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Drug Design, Development and Therapy Volume 12, 2018 - Issue
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Original Research

Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway

Wenting Cai1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
,
Donghui Yu1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
,
Jiaqi Fan2 Department of Ophthalmology, Nanjing Medical University, Nanjing, People’s Republic of China
,
Xiuwei Liang3 Department of Ophthalmology, Nanchang University, Nanchang, People’s Republic of China
,
Huizi Jin1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
,
Chang Liu2 Department of Ophthalmology, Nanjing Medical University, Nanjing, People’s Republic of China
,
Meijiang Zhu1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
,
Tianyi Shen1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
,
Ruiling Zhang1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
,
Weinan Hu4 Department of Ophthalmology, Anhui University of Science and Technology, Huainan, People’s Republic of China
,
Qingquan Wei1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected]
&
Jing Yu1 Department of Ophthalmology, Shanghai Tenth People’s Hospital Affiliated with Tongji University, Shanghai, People’s Republic of China, [email protected];5 Department of Ophthalmology, Ninghai First Hospital, Zhejiang, People’s Republic of China, [email protected]Correspondence[email protected]
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Pages 4149-4161 | Published online: 06 Dec 2018

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Miłosz Caban & Urszula Lewandowska. (2023) Polyphenols and Posterior Segment Eye Diseases: Effects on Angiogenesis, Invasion, Migration and Epithelial-Mesenchymal Transition. Food Reviews International 39:6, pages 3415-3443.
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Yuliya Semenova & Geir Bjørklund. (2023) Antioxidants and neurodegenerative eye disease. Critical Reviews in Food Science and Nutrition 0:0, pages 1-19.
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Nagalakshmi Annam, Abraham Peele Karlapudi, Mukesh Doble, Krupanidhi Srirama & Venkateswarulu T.C.. (2023) An in silico study on pulmonary fibrosis inhibitors from Tinospora cordifolia and Curcuma longa targeting TGF-β RI. Journal of Biomolecular Structure and Dynamics 41:7, pages 3145-3161.
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Articles from other publishers (17)

Dandan Liu, Chaoyang Zhang, Jingting Zhang, Guo-Tong Xu & Jingfa Zhang. (2023) Molecular pathogenesis of subretinal fibrosis in neovascular AMD focusing on epithelial-mesenchymal transformation of retinal pigment epithelium. Neurobiology of Disease 185, pages 106250.
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Hehua Wang, Ziyu Dong, Jinhai Liu, Zhaoyu Zhu & Masoud Najafi. (2023) Mechanisms of Cancer-killing by Quercetin; A Review on Cell Death Mechanisms. Anti-Cancer Agents in Medicinal Chemistry 23:9, pages 999-1012.
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Daisy Shu, Suman Chaudhary, Kin-Sang Cho, Anton Lennikov, William Miller, David Thorn, Menglu Yang & Tina McKay. (2023) Role of Oxidative Stress in Ocular Diseases: A Balancing Act. Metabolites 13:2, pages 187.
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Meirong Huo, Jiyuan Zhou, Honglan Wang, Yuzhao Zheng, Yuqing Tong, Jianping Zhou, Jiyong Liu & Tingjie Yin. (2022) A pHe sensitive nanodrug for collaborative penetration and inhibition of metastatic tumors. Journal of Controlled Release 352, pages 893-908.
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Saori Ohmae, Sota Akazawa, Toshio Takahashi, Takayuki Izumo, Tomohiro Rogi & Masaaki Nakai. (2022) Quercetin attenuates adipogenesis and fibrosis in human skeletal muscle. Biochemical and Biophysical Research Communications 615, pages 24-30.
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Mohsin Ali Khan, Zaw Ali Khan, Zainab Siddiqui Siddiqui, Mark Charles, Pushpendra Pratap, Abdul Naeem, Nishat Fatima, Nigar Naqvi, Shikha Srivastava & Sarina Zehra. 2022. Regenerative Therapies in Ischemic Stroke Recovery. Regenerative Therapies in Ischemic Stroke Recovery 317 353 .
Guang Zheng, Junmei Zhao, Jiaqi Ru & Hongtao Guo. (2021) The Anti-atherosclerosis Protein Regulation Network Delivered by Onion Quercetin. The Anti-atherosclerosis Protein Regulation Network Delivered by Onion Quercetin.
Kyoko Igarashi, Koji Sugimoto & Eiichi Hirano. (2021) Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells. BMC Research Notes 14:1.
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Sun Young Park, Woo Chang Song, Beomjin Kim, Jin-Woo Oh & Geuntae Park. (2021) Nano-Graphene Oxide-Promoted Epithelial–Mesenchymal Transition of Human Retinal Pigment Epithelial Cells through Regulation of Phospholipase D Signaling. Nanomaterials 11:10, pages 2546.
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Lianghui Zhao, Hongwei Wang & Xianli Du. (2021) The therapeutic use of quercetin in ophthalmology: recent applications. Biomedicine & Pharmacotherapy 137, pages 111371.
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Olina Dagher, Pauline Mury, Nathalie Thorin-Trescases, Pierre Emmanuel Noly, Eric Thorin & Michel Carrier. (2021) Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases. Frontiers in Cardiovascular Medicine 8.
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Sai Manohar Thota, Venkatesh Balan & Venketesh Sivaramakrishnan. (2020) Natural products as home‐based prophylactic and symptom management agents in the setting of COVID ‐19 . Phytotherapy Research 34:12, pages 3148-3167.
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Hui Zou, Chenli Shan, Linlin Ma, Jia Liu, Ning Yang & Jinsong Zhao. (2020) Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy. PeerJ 8, pages e10136.
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Marta Prieto-Vila, Iwao Shimomura, Akiko Kogure, Wataru Usuba, Ryou-u Takahashi, Takahiro Ochiya & Yusuke Yamamoto. (2020) Quercetin Inhibits Lef1 and Resensitizes Docetaxel-Resistant Breast Cancer Cells. Molecules 25:11, pages 2576.
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Laura Mosca, Michele Minopoli, Martina Pagano, Francesca Vitiello, Maria Carriero, Giovanna Cacciapuoti & Marina Porcelli. (2020) Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. International Journal of Oncology.
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So Ra Kim, Eun Young Lee, Da Jeong Kim, Hye Jung Kim & Hae Ryoun Park. (2020) Quercetin Inhibits Cell Survival and Metastatic Ability via the EMT-Mediated Pathway in Oral Squamous Cell Carcinoma. Molecules 25:3, pages 757.
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Abu Sufiyan Chhipa, Swapnil P. Borse, Ruma Baksi, Sunali Lalotra & Manish Nivsarkar. (2019) Targeting receptors of advanced glycation end products (RAGE): Preventing diabetes induced cancer and diabetic complications. Pathology - Research and Practice 215:11, pages 152643.
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