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Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

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Pages 513-534 | Published online: 10 Jan 2014

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Eveline DeCoster, Ana Alves de Medeiros, Jessica Bostoen, Annelies Stockman, Nanja van Geel, Hilde Lapeere & Jo Lambert. (2016) A multileveled approach in psoriasis assessment and follow-up: A proposal for a tailored guide for the dermatological practice. Journal of Dermatological Treatment 27:4, pages 298-310.
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Lynnette R Ferguson. (2010) Nutrigenomics and inflammatory bowel diseases. Expert Review of Clinical Immunology 6:4, pages 573-583.
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Mirko Hu, Guido Caldarelli & Tommaso Gili. (2023) Inflammatory bowel disease biomarkers revealed by the human gut microbiome network. Scientific Reports 13:1.
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Gerardo Alfonso Perez & Raquel Castillo. (2023) Gene Identification in Inflammatory Bowel Disease via a Machine Learning Approach. Medicina 59:7, pages 1218.
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Mahmoud Khatib A.A. Al-Ruweidi, Nada Khater, Haya Rashid Alkaabi, Maram Hasan & Huseyin C. Yalcin. 2022. Immunology of the GI Tract - Recent Advances. Immunology of the GI Tract - Recent Advances.
Sabiye Akbulut. (2022) An assessment of serum vitamin B12 and folate in patients with Crohn’s disease. Medicine 101:50, pages e31892.
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Tanush Vig, Prasenjit Das, Puja Sakhuja, Kavita Gaur, Kaushik Majumdar & Anna Pulimood. 2022. Surgical Pathology of the Gastrointestinal System. Surgical Pathology of the Gastrointestinal System 405 480 .
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Bryan P. Kline, Taelor Weaver, David L. Brinton, Sue Deiling, Gregory S. Yochum, Arthur S. Berg & Walter A. Koltun. (2020) Clinical and Genetic Factors Associated With Complications After Crohn’s Ileocolectomy. Diseases of the Colon & Rectum 63:3, pages 357-364.
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Jeana Hong, Hye Ran Yang, Jin Soo Moon, Ju Young Chang & Jae Sung Ko. (2019) Association of IL23R Variants With Crohn’s Disease in Korean Children. Frontiers in Pediatrics 7.
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Bente Mertz Nørgård, Line Riis Jølving, Michael Due Larsen & Sonia Friedman. (2019) Parental IBD and Long-term Health Outcomes in the Offspring. Inflammatory Bowel Diseases 25:8, pages 1339-1348.
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Bobbi B Laing, Anecita Gigi Lim & Lynnette R Ferguson. (2019) A Personalised Dietary Approach—A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease. Nutrients 11:7, pages 1532.
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Yu Yu, Kang-Chen Chen & Jie Chen. (2019) Exclusive enteral nutrition versus corticosteroids for treatment of pediatric Crohn’s disease: a meta-analysis. World Journal of Pediatrics 15:1, pages 26-36.
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Marie-Eve Fecteau, Dipti W. Pitta, Bonnie Vecchiarelli, Nagaraju Indugu, Sanjay Kumar, Susan C. Gallagher, Terry L. Fyock & Raymond W. Sweeney. (2016) Dysbiosis of the Fecal Microbiota in Cattle Infected with Mycobacterium avium subsp. paratuberculosis. PLOS ONE 11:8, pages e0160353.
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Nobuhiko Kamada & Gerhard Rogler. (2016) The Innate Immune System: A Trigger for Many Chronic Inflammatory Intestinal Diseases. Inflammatory Intestinal Diseases 1:2, pages 70-77.
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I.Y.K. Iskandar, D.M. Ashcroft, R.B. Warren, Z.Z.N. Yiu, K. McElhone, M. Lunt, J.N.W.N. Barker, A.D. Burden, A.D. Ormerod, N.J. Reynolds, C.H. Smith & C.E.M. Griffiths. (2015) Demographics and disease characteristics of patients with psoriasis enrolled in the B ritish A ssociation of D ermatologists B iologic I nterventions R egister . British Journal of Dermatology 173:2, pages 510-518.
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Luc Biedermann & Gerhard Rogler. (2015) The intestinal microbiota: its role in health and disease. European Journal of Pediatrics 174:2, pages 151-167.
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Mònica Aguilera, Trevor Darby & Silvia Melgar. (2014) The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases – Lessons learned from experimental models. Cytokine & Growth Factor Reviews 25:6, pages 715-730.
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Ying WangJing TongBing ChangBai-Fang WangDai ZhangBing-Yuan Wang. (2014) Genetic Polymorphisms in the IL-18 Gene and Ulcerative Colitis Risk: A Meta-Analysis . DNA and Cell Biology 33:7, pages 438-447.
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Bobbi Laing, Dug Han & Lynnette Ferguson. (2013) Candidate Genes Involved in Beneficial or Adverse Responses to Commonly Eaten Brassica Vegetables in a New Zealand Crohn’s Disease Cohort. Nutrients 5:12, pages 5046-5064.
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Chang Mo Moon, Dong‐Jik Shin, Nak‐Hoon Son, Eun‐Soon Shin, Sung Pil Hong, Tae Il Kim, Won Ho Kim & Jae Hee Cheon. (2013) Genetic variants in the IL12B gene are associated with inflammatory bowel diseases in the K orean population . Journal of Gastroenterology and Hepatology 28:10, pages 1588-1594.
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Hui Zhang, Li Ma, Lian-qiang Dong, Cheng Shu & Jia-long Xu. (2013) Association of the macrophage migration inhibitory factor gene −173G/C polymorphism with inflammatory bowel disease: A meta-analysis of 4296 subjects. Gene 526:2, pages 228-231.
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Scott Plevy, Mark S. Silverberg, Steve Lockton, Tom Stockfisch, Lisa Croner, Jordan Stachelski, Michelle Brown, Cheryl Triggs, Emil Chuang, Fred Princen & Sharat Singh. (2013) Combined Serological, Genetic, and Inflammatory Markers Differentiate Non-IBD, Crohnʼs Disease, and Ulcerative Colitis Patients. Inflammatory Bowel Diseases 19:6, pages 1139-1148.
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Seung Hyuk BaikKyu Joo ParkKang Young LeeYong Beom ChoGyu-Seog ChoiKil Yeon LeeSang Nam YoonChang Sik Yu. (2013) Characteristic Phenotypes in Korean Crohn's Disease Patients Who Underwent Intestinal Surgery for the Treatment. Journal of Korean Medical Science 28:4, pages 575.
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Jiayu Zhai, Ju Rong, Qiuxia Li & Jieruo Gu. (2013) Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?. Clinical and Developmental Immunology 2013, pages 1-6.
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Satoru Suzuki, Takako Takai-Igarashi, Yutaka Fukuoka, Dennis P Wall, Hiroshi Tanaka & Peter J Tonellato. (2012) Systems analysis of inflammatory bowel disease based on comprehensive gene information. BMC Medical Genetics 13:1.
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T W Eglinton, R Roberts, J Pearson, M Barclay, T R Merriman, F A Frizelle & R B Gearry. (2012) Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort. American Journal of Gastroenterology 107:4, pages 589-596.
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Petter Malmborg, Shahram Bahmanyar, Lena Grahnquist, Hans Hildebrand & Scott Montgomery. (2012) Cesarean section and the risk of pediatric Crohnʼs disease. Inflammatory Bowel Diseases 18:4, pages 703-708.
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Rishabh Sehgal, Arthur Berg, Joseph I. Polinski, John P. Hegarty, Zhenwu Lin, Kevin J. McKenna, David B. Stewart, Lisa S. Poritz & Walter A. Koltun. (2012) Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohn's Disease. Diseases of the Colon & Rectum 55:2, pages 115-121.
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Seung Hyuk BaikWon Ho Kim. (2012) A Comprehensive Review of Inflammatory Bowel Disease Focusing on Surgical Management. Journal of the Korean Society of Coloproctology 28:3, pages 121.
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Cathrine Jespersgaard, Peder Fode, Marianne Dybdahl, Ida Vind, Ole Haagen Nielsen, Claudio Csillag, Pia Munkholm, Ben Vainer, Lene Riis, Margarita Elkjaer, Natalia Pedersen, Elisabeth Knudsen & Paal Skytt Andersen. (2011) Alpha-Defensin DEFA1A3 Gene Copy Number Elevation in Danish Crohn’s Disease Patients. Digestive Diseases and Sciences 56:12, pages 3517-3524.
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Filip Van Hauwermeiren, Roosmarijn E. Vandenbroucke & Claude Libert. (2011) Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1. Cytokine & Growth Factor Reviews 22:5-6, pages 311-319.
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Zhenwu Lin, Gerrit John, John P. Hegarty, Arthur Berg, Wei Yu, Yunhua Wang, Ashley A. Kelly, Blaise Z. Peterson, Lisa S. Poritz, Joanna Floros & Walter A. Koltun. (2011) Genetic Variants and Monoallelic Expression of Surfactant Protein-D in Inflammatory Bowel Disease. Annals of Human Genetics 75:5, pages 559-568.
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Elaine R. Nimmo, Craig Stevens, Anne M. Phillips, Amanda Smith, Hazel E. Drummond, Colin L. Noble, Michael Quail, Gail Davies, Marian C. Aldhous, David C. Wilson & Jack Satsangi. (2011) TLE1 Modifies the Effects of NOD2 in the Pathogenesis of Crohn's Disease. Gastroenterology 141:3, pages 972-981.e2.
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Gerrit John, John P. Hegarty, Wei Yu, Arthur Berg, Danielle M. Pastor, Ashley A. Kelly, Yunhua Wang, Lisa S. Poritz, Stefan Schreiber, Walter A. Koltun & Zhenwu Lin. (2011) NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT. Molecular Genetics and Metabolism 104:1-2, pages 174-179.
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Matti Waterman, Wei Xu, Joanne M. Stempak, Raquel Milgrom, Charles N. Bernstein, Anne M. Griffiths, Gordon R. Greenberg, Hillary A. Steinhart & Mark S. Silverberg. (2011) Distinct and overlapping genetic loci in crohnʼs disease and ulcerative colitis: Correlations with pathogenesis. Inflammatory Bowel Diseases 17:9, pages 1936-1942.
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Paul FlanaganBarry J. CampbellJonathan M. Rhodes. (2011) Bacteria in the pathogenesis of inflammatory bowel disease. Biochemical Society Transactions 39:4, pages 1067-1072.
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Siddharth Banka, Kate Ryan, Wendy Thomson & William G. Newman. (2011) Pernicious anemia – Genetic insights. Autoimmunity Reviews 10:8, pages 455-459.
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Richard Kellermayer, Scot E. Dowd, R. Alan Harris, Alfred Balasa, Tiffany D. Schaible, Randy D. Wolcott, Nina Tatevian, Reka Szigeti, Zhijie Li, James Versalovic & C. Wayne Smith. (2011) Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll‐like receptor 2‐knockout mice. The FASEB Journal 25:5, pages 1449-1460.
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Vibeke Andersen, Elaine Nimmo, Henrik B. Krarup, Hazel Drummond, Jane Christensen, Gwo-tzer Ho, Mette stergaard, Anja Ernst, Charlie Lees, Bent A. Jacobsen, Jack Satsangi & Ulla Vogel. (2011) Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case–control study. Inflammatory Bowel Diseases 17:4, pages 937-946.
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Bouchra Edderkaoui. 2011. Gene Discovery for Disease Models. Gene Discovery for Disease Models 281 301 .
Hamed LarouiDavid S. WilsonGuillaume DalmassoKhalid Salaita, Niren MurthyShanthi V. SitaramanDidier Merlin. (2011) Nanomedicine in GI. American Journal of Physiology-Gastrointestinal and Liver Physiology 300:3, pages G371-G383.
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Alexandra I. Thompson & Charlie W. Lees. (2011) Genetics of ulcerative colitis. Inflammatory Bowel Diseases 17:3, pages 831-848.
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Paul Henderson & Jack Satsangi. (2011) Genes in inflammatory bowel disease: lessons from complex diseases. Clinical Medicine 11:1, pages 8-10.
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Russell D. Cohen. 2011. Inflammatory Bowel Disease. Inflammatory Bowel Disease 27 39 .
Walter A. Koltun. 2011. The ASCRS Textbook of Colon and Rectal Surgery. The ASCRS Textbook of Colon and Rectal Surgery 449 462 .
Paul Henderson, Johan E. van Limbergen, David C. Wilson, Jack Satsangi & Richard K. Russell. (2011) Genetics of childhood-onset inflammatory bowel disease. Inflammatory Bowel Diseases 17:1, pages 346-361.
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Richard Kellermayer. (2010) “Omics” as the filtering gateway between environment and phenotype: The inflammatory bowel diseases example. American Journal of Medical Genetics Part A 152A:12, pages 3022-3025.
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Chao Chen, Xuesong Zhang & Yan Wang. (2010) Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population. Clinical Immunology 136:3, pages 442-446.
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Laurent-Herve Perez, Matt Butler, Tammy Creasey, JoAnn Dzink-Fox, John Gounarides, Stephanie Petit, Anna Ropenga, Neil Ryder, Kathryn Smith, Philip Smith & Scott J. Parkinson. (2010) Direct Bacterial Killing In Vitro by Recombinant Nod2 Is Compromised by Crohn's Disease-Associated Mutations. PLoS ONE 5:6, pages e10915.
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Luigi Naldi & Santo Raffaele Mercuri. (2010) Epidemiology of comorbidities in psoriasis. Dermatologic Therapy 23:2, pages 114-118.
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