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Expert Review of Clinical Pharmacology Volume 7, 2014 - Issue 2
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Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity

Dana FelkerUniversity of California, Berkeley, Morgan Hall, Berkeley, CA 94720-3104, USA
,
Alexandra LynnUniversity of California, Berkeley, Morgan Hall, Berkeley, CA 94720-3104, USA
,
Sue WangUniversity of California, Berkeley, Morgan Hall, Berkeley, CA 94720-3104, USA
&
Dale E JohnsonUniversity of California, Berkeley, Morgan Hall, Berkeley, CA 94720-3104, USA;University of Michigan, Ann Arbor, MI 48109, USACorrespondence[email protected]
Pages 211-218 | Published online: 22 Jan 2014

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Olaniyi Solomon Ola & Kayode Ezekiel Adewole. (2021) Anticlastogenic and hepatoprotective effects of Kolaviron on sodium valproate-induced oxidative toxicity in Wistar rats. Egyptian Journal of Basic and Applied Sciences 8:1, pages 167-179.
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Vijay Gayam, Amrendra Kumar Mandal, Mazin Khalid, Binav Shrestha, Pavani Garlapati & Mowyad Khalid. (2018) Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review. Journal of Community Hospital Internal Medicine Perspectives 8:5, pages 311-314.
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Articles from other publishers (32)

Alejandra Schiavo, Cecilia Maldonado, Marta Vázquez, Pietro Fagiolino, Iñaki F. Trocóniz & Manuel Ibarra. (2023) Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation. European Journal of Pharmaceutical Sciences 183, pages 106399.
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Philippe Nguyen, Lucie Chevillard, Ahmed S. Gouda, Hervé Gourlain, Laurence Labat, Isabelle Malissin, Nicolas Deye, Sebastian Voicu & Bruno Mégarbane. (2022) L-carnitine does not improve valproic acid poisoning management: a cohort study with toxicokinetics and concentration/effect relationships. Annals of Intensive Care 12:1.
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Yiyi Ma, Minglu Wang, Shuaishuai Guo, Tong Li, Xiaodong Liu & Limei Zhao. (2022) The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury. Frontiers in Pharmacology 13.
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Aurelio A. Moya-García, Andrés González-Jiménez, Fernando Moreno, Camilla Stephens, María Isabel Lucena & Juan A. G. Ranea. (2022) Identification of New Toxicity Mechanisms in Drug-Induced Liver Injury through Systems Pharmacology. Genes 13:7, pages 1292.
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Muhammad Omer Iqbal, Majid Manzoor, Asma Mumtaz, Romana Riaz, Shafia Arshad, Imran Ahmad Khan, Usman Javaid, Zahid Manzoor, Shaukat Hussain Munawar, Shumaila Andleeb, Muhammad Masood Ahmed & Aqsa Aslam. (2022) Evaluation of the hepatoprotective activity of hydroalcoholic extract of Alhagi camelorum against valproic acid-induced hepatotoxicity in rats. Biomedicine & Pharmacotherapy 150, pages 112953.
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Tomoaki Ishida, Kei Kawada, Kohei Jobu, Tetsushi Kawazoe, Naohisa Tamura & Mitsuhiko Miyamura. (2022) Analysis of Drug-Induced Liver Injury from Bofutsushosan Administration Using Japanese Adverse Drug Event Report (JADER) Database. Biological and Pharmaceutical Bulletin 45:4, pages 460-466.
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John W. Steele, Ying Linda Lin, Nellie Chen, Bogdan J. Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Robert M. Cabrera, Steven S. Gross & Richard H. Finnell. (2022) Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects. Frontiers in Cell and Developmental Biology 10.
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I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera & M. F. B. Silva. (2021) Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis. Cellular and Molecular Life Sciences 78:23, pages 7451-7468.
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Marta Moreno-Torres, Guillem García-Llorens, Erika Moro, Rebeca Méndez, Guillermo Quintás & José Vicente Castell. (2021) Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey. Scientific Reports 11:1.
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Mohammad Javad Khodayar, Heibatullah Kalantari, Layasadat Khorsandi, Nematollah Ahangar, Azin Samimi & Hadis Alidadi. (2021) Taurine attenuates valproic acid-induced hepatotoxicity via modulation of RIPK1/RIPK3/MLKL-mediated necroptosis signaling in mice. Molecular Biology Reports 48:5, pages 4153-4162.
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Qiongling Bao, Liang Yu, Deying Chen & Lanjuan Li. (2019) Variation in the gut microbial community is associated with the progression of liver regeneration. Hepatology Research 50:1, pages 121-136.
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Moein Askarpour, Kurosh Djafarian, Ehsan Ghaedi, Omid Sadeghi, Ali Sheikhi & Sakineh Shab-Bidar. (2020) Effect of L-Carnitine Supplementation on Liver Enzymes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Archives of Medical Research 51:1, pages 82-94.
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Renhao Chen, Qi Wang, Lanjun Zhao, Shilin Yang, Zhifeng Li, Yulin Feng, Jiaqing Chen, Choon Nam Ong & Hui Zhang. (2019) Lomatogonium Rotatum for Treatment of Acute Liver Injury in Mice: A Metabolomics Study. Metabolites 9:10, pages 227.
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Matheus William Becker, Michele John Muller Lunardelli, Cristiane Valle Tovo & Carine Raquel Blatt. (2019) Drug and herb-induced liver injury: A critical review of Brazilian cases with proposals for the improvement of causality assessment using RUCAM. Annals of Hepatology 18:5, pages 742-750.
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Xiaoxiao Xu, Chao Guo, Xiaoliu Liang, Rong Li & Jian Chen. (2019) Potential biomarker of fibroblast growth factor 21 in valproic acid‐treated livers. BioFactors 45:5, pages 740-749.
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Raúl J. Andrade, Guruprasad P. Aithal, Einar S. Björnsson, Neil Kaplowitz, Gerd A. Kullak-Ublick, Dominique Larrey & Tom H. Karlsen. (2019) EASL Clinical Practice Guidelines: Drug-induced liver injury. Journal of Hepatology 70:6, pages 1222-1261.
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Hong-Li Guo, Xia Jing, Jie-Yu Sun, Ya-hui Hu, Ze-Jun Xu, Ming-Ming Ni, Feng Chen, Xiao-Peng Lu, Jin-Chun Qiu & Tengfei Wang. (2019) Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update. Current Pharmaceutical Design 25:3, pages 343-351.
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Camilla Stephens, M. Isabel Lucena & Raúl J. Andrade. 2019. Evidence-based Gastroenterology and Hepatology 4e. Evidence-based Gastroenterology and Hepatology 4e 715 728 .
Michael J. Marmura & Aliza S. Kumpinsky. (2018) Refining the Benefit/Risk Profile of Anti-Epileptic Drugs in Headache Disorders. CNS Drugs 32:8, pages 735-746.
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C. Stephens, M.I. Lucena & R.J. Andrade. 2018. Comprehensive Toxicology. Comprehensive Toxicology 625 650 .
Camilla Stephens, M. Isabel Lucena & Raúl J. Andrade. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity 477 496 .
Marcial Sebode, Lisa Schulz & Ansgar Lohse. (2017) “Autoimmune(-Like)” Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis. International Journal of Molecular Sciences 18:9, pages 1954.
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Qiang Shi, Xi Yang, James J. Greenhaw, Alec Thomas Salminen, Gary M. Russotti & William F. Salminen. (2017) Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status. International Journal of Toxicology 36:5, pages 365-379.
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Chun-Yi Wu, Tusty-Jiuan Hsieh, Wei-Lung Tseng, Chun-Lan Keng & Chi-Yu Lu. (2017) A mass spectrometry-based strategy combined with bioinformatics: A simple preclinical model for profiling valproic-acid-induced major proteins and modifications in human liver cells. Process Biochemistry 58, pages 78-84.
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Dale E. Johnson & Rudy J. Richardson. 2017. Computational Systems Pharmacology and Toxicology. Computational Systems Pharmacology and Toxicology 300 323 .
E. D. Belousova. (2017) The decreased level of plasma carnitine in patients with epilepsy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 117:6, pages 106.
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Wayne R. Snodgrass & Chia Wei Hsu. 2017. Critical Care Toxicology. Critical Care Toxicology 1083 1094 .
Aida Ortega-Alonso, Camilla Stephens, M. Lucena & Raúl Andrade. (2016) Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury. International Journal of Molecular Sciences 17:5, pages 714.
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Minjun Chen, Ayako Suzuki, Jürgen Borlak, Raúl J. Andrade & M Isabel Lucena. (2015) Drug-induced liver injury: Interactions between drug properties and host factors. Journal of Hepatology 63:2, pages 503-514.
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Joost Willebrords, Isabel Veloso Alves Pereira, Michaël Maes, Sara Crespo Yanguas, Isabelle Colle, Bert Van Den Bossche, Tereza Cristina Da Silva, Cláudia Pinto Marques Souza de Oliveira, Wellington Andraus, Venâncio Avancini Alves, Bruno Cogliati & Mathieu Vinken. (2015) Strategies, models and biomarkers in experimental non-alcoholic fatty liver disease research. Progress in Lipid Research 59, pages 106-125.
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Rafaz Hoque & Wajahat Z. Mehal. (2015) Inflammasomes in pancreatic physiology and disease. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:8, pages G643-G651.
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Wayne R. Snodgrass & Chia Wei Hsu. 2016. Critical Care Toxicology. Critical Care Toxicology 1 12 .

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