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Expert Review of Clinical Pharmacology Volume 4, 2011 - Issue 6
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Review

Pharmacokinetic–pharmacodynamic modeling in acute and chronic pain: an overview of the recent literature

Christian Martini Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands; Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands
,
Erik Olofsen Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands; Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands
,
Ashraf Yassen Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Europe, Leiderdorp, The Netherlands; Global Clinical Pharmacology and Exploratory Development, Astellas Pharma Global Development Europe, Leiderdorp, The Netherlands
,
Leon Aarts Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands; Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands
&
Albert Dahan Department of Anesthesiology, Leiden University Medical Center, 2330 RC Leiden, The Netherlands;[email protected]
Pages 719-728 | Published online: 10 Jan 2014

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Manuel A. Baarslag, Karel Allegaert, John N. Van Den Anker, Catherijne A.J. Knibbe, Monique Van Dijk, Sinno H.P. Simons & Dick Tibboel. (2017) Paracetamol and morphine for infant and neonatal pain; still a long way to go?. Expert Review of Clinical Pharmacology 10:1, pages 111-126.
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Radu Tanasescu & Cris S Constantinescu. (2013) Pharmacokinetic evaluation of nabiximols for the treatment of multiple sclerosis pain. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1219-1228.
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Nuggehally R. Srinivas. (2013) Do We Have Clarity on the Therapeutic Levels of Morphine and Its Metabolites: Seeking Answers for the Dilemma?. Journal of Pain & Palliative Care Pharmacotherapy 27:2, pages 163-166.
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Articles from other publishers (31)

Maarten van Lemmen, Jeffrey Florian, Zhihua Li, Monique van Velzen, Eveline van Dorp, Marieke Niesters, Elise Sarton, Erik Olofsen, Rutger van der Schrier, David G. Strauss & Albert Dahan. (2023) Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest. Anesthesiology 139:3, pages 342-353.
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Pieter Simons, Rutger van der Schrier, Maarten van Lemmen, Simone Jansen, Kiki W.K. Kuijpers, Monique van Velzen, Elise Sarton, Todd Nicklas, Cathy Michalsky, Mark A. Demitrack, Michael Fossler, Erik Olofsen, Marieke Niesters & Albert Dahan. (2022) Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic–Pharmacodynamic Comparison with Morphine. Anesthesiology 138:3, pages 249-263.
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I.M. Lovchev, D.A. Shmidt, D.A. Sorokina & M.V. Churyukanov. (2023) Catastrophizing and chronic pain: a modern view on the problem. Russian Journal of Pain 21:1, pages 60.
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André Farkouh, Margit Hemetsberger, Christian R. Noe & Christoph Baumgärtel. (2022) Interpreting the Benefit and Risk Data in Between-Drug Comparisons: Illustration of the Challenges Using the Example of Mefenamic Acid versus Ibuprofen. Pharmaceutics 14:10, pages 2240.
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Sjoerd de Hoogd, Sebastiaan C. Goulooze, Abraham J. Valkenburg, Elke H. J. Krekels, Monique van Dijk, Dick Tibboel & Catherijne A. J. Knibbe. (2021) Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations. Pediatric Research 90:6, pages 1201-1206.
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Koki Shimoji & Hitoshi Fujioka. 2021. Chronic Pain Management in General and Hospital Practice. Chronic Pain Management in General and Hospital Practice 55 86 .
Kris Rutten. 2021. Modern CNS Drug Discovery. Modern CNS Drug Discovery 77 91 .
Sam R.J. Hoare, Beth A. Fleck, John P. Williams & Dimitri E. Grigoriadis. (2020) The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program. Drug Discovery Today 25:1, pages 7-14.
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Diane Reckziegel, Etienne Vachon-Presseau, Bogdan Petre, Thomas J. Schnitzer, Marwan N. Baliki & A. Vania Apkarian. (2019) Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain. Pain 160:1, pages S37-S48.
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Stephen Chin Beng Lim, Stephan Schug & Janakan Krishnarajah. (2019) The Pharmacokinetics and Local Tolerability of a Novel Sublingual Formulation of Buprenorphine. Pain Medicine 20:1, pages 143-152.
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Patrick D. Dißmann, Maxime Maignan, Paul D. Cloves, Blanca Gutierrez Parres, Sara Dickerson & Alice Eberhardt. (2018) A Review of the Burden of Trauma Pain in Emergency Settings in Europe. Pain and Therapy 7:2, pages 179-192.
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Michiel J. Esdonk, Ian Lindeman, Pieter Okkerse, Marieke L. Kam, Geert J. Groeneveld & Jasper Stevens. (2018) Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects. CPT: Pharmacometrics & Systems Pharmacology 7:9, pages 573-580.
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Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl‐Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Günter Vollmer, Heather Wallace, Diane Benford, Girolamo Calò, Albert Dahan, Birgit Dusemund, Patrick Mulder, Éva Németh‐Zámboriné, Davide Arcella, Katleen Baert, Claudia Cascio, Sara Levorato, Marijke Schutte & Christiane Vleminckx. (2018) Update of the Scientific Opinion on opium alkaloids in poppy seeds. EFSA Journal 16:5.
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T. van de Donk, S. Ward, R. Langford & A. Dahan. (2018) Pharmacokinetics and pharmacodynamics of sublingual sufentanil for postoperative pain management. Anaesthesia 73:2, pages 231-237.
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Sjoerd de Hoogd, Pyry A. J. Välitalo, Albert Dahan, Simone van Kralingen, Michael M. W. Coughtrie, Eric P. A. van Dongen, Bert van Ramshorst & Catherijne A. J. Knibbe. (2017) Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide. Clinical Pharmacokinetics 56:12, pages 1577-1587.
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Sebastiaan C. Goulooze, Elke H.J. Krekels, Monique van Dijk, Dick Tibboel, Piet H. van der Graaf, Thomas Hankemeier, Catherijne A.J. Knibbe & J.G. Coen van Hasselt. (2017) Towards personalized treatment of pain using a quantitative systems pharmacology approach. European Journal of Pharmaceutical Sciences 109, pages S32-S38.
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A. Taneja, O. Della Pasqua & M. Danhof. (2017) Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm. European Journal of Clinical Pharmacology 73:10, pages 1219-1236.
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Pieter Okkerse, Guido Amerongen, Marieke L. Kam, Jasper Stevens, Richard P. Butt, Rachel Gurrell, Albert Dahan, Joop M. Gerven, Justin L. Hay & Geert Jan Groeneveld. (2017) The use of a battery of pain models to detect analgesic properties of compounds: a two‐part four‐way crossover study. British Journal of Clinical Pharmacology 83:5, pages 976-990.
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Juliana Zampoli Boava Papini, Cíntia Maria Saia Cereda, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Daniele Ribeiro de Araújo & Giovana Radomille Tofoli. (2017) Pharmacokinetics and Pharmacodynamics Evaluation of Tramadol in Thermoreversible Gels. BioMed Research International 2017, pages 1-7.
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Gerald H. Lushington & Rathnam Chaguturu. 2017. Innovative Approaches in Drug Discovery. Innovative Approaches in Drug Discovery 295 314 .
Mohammed H. Elkomy, David R. Drover, Jeffery L. Galinkin, Gregory B. Hammer & Kristi L. Glotzbach. (2016) Pharmacodynamic Analysis of Morphine Time-to-Remedication Events in Infants and Young Children After Congenital Heart Surgery. Clinical Pharmacokinetics 55:10, pages 1217-1226.
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Meghan MacKenzie, Peter J. Zed & Mary H. H. Ensom. (2016) Opioid Pharmacokinetics-Pharmacodynamics. Annals of Pharmacotherapy 50:3, pages 209-218.
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Sally K. Guthrie & Christian Teter. 2016. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents 267 301 .
Anne Estrup Olesen, Erik Olofsen, Trine Andresen, Carina Graversen, Asbjørn Mohr Drewes & Albert Dahan. (2015) Stochastic Pharmacokinetic–Pharmacodynamic Analysis of the Effect of Transdermal Buprenorphine on Electroencephalogram and Analgesia. Anesthesia & Analgesia 121:5, pages 1165-1175.
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Sabine J. G. M Ahlers, Pyry A. J. Välitalo, Mariska Y. M. Peeters, Laura van Gulik, Eric P. A. van Dongen, Albert Dahan, Dick Tibboel & Catherijne A. J. Knibbe. (2015) Morphine Glucuronidation and Elimination in Intensive Care Patients. Anesthesia & Analgesia 121:5, pages 1261-1273.
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Rasmus V. Juul, David J.R. Foster, Richard N. Upton, Trine Andresen, Carina Graversen, Asbjørn M. Drewes, Lona L. Christrup & Mads Kreilgaard. (2014) Pharmacodynamic Modelling of Placebo and Buprenorphine Effects on Event-Related Potentials in Experimental Pain. Basic & Clinical Pharmacology & Toxicology 115:4, pages 343-351.
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Jennifer S. Gewandter, Robert H. Dworkin, Dennis C. Turk, Michael P. McDermott, Ralf Baron, Marc R. Gastonguay, Ian Gilron, Nathaniel P. Katz, Cyrus Mehta, Srinivasa N. Raja, Stephen Senn, Charles Taylor, Penney Cowan, Paul Desjardins, Rozalina Dimitrova, Raymond Dionne, John T. Farrar, David J. Hewitt, Smriti Iyengar, Gary W. Jay, Eija Kalso, Robert D. Kerns, Richard Leff, Michael Leong, Karin L. Petersen, Bernard M. Ravina, Christine Rauschkolb, Andrew S.C. Rice, Michael C. Rowbotham, Cristina Sampaio, Sren H. Sindrup, Joseph W. Stauffer, Ilona Steigerwald, Jonathan Stewart, Jeffrey Tobias, Rolf-Detlef Treede, Mark Wallace & Richard E. White. (2014) Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations. Pain 155:9, pages 1683-1695.
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A. Taneja, I. F. Troconiz, M. Danhof & O. Della Pasqua. (2013) Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain. Pharmaceutical Research 31:3, pages 593-606.
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P. VÄLITALO, V.-P. RANTA, A. C. HOOKER, M. KOKKI & H. KOKKI. (2014) Population pharmacometrics in support of analgesics studies. Acta Anaesthesiologica Scandinavica 58:2, pages 143-156.
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A. Dahan. 2013. Leerboek anesthesiologie. Leerboek anesthesiologie 121 133 .
Mellar P. Davis & Geoffrey Mitchell. (2012) Reconstructing analgesic trials. Current Opinion in Supportive & Palliative Care 6:4, pages 490-493.
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