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Drug Design, Development and Therapy Volume 13, 2019 - Issue
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Original Research

A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers

Wonsuk Shin1 Department of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea, [email protected]
,
Kyoung Soo Lim1 Department of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea, [email protected]
,
Min-Kyoung Kim1 Department of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea, [email protected]
,
Hyun Sook Kim2 Department of Neurology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea
,
Jihwa Hong3 Department of Scientific Affairs, PAREXEL International, Waltham, MA, USA
,
Stanford Jhee3 Department of Scientific Affairs, PAREXEL International, Waltham, MA, USA
,
Joseph Kim3 Department of Scientific Affairs, PAREXEL International, Waltham, MA, USA
,
Sungeun Yoo4 Kainos Medicine Inc., Seongnam, Republic of Korea
,
Yeon-Tae Chung4 Kainos Medicine Inc., Seongnam, Republic of Korea
,
Jae Moon Lee4 Kainos Medicine Inc., Seongnam, Republic of Korea
&
Doo-Yeoun Cho1 Department of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea, [email protected]Correspondence[email protected]
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Pages 1011-1022 | Published online: 29 Mar 2019

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Daniele Colombo, Paraskevi Pnevmatikou, Elsa Melloni & Charlotte Keywood. (2020) Therapeutic innovation in Parkinson’s disease: a 2020 update on disease-modifying approaches. Expert Review of Neurotherapeutics 20:10, pages 1047-1064.
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Articles from other publishers (6)

Victoria Sidoroff, Pam Bower, Nadia Stefanova, Alessandra Fanciulli, Iva Stankovic, Werner Poewe, Klaus Seppi, Gregor K. Wenning & Florian Krismer. (2022) Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?. Journal of Parkinson's Disease 12:5, pages 1369-1387.
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Lorenzo Barba, Federico Paolini Paoletti, Giovanni Bellomo, Lorenzo Gaetani, Steffen Halbgebauer, Patrick Oeckl, Markus Otto & Lucilla Parnetti. (2022) Alpha and Beta Synucleins: From Pathophysiology to Clinical Application as Biomarkers. Movement Disorders 37:4, pages 669-683.
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Bok-Seok Kim, Jin-A Song, Ki-Hong Jang, Taeik Jang, Bumjun Jung, Sung-Eun Yoo, Jae Moon Lee & Eunhee Kim. (2022) Pharmacological Intervention Targeting FAF1 Restores Autophagic Flux for α-Synuclein Degradation in the Brain of a Parkinson’s Disease Mouse Model. ACS Chemical Neuroscience 13:6, pages 806-817.
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Bhupesh Vaidya, Kritika Dhamija, Priyanka Guru & Shyam Sunder Sharma. (2021) Parkinson's disease in women: Mechanisms underlying sex differences. European Journal of Pharmacology 895, pages 173862.
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Hyun Soo Park, Yoo Sung Song, Byung Seok Moon, Sung-Eun Yoo, Jae Moon Lee, Yeon-Tae Chung, Eunhee Kim, Byung Chul Lee & Sang Eun Kim. (2020) Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F]FE-PE2I Positron Emission Tomography Analysis Study. Frontiers in Pharmacology 11.
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Federico Paolini Paoletti, Lorenzo Gaetani & Lucilla Parnetti. (2020) The Challenge of Disease-Modifying Therapies in Parkinson’s Disease: Role of CSF Biomarkers. Biomolecules 10:2, pages 335.
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