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Review

Receptor-activating autoantibodies and disease: preeclampsia and beyond

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Pages 659-674 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Ziba Rahimi, Maryam Zangeneh, Arezoo Rezaeyan, Ebrahim Shakiba & Zohreh Rahimi. (2018) MMP-8 C-799T and MMP-8 C+17G polymorphisms in mild and severe preeclampsia: Association between MMP-8 C-799T with susceptibility to severe preeclampsia. Clinical and Experimental Hypertension 40:2, pages 175-178.
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Daniele Focosi. (2016) Advances in Pretransplant Donor-Specific Antibody Testing in Solid Organ Transplantation: From Bench to Bedside. International Reviews of Immunology 35:4, pages 351-368.
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Vikki M Abrahams. (2011) Reproductive immunology: the clinical view. Expert Review of Clinical Immunology 7:5, pages 555-556.
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Articles from other publishers (44)

Dan Wang, Dong Yang, Liuhui Yang, Lihong Diao, Yuqi Zhang, Yang Li, Hongye Wang, Jing Ren, Linlin Cheng, Qiaoyun Tan, Ran Zhang, Xiaohong Han, Xiaohan Zhang, Bingwei Wang, Dong Li, Meng Chen, Henning Hermjakob, Yongzhe Li, Joshua LaBaer, Zhou Zhou & Xiaobo Yu. (2023) Human Autoantigen Atlas: Searching for the Hallmarks of Autoantigens. Journal of Proteome Research 22:6, pages 1800-1815.
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Srividya Parthasarathy, Prathyusha Soundararajan, Meenakumari Sakthivelu, Kanchana Mala Karuppiah, Palaniyandi Velusamy, Subash C.B. Gopinath & Raman Pachaiappan. (2023) The role of prognostic biomarkers and their implications in early detection of preeclampsia: A systematic review. Process Biochemistry 126, pages 238-251.
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Owen Herrock, Evangeline Deer & Babbette LaMarca. (2023) Setting a stage: Inflammation during preeclampsia and postpartum. Frontiers in Physiology 14.
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Ian Tizard. 2023. Autoimmune Diseases in Domestic Animals. Autoimmune Diseases in Domestic Animals 29 40 .
Asadollah Mohammadi, Kazem Mashayekhi, Jamshid Gholizadeh Navashenaq & Saeed Mohammadian Haftcheshmeh. (2022) Curcumin as a Natural Modulator of B Lymphocytes: Evidence from In Vitro and In Vivo Studies. Mini-Reviews in Medicinal Chemistry 22:18, pages 2361-2370.
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George W. Booz, Daniel Kennedy, Michael Bowling, Taprieka Robinson, Daniel Azubuike, Brandon Fisher, Karen Brooks, Pooja Chinthakuntla, Ngoc H. Hoang, Jonathan P. Hosler & Mark W. CunninghamJr.Jr.. (2021) Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia. Biology of Sex Differences 12:1.
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Karin Tammelin, Anna Lundgren, Mats Holmberg, Bengt Andersson & Helena Filipsson Nyström. (2021) β1-adrenergic and Muscarinic Acetylcholine Type 2 Receptor Antibodies are Increased in Graves’ Hyperthyroidism and Decrease During Antithyroid Therapy. Experimental and Clinical Endocrinology & Diabetes 129:11, pages 783-790.
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Cong Sun, Jiebei Lu, Yaolin Long, Shuai Guo, Weiwei Jia, Na Ning, Haihu Hao, Xiaohui Wang, Yunfei Bian, Huirong Liu & Li Wang. (2021) Adiponectin up‐regulates the decrease of myocardial autophagic flux induced by β 1 ‐adrenergic receptor autoantibody partly dependent on AMPK . Journal of Cellular and Molecular Medicine 25:17, pages 8464-8478.
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Khuraijam Dhanachandra Singh & Sadashiva S. Karnik. (2021) Current Trends in GPCR Allostery. The Journal of Membrane Biology 254:3, pages 293-300.
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Alvin P Chan, Marjorie‐Anne R Guerra, Maura Rossetti, Michelle J Hickey, Robert S Venick, Elizabeth A Marcus, Suzanne V McDiarmid, Douglas G Farmer, Elaine F Reed & Laura J Wozniak. (2021) Non‐HLA AT1R antibodies are highly prevalent after pediatric intestinal transplantation. Pediatric Transplantation 25:3.
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Kathryn L. Bradford, Meghan Pearl, Donald B. Kohn, Patricia Weng, Ora Yadin, La Vette Bowles, Satiro N. De Oliveira & Theodore B. Moore. (2020) AT1R Activating Autoantibodies in Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 26:11, pages 2061-2067.
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Xin Duan, Rong Liu, Xiao‐Liang Luo, Xiao‐Jin Gao, Feng‐Huan Hu, Chao Guo, Juan Wang, Xiao‐Ying Hu, Yu‐Shi Chun, Jian‐Song Yuan, Jin‐Gang Cui, Wei‐Xian Yang & Shu-Bin Qiao. (2020) The relationship between β 1 ‐adrenergic and M 2 ‐muscarinic receptor autoantibodies and hypertrophic cardiomyopathy . Experimental Physiology 105:3, pages 522-530.
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Barbara Szeiffova Bacova, Jana Radosinska, Gerd Wallukat, Miroslav Barancik, Anne Wallukat, Vladimir Knezl, Matus Sykora, Ludovit Paulis & Narcis Tribulova. (2020) Suppression of β1-Adrenoceptor Autoantibodies is Involved in the Antiarrhythmic Effects of Omega-3 Fatty Acids in Male and Female Hypertensive Rats. International Journal of Molecular Sciences 21:2, pages 526.
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Hanna Davideit, Annekathrin Haberland, Sabine Bartel, Sarah Schulze-Rothe, Johannes Müller & Katrin Wenzel. 2019. Autoantibodies. Autoantibodies 95 102 .
Martin Oaks, Karen Michel, Francis X. Downey & Vinay Thohan. (2018) Xenoreactive antibodies and latent fibrin formation in VAD and cardiac transplant recipients can confound the detection and measurement of anti-AT1R antibodies. American Journal of Transplantation 18:11, pages 2763-2771.
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Katrin Wenzel, Sarah Schulze-Rothe, Johannes Müller, Gerd Wallukat & Annekathrin Haberland. (2018) Difference between beta1-adrenoceptor autoantibodies of human and animal origin—Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology. PLOS ONE 13:2, pages e0192615.
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Chen LiuRodney E. KellemsYang Xia. (2017) Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase. American Journal of Hypertension 30:8, pages 756-764.
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Ufuk İlgen, Müçteba Enes Yayla & Nurşen Düzgün. (2016) Anti-angiotensin II type 1 receptor autoantibodies (AT1R-AAs) in patients with systemic sclerosis: lack of association with disease manifestations. Rheumatology International 37:4, pages 593-598.
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A. O. Shpakov, O. A. Zharova & K. V. Derkach. (2017) Antibodies to extracellular regions of G protein-coupled receptors and receptor tyrosine kinases as one of the causes of autoimmune diseases. Journal of Evolutionary Biochemistry and Physiology 53:2, pages 93-110.
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J. Müller, G. Wallukat & I. Schimke. 2017. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases 659 679 .
B. Bornholz, G. Wallukat, D. Roggenbuck & I. Schimke. 2017. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases 49 63 .
Annekathrin Haberland, Martin Holtzhauer, Alice Schlichtiger, Sabine Bartel, Ingolf Schimke, Johannes Müller, Michael Dandel, Peter B. Luppa & Gerd Wallukat. (2016) Aptamer BC 007 – A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors. European Journal of Pharmacology 789, pages 37-45.
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Shivanjali Joshi-Barr, Annekathrin Haberland, Sabine Bartel, Johannes Müller, Ted Choi & Gerd Wallukat. (2016) High throughput bioassay for beta1-adrenoceptor autoantibody detection. International Journal of Cardiology 219, pages 98-104.
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Yuanhua Ye, Yujie Kong & Yan Zhang. (2016) Complement Split Products C3a/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia?. Gynecologic and Obstetric Investigation 81:1, pages 28-33.
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Matthew R. Weir, Ellen D. Burgess, James E. Cooper, Andrew Z. Fenves, David Goldsmith, Dianne McKay, Anita Mehrotra, Mark M. Mitsnefes, Domenic A. Sica & Sandra J. Taler. (2015) Assessment and Management of Hypertension in Transplant Patients. Journal of the American Society of Nephrology 26:6, pages 1248-1260.
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Kathleen M. Powis & Roger L. Shapiro. (2015) Protease Inhibitors and Adverse Birth Outcomes: Is Progesterone the Missing Piece to the Puzzle?. Journal of Infectious Diseases 211:1, pages 4-7.
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Andreas Pohlmann, Peter Karczewski, Min-Chi Ku, Babette Dieringer, Helmar Waiczies, Natali Wisbrun, Stefanie Kox, Irina Palatnik, Henning Matthias Reimann, Christina Eichhorn, Sonia Waiczies, Petra Hempel, Bernd Lemke, Thoralf Niendorf & Marion Bimmler. (2014) Cerebral blood volume estimation by ferumoxytol-enhanced steady-state MRI at 9.4 T reveals microvascular impact of α 1 -adrenergic receptor antibodies . NMR in Biomedicine 27:9, pages 1085-1093.
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Stephen Pastan & Divya Gupta. 2014. Textbook of Organ Transplantation. Textbook of Organ Transplantation 1030 1058 .
Annekathrin Haberland, Gerd Wallukat, Sabine Berg, Angela-Martina Schulz, Ernst-Joachim Freyse, Roland Vetter, Eckhard Salzsieder, Johannes Müller, Reinhold Kreutz & Ingolf Schimke. (2014) Neutralization of pathogenic beta1-receptor autoantibodies by aptamers in vivo: the first successful proof of principle in spontaneously hypertensive rats. Molecular and Cellular Biochemistry 393:1-2, pages 177-180.
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Melanie Moore, Jackie Ferguson & Chris Burns. (2014) Applications of cell-based bioassays measuring the induced expression of endogenous genes. Bioanalysis 6:11, pages 1563-1574.
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Gerd Wallukat & Ingolf Schimke. (2014) Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases. Seminars in Immunopathology 36:3, pages 351-363.
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Melvin Berger, Daniel E. McCallus & Cindy Shin‐Yi Lin. (2013) Rapid and reversible responses to IVIG in autoimmune neuromuscular diseases suggest mechanisms of action involving competition with functionally important autoantibodies . Journal of the Peripheral Nervous System 18:4, pages 275-296.
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Beje Thomas, David J. Taber & Titte R. Srinivas. (2013) Hypertension after Kidney Transplantation: A Pathophysiologic Approach. Current Hypertension Reports 15:5, pages 458-469.
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Sabine I. Wolf, Sarah Howat, David J. Abraham, Jeremy D. Pearson & Charlotte Lawson. (2013) Agonistic anti-ICAM-1 antibodies in scleroderma: Activation of endothelial pro-inflammatory cascades. Vascular Pharmacology 59:1-2, pages 19-26.
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Yang XiaRodney E. Kellems. (2013) Angiotensin Receptor Agonistic Autoantibodies and Hypertension. Circulation Research 113:1, pages 78-87.
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Dong-bao Chen & Wen Wang. (2013) Human Placental MicroRNAs and Preeclampsia1. Biology of Reproduction 88:5.
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Kathleen M. Powis, Thomas F. McElrath, Michael D. Hughes, Anthony Ogwu, Sajini Souda, Saul A. Datwyler, Erik von Widenfelt, Sikhulile Moyo, Marisa Nádas, Joseph Makhema, Esther Machakaire, Shahin Lockman, Max Essex & Roger L. Shapiro. (2013) High Viral Load and Elevated Angiogenic Markers Associated With Increased Risk of Preeclampsia Among Women Initiating Highly Active Antiretroviral Therapy in Pregnancy in the Mma Bana Study, Botswana. JAIDS Journal of Acquired Immune Deficiency Syndromes 62:5, pages 517-524.
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Annekathrin HaberlandGerd Wallukat & Ingolf Schimke. (2013) The patent situation concerning the treatment of diseases associated with autoantibodies directed against G-protein-coupled receptors. Pharmaceutical Patent Analyst 2:2, pages 231-248.
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Hongliang Li, Benjamin J. Scherlag, David C. Kem, Caitlin Zillner, Shailesh Male, Sorkko Thirunavukkarasu, Xiaohua Shen, Jan V. Pitha, Madeleine W. Cunningham, Ralph Lazzara & Xichun Yu. (2013) Atrial tachycardia provoked in the presence of activating autoantibodies to β2-adrenergic receptor in the rabbit. Heart Rhythm 10:3, pages 436-441.
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Annekathrin Haberland, Silvia Gilka Munoz Saravia, Gerd Wallukat, Reinhard Ziebig & Ingolf Schimke. (2013) Chronic Chagas disease: from basics to laboratory medicine. Clinical Chemistry and Laboratory Medicine (CCLM) 51:2, pages 271-294.
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Wei WangRoxanna A. IraniYujin ZhangSusan M. RaminSean C. BlackwellLijian TaoRodney E. KellemsYang Xia. (2012) Autoantibody-Mediated Complement C3a Receptor Activation Contributes to the Pathogenesis of Preeclampsia. Hypertension 60:3, pages 712-721.
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Annekathrin Haberland, Gerd Wallukat & Ingolf Schimke. (2011) Aptamer Binding and Neutralization of β1-Adrenoceptor Autoantibodies: Basics and a Vision of Its Future in Cardiomyopathy Treatment☆ ☆This work was supported by the European Regional Development Fund (10141685; Berlin, Germany) and Stiftung Pathobiochemie, Deutsche Gesellschaft für Klinische Chemie und Laboratoriumsmedizin (66/2007) and 48/2011, Germany).. Trends in Cardiovascular Medicine 21:6, pages 177-182.
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