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Review

Experimental rabies vaccines for humans

Pages 1177-1186 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Chenjuan Shi, Li Tian, Wenwen Zheng, Yelei Zhu, Peilu Sun, Lele Liu, Wenkai Liu, Yanyan Song, Xianzhu Xia, Xianghong Xue & Xuexing Zheng. (2022) Recombinant adeno-associated virus serotype 9 AAV-RABVG expressing a Rabies Virus G protein confers long-lasting immune responses in mice and non-human primates. Emerging Microbes & Infections 11:1, pages 1439-1451.
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Pingsen Zhao, Sharula Guo, Zhixiong Zhong, Songtao Yang & Xianzhu Xia. (2021) Quantitative characterization of the B cell receptor repertoires of human immunized with commercial rabies virus vaccine. Human Vaccines & Immunotherapeutics 17:8, pages 2538-2546.
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A El-Sayed. (2018) Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms. International Journal of Veterinary Science and Medicine 6:1, pages 8-15.
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Jiaojiao Peng, Shenghe Zhu, Lili Hu, Pingping Ye, Yifei Wang, Qin Tian, Mingzhu Mei, Hao Chen & Xiaofeng Guo. (2016) Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines. Autophagy 12:10, pages 1704-1720.
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Manpreet Kaur, Rajni Garg, Samer Singh & Rakesh Bhatnagar. (2015) Rabies vaccines: where do we stand, where are we heading?. Expert Review of Vaccines 14:3, pages 369-381.
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Articles from other publishers (41)

Michelle D. Zajac, Maria Teresa Ortega & Susan M. Moore. (2023) Development and Evaluation of an Enzyme-Linked Immunosorbent Assay Targeting Rabies-Specific IgM and IgG in Human Sera. Viruses 15:4, pages 874.
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Rita V Burke, Pierantonio Russo, Michael Sicilia, William Wolowich, Novinyo Amega & Huy-Binh Nguyen. (2022) Epidemiology of rabies immune globulin use in paediatric and adult patients in the USA: a cross-sectional prevalence study. BMJ Open 12:4, pages e055411.
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Rupal Ojha & Vijay Kumar Prajapati. (2021) Cognizance of posttranslational modifications in vaccines: A way to enhanced immunogenicity. Journal of Cellular Physiology 236:12, pages 8020-8034.
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Gerrit J. Viljoen, Hermann Unger, Viskam Wijewardana & Ivancho Naletoski. 2021. Veterinary Vaccines. Veterinary Vaccines 119 134 .
Kannan Damodharan, Gandarvakottai Senthilkumar Arumugam, Suresh Ganesan, Mukesh Doble & Sathiah Thennarasu. (2021) A comprehensive overview of vaccines developed for pandemic viral pathogens over the past two decades including those in clinical trials for the current novel SARS-CoV-2. RSC Advances 11:33, pages 20006-20035.
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Verena te Kamp, Virginia Friedrichs, Conrad M. Freuling, Ad Vos, Madlin Potratz, Antonia Klein, Luca M. Zaeck, Elisa Eggerbauer, Peter Schuster, Christian Kaiser, Steffen Ortmann, Antje Kretzschmar, Katharina Bobe, Michael R. Knittler, Anca Dorhoi, Stefan Finke & Thomas Müller. (2021) Comparable Long-Term Rabies Immunity in Foxes after IntraMuscular and Oral Application Using a Third-Generation Oral Rabies Virus Vaccine. Vaccines 9:1, pages 49.
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Ting Li, Xin Wang & Hongbin Cheng. (2020) Meta-analysis of immunogenicity and safety of human rabies vaccination under Zagreb and Essen regimens. Journal of Comparative Effectiveness Research 9:7, pages 459-468.
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Joseph R. Plummer & James P. McGettigan. (2019) Incorporating B cell activating factor (BAFF) into the membrane of rabies virus (RABV) particles improves the speed and magnitude of vaccine-induced antibody responses. PLOS Neglected Tropical Diseases 13:11, pages e0007800.
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Xiang Wang, Zihao Fang, Jun Xiong, Kaiyan Yang, Yudan Chi, Xinying Tang, Li Ma, Renhuai Zhang, Fei Deng, Ke Lan & Dongming Zhou. (2019) A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge. Virology 536, pages 32-38.
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Rebecca Poston, Richard Hill, Cynthia Allen, Warren Casey, Donna Gatewood, Robin Levis, Laurent Mallet, Dean Smith, Geetha Srinivas, Catrina Stirling & David Allen. (2019) Achieving scientific and regulatory success in implementing non-animal approaches to human and veterinary rabies vaccine testing: A NICEATM and IABS workshop report. Biologicals 60, pages 8-14.
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Rohan Keshwara, Thomas Shiels, Elena Postnikova, Drishya Kurup, Christoph Wirblich, Reed F. Johnson & Matthias J. Schnell. (2019) Rabies-based vaccine induces potent immune responses against Nipah virus. npj Vaccines 4:1.
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Rohan Keshwara, Katie R. Hagen, Tiago Abreu-Mota, Amy B. Papaneri, David Liu, Christoph Wirblich, Reed F. Johnson & Matthias J. Schnell. (2019) A Recombinant Rabies Virus Expressing the Marburg Virus Glycoprotein Is Dependent upon Antibody-Mediated Cellular Cytotoxicity for Protection against Marburg Virus Disease in a Murine Model. Journal of Virology 93:6.
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Kevin L. Williams. 2019. Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems. Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems 17 52 .
Ilchan Song, Sol-Ah Park, Dalmuri Han, Hae Kyung Lee, Hyun Joo An & Kisung Ko. (2018) Expression, glycosylation, and function of an anti-rabies virus monoclonal antibody in tobacco and Arabidopsis plants. Horticulture, Environment, and Biotechnology 59:2, pages 285-292.
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Prasad S. KulkarniJulia L. HurwitzEric A.F. SimõesPedro A. Piedra. (2018) Establishing Correlates of Protection for Vaccine Development: Considerations for the Respiratory Syncytial Virus Vaccine Field. Viral Immunology 31:2, pages 195-203.
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Vahid AsgaryAlireza ShoariMajid Afshar MoayadMehdi Shafiee ArdestaniRazieh BigdeliLeila GhazizadehMohammad Sadeq KhosravyErfan PanahnejadAlireza JananiRouzbeh BasharMaliheh AbediReza Ahangari Cohan. (2018) Evaluation of G2 Citric Acid-Based Dendrimer as an Adjuvant in Veterinary Rabies Vaccine. Viral Immunology 31:1, pages 47-54.
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Charles E. Rupprecht, Thirumeni Nagarajan & Hildegund Ertl. 2018. Plotkin's Vaccines. Plotkin's Vaccines 918 942.e12 .
Shannon L. Haley, Evgeni P. Tzvetkov, Andrew G. Lytle, Kishore R. Alugupalli, Joseph R. Plummer & James P. McGettigan. (2017) APRIL:TACI axis is dispensable for the immune response to rabies vaccination. Antiviral Research 144, pages 130-137.
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Ludivine Chapat, Florence Hilaire, Jérome Bouvet, Daniel Pialot, Corinne Philippe-Reversat, Anne-Laure Guiot, Lydie Remolue, Jacques Lechenet, Christine Andreoni, Hervé Poulet, Michael J. Day, Karelle De Luca, Carine Cariou & Lionel Cupillard. (2017) Multivariate analysis of the immune response to a vaccine as an alternative to the repetition of animal challenge studies for vaccines with demonstrated efficacy. Veterinary Immunology and Immunopathology 189, pages 58-65.
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Shannon L. Haley, Evgeni P. Tzvetkov, Samantha Meuwissen, Joseph R. Plummer & James P. McGettigan. (2017) Targeting Vaccine-Induced Extrafollicular Pathway of B Cell Differentiation Improves Rabies Postexposure Prophylaxis. Journal of Virology 91:8.
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Karen L. Mansfield, Nick Andrews, Hooman Goharriz, Trudy Goddard, Lorraine M. McElhinney, Kevin E. Brown & Anthony R. Fooks. (2016) Rabies pre-exposure prophylaxis elicits long-lasting immunity in humans. Vaccine 34:48, pages 5959-5967.
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Anna Carolina A. Yendo, Fernanda de Costa, Samuel P. Cibulski, Thais F. Teixeira, Luana C. Colling, Mauricio Mastrogiovanni, Silvia Soulé, Paulo M. Roehe, Grace Gosmann, Fernando A. Ferreira & Arthur G. Fett-Neto. (2016) A rabies vaccine adjuvanted with saponins from leaves of the soap tree (Quillaja brasiliensis) induces specific immune responses and protects against lethal challenge. Vaccine 34:20, pages 2305-2311.
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Charles E Rupprecht & Ivan V Kuzmin. (2015) Why we can prevent, control and possibly treat – but will not eradicate – rabies. Future Virology 10:5, pages 517-535.
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Andrew G. Lytle, Shixue Shen & James P. McGettigan. (2015) Lymph Node but Not Intradermal Injection Site Macrophages Are Critical for Germinal Center Formation and Antibody Responses to Rabies Vaccination. Journal of Virology 89:5, pages 2842-2848.
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Amy B. Papaneri, John G. Bernbaum, Joseph E. Blaney, Peter B. Jahrling, Matthias J. Schnell & Reed F. Johnson. (2015) Controlled viral glycoprotein expression as a safety feature in a bivalent rabies-ebola vaccine. Virus Research 197, pages 54-58.
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Nicholas Johnson. (2015) Interplay between rabies virus and the mammalian immune system. World Journal of Clinical Infectious Diseases 5:4, pages 67.
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Yuan Fang, Li Chen, Man-Qing Liu, Zheng-Gang Zhu, Ze-Rong Zhu & Quan Hu. (2014) Comparison of Safety and Immunogenicity of PVRV and PCECV Immunized in Patients with WHO Category II Animal Exposure: A Study Based on Different Age Groups. PLoS Neglected Tropical Diseases 8:12, pages e3412.
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Ye Liu, Yingying Xu, Yue Tian, Chunying Chen, Chen Wang & Xingyu Jiang. (2014) Functional Nanomaterials Can Optimize the Efficacy of Vaccines. Small 10:22, pages 4505-4520.
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Bruce A. Kimball, Maryanne Opiekun, Kunio Yamazaki & Gary K. Beauchamp. (2014) Immunization alters body odor. Physiology & Behavior 128, pages 80-85.
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James E. Norton, Andrew G. Lytle, Shixue Shen, Evgeni P. Tzvetkov, Corin L. Dorfmeier & James P. McGettigan. (2014) ICAM-1-Based Rabies Virus Vaccine Shows Increased Infection and Activation of Primary Murine B Cells In Vitro and Enhanced Antibody Titers In-Vivo. PLoS ONE 9:1, pages e87098.
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Sudhi Ranjan GargSudhi Ranjan Garg. 2014. Rabies in Man and Animals. Rabies in Man and Animals 75 87 .
Amy B. Papaneri, Christoph Wirblich, Wilfred E. Marissen & Matthias J. Schnell. (2013) Alanine scanning of the rabies virus glycoprotein antigenic site III using recombinant rabies virus: Implication for post-exposure treatment. Vaccine 31:49, pages 5897-5902.
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Corin L. Dorfmeier, Shixue Shen, Evgeni P. Tzvetkov & James P. McGettigan. (2013) Reinvestigating the Role of IgM in Rabies Virus Postexposure Vaccination. Journal of Virology 87:16, pages 9217-9222.
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Andrew G. Lytle, James E. NortonJrJr, Corin L. Dorfmeier, Shixue Shen & James P. McGettigan. (2013) B Cell Infection and Activation by Rabies Virus-Based Vaccines. Journal of Virology 87:16, pages 9097-9110.
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Corin L. Dorfmeier, Evgeni P. Tzvetkov, Anthony Gatt & James P. McGettigan. (2013) Investigating the Role for IL-21 in Rabies Virus Vaccine-induced Immunity. PLoS Neglected Tropical Diseases 7:3, pages e2129.
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