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Expert Review of Anticancer Therapy Volume 13, 2013 - Issue 4
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Theme: Lung Cancer - Review

Anaplastic lymphoma kinase: a glimmer of hope in lung cancer treatment?

Renato Franco Pathology Unit, National Cancer Institute, Pascale Hospital, Naples, Italy. [email protected]; Pathology Unit, National Cancer Institute, Pascale Hospital, Naples, Italy. [email protected]
,
Gaetano Rocco Thoracic Surgery, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy; Thoracic Surgery, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy
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Federica Zito Marino Thoracic Surgery, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy; Thoracic Surgery, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy
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Giuseppe Pirozzi Department of Experimental Oncology, National Cancer Institute, Pascale Hospital, Naples, Italy; Department of Experimental Oncology, National Cancer Institute, Pascale Hospital, Naples, Italy
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Nicola Normanno Department of Experimental Oncology, National Cancer Institute, Pascale Hospital, Naples, Italy; Department of Experimental Oncology, National Cancer Institute, Pascale Hospital, Naples, Italy
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Alessandro Morabito Medical Oncology Unit, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy; Medical Oncology Unit, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy
,
Pasquale Sperlongano Department of General Surgery, Second University of Naples, Naples, Italy; Department of General Surgery, Second University of Naples, Naples, Italy
,
Paola Stiuso Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
,
Amalia Luce Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
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Gerardo Botti Thoracic Surgery, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy; Thoracic Surgery, Department of Thoraco-Pulmonary, National Cancer Institute, Pascale Hospital, Naples, Italy
&
Michele Caraglia Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy
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Pages 407-420 | Published online: 10 Jan 2014

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Rumeng Gu, Ziling Shi, Ting Duan & Meijun Song. (2021) Feasibility and Safety of Neoadjuvant Alectinib in Pulmonary Invasive Mucinous Adenocarcinoma with ALK Rearrangement: Case Report and Literature Review. OncoTargets and Therapy 14, pages 5107-5113.
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Giuseppe D’Abbronzo & Renato Franco. (2021) The changing role of the pathologist in the era of targeted therapy in personalized medicine. Expert Review of Precision Medicine and Drug Development 6:5, pages 295-297.
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Federica Zito Marino, Matteo Brunelli, Giulio Rossi, Giuseppe Calabrese, Anna Caliò, Pamela Nardiello, Guido Martignoni, Jeremy A. Squire, Liang Cheng, Daniela Massi & Renato Franco. (2021) Multitarget fluorescence in situ hybridization diagnostic applications in solid and hematological tumors. Expert Review of Molecular Diagnostics 21:2, pages 161-173.
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Yunju Nam, Dongkeun Hwang, Namdoo Kim, Hong-Seog Seo, Khalid B. Selim & Taebo Sim. (2019) Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as potent ALK-L1196M inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1426-1438.
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Federica Zito Marino, Gaetano Rocco, Alessandro Morabito, Chiara Mignogna, Martina Intartaglia, Giuseppina Liguori, Gerardo Botti & Renato Franco. (2016) A new look at the ALK gene in cancer: copy number gain and amplification. Expert Review of Anticancer Therapy 16:5, pages 493-502.
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Articles from other publishers (12)

Yanxia Xiao, Pu Liu, Jie Wei, Xin Zhang, Jun Guo & Yajun Lin. (2023) Recent progress in targeted therapy for non-small cell lung cancer. Frontiers in Pharmacology 14.
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Savvas Papageorgiou, Sarah L. Pashley, Laura O’Regan, Sam Khan, Richard Bayliss & Andrew M. Fry. (2022) Alternative Treatment Options to ALK Inhibitor Monotherapy for EML4-ALK-Driven Lung Cancer. Cancers 14:14, pages 3452.
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Ramgopal Dhakar, Tikam Chand Dakal & Amit Sharma. (2022) Genetic determinants of lung cancer: Understanding the oncogenic potential of somatic missense mutations. Genomics 114:4, pages 110401.
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Federica Zito Marino, Gerardo Botti, Gabriella Aquino, Stefano Ferrero, Gabriella Gaudioso, Alessandro Palleschi, Danilo Rocco, Rosario Salvi, Maria Carolina Micheli, Pietro Micheli, Alessandro Morabito, Gaetano Rocco, Antonio Giordano, Rossella De Cecio & Renato Franco. (2020) Unproductive Effects of ALK Gene Amplification and Copy Number Gain in Non-Small-Cell Lung Cancer. ALK Gene Amplification and Copy Gain in NSCLC. International Journal of Molecular Sciences 21:14, pages 4927.
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Xue Du, Yun Shao, Hai-Feng Qin, Yan-Hong Tai & Hong-Jun Gao. (2018) ALK- rearrangement in non-small-cell lung cancer (NSCLC) . Thoracic Cancer 9:4, pages 423-430.
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Federica Zito Marino, Giulio Rossi, Matteo Brunelli, Maria Gabriella Malzone, Giuseppina Liguori, Giuseppe Bogina, Alessandro Morabito, Gaetano Rocco, Renato Franco & Gerardo Botti. (2017) Diagnosis of anaplastic lymphoma kinase rearrangement in cytological samples through a fluorescence in situ hybridization-based assay: Cytological smears versus cell blocks. Cancer Cytopathology 125:5, pages 303-312.
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Raffaele Palmirotta, Davide Quaresmini, Domenica Lovero & Franco Silvestris. (2017) ALK gene alterations in cancer: biological aspects and therapeutic implications . Pharmacogenomics 18:3, pages 277-292.
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Vijaykumar R. Holla, Yasir Y. Elamin, Ann Marie Bailey, Amber M. Johnson, Beate C. Litzenburger, Yekaterina B. Khotskaya, Nora S. Sanchez, Jia Zeng, Md Abu Shufean, Kenna R. Shaw, John Mendelsohn, Gordon B. Mills, Funda Meric-Bernstam & George R. Simon. (2017) ALK: a tyrosine kinase target for cancer therapy. Molecular Case Studies 3:1, pages a001115.
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Federica Zito Marino, Alessandro Morabito, Cesare Gridelli, Gaetano Rocco, Giuseppina Liguori, Nicla De Rosa, Gerardo Botti & Renato Franco. (2016) Crizotinib Response in a Late Relapse of ALK-positive Lung Adenocarcinoma. Applied Immunohistochemistry & Molecular Morphology 24:9, pages e86-e88.
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Federica Zito Marino, Giuseppina Liguori, Gabriella Aquino, Elvira La Mantia, Silvano Bosari, Stefano Ferrero, Lorenzo Rosso, Gabriella Gaudioso, Nicla De Rosa, Marianna Scrima, Nicola Martucci, Antonello La Rocca, Nicola Normanno, Alessandro Morabito, Gaetano Rocco, Gerardo Botti & Renato Franco. (2015) Intratumor Heterogeneity of ALK-Rearrangements and Homogeneity of EGFR-Mutations in Mixed Lung Adenocarcinoma. PLOS ONE 10:9, pages e0139264.
Crossref
Leilei Liu, Ping Zhan, Xiaodie Zhou, Yong Song, Xiaojun Zhou, Like Yu & Jiandong Wang. (2015) Detection of EML4-ALK in Lung Adenocarcinoma Using Pleural Effusion with FISH, IHC, and RT-PCR Methods. PLOS ONE 10:3, pages e0117032.
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Tomiteru Togano, Mariko Watanabe, Kinji Itoh, Kazuo Umezawa, Noriyuki Masuda, Masaaki Higashihara & Ryouichi Horie. (2014) Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells. Lung Cancer 83:2, pages 139-145.
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