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Drug Design, Development and Therapy Volume 14, 2020 - Issue
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Original Research

The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling

Amira M Ghoneim1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2963-2135
ORCID Icon &
Suzan M Mansour2 Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt;3 Department of Pharmacology, Toxicology & Biochemistry, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-9235-7351
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Pages 1469-1479 | Published online: 14 Apr 2020

Citations (6)

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Nicolas Simon, Romain Torrents & Jean-Michel Azorin. (2022) Comorbidities and the right dose: antipsychotics. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 507-518.
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Articles from other publishers (5)

Hussein O. Ammar, Rehab N. Shamma, Carol Yousry, Rasha S. Elbatanony, Basma Khater & Amira M. Ghoneim. (2023) Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles. Future Journal of Pharmaceutical Sciences 9:1.
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Vianney Tuloup, Sylvain Goutelle, Michel Tod & Laurent Bourguignon. (2023) Evaluation of Renal Impairment Influence on Metabolic Drug Clearance using a Modelling Approach. Clinical Pharmacokinetics 62:2, pages 307-319.
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Juanhong Zhang & Rong Wang. (2022) Changes in CYP3A4 Enzyme Expression and Biochemical Markers Under Acute Hypoxia Affect the Pharmacokinetics of Sildenafil. Frontiers in Physiology 13.
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Shahinaze A. Fouad, Fady A. Malaak, Mohamed A. El-Nabarawi, Khalid Abu Zeid & Amira M. Ghoneim. (2021) Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling. PLOS ONE 16:1, pages e0245482.
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Joomi Lee, Min-Gul Kim, Hyeon-Cheol Jeong & Kwang-Hee Shin. (2021) Physiologically-based pharmacokinetic model for clozapine in Korean patients with schizophrenia. Translational and Clinical Pharmacology 29:1, pages 33.
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