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Expert Review of Vaccines Volume 10, 2011 - Issue 4
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Review

Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer

Govind Ragupathi Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;[email protected]
,
Jeffrey R Gardner Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
,
Philip O Livingston Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Laboratory of Tumor Vaccinology, Melanoma and Sarcoma Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
&
David Y Gin Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
Pages 463-470 | Published online: 09 Jan 2014

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Shiqi Zhou, Yuan Luo & Jonathan F. Lovell. (2023) Vaccine approaches for antigen capture by liposomes. Expert Review of Vaccines 22:1, pages 1022-1040.
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Zhi-Yong Zeng, Jin-Xi Liao, Zhen-Ni Hu, De-Yong Liu, Qing-Ju Zhang & Jian-Song Sun. (2021) Chemical synthesis of quillaic acid, the aglycone of QS-21. Organic Chemistry Frontiers 8:4, pages 748-753.
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Yizhi Qi & Christopher B. Fox. (2021) A Two-Step Orthogonal Chromatographic Process for Purifying the Molecular Adjuvant QS-21 with High Purity and Yield. Journal of Chromatography A 1635, pages 461705.
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Elisabeth M. S. Beijnen & Simon D. van Haren. (2020) Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation. Frontiers in Immunology 11.
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Zhi-Yong Zeng, Jin-Xi Liao, Zhen-Ni Hu, De-Yong Liu, Qing-Ju Zhang & Jian-Song Sun. (2020) Synthetic Investigation toward QS-21 Analogues. Organic Letters 22:21, pages 8613-8617.
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Crossref
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Li‐Juan Deng, Ming Qi, Nan Li, Yu‐He Lei, Dong‐Mei Zhang & Jia‐Xu Chen. (2020) Natural products and their derivatives: Promising modulators of tumor immunotherapy. Journal of Leukocyte Biology 108:2, pages 493-508.
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Shiran Ferber, Rodrigo J. Gonzalez, Alexander M. Cryer, Ulrich H. von Andrian & Natalie Artzi. (2019) Immunology‐Guided Biomaterial Design for Mucosal Cancer Vaccines. Advanced Materials 32:13.
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Crossref
Thomas Ebensen, Barbara Fuchs, Kai Schulze & Carlos Alberto Guzmán. 2020. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids 285 315 .
Molly Mombeshora & Stanley Mukanganyama. (2019) Antibacterial activities, proposed mode of action and cytotoxicity of leaf extracts from Triumfetta welwitschii against Pseudomonas aeruginosa. BMC Complementary and Alternative Medicine 19:1.
Crossref
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Yve VS Magedans, Anna CA Yendo, Fernanda de Costa, Grace Gosmann & Arthur G Fett-Neto. (2019) Foamy matters: an update on Quillaja saponins and their use as immunoadjuvants . Future Medicinal Chemistry 11:12, pages 1485-1499.
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Crossref
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Crossref
Ya-nan Tong, Liu-yang Yang, Yun Yang, Zhen Song, Liu-sheng Peng, Ji-ning Gao, Hao Zeng, Quan-ming Zou, Hong-wu Sun & Xu-hu Mao. (2018) An immunopotentiator, ophiopogonin D, encapsulated in a nanoemulsion as a robust adjuvant to improve vaccine efficacy. Acta Biomaterialia 77, pages 255-267.
Crossref
Wei Shi, Yiming Kou, Jinghui Xiao, Lijuan Zhang, Feng Gao, Wei Kong, Weiheng Su, Chunlai Jiang & Yong Zhang. (2018) Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Vaccine 36:33, pages 5020-5029.
Crossref
Rashad R. Karimov, Derek S. Tan & David Y. Gin. (2018) Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement–intramolecular ketene hetero-Diels–Alder reaction. Tetrahedron 74:26, pages 3370-3383.
Crossref
Meng‐Man Wei, Yong‐Shi Wang & Xin‐Shan Ye. (2018) Carbohydrate‐based vaccines for oncotherapy. Medicinal Research Reviews 38:3, pages 1003-1026.
Crossref
Zhuting Hu, Patrick A. Ott & Catherine J. Wu. (2017) Towards personalized, tumour-specific, therapeutic vaccines for cancer. Nature Reviews Immunology 18:3, pages 168-182.
Crossref
Abdelmounaim Nouri, Faez Amokrane Nait Mohamed & Fatima Laraba-Djebari. (2018) New and safe formulation for scorpion immunotherapy: Comparative study between saponin and FCA adjuvants associated to attenuated venom. Vaccine 36:13, pages 1720-1727.
Crossref
Nathalie Garçon & Martin Friede. 2018. Plotkin's Vaccines. Plotkin's Vaccines 61 74.e4 .
Miho Nakajima & Shakeel Modak. 2018. Immunotherapy for Pediatric Malignancies. Immunotherapy for Pediatric Malignancies 217 242 .
Marzio Pennisi, Giulia Russo, Silvia Ravalli & Francesco Pappalardo. (2017) Combining agent based-models and virtual screening techniques to predict the best citrus-derived vaccine adjuvants against human papilloma virus. BMC Bioinformatics 18:S16.
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Marie-Aleth Lacaille-Dubois & Hildebert Wagner. (2017) New perspectives for natural triterpene glycosides as potential adjuvants. Phytomedicine 37, pages 49-57.
Crossref
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Crossref
Srinivasa Reddy Bonam, Charalambos D. Partidos, Sampath Kumar M. Halmuthur & Sylviane Muller. (2017) An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy. Trends in Pharmacological Sciences 38:9, pages 771-793.
Crossref
Maohui Chen, Vinod Balhara, Ana Maria Jaimes Castillo, John Balsevich & Linda J. Johnston. (2017) Interaction of saponin 1688 with phase separated lipid bilayers. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:7, pages 1263-1272.
Crossref
Tomasz R. Sosnowski, Paweł Kubski & Kamil Wojciechowski. (2017) New experimental model of pulmonary surfactant for biophysical studies. Colloids and Surfaces A: Physicochemical and Engineering Aspects 519, pages 27-33.
Crossref
Bindhya Jayashankar, Divya Singh, Himanshi Tanwar, KP Mishra, Swetha Murthy, Sudipta Chanda, Jigni Mishra, R Tulswani, K Misra, SB Singh & Lilly Ganju. (2017) Augmentation of humoral and cellular immunity in response to Tetanus and Diphtheria toxoids by supercritical carbon dioxide extracts of Hippophae rhamnoides L. leaves. International Immunopharmacology 44, pages 123-136.
Crossref
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Crossref
Rashad R. Karimov, Derek S. Tan & David Y. Gin. (2017) Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C 6 F 5 ) 3 -catalyzed glycosylation of sterically-hindered precursors . Chemical Communications 53:43, pages 5838-5841.
Crossref
Nuria Martínez-Sáez, Jesús M. Peregrina & Francisco Corzana. (2017) Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptides. Chemical Society Reviews 46:23, pages 7154-7175.
Crossref
Woo Jung Shin, Hyun Jong Noh, Young-Woock Noh, Sohyun Kim, Soong Ho Um & Yong Taik Lim. (2017) Hyaluronic acid-supported combination of water insoluble immunostimulatory compounds for anti-cancer immunotherapy. Carbohydrate Polymers 155, pages 1-10.
Crossref
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N. Muñoz-Wolf, S. McCluskey & E.C. Lavelle. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 23 42 .
Livia Brunner, Christophe Barnier-Quer & Nicolas Collin. 2017. Vaccine Adjuvants. Vaccine Adjuvants 73 86 .
Alberto Fernández-Tejada, William E. Walkowicz, Derek S. Tan & David Y. Gin. 2017. Vaccine Adjuvants. Vaccine Adjuvants 45 71 .
Sophie Detienne, Iain Welsby, Catherine Collignon, Sandrine Wouters, Margherita Coccia, Sophie Delhaye, Laurye Van Maele, Séverine Thomas, Maëlle Swertvaegher, Aurélie Detavernier, Abdelatif Elouahabi, Stanislas Goriely & Arnaud M. Didierlaurent. (2016) Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01. Scientific Reports 6:1.
Crossref
Kamil Wojciechowski, Marta Orczyk, Marcus Trapp & Thomas Gutberlet. (2016) Effect of triterpene and steroid saponins on lecithin bilayers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 510, pages 150-158.
Crossref
Pengfei Wang, Dattatray A. Devalankar, Qipu Dai, Ping Zhang & Suzanne M. Michalek. (2016) Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide. The Journal of Organic Chemistry 81:20, pages 9560-9566.
Crossref
Alberto Fernández-Tejada, Derek S. Tan & David Y. Gin. (2016) Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Accounts of Chemical Research 49:9, pages 1741-1756.
Crossref
Krishnamurthy Konduru, Amy C. Shurtleff, Steven B. Bradfute, Siham Nakamura, Sina Bavari & Gerardo Kaplan. (2016) Ebolavirus Glycoprotein Fc Fusion Protein Protects Guinea Pigs against Lethal Challenge. PLOS ONE 11:9, pages e0162446.
Crossref
Hwee-Ing Ng, Germain J. P. Fernando, Alexandra C. I. Depelsenaire & Mark A. F. Kendall. (2016) Potent response of QS-21 as a vaccine adjuvant in the skin when delivered with the Nanopatch, resulted in adjuvant dose sparing. Scientific Reports 6:1.
Crossref
B Jayashankar, D Singh, KP Mishra, SN Madhusudana & YB Ashwin. (2016) Supercritical Carbon Dioxide Extract of Seabuckthorn Leaves Enhances Rabies Virus Neutralizing Antibody Titers and CTL Response in Swiss Albino Mice. Journal of Vaccines and Immunology 2:1, pages 004-009.
Crossref
Emilia Bigaeva, Eva van Doorn, Heng Liu & Eelko Hak. (2016) Meta-Analysis on Randomized Controlled Trials of Vaccines with QS-21 or ISCOMATRIX Adjuvant: Safety and Tolerability. PLOS ONE 11:5, pages e0154757.
Crossref
Samuel Paulo Cibulski, Gustavo Mourglia-Ettlin, Thais Fumaco Teixeira, Lenora Quirici, Paulo Michel Roehe, Fernando Ferreira & Fernando Silveira. (2016) Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake. Vaccine 34:9, pages 1162-1171.
Crossref
Robyn Marty-Roix, Gregory I. Vladimer, Kimberly Pouliot, Dan Weng, Rachel Buglione-Corbett, Kim West, John D. MacMicking, Jonathan D. Chee, Shixia Wang, Shan Lu & Egil Lien. (2016) Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. Journal of Biological Chemistry 291:3, pages 1123-1136.
Crossref
William E. Walkowicz, Alberto Fernández-Tejada, Constantine George, Francisco Corzana, Jesús Jiménez-Barbero, Govind Ragupathi, Derek S. Tan & David Y. Gin. (2016) Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities. Chemical Science 7:3, pages 2371-2380.
Crossref
Burcu Temizoz, Etsushi Kuroda, Kouji Kobiyama, Taiki Aoshi & Ken J. Ishii. 2016. Immunotherapy of Cancer. Immunotherapy of Cancer 247 260 .
Marta Orczyk & Kamil Wojciechowski. (2015) Comparison of the effect of two Quillaja bark saponin extracts on DPPC and DPPC/cholesterol Langmuir monolayers. Colloids and Surfaces B: Biointerfaces 136, pages 291-299.
Crossref
Ben W. Greatrex, Alison M. Daines, Sarah Hook, Dirk H. Lenz, Warren McBurney, Thomas Rades & Phillip M. Rendle. (2015) Synthesis, Formulation, and Adjuvanticity of Monodesmosidic Saponins with Olenanolic Acid, Hederagenin and Gypsogenin Aglycones, and some C-28 Ester Derivatives. ChemistryOpen 4:6, pages 740-755.
Crossref
Hyun Jong Noh, Mohammed Y. E. Chowdhury, Seonghun Cho, Jae-Hoon Kim, Hye Sun Park, Chul-Joong Kim, Haryoung Poo, Moon-Hee Sung, Jong-Soo Lee & Yong Taik Lim. (2015) Programming of Influenza Vaccine Broadness and Persistence by Mucoadhesive Polymer-Based Adjuvant Systems. The Journal of Immunology 195:5, pages 2472-2482.
Crossref
Alberto Fernández-Tejada, F. Javier Cañada & Jesús Jiménez-Barbero. (2015) Glycans in Medicinal Chemistry: An Underexploited Resource. ChemMedChem 10:8, pages 1291-1295.
Crossref
Konstantin O. Zhurov, Laure Menin, Thomas Di Franco & Yury O. Tsybin. (2015) A Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets. Journal of the American Society for Mass Spectrometry 26:7, pages 1221-1232.
Crossref
Ghalia Boubaker, Andrew Hemphill, Cristina Olivia Huber, Markus Spiliotis, Hamouda Babba & Bruno Gottstein. (2015) Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen. PLOS Neglected Tropical Diseases 9:6, pages e0003795.
Crossref
Zhaojun Yin & Xuefei Huang. 2015. Carbohydrates in Drug Design and Discovery. Carbohydrates in Drug Design and Discovery 132 150 .
Alberto Fernández-Tejada, Derek S. Tan & David Y. Gin. (2015) Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical Communications 51:73, pages 13949-13952.
Crossref
Monica Scognamiglio, Valeria Severino, Brigida D’Abrosca, Angela Chambery & Antonio Fiorentino. 2015. 85 120 .
C. McEntee, E.C. Lavelle & D.T. O’Hagan. 2015. Mucosal Immunology. Mucosal Immunology 1211 1231 .
Stephanie Zimmermann & Bernd Lepenies. 2015. Carbohydrate-Based Vaccines. Carbohydrate-Based Vaccines 11 26 .
Alberto Fernández-Tejada, Eric K. Chea, Constantine George, Jeffrey R. Gardner, Philip O. Livingston, Govind Ragupathi, Derek S. Tan & David Y. Gin. (2014) Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol. Bioorganic & Medicinal Chemistry 22:21, pages 5917-5923.
Crossref
Hongxiang Sun, Shuwang He & Minghua Shi. (2014) Adjuvant-active fraction from Albizia julibrissin saponins improves immune responses by inducing cytokine and chemokine at the site of injection. International Immunopharmacology 22:2, pages 346-355.
Crossref
Pamita Bhandari, Neeraj Kumar Patel, Rahul P. Gangwal, Abhay T. Sangamwar & Kamlesh Kumar Bhutani. (2014) Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: Synthesis, biological evaluation and docking studies. Bioorganic & Medicinal Chemistry Letters 24:17, pages 4114-4119.
Crossref
Arnaud M. Didierlaurent, Catherine Collignon, Patricia Bourguignon, Sandrine Wouters, Kaat Fierens, Michel Fochesato, Najoua Dendouga, Christelle Langlet, Bernard Malissen, Bart N. Lambrecht, Nathalie Garçon, Marcelle Van Mechelen & Sandra Morel. (2014) Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells. The Journal of Immunology 193:4, pages 1920-1930.
Crossref
Alberto Fernández-Tejada, Eric K. Chea, Constantine George, NagaVaraKishore Pillarsetty, Jeffrey R. Gardner, Philip O. Livingston, Govind Ragupathi, Jason S. Lewis, Derek S. Tan & David Y. Gin. (2014) Development of a minimal saponin vaccine adjuvant based on QS-21. Nature Chemistry 6:7, pages 635-643.
Crossref
Rosi Bissinger, Paola Modicano, Kousi Alzoubi, Sabina Honisch, Caterina Faggio, Majed Abed & Florian Lang. (2014) Effect of saponin on erythrocytes. International Journal of Hematology 100:1, pages 51-59.
Crossref
Conrado Pedebos, Laércio Pol-Fachin, Ramon Pons, Cilâine Teixeira & Hugo Verli. (2014) Atomic Model and Micelle Dynamics of QS-21 Saponin. Molecules 19:3, pages 3744-3760.
Crossref
Na Qiao, Qi Liu, He Meng & Dayun Zhao. (2014) Haemolytic activity and adjuvant effect of soyasaponins and some of their derivatives on the immune responses to ovalbumin in mice. International Immunopharmacology 18:2, pages 333-339.
Crossref
Sara Carbonetti, Brian G. Oliver, Jolene Glenn, Leonidas Stamatatos & D. Noah Sather. (2014) Soluble HIV-1 Envelope Immunogens Derived from an Elite Neutralizer Elicit Cross-Reactive V1V2 Antibodies and Low Potency Neutralizing Antibodies. PLoS ONE 9:1, pages e86905.
Crossref
Shuang Wang, Yang Yu, Shuang Geng, Dongmei Wang, Li Zhang, Xiaoping Xie, Bing Wu, Chaofan Li, Hanqian Xu, Xiaolin Li, Yanxin Hu, Lianfeng Zhang, Christoph Kaether & Bin Wang. (2014) A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer’s disease model. Alzheimer's Research & Therapy 6:3, pages 26.
Crossref
Guofeng Gu, Lian An, Min Fang & Zhongwu Guo. (2014) Efficient one-pot synthesis of tigogenin saponins and their antitumor activities. Carbohydrate Research 383, pages 21-26.
Crossref
Pengfei Wang, Qipu Dai, Punith Thogaripally, Ping Zhang & Suzanne M. Michalek. (2013) Synthesis of QS-21-Based Immunoadjuvants. The Journal of Organic Chemistry 78:22, pages 11525-11534.
Crossref
Guofeng Gu, Yisheng Zhao & Zhongwu Guo. (2013) Synthesis of Leonosides E and F derived from Leonurus japonicas Houtt. Carbohydrate Research 380, pages 174-180.
Crossref
Jia Hao, Jun Liu, Xiaoan Wen & Hongbin Sun. (2013) Synthesis and cytotoxicity evaluation of oleanolic acid derivatives. Bioorganic & Medicinal Chemistry Letters 23:7, pages 2074-2077.
Crossref
Ganesh Barhate, Manish Gautam, Sunil Gairola, Suresh Jadhav & Varsha Pokharkar. (2013) Quillaja saponaria extract as mucosal adjuvant with chitosan functionalized gold nanoparticles for mucosal vaccine delivery: Stability and immunoefficiency studies. International Journal of Pharmaceutics 441:1-2, pages 636-642.
Crossref
Nathalie. Garçon, Stanley. Hem & Martin. Friede. 2013. Vaccines. Vaccines 58 70 .
Claire Hearnden & Ed C. Lavelle. 2013. Cancer Immunotherapy. Cancer Immunotherapy 333 349 .
Darren R. Flower. 2013. Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines 155 180 .
Eric K. Chea, Alberto Fernández-Tejada, Payal Damani, Michelle M. Adams, Jeffrey R. Gardner, Philip O. Livingston, Govind Ragupathi & David Y. Gin. (2012) Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes. Journal of the American Chemical Society 134:32, pages 13448-13457.
Crossref
Eli Harlev, Eviatar Nevo, Ephraim P. Lansky, Shifra Lansky & Anupam Bishayee. (2012) Anticancer attributes of desert plants. Anti-Cancer Drugs 23:3, pages 255-271.
Crossref
Fiona A. Sharp & Ed C. Lavelle. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 14 .

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