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Expert Review of Clinical Pharmacology Volume 5, 2012 - Issue 3
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Drug Profile

Ticagrelor: a P2Y12 antagonist for use in acute coronary syndromes

Yanushi Dullewe Wijeyeratne Cardiovascular Medicine, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
,
Rashi Joshi Cardiovascular Medicine, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
&
Stan Heptinstall Cardiovascular Medicine, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK. [email protected]
Pages 257-269 | Published online: 10 Jan 2014

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Jin Wang, Huan Zhang, Rui Wang & Yun Cai. (2021) Pharmacokinetics, Bioequivalence and Safety Evaluation of Two Ticagrelor Tablets Under Fasting and Fed Conditions in Healthy Chinese Subjects. Drug Design, Development and Therapy 15, pages 1181-1193.
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Young-Guk Na, Jin-Ju Byeon, Miao Wang, Hyun Wook Huh, Gi-Ho Son, Sung-Hoon Jeon, Ki-Hyun Bang, Sung-Jin Kim, Hye-Jin Lee, Hong-Ki Lee & Cheong-Weon Cho. (2019) Strategic approach to developing a self-microemulsifying drug delivery system to enhance antiplatelet activity and bioavailability of ticagrelor. International Journal of Nanomedicine 14, pages 1193-1212.
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Mark R. Thomas & Robert F. Storey. (2015) The future of P2Y12 receptor antagonists. Platelets 26:5, pages 392-398.
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Wah Wah Htun & Steven R Steinhubl. (2013) Ticagrelor: the first novel reversible P2Y12 inhibitor. Expert Opinion on Pharmacotherapy 14:2, pages 237-245.
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Articles from other publishers (12)

Hoorub Ahmad, Muhammad Bilal, Tahir Maqbool, Nasir Rasool, Syed Adnan Ali Shah & Zainul Amiruddin Zakaria. (2023) Recent advances on copper-catalyzed asymmetric synthesis and their potential biological applications. Journal of Saudi Chemical Society 27:4, pages 101658.
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Changli Che, Wenhe Zhang, Yuxi Men, Hengyu Li, Bin Qin, Xian Jia & Song You. (2023) Development of an enzymatic process for the synthesis of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol, the key intermediate of ticagrelor. Molecular Catalysis 537, pages 112963.
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Hua-Tao Liu, Chun-Yue Weng, Shen-Yuan Xu, Shu-Fang Li, Ya-Jun Wang & Yu-Guo Zheng. (2022) Directed evolution of a carbonyl reductase LsCR for the enantioselective synthesis of (1S)-2-chloro-1-(3,4-difluorophenyl) ethanol. Bioorganic Chemistry 127, pages 105991.
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John J. Monteith & Sophie A.L. Rousseaux. 2022. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.
Julia Altarejos, David Sucunza, Juan J. Vaquero & Javier Carreras. (2021) Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates. Organic Letters 23:15, pages 6174-6178.
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Adella Aparna, Yamsani Shravan Kumar & Darna V.R.N. Bhikshapathi. (2021) Formulation and In Vivo Evaluation of Ticagrelor Self-nanoemulsifying Drug Delivery Systems. Pharmaceutical Nanotechnology 9:1, pages 61-69.
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Yonggu Lee, Young-Hyo Lim, Yongwhi Park & Jinho Shin. (2020) Real-World Bleeding and Ischemic Events in Asian Patients on P2Y12-Inhibitors After Percutaneous Coronary Intervention: A National Claims Data Analysis. Advances in Therapy 38:1, pages 562-578.
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James P. Phelan, Simon B. Lang, Jordan S. Compton, Christopher B. Kelly, Ryan Dykstra, Osvaldo Gutierrez & Gary A. Molander. (2018) Redox-Neutral Photocatalytic Cyclopropanation via Radical/Polar Crossover. Journal of the American Chemical Society 140:25, pages 8037-8047.
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Kari E. Hernandez, Hans Renata, Russell D. Lewis, S. B. Jennifer Kan, Chen Zhang, Jared Forte, David Rozzell, John A. McIntosh & Frances H. Arnold. (2016) Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor. ACS Catalysis 6:11, pages 7810-7813.
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Kousaku Ohno, Atsuyuki Tomizawa, Joseph A. Jakubowski, Makoto Mizuno & Atsuhiro Sugidachi. (2015) Prevention of occlusive arterial thrombus formation by a single loading dose of prasugrel suppresses neointimal hyperplasia in mice. Thrombosis Research 136:6, pages 1245-1251.
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A Sugidachi, K Ohno, T Ogawa, JA Jakubowski, M Hashimoto & A Tomizawa. (2013) A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats. British Journal of Pharmacology 169:1, pages 82-89.
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Atsuyuki Tomizawa, Kousaku Ohno, Joseph A. Jakubowski, Makoto Mizuno & Atsuhiro Sugidachi. (2017) Comparison of antiplatelet effects of prasugrel and ticagrelor in cynomolgus monkeys by an ELISA-based VASP phosphorylation assay and platelet aggregation. Thrombosis and Haemostasis 110:10, pages 769-776.
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