282
Views
62
CrossRef citations to date
0
Altmetric
Drug Profile

Tocilizumab for the treatment of rheumatoid arthritis

, &
Pages 843-854 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Reena Shah, Jasmit Shah, Jaimini Gohil, Gunturu Revathi & Salim Surani. (2022) Secondary Infections in Patients with COVID-19 Pneumonia Treated with Tocilizumab Compared to Those Not Treated with Tocilizumab: A Retrospective Study at a Tertiary Hospital in Kenya. International Journal of General Medicine 15, pages 2415-2425.
Read now
Vanesa Calvo-Río, Ricardo Blanco, Montserrat Santos-Gómez, David Díaz-Valle, Esperanza Pato, Javier Loricera, María C. González-Vela, Rosalía Demetrio-Pablo, José L. Hernández & Miguel A. González-Gay. (2017) Efficacy of Anti-IL6-Receptor Tocilizumab in Refractory Cystoid Macular Edema of Birdshot Retinochoroidopathy Report of Two Cases and Literature Review. Ocular Immunology and Inflammation 25:5, pages 609-614.
Read now
Toshio Tanaka, Yoshihiro Hishitani & Atsushi Ogata. (2014) Monoclonal antibodies in rheumatoid arthritis: comparative effectiveness of tocilizumab with tumor necrosis factor inhibitors. Biologics: Targets and Therapy 8, pages 141-153.
Read now
Paola Cipriani, Piero Ruscitti, Francesco Carubbi, Vasiliki Liakouli & Roberto Giacomelli. (2014) Methotrexate: an old new drug in autoimmune disease. Expert Review of Clinical Immunology 10:11, pages 1519-1530.
Read now
Patrick Mathieu, Marie-Chloé Boulanger & Rihab Bouchareb. (2014) Molecular biology of calcific aortic valve disease: towards new pharmacological therapies. Expert Review of Cardiovascular Therapy 12:7, pages 851-862.
Read now
Toru Hirano, Nobuyuki Ohguro, Satoshi Hohki, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata, Kazuyuki Yoshizaki, Atsushi Kumanogoh, Tadamitsu Kishimoto & Toshio Tanaka. (2012) A case of Behçet’s disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab. Modern Rheumatology 22:2, pages 298-302.
Read now
Yoshihito Shima, Tetsuya Tomita, Taeko Ishii, Atsuyoshi Morishima, Yuichi Maeda, Atsushi Ogata, Tadamitsu Kishimoto & Toshio Tanaka. (2011) Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorated clinical symptoms and MRI findings of a patient with ankylosing spondylitis. Modern Rheumatology 21:4, pages 436-439.
Read now
Sumiyuki Nishida, Tomio Kawasaki, Hirokazu Kashiwagi, Atsuyoshi Morishima, Yoshihiro Hishitani, Mari Kawai, Toru Hirano, Taeko Ishii, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata, Yoshihiro Oka, Tadamitsu Kishimoto & Toshio Tanaka. (2011) Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab. Modern Rheumatology 21:4, pages 420-422.
Read now

Articles from other publishers (54)

Kenji Takami & Shigeyoshi Tsuji. (2023) Real-world retention rates of biologics in patients with rheumatoid arthritis. Scientific Reports 13:1.
Crossref
Janu Thuraiaiyah, Mai Erritzøe-Jervild, Haidar Muhsen Al-Khazali, Henrik Winther Schytz & Samaira Younis. (2022) The role of cytokines in migraine: A systematic review. Cephalalgia 42:14, pages 1565-1588.
Crossref
Cynthia L. Miller & Joren C. Madsen. (2022) Targeting IL-6 to prevent cardiac allograft rejection. American Journal of Transplantation 22, pages 12-17.
Crossref
Mariana Boulos, Tamara Bassal, Asad Layyous, Maamoun Basheer & Nimer Assy. (2022) Inflammation in COVID-19: A Risk for Superinfections. COVID 2:11, pages 1609-1624.
Crossref
Mansur Aliyu, Fatema Tuz Zohora, Abubakar Umar Anka, Kashif Ali, Shayan Maleknia, Mohammad Saffarioun & Gholamreza Azizi. (2022) Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach. International Immunopharmacology 111, pages 109130.
Crossref
Maria Casal-Dominguez, Iago Pinal-Fernández & Andrew L Mammen. (2022) Utility of Myositis-Specific Autoantibodies for Treatment Selection in Myositis. Current Treatment Options in Rheumatology 8:4, pages 105-116.
Crossref
Foad Rommasi, Mohammad Javad Nasiri & Mehdi Mirsaeidi. (2022) Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features. Molecular and Cellular Biochemistry 477:3, pages 711-726.
Crossref
Alexandru Caraba, Flavia Corina Babalic, Andreea Munteanu & Otilia Tomulescu. 2022. Rheumatoid Arthritis. Rheumatoid Arthritis.
Tiago Borges, Arsénio Barbosa & Sérgio Silva. 2022. Translational Autoimmunity. Translational Autoimmunity 83 114 .
Antonella Laria, Alfredomaria Lurati, Laura Castelnovo, Antonio Tamburello, Paola Maria Faggioli & Antonino Mazzone. (2021) Rheumatic immune-related adverse events from checkpoint inhibitor therapy: a case series. Beyond Rheumatology 3:2.
Crossref
Pobitra Borah, Pran Kishore Deb, Balakumar Chandrasekaran, Manoj Goyal, Monika Bansal, Snawar Hussain, Pottathil Shinu, Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Satyendra Deka & Vinayak Singh. (2021) Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted. Frontiers in Molecular Biosciences 8.
Crossref
Luxi Sun, Jinjing Liu, Xiufeng Jin, Zhimian Wang, Lu Li, Wei Bai, Yunjiao Yang, Chanyuan Wu, Wei Chen, Shangdong Xu, Jun Zheng & Wenjie Zheng. (2021) Perioperative management with biologics on severe aortic valve regurgitation caused by Behçet syndrome: the experience from a single center. Therapeutic Advances in Chronic Disease 12, pages 204062232110267.
Crossref
Reza Malekzadeh, Atefeh Abedini, Behzad Mohsenpour, Ehsan Sharifipour, Roya Ghasemian, Seyed Ali Javad-Mousavi, Rozita Khodashahi, Mahboobeh Darban, Saeed Kalantari, Nafiseh Abdollahi, Mohammad Reza Salehi, Abbas Rezaei Hosseinabadi, Farzin Khorvash, Melika Valizadeh, Farzaneh Dastan, Sahar Yousefian, Hamed Hosseini, Nassim Anjidani & Payam Tabarsi. (2020) Subcutaneous tocilizumab in adults with severe and critical COVID-19: A prospective open-label uncontrolled multicenter trial. International Immunopharmacology 89, pages 107102.
Crossref
Lun Wang, Yang Zhang & Shuyang Zhang. (2020) Cardiovascular Impairment in COVID-19: Learning From Current Options for Cardiovascular Anti-Inflammatory Therapy. Frontiers in Cardiovascular Medicine 7.
Crossref
Kenji Oku & Tatsuya Atsumi. (2019) Rheumatology practice in Japan: challenges and opportunities. Rheumatology International 39:9, pages 1499-1505.
Crossref
Jesse Pace, Praharshasai Paladugu, Bhaskar Das, John C. He & Sandeep K. Mallipattu. (2019) Targeting STAT3 signaling in kidney disease. American Journal of Physiology-Renal Physiology 316:6, pages F1151-F1161.
Crossref
Kei Suzuki, Takeshi Matsumoto, Yoshiaki Iwashita, Ken Ishikura, Masaki Fujioka, Hideo Wada, Naoyuki Katayama & Hiroshi Imai. (2019) Clinicopathological features of TAFRO syndrome complicated by acquired hemophilia A and development of cardiopulmonary arrest that were successfully treated with VA-ECMO and tocilizumab. International Journal of Hematology 109:6, pages 737-743.
Crossref
Makoto Takada, Yoshihito Ohba, Seitaro Kamiya, Tsutomu Kabashima & Kenichiro Nakashima. (2019) Simple and rapid analysis of tocilizumab using HPLC‐fluorescence detection method. Luminescence 34:3, pages 347-352.
Crossref
Masashi Narazaki & Tadamitsu Kishimoto. (2018) The Two-Faced Cytokine IL-6 in Host Defense and Diseases. International Journal of Molecular Sciences 19:11, pages 3528.
Crossref
Fabiola Atzeni, Rossella Talotta, Ignazio Francesco Masala, Maria Chiara Gerardi, Roberto Casale & Piercarlo Sarzi-Puttini. (2018) Central nervous system involvement in rheumatoid arthritis patients and the potential implications of using biological agents. Best Practice & Research Clinical Rheumatology 32:4, pages 500-510.
Crossref
Jarushka Naidoo, Laura C. Cappelli, Patrick M. Forde, Kristen A. Marrone, Evan J. Lipson, Hans J. Hammers, William H. Sharfman, Dung T. Le, Alan N. Baer, Ami A. Shah, Jemima Albayda, Rebecca L. Manno, Uzma Haque, Anna Kristina Gutierrez, Clifton O. BinghamIIIIII & Julie R. Brahmer. (2017) Inflammatory Arthritis: A Newly Recognized Adverse Event of Immune Checkpoint Blockade. The Oncologist 22:6, pages 627-630.
Crossref
T. Dimitroulas, A. Sandoo, S. Skeoch, M. O’Sullivan, M. Yessirkepov, L. Ayvazyan, A.Y. Gasparyan, G. Metsios & G.D. Kitas. 2017. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases 129 165 .
Hong Ye, Yali Wang, Jun Yan & A. Bennett Jenson. (2016) Characterization of the anti-inflammation mechanism for the AO herbal extract. Experimental and Molecular Pathology 101:3, pages 341-345.
Crossref
A. Deroux, F. Andry & L. Bouillet. (2016) Syndrome d’activation macrophagique sous tocilizumab : mythe ou réalité ?. La Revue de Médecine Interne 37:8, pages 564-566.
Crossref
Alban Deroux, Chistophe Chiquet & Laurence Bouillet. (2016) Tocilizumab in severe and refractory Behcet’s disease: Four cases and literature review. Seminars in Arthritis and Rheumatism 45:6, pages 733-737.
Crossref
Fernando Lopes, Rabea Graepel, Jose Luis Reyes, Arthur Wang, Björn Petri, Jason J. McDougall, Keith A. Sharkey & Derek M. McKay. (2016) Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice. Arthritis & Rheumatology 68:2, pages 542-552.
Crossref
Kazuko Uno, Kazuyuki Yoshizaki, Mitsuhiro Iwahashi, Jiro Yamana, Seizo Yamana, Miki Tanigawa & Katsumi Yagi. (2015) Pretreatment Prediction of Individual Rheumatoid Arthritis Patients’ Response to Anti-Cytokine Therapy Using Serum Cytokine/Chemokine/Soluble Receptor Biomarkers. PLOS ONE 10:7, pages e0132055.
Crossref
Timo Rath, Ulrike Billmeier, Maximilian J. Waldner, Raja Atreya & Markus F. Neurath. (2015) From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Archives of Toxicology 89:4, pages 541-554.
Crossref
Sudha Krishnamurthy, Kristy A. Warner, Zhihong Dong, Atsushi Imai, Carolina Nör, Brent B. Ward, Joseph I. Helman, Russell S. Taichman, Emily L. Bellile, Laurie K. McCauley, Peter J. Polverini, Mark E. Prince, Max S. Wicha & Jacques E. Nör. (2014) Endothelial Interleukin-6 Defines the Tumorigenic Potential of Primary Human Cancer Stem Cells. Stem Cells 32:11, pages 2845-2857.
Crossref
Afaf Sahraoui, Kristine Kloster-Jensen, Thor Ueland, Olle Korsgren, Aksel Foss & Hanne Scholz. (2014) Anakinra and Tocilizumab Enhance Survival and Function of Human Islets during Culture: Implications for Clinical Islet Transplantation. Cell Transplantation 23:10, pages 1199-1211.
Crossref
Diala El Husseini, Marie-Chloé Boulanger, Ablajan Mahmut, Rihab Bouchareb, Marie-Hélène Laflamme, Dominique Fournier, Philippe Pibarot, Yohan Bossé & Patrick Mathieu. (2014) P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease. Journal of Molecular and Cellular Cardiology 72, pages 146-156.
Crossref
Ingrid Bandeira Moss, Monique Bandeira Moss, Debora Silva dos Reis & Reno Martins Coelho. (2014) Immediate infusional reactions to intravenous immunobiological agents for the treatment of autoimmune diseases: experience of 2126 procedures in a non-oncologic infusion centre. Revista Brasileira de Reumatologia (English Edition) 54:2, pages 102-109.
Crossref
Ingrid Bandeira Moss, Monique Bandeira Moss, Debora Silva dos Reis & Reno Martins Coelho. (2014) Reações infusionais imediatas a agentes imunobiológicos endovenosos no tratamento de doenças autoimunes: experiência de 2.126 procedimentos em um centro de infusão não oncológico. Revista Brasileira de Reumatologia 54:2, pages 102-109.
Crossref
Takuma Tsuzuki Wada, Yasuto Araki, Kojiro Sato, Yoshimi Aizaki, Kazuhiro Yokota, Yoon Taek Kim, Hiromi Oda, Riki Kurokawa & Toshihide Mimura. (2014) Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts. Biochemical and Biophysical Research Communications 444:4, pages 682-686.
Crossref
Yuji Yoshida & Toshio Tanaka. (2014) Interleukin 6 and Rheumatoid Arthritis. BioMed Research International 2014, pages 1-12.
Crossref
Kenji Yamagata, Nobutake Shimojo, Hiroyuki Ito, Junya Ijima, Shogo Hasegawa, Toru Yanagawa, Taro Mizutani & Hiroki Bukawa. (2014) Severe Pulmonary Suppuration with Infection-Induced Systemic Inflammatory Response Syndrome following Tongue Cancer Surgery in a Patient Undergoing Tocilizumab Therapy for Rheumatoid Arthritis. Case Reports in Dentistry 2014, pages 1-5.
Crossref
Marc Cohen, Mohammed A Omair & Edward C Keystone. (2013) Monoclonal antibodies in rheumatoid arthritis. International Journal of Clinical Rheumatology 8:5, pages 541-556.
Crossref
Said Younis, Itzhak Rosner, Doron Rimar, Nina Boulman, Michael Rozenbaum, Majed Odeh & Gleb Slobodin. (2013) Weight change during pharmacological blockade of interleukin-6 or tumor necrosis factor-α in patients with inflammatory rheumatic disorders: A 16-week comparative study. Cytokine 61:2, pages 353-355.
Crossref
Toshio Tanaka, Atsushi OgataMasashi Narazaki. (2013) Tocilizumab: An Updated Review of Its Use in the Treatment of Rheumatoid Arthritis and Its Application for Other Immune-Mediated Diseases. Clinical Medicine Insights: Therapeutics 5, pages CMT.S9282.
Crossref
Said Younis, Itzhak Rosner, Doron Rimar, Nina Boulman, Michael Rozenbaum, Majed Odeh & Gleb Slobodin. (2013) Interleukin 6 Blockade–Associated Weight Gain With Abdominal Enlargement in a Patient With Rheumatoid Arthritis. JCR: Journal of Clinical Rheumatology 19:1, pages 48-49.
Crossref
Atsushi Ogata, Atsushi Kumanogoh & Toshio Tanaka. (2012) Pathological Role of Interleukin-6 in Psoriatic Arthritis. Arthritis 2012, pages 1-6.
Crossref
L. Henningsson, P. Jirholt, Y. R. Bogestal, T. Eneljung, M. Adiels, C. Lindholm, I. McInnes, S. Bulfone-Paus, U. H. Lerner & I. Gjertsson. (2012) Interleukin 15 Mediates Joint Destruction in Staphylococcus Aureus Arthritis. Journal of Infectious Diseases 206:5, pages 687-696.
Crossref
Rebecca E. Slager, Gregory A. Hawkins, Xingnan Li, Dirkje S. Postma, Deborah A. Meyers & Eugene R. Bleecker. (2012) Genetics of Asthma Susceptibility and Severity. Clinics in Chest Medicine 33:3, pages 431-443.
Crossref
Peter J Bugelski & Pauline L Martin. (2012) Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets. British Journal of Pharmacology 166:3, pages 823-846.
Crossref
Atsushi Ogata, Noriko Umegaki, Ichiro Katayama, Atsushi Kumanogoh & Toshio Tanaka. (2012) Rhumatisme psoriasique chez deux patients en échec de traitement par le tocilizumab. Revue du Rhumatisme 79:2, pages 168-170.
Crossref
Toshio TanakaMasashi NarazakiTadamitsu Kishimoto. (2012) Therapeutic Targeting of the Interleukin-6 Receptor. Annual Review of Pharmacology and Toxicology 52:1, pages 199-219.
Crossref
Atsushi OgataToru HiranoYoshihiro HishitaniToshio Tanaka. (2012) Safety and Efficacy of Tocilizumab for the Treatment of Rheumatoid Arthritis. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 5, pages CMAMD.S7371.
Crossref
Toshio Tanaka & Tadamitsu Kishimoto. (2012) Immunotherapeutic implication of IL-6 blockade. Immunotherapy 4:1, pages 87-105.
Crossref
Atsushi Ogata & Toshio Tanaka. (2012) Tocilizumab for the Treatment of Rheumatoid Arthritis and Other Systemic Autoimmune Diseases: Current Perspectives and Future Directions. International Journal of Rheumatology 2012, pages 1-14.
Crossref
Atsushi Ogata, Noriko Umegaki, Ichiro Katayama, Atsushi Kumanogoh & Toshio Tanaka. (2012) Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab. Joint Bone Spine 79:1, pages 85-87.
Crossref
Toshio Tanaka, Masashi Narazaki & Tadamitsu Kishimoto. (2011) Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases. FEBS Letters 585:23, pages 3699-3709.
Crossref
Toshio Tanaka, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata & Atsushi Kumanogoh. (2011) Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for the treatment of autoimmune disorders. Drug Development Research 72:8, pages 717-732.
Crossref
Yoshihito Shima, Tetsuya Tomita, Taeko Ishii, Atsuyoshi Morishima, Yuichi Maeda, Atsushi Ogata, Tadamitsu Kishimoto & Toshio Tanaka. (2011) Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorated clinical symptoms and MRI findings of a patient with ankylosing spondylitis. Modern Rheumatology 21:4, pages 436-439.
Crossref
M. Narazaki, K. Hagihara, Y. Shima, A. Ogata, T. Kishimoto & T. Tanaka. (2011) Therapeutic effect of tocilizumab on two patients with polymyositis. Rheumatology 50:7, pages 1344-1346.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.