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Original Research

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

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Pages 3501-3516 | Published online: 17 Oct 2018

Keep up to date with the latest research on this topic with citation updates for this article.

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Raed I. Felimban, Hossam H. Tayeb, Adeel G Chaudhary, Majed A. Felemban, Fuad H. Alnadwi, Sarah A. Ali, Jazia A. Alblowi, Eman ALfayez, Deena Bukhary, Mohammed Alissa & Safa H. Qahl. (2023) Utilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line. Drug Delivery 30:1, pages 83-96.
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Mohammed H. Elkomy, Shahira F. El Menshawe, Rasha M. Kharshoum, Amany M. Abdeltwab, Raghda R. S. Hussein, Doaa S. Hamad, Izzeddin Alsalahat & Heba M. Aboud. (2022) Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation. Drug Delivery 29:1, pages 2058-2071.
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Motahareh Shabani Dargah & Afra Hadjizadeh. (2022) Improvement of ascorbic acid delivery into human skin via hyaluronic acid-coated niosomes. Journal of Microencapsulation 39:6, pages 552-562.
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Heba F Salem, Rasha M Kharshoum, Sara M Awad, Mai Ahmed Mostafa & Heba A Abou-Taleb. (2021) Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study. International Journal of Nanomedicine 16, pages 4251-4276.
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Mona A. Shewaiter, Adli A. Selim, Hassan M. Rashed, Yasser M. Moustafa & Shadeed Gad. (2023) Niosomal formulation of mefenamic acid for enhanced cancer targeting; preparation, characterization and biodistribution study using radiolabeling technique. Journal of Cancer Research and Clinical Oncology 149:20, pages 18065-18080.
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Ahmet Doğan Ergin, Burcu Üner, Şencan Balcı, Çağlar Demirbağ, Camillo Benetti & Çağatay Oltulu. (2023) Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes. Journal of Pharmaceutical Sciences 112:11, pages 2921-2932.
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Alaa Raad Al Jayoush, Hatem A.F.M. Hassan, Hawraa Asiri, Maryam Jafar, Reem Saeed, Rania Harati & Mohamed Haider. (2023) Niosomes for nose-to-brain delivery: A non-invasive versatile carrier system for drug delivery in neurodegenerative diseases. Journal of Drug Delivery Science and Technology 89, pages 105007.
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Marwa H. Abdallah, Hemat El-Sayed El-Horany, Hanan M. El-Nahas & Tarek M. Ibrahim. (2023) Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route. Pharmaceutics 15:11, pages 2521.
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Mishkaat Parveen Izhar, Abdul Hafeez, Poonam Kushwaha & Simrah. (2023) Drug Delivery Through Niosomes: A Comprehensive Review with Therapeutic Applications. Journal of Cluster Science 34:5, pages 2257-2273.
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Sumit Sharma, Neha Kumari, Deepika Garg & Samrat Chauhan. (2023) A Compendium of Bioavailability Enhancement via Niosome Technology. Pharmaceutical Nanotechnology 11:4, pages 324-338.
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Paramita Saha, Himanshu Kathuria & Murali Monohar Pandey. (2023) Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease. Journal of Controlled Release 358, pages 293-318.
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Sweta Kar & Sandeep Kumar Singh. (2023) Cationic nanoliposomes of carvedilol for intranasal application: In vitro, in vivo and in silico studies. Journal of Drug Delivery Science and Technology 80, pages 104178.
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SAEED A. S. AL-ZUHAIRY, HOSSAM`` S. EL-SAWY, MOHAMED A. EL-NABARAWI & MAHMOUD H. TEAIMA. (2023) FOCUS ON NIOSOMAL–BASED DRUG DELIVERY SYSTEMS FOR NASAL ROUTE: APPLICATIONS AND CHALLENGES. International Journal of Applied Pharmaceutics, pages 36-43.
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Mahmoud H. Teaima, Doaa A. Helal, Jihad M. Alsofany, Mohamed A. El-Nabarawi & Mohamed Yasser. (2022) Ion-Triggered In Situ Gelling Intranasal Spray of Dronedarone Hydrochloride Nanocarriers: In Vitro Optimization and In Vivo Pharmacokinetic Appraisal. Pharmaceutics 14:11, pages 2405.
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Marina A. Bekhet, Adel A. Ali, Rasha M. Kharshoum, Fatma I. Abo El-Ela & Heba F. Salem. (2022) Intranasal Niosomal In Situ Gel As A Novel Strategy for Improving Citicoline Efficacy and Brain Delivery in Treatment of Epilepsy: In Vitro and Ex Vivo Characterization and In Vivo Pharmacodynamics Investigation. Journal of Pharmaceutical Sciences 111:8, pages 2258-2269.
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Lixia Li, Mengxue He, Chunlin Fang, Yu Zhang, Yiming Wang, Xu Song, Yuanfeng Zou, Renyong Jia, Xiaoxia Liang, Lizi Yin, Cheng Lv, Hongping Wan, Xinghong Zhao & Zhongqiong Yin. (2022) Preparation, characterization, ex vivo transdermal properties and skin irritation evaluation of 1,8-cineole nanoemulsion gel. International Journal of Pharmaceutics 624, pages 121982.
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Snehal K Shukla, Veronica Nguyen, Mimansa Goyal & Vivek Gupta. (2022) Cationically modified inhalable nintedanib niosomes: enhancing therapeutic activity against non-small-cell lung cancer. Nanomedicine 17:13, pages 935-958.
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Waleed Y. Rizg, Khaled M. Hosny, Samar S. Mahmoud, Ahmed K. Kammoun, Abdulmohsin J. Alamoudi, Hossam H. Tayeb, Haitham A. Bukhary, Moutaz Y. Badr, Samar S. A. Murshid, Eman Alfayez, Sarah A. Ali, Rayan Y. Mushtaq & Walaa A. Abualsunun. (2022) Repurposing Lovastatin Cytotoxicity against the Tongue Carcinoma HSC3 Cell Line Using a Eucalyptus Oil-Based Nanoemulgel Carrier. Gels 8:3, pages 176.
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Pallavi Gupta & Khushwant S. Yadav. (2022) Formulation and evaluation of brinzolamide encapsulated niosomal in-situ gel for sustained reduction of IOP in rabbits. Journal of Drug Delivery Science and Technology 67, pages 103004.
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Waleed Y. Rizg, Khaled M. Hosny, Samar S. Elgebaly, Abdulmohsin J. Alamoudi, Raed I. Felimban, Hossam H. Tayeb, Majed Alharbi, Haitham A. Bukhary, Walaa A. Abualsunun, Alshaimaa M. Almehmady & Rasha A. Khallaf. (2021) Preparation and Optimization of Garlic Oil/Apple Cider Vinegar Nanoemulsion Loaded with Minoxidil to Treat Alopecia. Pharmaceutics 13:12, pages 2150.
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Mai M. El Taweel, Mona H. Aboul-Einien, Mohammed A. Kassem & Nermeen A. Elkasabgy. (2021) Intranasal Zolmitriptan-Loaded Bilosomes with Extended Nasal Mucociliary Transit Time for Direct Nose to Brain Delivery. Pharmaceutics 13:11, pages 1828.
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Myriam Sainz-Ramos, Ilia Villate-Beitia, Idoia Gallego, Nuseibah AL Qtaish, Margarita Menéndez, Laura Lagartera, Santiago Grijalvo, Ramón Eritja, Gustavo Puras & José Luis Pedraz. (2021) Correlation between Biophysical Properties of Niosomes Elaborated with Chloroquine and Different Tensioactives and Their Transfection Efficiency. Pharmaceutics 13:11, pages 1787.
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Moein Masjedi & Talieh Montahaei. (2021) An illustrated review on nonionic surfactant vesicles (niosomes) as an approach in modern drug delivery: Fabrication, characterization, pharmaceutical, and cosmetic applications. Journal of Drug Delivery Science and Technology 61, pages 102234.
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Heba F. Salem, Rasha M. Kharshoum, Heba A. Abou-Taleb, Hanan Osman Farouk & Randa Mohammed Zaki. (2021) Fabrication and Appraisal of Simvastatin via Tailored Niosomal Nanovesicles for Transdermal Delivery Enhancement: In Vitro and In Vivo Assessment. Pharmaceutics 13:2, pages 138.
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Poonam Negi, Chetna Hemrajani & Shweta Agarwal. 2021. Design of Experiments for Pharmaceutical Product Development. Design of Experiments for Pharmaceutical Product Development 129 150 .
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Marianne J. Naguib, Salwa Salah, Sally A. Abdel Halim & Shaimaa M. Badr-Eldin. (2020) Investigating the potential of utilizing glycerosomes as a novel vesicular platform for enhancing intranasal delivery of lacidipine. International Journal of Pharmaceutics 582, pages 119302.
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