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Original Research

The impact of dual bronchodilation on cardiovascular serious adverse events and mortality in COPD: a quantitative synthesis

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Pages 3469-3485 | Published online: 05 Dec 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Marc Miravitlles, Katia Verhamme, Peter M A Calverley, Michael Dreher, Valentina Bayer, Asparuh Gardev, Alberto de la Hoz, Jadwiga Wedzicha & David Price. (2022) A Pooled Analysis of Mortality in Patients with COPD Receiving Dual Bronchodilation with and without Additional Inhaled Corticosteroid. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 545-558.
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Tanja Fens, Guiling Zhou, Maarten J. Postma, Eugène P. van Puijenbroek & Job F.M. van Boven. (2021) Economic evaluations of chronic obstructive pulmonary disease pharmacotherapy: how well are the real-world issues of medication adherence, comorbidities and adverse drug-reactions addressed?. Expert Opinion on Pharmacotherapy 22:7, pages 923-935.
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Beatrice Ludovica Ritondo, Ermanno Puxeddu, Luigino Calzetta, Mario Cazzola & Paola Rogliani. (2021) Efficacy and safety of triple combination therapy for treating chronic obstructive pulmonary disease: an expert review. Expert Opinion on Pharmacotherapy 22:5, pages 611-620.
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Luigino Calzetta, Beatrice Ludovica Ritondo, Patrizia de Marco, Mario Cazzola & Paola Rogliani. (2021) Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies. Expert Review of Respiratory Medicine 15:1, pages 143-152.
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Stefan Andreas, Lorcan McGarvey, Ulrich Bothner, Matthias Trampisch, Alberto de la Hoz, Matjaz Fležar, Roland Buhl & Peter Alter. (2020) Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 1935-1944.
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Paola Rogliani, Beatrice Ludovica Ritondo, Bartolomeo Zerillo, Mario Cazzola, Maria Gabriella Matera & Luigino Calzetta. (2020) Adding a Second Bronchodilator in COPD: A Meta-Analysis on the Risk of Specific Cardiovascular Serious Adverse Events of Tiotropium/Olodaterol Fixed-Dose Combination. COPD: Journal of Chronic Obstructive Pulmonary Disease 17:2, pages 215-223.
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Paola Rogliani, Luigino Calzetta, Maria Gabriella Matera, Nicola di Daniele, Andrea Girolami, Mario Cazzola & Josuel Ora. (2019) Inhaled therapies and cardiovascular risk in patients with chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 20:6, pages 737-750.
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Paola Rogliani, Josuel Ora, Maria Gabriella Matera, Mario Cazzola & Luigino Calzetta. (2018) The safety of dual bronchodilation on cardiovascular serious adverse events in COPD. Expert Opinion on Drug Safety 17:6, pages 589-596.
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Maria Gabriella Matera, Luigino Calzetta, Ermanno Puxeddu, Paola Rogliani & Mario Cazzola. (2018) A safety comparison of LABA+LAMA vs LABA+ICS combination therapy for COPD. Expert Opinion on Drug Safety 17:5, pages 509-517.
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Articles from other publishers (22)

O. N. Titova, N. A. Kuzubova, A. G. Kozyrev & A. A. Shumilov. (2023) Bronchodilator therapy in patients with chronic obstructive pulmonary disease: what should be considered in clinical practice when choosing a dosing regimen?. PULMONOLOGIYA 33:1, pages 44-50.
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Roberto G. Carbone, Giovanni Bottino, Simone Negrini & Francesco Puppo. (2023) Early COPD diagnosis and treatment: A case report. Respiratory Medicine Case Reports 42, pages 101821.
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Nightingale Syabbalo. (2021) The role of airway remodeling in the pathogenesis and treatment of chronic obstructive pulmonary disease. Journal of Lung, Pulmonary & Respiratory Research 8:3, pages 96-102.
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Klaus F. Rabe, James D. Chalmers, Marc Miravitlles, Janwillem W. H. Kocks, Ioanna Tsiligianni, Alberto de la Hoz, Wenqiong Xue, Dave Singh, Gary T. Ferguson & Jadwiga Wedzicha. (2020) Tiotropium/Olodaterol Delays Clinically Important Deterioration Compared with Tiotropium Monotherapy in Patients with Early COPD: a Post Hoc Analysis of the TONADO® Trials. Advances in Therapy 38:1, pages 579-593.
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Nicola C. Day, Subramanya Kumar, Gerard Criner, Mark Dransfield, David M. G. Halpin, MeiLan K. Han, C. Elaine Jones, Morrys C. Kaisermann, Sally Kilbride, Peter Lange, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert Wise & David A. Lipson. (2020) Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD: results on cardiovascular safety from the IMPACT trial. Respiratory Research 21:1.
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Irina E. Chazova, Vera A. Nevzorova, Lali G. Ambatiello, Tat’iana A. Brodskaia, Elena V. Oshchepkova, Andrei S. Belevskii, Juliya V. Zhernakova, Zaurbek R. Aisanov, Svetlana I. Ovcharenko & Aleksandr G. Chuchalin. (2020) Clinical practice guidelines on the diagnosis and treatment of patients with arterial hypertension and chronic obstructive pulmonary disease. Systemic Hypertension 17:3, pages 7-34.
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Roland Buhl, Dave Singh, Alberto de la Hoz, Wenqiong Xue & Gary T. Ferguson. (2020) Benefits of Tiotropium/Olodaterol Compared with Tiotropium in Patients with COPD Receiving only LAMA at Baseline: Pooled Analysis of the TONADO® and OTEMTO® Studies. Advances in Therapy 37:8, pages 3485-3499.
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Daiana Stolz & Mario Cazzola. 2020. Cardiovascular Complications of Respiratory Disorders. Cardiovascular Complications of Respiratory Disorders 238 250 .
Paola Rogliani, Maria Gabriella Matera, Beatrice Ludovica Ritondo, Ilaria De Guido, Ermanno Puxeddu, Mario Cazzola & Luigino Calzetta. (2019) Efficacy and cardiovascular safety profile of dual bronchodilation therapy in chronic obstructive pulmonary disease: A bidimensional comparative analysis across fixed-dose combinations. Pulmonary Pharmacology & Therapeutics 59, pages 101841.
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Luigino Calzetta, Maria Gabriella Matera, Mario Cazzola & Paola Rogliani. (2019) Optimizing the Development Strategy of Combination Therapy in Respiratory Medicine: From Isolated Airways to Patients. Advances in Therapy 36:12, pages 3291-3298.
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Tanja Fens, Simon van der Pol, Janwillem W.H. Kocks, Maarten J. Postma & Job F.M. van Boven. (2019) Economic Impact of Reducing Inappropriate Inhaled Corticosteroids Use in Patients With Chronic Obstructive Pulmonary Disease: ISPOR's Guidance on Budget Impact in Practice. Value in Health 22:10, pages 1092-1101.
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Paola Rogliani & Luigino Calzetta. (2019) Critical interpretation of pairwise and network meta-analysis of randomized respiratory clinical trials. AboutOpen 5:1, pages 55-61.
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Hannah A. Blair. (2019) Tiotropium/Olodaterol: A Review in COPD. Drugs 79:9, pages 997-1008.
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Lowie E.G.W. Vanfleteren, Anders Ullman, Anita Nordenson, Anders Andersson, Kristina Andelid & Leonardo M. Fabbri. (2019) Triple therapy (ICS/LABA/LAMA) in COPD: thinking out of the box. ERJ Open Research 5:1, pages 00185-2018.
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Frederik Trinkmann, Joachim Saur, Martin Borggrefe & Ibrahim Akin. (2019) Cardiovascular Comorbidities in Chronic Obstructive Pulmonary Disease (COPD)—Current Considerations for Clinical Practice. Journal of Clinical Medicine 8:1, pages 69.
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Diego J. Maselli, Megan Hardin, Stephanie A. Christenson, Nicola A. Hanania, Craig P. Hersh, Sandra G. Adams, Antonio Anzueto, Jay I. Peters, MeiLan K. Han & Fernando J. Martinez. (2019) Clinical Approach to the Therapy of Asthma-COPD Overlap. Chest 155:1, pages 168-177.
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I. V. Leshchenko. (2018) Fixed dose long-acting bronchodilator combinations in chronic obstructive pulmonary disease: safety, effectiveness and cardiovascular system. Medical Council:15, pages 18-26.
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A. A. Vizel & I. Yu. Vizel. (2018) 12-Hour fixed-dose combination of andrenergic agonist and cholinergic antagonist in a new administration device: analytical review. Medical Council:15, pages 116-122.
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Mario Cazzola & Maria Gabriella Matera. (2018) POINT: Should LAMA/LABA Combination Therapy Be Used as Initial Maintenance Treatment for COPD? Yes. Chest 154:4, pages 746-748.
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Zhuying Li, Chunyan Tian, Xuehui Wang & Liqin Wang. (2018) A retrospective study of Yiqibushenhuoxue decoction for the treatment of chronic obstructive pulmonary disease. Medicine 97:31, pages e11684.
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Luigino Calzetta, Maria Gabriella Matera & Mario Cazzola. (2018) Pharmacological mechanisms leading to synergy in fixed-dose dual bronchodilator therapy. Current Opinion in Pharmacology 40, pages 95-103.
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Mario Cazzola & Maria Gabriella Matera. (2018) Combining Dual Bronchodilation and β-Blockade in Patients With an Overlap Between COPD and Cardiovascular Diseases. Chest 153:6, pages 1289-1291.
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