5,229
Views
34
CrossRef citations to date
0
Altmetric
Review

Pharmacokinetic–pharmacodynamic modeling in acute and chronic pain: an overview of the recent literature

, , , &
Pages 719-728 | Published online: 10 Jan 2014

References

  • Danhof M, de Jonghe J, deLange ECM, della Pasqua O, Ploeger BA, Voskuyl RA. Mechanism-based pharmacokinetic–pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis. Annu. Rev. Pharmacol. Toxicol.47, 357–400 (2007).
  • Minto CF, Schnider TW. Contributions of PK/PD modeling to intravenous anesthesia. Clin. Pharmacol. Ther.84, 37–38 (2008).
  • Segre G. Kinetics of interaction between drugs and biological systems. Farmaco. Sci.23(10), 907–918 (1968).
  • Hull CJ. Pharmacokinetics and pharmacodynamic. Br. J. Anaesth.51, 579–594 (1979).
  • Sheiner L, Stanski LB, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther.25, 358–371 (1979).
  • Yassen A, Olofsen E, Romberg R et al. Mechanism-based PK–PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers. Clin. Pharmacol. Ther.81, 50–58 (2007).
  • Miller R. Population pharmacokinetics. In: Principles of Clinical Pharmacology. Atkinson AJ, Daniels CE, Dedrick RL, Grudzinakis CV, Markey SP (Eds). Academic Press, CA, USA, 113–119 (2001).
  • Heeremans EH, Proost JH, Eleveld DJ, Absalom AR, Struys MM. Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine. Curr. Opion. Anaesthesiol.23, 479–484 (2010).
  • Beal BL, Sheiner LB, Boeckman AJ, Bauer RJ. NONMEM User’s Guide. Icon Development Solutions, MD, USA (1989–2009).
  • Shafer SL, Struys MMRF. Mixed effect modeling in analgesia trials. Anesth. Analg.107(1), 9–10 (2008).
  • Bekkering GE, Soares-Weiser K, Reid K et al. Can morphine still be considered to be the standard for treating chronic pain? A systematic review including pair-wise and network meta-analyses. Curr. Med. Res. Opin.27(7), 1477–1491 (2011).
  • Lötsch J. Pharmacokinetic–pharmacodynamic modeling of opioids. J. Pain Sympt. Manag.29(5 Suppl.), S90–S103 (2005).
  • Sarton E, Olofsen E, Romberg R et al. Sex differences in morphine analgesia: an experimental study in healthy volunteers. Anesthesiology93, 1245–1254 (2000).
  • Niesters M, Dahan A, Kest B et al. Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain151, 61–68 (2010).
  • Dahan A, van Dorp E, Smith TW, Yassen A. Morphine-6-glucuronide (M6G) for postoperative pain relief. Eur. J. Pain12, 403–411 (2008).
  • Romberg R, Olofsen E, Sarton E, den Hartigh J, Taschner PE, Dahan A. Pharmacokinetic–pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers: absence of sex differences. Anesthesiology100, 120–133 (2004).
  • Olofsen E, van Dorp E, Teppema L et al. Naloxone reversal of morphine- and morphione-6-glucuronide-induced respiratory depression in healthy volunteers: a mechanism-based pharmacokinetic–pharmacodynamic modeling study. Anesthesiology112, 1417–1427 (2010).
  • Garfield E. Current Comments: The 1982 John Scott Award goes to Jack Fishman and Harold Blumberg for synthesis and investigation of naloxone. Essays of an Information Scientist6, 121–130 (1983).
  • Dahan A, Aarts L, Smith TW. Incidence, reversal, and prevention of opioid-induced respiratory depression. Anesthesiology112(1), 226–238 (2010).
  • Mazoit JX, Butscher K, Samii K. Morphine in postoperative patients: pharmacokinetics and pharmacodynamics of metabolites. Anesth. Analg.105(1), 70–78 (2007).
  • Abou Hammoud H, Simon N, Urien S, Riou B, Lechat P, Aubrun F. Intravenous morphine titration in immediate postoperative pain management: population kinetic–pharmacodynamic and logistic regression analysis. Pain144, 139–146 (2009).
  • Yassen A, Olofsen E, Kan J, Dahan A, Danhof M. Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine. Clin. Pharmacokinet.46(5), 433–447 (2007).
  • Yassen A, Olofsen E, Romberg R et al. Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers. Clin. Pharmacol. Ther.81, 50–58 (2007).
  • Yassen A, Olofsen E, Romberg R, Sarton E, Danhof M, Dahan A. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers. Anesthesiology104, 1232–1242 (2006).
  • Noppers I, Niesters M, Aarts L, Smith T, Sraton E, Dahan A. Ketamine for treatment of chonic non-cancer pain. Expert Opin. Pharmacother.11(14), 2417–2429 (2010).
  • Herd DW, Anderson BK, Keene NA, Holford NK. Investigating pharmacodynamics of ketamine in children. Paediatr. Anaesth.18(1), 36–42 (2008).
  • Herd DW, Anderson BK, Holford NK. Modeling the norketamine metabolite in children and the implications for analgesia. Paediatr. Anesth.17(9), 831–840 (2007).
  • Sigtermans M, Dahan A, Mooren R et al.S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic–pharmacodynamic modeling study in healthy volunteers. Anesthesiology111, 892–903 (2009).
  • Kowalski KG, Olson S, Remmers AE, Hutmacher MM. Modeling and simulation to support dose selection and clinical development of SC-75416, a selective COX-2 inhibitor for the treatment of acute and chronic pain. Clin. Pharmacol. Ther.83, 857–866 (2008).
  • Li H, Mandema J, Wada R et al. Modeling the onset and offset of dental pain relief by ibuprofen. J. Clin. Pharmacol. DOI: 10.1177/0091270010389470 (2011) (Epub ahead of print).
  • Green B, Chandler S, MacDonald G, Elliott G, Roberts MS. Quantifying pain relief following administration of a novel formulation of paracetamol (acetaminophen). J. Clin. Pharmacol.50, 1406–1413 (2010).
  • Anderson BJ, Holford NH, Woollard GA, Kanagasundaram S, Mahadevan M. Perioperative pharmacodynamics of acetaminophen analgesia in children. Anesthesiology90(2), 411–421 (1999).
  • Olofsen E, Burm AG, Simon MJ, Veering BT, van Kleef JW, Dahan A. Population pharmacokinetic–pharmacodynamic modeling of epidural anesthesia. Anesthesiology109(4), 664–674 (2008).
  • Dahan A, Olofsen E, Sigtermans M et al. Population pharmacokinetic–pharmacodynamic modeling of ketamine-induced pain relief of chronic pain. Eur. J. Pain5(3), 258–267 (2011).
  • Byon W, Ouellet D, Chew M et al. Exposure-response analyses of the effects of pregabalin in patients with fibromyalgia using daily pain scores and patient global impression of change. J. Clin. Pharmacol.50, 803–815 (2010).
  • Sheiner LB. A new approach to the analysis of analgesic drug trials illustrated with bromfenac data. Clin. Pharmacol. Ther.56(3), 309–322 (1994).
  • Yassen A, Olofsen E, Kan J, Dahan A, Danhof M. Pharmacokinetic–pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats. Pharm. Res.25(1), 183–193 (2008).
  • Okie S. A flood of opioids, a rising tide of deaths. N. Eng. J. Med.363(21), 1981–1983 (2010).
  • Von Korff M, Dunn KM. Chronic pain reconsidered. Pain138, 267–276 (2008).
  • Abandanes S, van der Aart J, Barletta JA et al. Prediction of repeat-dose occupancy from single-dose data: characteristics of the relationship between plasma pharmacokinetics and brain target occupancy. J. Cereb. Blood Flow Metab.31, 944–952 (2011).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.