikaza. (2018) BALB/c and C57BL/6 Mice Cytokine Responses to Trypanosoma cruzi Infection Are Independent of Parasite Strain Infectivity. Frontiers in Microbiology 9.
Crossref
Maan Zrein, Elodie Granjon, Lucie Gueyffier, Julie Caillaudeau, Peter Liehl, Hans Pottel, Clareci Silva Cardoso, Claudia Di Lorenzo Oliveira, Lea Campos de Oliveira, Tzong-Hae Lee, Ariela Mota Ferreira, Antonio Luiz P. Ribeiro, Michael P. Busch & Ester Cerdeira Sabino. (2018) A novel antibody surrogate biomarker to monitor parasite persistence in Trypanosoma cruzi-infected patients. PLOS Neglected Tropical Diseases 12:2, pages e0006226.
Crossref
Julien Santi-Rocca, Fernando Fernandez-Cortes, Carlos Chillón-Marinas, María-Luisa González-Rubio, David Martin, Núria Gironès & Manuel Fresno. (2017) A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses. Scientific Reports 7:1.
Crossref
Lorenzo Zammarchi, Maurizio Bonati, Marianne Strohmeyer, Marco Albonico, Ana Requena-Méndez, Zeno Bisoffi, Alessandra Nicoletti, Hector H. García & Alessandro Bartoloni. (2017) Screening, diagnosis and management of human cysticercosis and Taenia solium taeniasis: technical recommendations by the COHEMI project study group . Tropical Medicine & International Health 22:7, pages 881-894.
Crossref
Jose Mateus, Elena Pérez-Antón, Paola Lasso, Adriana Egui, Nubia Roa, Bartolomé Carrilero, John M. González, M. Carmen Thomas, Concepción J. Puerta, Manuel C. López & Adriana Cuéllar. (2017) Antiparasitic Treatment Induces an Improved CD8+ T Cell Response in Chronic Chagasic Patients. The Journal of Immunology 198:8, pages 3170-3180.
Crossref
Ana Requena-Méndez, Sheila Bussion, Edelweiss Aldasoro, Yves Jackson, Andrea Angheben, David Moore, Maria-Jesús Pinazo, Joaquim Gascón, Jose Muñoz & Elisa Sicuri. (2017) Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: a Markov model analysis. The Lancet Global Health 5:4, pages e439-e447.
Crossref
Eric Chatelain. (2017) Chagas disease research and development: Is there light at the end of the tunnel?. Computational and Structural Biotechnology Journal 15, pages 98-103.
Crossref
Michael A. Miles. 2017. Infectious Diseases. Infectious Diseases 1065 1072.e1 .
Rosa T. Pinho, Mariana C. Waghabi, Fabíola Cardillo, José Mengel & Paulo R. Z. Antas. (2016) Scrutinizing the Biomarkers for the Neglected Chagas Disease: How Remarkable!. Frontiers in Immunology 7.
Crossref
Ana Fernandez-Villegas, M. Carmen Thomas, Bartolomé Carrilero, Paola Lasso, Adriana Egui, Laura Murcia, Manuel Segovia, Carlos Alonso & Manuel Carlos López. (2016) A 12-mer repetitive antigenic epitope from Trypanosoma cruzi is a potential marker of therapeutic efficacy in chronic Chagas' disease . Journal of Antimicrobial Chemotherapy 71:7, pages 2005-2009.
Crossref
Reza Ghiasvand & Mitra Hariri. 2016. Oxidative Stress and Antioxidant Protection. Oxidative Stress and Antioxidant Protection 205 220 .
Maria-Jesus Pinazo, Elizabeth de Jesus Posada, Luis Izquierdo, Dolors Tassies, Alexandre-Ferreira Marques, Elisa de Lazzari, Edelweiss Aldasoro, Jose Muñoz, Alba Abras, Silvia Tebar, Montserrat Gallego, Igor Correia de Almeida, Joan-Carles Reverter & Joaquim Gascon. (2016) Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic Response. PLOS Neglected Tropical Diseases 10:1, pages e0004269.
Crossref
Maria Roura, Andreu Domingo, Juan M Leyva-Moral & Robert Pool. (2015) Hispano-Americans in Europe: what do we know about their health status and determinants? A scoping review. BMC Public Health 15:1.
Crossref
S.M. Keating, X. Deng, F. Fernandes, E. Cunha-Neto, A.L. Ribeiro, B. Adesina, A.I. Beyer, P. Contestable, B. Custer, M.P. Busch & E.C. Sabino. (2015) Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease. International Journal of Cardiology 199, pages 451-459.
Crossref
Ernestina Carla Repetto, Rony Zachariah, Ajay Kumar, Andrea Angheben, Federico Gobbi, Mariella Anselmi, Ahmad Al Rousan, Carlota Torrico, Rosa Ruiz, Gabriel Ledezma, Maria Chiara Buoninsegna, Mohammed Khogali, Rafael Van den Bergh, Gianfranco De Maio, Ada Maristella Egidi, Barbara Maccagno & Silvia Garelli. (2015) Neglect of a Neglected Disease in Italy: The Challenge of Access-to-Care for Chagas Disease in Bergamo Area. PLOS Neglected Tropical Diseases 9:9, pages e0004103.
Crossref
Werner Apt, Arturo Arribada, Inés Zulantay, Miguel Saavedra, Eduardo Araya, Aldo Solari, Sylvia Ortiz, Katherine Arriagada & Jorge Rodríguez. (2015) Trypanosoma cruzi burden, genotypes, and clinical evaluation of Chilean patients with chronic Chagas cardiopathy. Parasitology Research 114:8, pages 3007-3018.
Crossref
Caryn Bern. (2015) Chagas’ Disease. New England Journal of Medicine 373:5, pages 456-466.
Crossref
Maria-Jesus Pinazo, Maria-Carmen Thomas, Juan Bustamante, Igor Correia de Almeida, Manuel-Carlos Lopez & Joaquim Gascon. (2015) Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives. Memórias do Instituto Oswaldo Cruz 110:3, pages 422-432.
Crossref
Núria Gironès, Sofía Carbajosa, Néstor A. Guerrero, Cristina Poveda, Carlos Chillón-Marinas & Manuel Fresno. (2014) Global Metabolomic Profiling of Acute Myocarditis Caused by Trypanosoma cruzi Infection. PLoS Neglected Tropical Diseases 8:11, pages e3337.
Crossref
Emi E. Okamoto, Jacqueline E. Sherbuk, Eva H. Clark, Morgan A. Marks, Omar Gandarilla, Gerson Galdos-Cardenas, Angel Vasquez-Villar, Jeong Choi, Thomas C. Crawford, Rose Q.Antonio B. Fernandez, Rony Colanzi, Jorge Luis Flores-Franco, Robert H. Gilman & Caryn Bern. (2014) Biomarkers in Trypanosoma cruzi-Infected and Uninfected Individuals with Varying Severity of Cardiomyopathy in Santa Cruz, Bolivia. PLoS Neglected Tropical Diseases 8:10, pages e3227.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.