Drug Design, Development and Therapy, Volume 14, Issue (2020)

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Drug Design, Development and Therapy, Volume 14, Issue (2020)

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Clinical Trial Report

Case Report
Safety, Tolerability, and Pharmacokinetics of Adrenomedullin in Healthy Males: A Randomized, Double-Blind, Phase 1 Clinical Trial
Toshihiro Kita, Yoshikazu Kaji & Kazuo Kitamura
Pages: 1-11
Published online: 06 Jan 2020
AbstractforSafety, Tolerability, and Pharmacokinetics of Adrenomedullin in Healthy Males: A Randomized, Double-Blind, Phase 1 Clinical Trial | Full Text | References | PDF (1.8 MB) | EPUB
  • 169 Views
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Open Access

Original Research

Article
NMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway
Guang-Yun Wang, Tie-Zheng Wang, Yuan-Yuan Zhang, Fang Li, Bo-Yang Yu & Jun-Ping Kou
Pages: 13-25
Published online: 06 Jan 2020
AbstractforNMMHC IIA Inhibition Ameliorates Cerebral Ischemic/Reperfusion-Induced Neuronal Apoptosis Through Caspase-3/ROCK1/MLC Pathway | Full Text | References | PDF (11.2 MB) | EPUB
  • 102 Views
  • 11 CrossRef citations
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Open Access
Article
Engineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation
Hajra Afeera Hameed, Shahzeb Khan, Muhammad Shahid, Riaz Ullah, Ahmed Bari, Syed Saeed Ali, Zahid Hussain, Muhammad Sohail, Shafi Ullah Khan & Thet Thet Htar
Pages: 27-41
Published online: 07 Jan 2020
AbstractforEngineering of Naproxen Loaded Polymer Hybrid Enteric Microspheres for Modified Release Tablets: Development, Characterization, in silico Modelling and in vivo Evaluation | Full Text | References | PDF (3.7 MB) | EPUB
  • 246 Views
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Open Access

Clinical Trial Report

Case Report
Comparison of the Pharmacokinetics, Safety, and Tolerability of the Autoinjector (AI) and Pre-Filled Syringe (PFS) of SB4 in Healthy Subjects
Donghoon Shin, Younsoo Kim, Ahra Go & Maria Velinova
Pages: 43-50
Published online: 08 Jan 2020
AbstractforComparison of the Pharmacokinetics, Safety, and Tolerability of the Autoinjector (AI) and Pre-Filled Syringe (PFS) of SB4 in Healthy Subjects | Full Text | References | PDF (427.9 KB) | EPUB
  • 124 Views
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Open Access

Original Research

Article
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway
Dequan Liu, Huilin Wang, Yangang Zhang & Zhan Zhang
Pages: 51-60
Published online: 07 Jan 2020
AbstractforProtective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway | Full Text | References | PDF (6.9 MB) | EPUB
  • 474 Views
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Open Access
Article
Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2
Xiaojing Shi, Guizhou Tao, Lili Ji & Ge Tian
Pages: 61-71
Published online: 08 Jan 2020
AbstractforSappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2 | Full Text | References | PDF (8.2 MB) | EPUB
  • 159 Views
  • 21 CrossRef citations
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Open Access
Article
Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway
Yulei Lu, Shengming Wu, Bangde Xiang, Lequn Li & Youzhi Lin
Pages: 73-85
Published online: 09 Jan 2020
AbstractforCurcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway | Full Text | References | PDF (10.2 MB) | EPUB
  • 254 Views
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Open Access
Article
In vitro Antifungal Effects of Berberine Against Candida spp. In Planktonic and Biofilm Conditions
Yufei Xie, Xiaosong Liu & Peiru Zhou
Pages: 87-101
Published online: 09 Jan 2020
AbstractforIn vitro Antifungal Effects of Berberine Against Candida spp. In Planktonic and Biofilm Conditions | Full Text | References | PDF (17.8 MB) | EPUB
  • 358 Views
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Open Access
Article
Suitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion
Sarah Fawaz, Breanna Dixon, Stephen Barton, Amna Mohamed & Shereen Nabhani-Gebara
Pages: 103-109
Published online: 10 Jan 2020
AbstractforSuitability of Amoxicillin–Clavulanic Acid for Administration via Prolonged Infusion | Full Text | References | PDF (3.2 MB) | EPUB
  • 285 Views
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Open Access
Article
Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry
Mohamed W Attwa, Adnan A Kadi & Hany W Darwish
Pages: 111-119
Published online: 10 Jan 2020
AbstractforMetabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry | Full Text | References | PDF (2.9 MB) | EPUB
  • 145 Views
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Open Access
Article
RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro
Xinying Yu, Fan Yang, Hong Jiang & Ling Fan
Pages: 121-128
Published online: 10 Jan 2020
AbstractforRGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro | Full Text | References | PDF (2.6 MB) | EPUB
  • 134 Views
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Open Access
Article
Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway
Shihao Xiang, Kan Chen, Ling Xu, Ting Wang & Chuanyong Guo
Pages: 129-143
Published online: 13 Jan 2020
AbstractforBergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway | Full Text | References | PDF (12.5 MB) | EPUB
  • 184 Views
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Open Access
Article
Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways
Ziqian Wang, Tuo Tang, Shengnan Wang, Tianyu Cai, Hong Tao, Qing Zhang, Shimei Qi & Zhilin Qi
Pages: 145-155
Published online: 14 Jan 2020
AbstractforAloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways | Full Text | References | PDF (7.8 MB) | EPUB
  • 147 Views
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Open Access
Article
Cost-Effectiveness Analysis of Ezetimibe as the Add-on Treatment to Moderate-Dose Rosuvastatin versus High-Dose Rosuvastatin in the Secondary Prevention of Cardiovascular Diseases in China: A Markov Model Analysis
Han Yang, Nan Li, Youlian Zhou, Zhilan Xiao, Haoming Tian, Ming Hu & Sheyu Li
Pages: 157-165
Published online: 14 Jan 2020
AbstractforCost-Effectiveness Analysis of Ezetimibe as the Add-on Treatment to Moderate-Dose Rosuvastatin versus High-Dose Rosuvastatin in the Secondary Prevention of Cardiovascular Diseases in China: A Markov Model Analysis | Full Text | References | PDF (2.6 MB) | EPUB
  • 264 Views
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Open Access
Article
Isoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages
Yunfei Wang, Zhengrong Li, Boxue Liu, Rumeng Wu, Haifeng Gong, Zhanhai Su & Shoude Zhang
Pages: 167-173
Published online: 15 Jan 2020
AbstractforIsoborneol Attenuates Low-Density Lipoprotein Accumulation and Foam Cell Formation in Macrophages | Full Text | References | PDF (1.6 MB) | EPUB
  • 136 Views
  • 10 CrossRef citations
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Open Access
Article
Edaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model
Zhao-Yin Fu, Zhi-Jiang Wu, Jun-Hui Zheng, Nuo Li, Jun-Yu Lu & Meng-Hua Chen
Pages: 175-183
Published online: 15 Jan 2020
AbstractforEdaravone Ameliorates Renal Warm Ischemia-Reperfusion Injury by Downregulating Endoplasmic Reticulum Stress in a Rat Resuscitation Model | Full Text | References | PDF (2.7 MB) | EPUB
  • 109 Views
  • 16 CrossRef citations
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Open Access
Article
Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines
Mahnaz Mohammadi Kian, Mahdieh Salemi, Mohammad Bahadoran, Atousa Haghi, Nasrin Dashti, Saeed Mohammadi, Shahrbano Rostami, Bahram Chahardouli, Davood Babakhani & Mohsen Nikbakht
Pages: 185-194
Published online: 15 Jan 2020
AbstractforCurcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines | Full Text | References | PDF (3.8 MB) | EPUB
  • 155 Views
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Open Access
Article
Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway
Ye Zhao, Hui-Ling Wang, Tong-Tong Li, Fei Yang & Chi-Meng Tzeng
Pages: 195-206
Published online: 15 Jan 2020
AbstractforBaicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway | Full Text | References | PDF (8.1 MB) | EPUB
  • 375 Views
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Open Access
Article
Discovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells
Yanyan Jia, Meijuan Li, Yuan Cao, Wenlong Feng, Xueru Li, Wenhua Xue & Huirong Shi
Pages: 207-216
Published online: 15 Jan 2020
AbstractforDiscovery of a Novel Benzenesulfonamide Analogue That Inhibits Proliferation and Metastasis Against Ovarian Cancer OVCAR-8 Cells | Full Text | References | PDF (3.3 MB) | EPUB
  • 148 Views
  • 9 CrossRef citations
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Open Access
Article
KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats
Kai Jia, Yan Wang, Xin Tong & Rong Wang
Pages: 217-231
Published online: 16 Jan 2020
AbstractforKGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats | Full Text | References | PDF (11.1 MB) | EPUB
  • 107 Views
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Open Access
Article
Electrospun PLA Fibers Containing Metronidazole for Periodontal Disease
Mária Budai-Szűcs, Attila Léber, Lu Cui, Muriel Józó, Péter Vályi, Katalin Burián, Balázs Kirschweng, Erzsébet Csányi & Béla Pukánszky
Pages: 233-242
Published online: 16 Jan 2020
AbstractforElectrospun PLA Fibers Containing Metronidazole for Periodontal Disease | Full Text | References | PDF (1.9 MB) | EPUB
  • 159 Views
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Open Access
Article
Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique
Shuqi Li, Jie Zhang, Yuqi Fang, Jun Yi, Zhufen Lu, Yanzhong Chen & Bohong Guo
Pages: 243-256
Published online: 16 Jan 2020
AbstractforEnhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique | Full Text | References | PDF (8.2 MB) | EPUB
  • 128 Views
  • 9 CrossRef citations
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Open Access
Article
The Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy
Yi-Sin Wong, Sheng-Feng Sung, Chi-Shun Wu, Yung-Chu Hsu, Yu-Hsiang Su, Ling-Chien Hung & Cheung-Ter Ong
Pages: 257-263
Published online: 17 Jan 2020
AbstractforThe Impact of Loading Dose on Outcome in Stroke Patients Receiving Low-Dose Tissue Plasminogen Activator Thrombolytic Therapy | Full Text | References | PDF (289.4 KB) | EPUB
  • 87 Views
  • 3 CrossRef citations
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Open Access
Article
An Updated Systematic Review With Meta-Analysis Of Randomized Trials On Topical Cyclosporin A For Dry-Eye Disease
Hsin-I Tuan, Sheng-Chu Chi & Yi-No Kang
Pages: 265-274
Published online: 17 Jan 2020
AbstractforAn Updated Systematic Review With Meta-Analysis Of Randomized Trials On Topical Cyclosporin A For Dry-Eye Disease | Full Text | References | PDF (5.2 MB) | EPUB
  • 182 Views
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Open Access

Clinical Trial Report

Case Report
Apatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study
Xinran Ma, Ling Li, Lei Zhang, Xiaorui Fu, Xin Li, Xinhua Wang, Jingjing Wu, Zhenchang Sun, Xudong Zhang, Xiaoyan Feng, Yu Chang, Zhiyuan Zhou, Feifei Nan, Jieming Zhang, Zhaoming Li & Mingzhi Zhang
Pages: 275-284
Published online: 22 Jan 2020
AbstractforApatinib in Patients with Relapsed or Refractory Diffuse Large B Cell Lymphoma: A Phase II, Open-Label, Single-Arm, Prospective Study | Full Text | References | PDF (1.4 MB) | EPUB
  • 74 Views
  • 7 CrossRef citations
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Open Access

Review

Review Article
Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
Jian Liu, Kun Zhang, Lin Cheng, He Zhu & Tianmin Xu
Pages: 285-296
Published online: 21 Jan 2020
AbstractforProgress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin | Full Text | References | PDF (1.6 MB) | EPUB
  • 6299 Views
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Open Access

Original Research

Article
The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation
Siqian Wang, Wenjuan Bi, Yi Liu, Jiayi Cheng, Wei Sun, Gang Wu & Xin Xu
Pages: 297-308
Published online: 22 Jan 2020
AbstractforThe Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation | Full Text | References | PDF (8.6 MB) | EPUB
  • 131 Views
  • 4 CrossRef citations
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Open Access
Article
In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment
Hassan Dana, Ghanbar Mahmoodi Chalbatani, Elahe Gharagouzloo, Seyed Rouhollah Miri, Fereidoon Memari, Reza Rasoolzadeh, Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi & Vahid Marmari
Pages: 309-329
Published online: 23 Jan 2020
AbstractforIn silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment | Full Text | References | PDF (14.8 MB) | EPUB
  • 1163 Views
  • 18 CrossRef citations
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Open Access
Article
Cardioprotective Effect of Monoammonium Glycyrrhizinate Injection Against Myocardial Ischemic Injury in vivo and in vitro: Involvement of Inhibiting Oxidative Stress and Regulating Ca2+ Homeostasis by L-Type Calcium Channels
Zhifeng Zhao, Miaomiao Liu, Yuanyuan Zhang, Yingran Liang, Donglai Ma, Hongfang Wang, Zhihong Ma, Shengjiang Guan, Zhonglin Wu, Xi Chu, Yue Lin & Li Chu
Pages: 331-346
Published online: 23 Jan 2020
AbstractforCardioprotective Effect of Monoammonium Glycyrrhizinate Injection Against Myocardial Ischemic Injury in vivo and in vitro: Involvement of Inhibiting Oxidative Stress and Regulating Ca2+ Homeostasis by L-Type Calcium Channels | Full Text | References | PDF (3.6 MB) | EPUB
  • 135 Views
  • 15 CrossRef citations
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Open Access
Article
Effect of Fimasartan versus Valsartan and Olmesartan on Office and Ambulatory Blood Pressure in Korean Patients with Mild-to-Moderate Essential Hypertension: A Randomized, Double-Blind, Active Control, Three-Parallel Group, Forced Titration, Multicenter, Phase IV Study (Fimasartan Achieving Systolic Blood Pressure Target (FAST) Study)
Woo-Baek Chung, Sang-Hyun Ihm, Sung-Won Jang, Sung-Ho Her, Chul Soo Park, Jong-Min Lee, Kiyuk Chang, Doo-Soo Jeon, Ki-Dong Yoo & Ki-Bae Seung
Pages: 347-360
Published online: 23 Jan 2020
AbstractforEffect of Fimasartan versus Valsartan and Olmesartan on Office and Ambulatory Blood Pressure in Korean Patients with Mild-to-Moderate Essential Hypertension: A Randomized, Double-Blind, Active Control, Three-Parallel Group, Forced Titration, Multicenter, Phase IV Study (Fimasartan Achieving Systolic Blood Pressure Target (FAST) Study) | Full Text | References | PDF (4.8 MB) | EPUB
  • 168 Views
  • 6 CrossRef citations
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Open Access
Article
Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling
Jin Yu, Caifeng Zhu, Jiazhen Yin, Dongrong Yu, Feng Wan, Xuanli Tang & Xue Jiang
Pages: 361-370
Published online: 28 Jan 2020
AbstractforTetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling | Full Text | References | PDF (3.1 MB) | EPUB
  • 95 Views
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Open Access
Article
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs
Jens Hagenow, Stefanie Hagenow, Kathrin Grau, Mohammad Khanfar, Lena Hefke, Ewgenij Proschak & Holger Stark
Pages: 371-393
Published online: 28 Jan 2020
AbstractforReversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs | Full Text | References | PDF (7.9 MB) | EPUB
  • 156 Views
  • 21 CrossRef citations
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Open Access
Article
Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway
MingBo Wei, YanLi Wu, Hui Liu & Chun Xie
Pages: 395-405
Published online: 29 Jan 2020
AbstractforGenipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway | Full Text | References | PDF (8.9 MB) | EPUB
  • 130 Views
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Open Access
Article
A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma
Haitham AlRabiah, Adnan A Kadi, Haya I Aljohar, Mohamed W Attwa, Nasser S Al-Shakliah, Sabry M Attia & Gamal AE Mostafa
Pages: 407-415
Published online: 28 Jan 2020
AbstractforA New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma | Full Text | References | PDF (6.2 MB) | EPUB
  • 99 Views
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Open Access
Article
Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis
Jia-An Zhang, Chao Luan, Dan Huang, Mei Ju, Kun Chen & Heng Gu
Pages: 417-428
Published online: 29 Jan 2020
AbstractforInduction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis | Full Text | References | PDF (3 MB) | EPUB
  • 147 Views
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Open Access
Article
Calycosin Influences the Metabolism of Five Probe Drugs in Rats
Mei-ling Wu, Yi-ping Lin, Yan-li Wei, Hong-jian Du, Xiao-qian Ying, Wen-zhuang Tan & Bi-e Tang
Pages: 429-434
Published online: 29 Jan 2020
AbstractforCalycosin Influences the Metabolism of Five Probe Drugs in Rats | Full Text | References | PDF (371.5 KB) | EPUB
  • 92 Views
  • 4 CrossRef citations
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Open Access
Article
Comparative Pharmacokinetics, Bioequivalence and Safety Study of Two Recombinant Human Chorionic Gonadotropin Injections in Healthy Chinese Subjects
Jin Wang, Tianli Yang, Hekun Mei, Xueming Yu, Hongmei Peng, Rui Wang & Yun Cai
Pages: 435-444
Published online: 29 Jan 2020
AbstractforComparative Pharmacokinetics, Bioequivalence and Safety Study of Two Recombinant Human Chorionic Gonadotropin Injections in Healthy Chinese Subjects | Full Text | References | PDF (1 MB) | EPUB
  • 198 Views
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Open Access
Article
Development of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans
Kyung Hun Kim, Seo Hyun Lim, Cho Rok Shim, Junsung Park, Woo Heon Song, Min Chang Kwon, Jong Hyuk Lee, Jun Sang Park & Han-Gon Choi
Pages: 445-456
Published online: 30 Jan 2020
AbstractforDevelopment of a Novel Controlled-Release Tablet of Pregabalin: Formulation Variation and Pharmacokinetics in Dogs and Humans | Full Text | References | PDF (5 MB) | EPUB
  • 460 Views
  • 9 CrossRef citations
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Article
Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
Ganhua You, Xiangshu Long, Fang Song, Jing Huang, Maobo Tian, Yan Xiao, Shiyan Deng & Qiang Wu
Pages: 457-468
Published online: 03 Feb 2020
AbstractforMetformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis | Full Text | References | PDF (6.1 MB) | EPUB
  • 161 Views
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Review

Review Article
Clinical Evidence and Safety Profile of Emicizumab for the Management of Children with Hemophilia A
Sandra Le Quellec
Pages: 469-481
Published online: 03 Feb 2020
AbstractforClinical Evidence and Safety Profile of Emicizumab for the Management of Children with Hemophilia A | Full Text | References | PDF (1.3 MB) | EPUB
  • 322 Views
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Original Research

Article
New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity
Reem I Al-Wabli, Aliyah A Almomen, Maha S Almutairi, Adam B Keeton, Gary A Piazza & Mohamed I Attia
Pages: 483-495
Published online: 03 Feb 2020
AbstractforNew Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity | Full Text | References | PDF (679 KB) | EPUB
  • 201 Views
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Open Access
Article
Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety
Mohammad M Al-Sanea, Lizaveta Gotina, Mamdouh FA Mohamed, Della Grace Thomas Parambi, Hesham A M Gomaa, Bijo Mathew, Bahaa G M Youssif, Khalid Saad Alharbi, Zainab M Elsayed, Mohamed A Abdelgawad & Wagdy M Eldehna
Pages: 497-508
Published online: 04 Feb 2020
AbstractforDesign, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety | Full Text | References | PDF (6.2 MB) | EPUB
  • 246 Views
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Article
Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments
Chao Ma, Zongming Zhuang, Qisheng Su, Jianfeng He & Haoyu Li
Pages: 509-518
Published online: 04 Feb 2020
AbstractforCurcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments | Full Text | References | PDF (5.8 MB) | EPUB
  • 237 Views
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Article
Hesperetin-5,7,3ʹ-O-Trimethylether Dually Inhibits Phosphodiesterase 3/4 and Methacholine-Induced Airway Hyperresponsiveness in Sensitized and Challenged Mice
Chung-Hung Shih, Wen-Hung Wang, Chi-Ming Chen & Wun-Chang Ko
Pages: 519-526
Published online: 04 Feb 2020
AbstractforHesperetin-5,7,3ʹ-O-Trimethylether Dually Inhibits Phosphodiesterase 3/4 and Methacholine-Induced Airway Hyperresponsiveness in Sensitized and Challenged Mice | Full Text | References | PDF (5.4 MB) | EPUB
  • 90 Views
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Open Access
Article
Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats
Ling Xie, Ruonan Zhai, Teng Chen, Chongting Gao, Rui Xue, Niansong Wang, Jianbo Wang, Youhua Xu & Dingkun Gui
Pages: 527-538
Published online: 05 Feb 2020
AbstractforPanax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats | Full Text | References | PDF (10.5 MB) | EPUB
  • 140 Views
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Open Access

Erratum

Correction
In silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum]
Page: 539
Published online: 05 Feb 2020
CitationforIn silico Analysis, Molecular Docking, Molecular Dynamic, Cloning, Expression and Purification of Chimeric Protein in Colorectal Cancer Treatment [Erratum] | Full Text | PDF (145.9 KB) | EPUB
  • 74 Views
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Review

Review Article
Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review
Mandana Ohadi, Arash Shahravan, Negar Dehghannoudeh, Touba Eslaminejad, Ibrahim M Banat & Gholamreza Dehghannoudeh
Pages: 541-550
Published online: 05 Feb 2020
AbstractforPotential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review | Full Text | References | PDF (380.5 KB) | EPUB
  • 1051 Views
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Review Article
Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases
Hai Liu, Jianqiong Yang, Wanqing Yang, Shaonan Hu, Yali Wu, Bo Zhao, Haiyan Hu & Shouying Du
Pages: 551-565
Published online: 07 Feb 2020
AbstractforFocus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases | Full Text | References | PDF (2.6 MB) | EPUB
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Original Research

Article
Optimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly
Jay Chauhan, Wenbo Yu, Steven Cardinale, Timothy J Opperman, Alexander D MacKerell Jr, Steven Fletcher & Erik PH de Leeuw
Pages: 567-574
Published online: 10 Feb 2020
AbstractforOptimization of a Benzothiazole Indolene Scaffold Targeting Bacterial Cell Wall Assembly | Full Text | References | PDF (1.7 MB) | EPUB
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Corrigendum

Correction
Minoxidil and Its Use in Hair Disorders: A Review [Corrigendum]
Page: 575
Published online: 10 Feb 2020
CitationforMinoxidil and Its Use in Hair Disorders: A Review [Corrigendum] | Full Text | PDF (146.3 KB) | EPUB
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Original Research

Article
Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells
Qing Tang, Lihua Liu, Hongyan Zhang, Jing Xiao & Swei Sunny Hann
Pages: 577-589
Published online: 11 Feb 2020
AbstractforRegulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells | Full Text | References | PDF (4.8 MB) | EPUB
  • 125 Views
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Review

Review Article
Lysosomal Acid Lipase Deficiency: Therapeutic Options
Gregory M Pastores & Derralynn A Hughes
Pages: 591-601
Published online: 11 Feb 2020
AbstractforLysosomal Acid Lipase Deficiency: Therapeutic Options | Full Text | References | PDF (327.2 KB) | EPUB
  • 250 Views
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Original Research

Article
Silibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney
Ronggui Liu, Qinqin Wang, Zhaoyan Ding, Xiaojuan Zhang, Yunping Li, Yichen Zang & Guijun Zhang
Pages: 603-611
Published online: 13 Feb 2020
AbstractforSilibinin Augments the Antifibrotic Effect of Valsartan Through Inactivation of TGF-β1 Signaling in Kidney | Full Text | References | PDF (5.2 MB) | EPUB
  • 124 Views
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Clinical Trial Report

Case Report
Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers
Jian Liu, You Zhai, Lihua Wu, Guolan Wu, Yunliang Zheng, Xingjiang Hu & Jianzhong Shentu
Pages: 613-620
Published online: 13 Feb 2020
AbstractforPharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers | Full Text | References | PDF (481.7 KB) | EPUB
  • 83 Views
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Original Research

Article
Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway
Fengxia Lin, Yiying Yang, Shanyin Wei, Xiaojing Huang, Zhijian Peng, Xiao Ke, Zhicong Zeng & Yinzhi Song
Pages: 621-633
Published online: 14 Feb 2020
AbstractforHydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway | Full Text | References | PDF (11 MB) | EPUB
  • 180 Views
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Article
A Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension
Anna Stene Hurtsén, Ilya Zorikhin Nilsson, Emanuel M Dogan & Kristofer F Nilsson
Pages: 635-645
Published online: 17 Feb 2020
AbstractforA Comparative Study of Inhaled Nitric Oxide and an Intravenously Administered Nitric Oxide Donor in Acute Pulmonary Hypertension | Full Text | References | PDF (468.4 KB) | EPUB
  • 134 Views
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Article
Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles
Yun Bian & Dong Guo
Pages: 647-659
Published online: 18 Feb 2020
AbstractforTargeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles | Full Text | References | PDF (7.7 MB) | EPUB
  • 386 Views
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Article
Comparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers
Deok Yong Yoon, Sang-In Park, Jin-A Jung, Yong-Il Kim, In-Jin Jang & Jae-Yong Chung
Pages: 661-668
Published online: 19 Feb 2020
AbstractforComparison of Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan/Rosuvastatin with Concomitant Administration of Amlodipine/Losartan and Rosuvastatin in Healthy Volunteers | Full Text | References | PDF (594.5 KB) | EPUB
  • 240 Views
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Article
Impacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients
Min Zhang, Jiangrong Wang, Yong Zhang, Pei Zhang, Zhisheng Jia, Manyi Ren, Xiaomeng Jia, Liping Ma, Mei Gao & Yinglong Hou
Pages: 669-676
Published online: 19 Feb 2020
AbstractforImpacts of CYP2C19 Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients | Full Text | References | PDF (3.3 MB) | EPUB
  • 101 Views
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Article
Colon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits
Eman Ebrahim El Naggar, Elham Abdelmonem Mohamed, Thanaa Mohamed Borg, Ahmed Ramadan El-Sheakh & Mohammed Fawzy Hamed
Pages: 677-696
Published online: 19 Feb 2020
AbstractforColon Targeting of Naringin for Enhanced Cytoprotection Against Indomethacin-Induced Colitis in Rabbits | Full Text | References | PDF (19 MB) | EPUB
  • 182 Views
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Article
Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment 
Li Du, De-Hui Du, Biao Chen, Yue Ding, Tong Zhang & Wei Xiao
Pages: 697-713
Published online: 20 Feb 2020
AbstractforAnti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment  | Full Text | References | PDF (10.7 MB) | EPUB
  • 508 Views
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Study Protocol

Brief Report
Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate
Lin-lin Pei, Wen-zhu Yang, Jing-yuan Fu, Meng-xi Liu, Ting-ting Zhang, Dong-bo Li, Ruo-yue Huang, Li Zhang, Guang-neng Peng, Gang Shu, Zhi-xiang Yuan, Ju-chun Lin, Wei Zhang, Zhi-jun Zhong, Ling Zhao & Hua-lin Fu
Pages: 715-730
Published online: 24 Feb 2020
AbstractforSynthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate | Full Text | References | PDF (7.3 MB) | EPUB
  • 231 Views
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Original Research

Article
Ox-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated Inflammasome Activation via Endoplasmic Reticulum Stress
Liwei Hang, Yan Peng, Rui Xiang, Xiangdong Li & Zhiliang Li
Pages: 731-744
Published online: 24 Feb 2020
AbstractforOx-LDL Causes Endothelial Cell Injury Through ASK1/NLRP3-Mediated Inflammasome Activation via Endoplasmic Reticulum Stress | Full Text | References | PDF (7.9 MB) | EPUB
  • 141 Views
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Article
NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo
Yuhui Hua, Weijia Wang, Xiaoli Zheng, Ling Yang, Hongjin Wu, Zhaoyang Hu, Ying Li, Jing Yue, Zhenzhen Jiang, Xiaoyan Zhang, Qiang Hou & Shixiu Wu
Pages: 745-755
Published online: 24 Feb 2020
AbstractforNVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo | Full Text | References | PDF (7.8 MB) | EPUB
  • 90 Views
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Article
Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships
Katherine Hu, Zhaowen Zhu, Meleah M Mathahs, Huy Tran, Jerry Bommer, Charles A Testa & Warren N Schmidt
Pages: 757-771
Published online: 24 Feb 2020
AbstractforMetalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships | Full Text | References | PDF (8.5 MB) | EPUB
  • 106 Views
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Article
Fisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways
Yanshu Li, Shiheng Jia & Wei Dai
Pages: 773-782
Published online: 25 Feb 2020
AbstractforFisetin Modulates Human Oral Squamous Cell Carcinoma Proliferation by Blocking PAK4 Signaling Pathways | Full Text | References | PDF (7.4 MB) | EPUB
  • 142 Views
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Article
Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies
Mohamed W Attwa, Adnan A Kadi, Ali S Abdelhameed & Hassan A Alhazmi
Pages: 783-793
Published online: 25 Feb 2020
AbstractforMetabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies | Full Text | References | PDF (4.6 MB) | EPUB
  • 237 Views
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Article
Ubiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα
Xiaolei Hu, Hengyan Zhang, Langen Zhuang, Guoxi Jin, Qingqing Yang, Min Li, Weihua Sun & Fengling Chen
Pages: 795-810
Published online: 25 Feb 2020
AbstractforUbiquitin-Fold Modifier-1 Participates in the Diabetic Inflammatory Response by Regulating NF-κB p65 Nuclear Translocation and the Ubiquitination and Degradation of IκBα | Full Text | References | PDF (13.6 MB) | EPUB
  • 107 Views
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Article
Contribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life
Suein Choi, Sangil Jeon, Dong-Seok Yim & Seunghoon Han
Pages: 811-821
Published online: 25 Feb 2020
AbstractforContribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life | Full Text | References | PDF (4.4 MB) | EPUB
  • 108 Views
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Article
Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles
Junjian Wang
Pages: 823-832
Published online: 26 Feb 2020
AbstractforCombination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles | Full Text | References | PDF (6.3 MB) | EPUB
  • 421 Views
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Article
AZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells
Xuemei Chen, Xuejiao Zhang, Jiajun Xu, Yiqing Zhao, Jiachun Bao, Zhanxiong Zheng & Jibo Han
Pages: 833-844
Published online: 26 Feb 2020
AbstractforAZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells | Full Text | References | PDF (5.6 MB) | EPUB
  • 115 Views
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Review

Review Article
The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review
Xing-Ru Zhang, Zhi-Yu Jiang, Zeng-Rui Zhang, Hui-Jun Chen, Ke Wu, Jin-Cai He & Cheng-Long Xie
Pages: 845-854
Published online: 26 Feb 2020
AbstractforThe Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson’s Disease: A Systematic Review | Full Text | References | PDF (1.6 MB) | EPUB
  • 126 Views
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Original Research

Article
Inhibitory Effect of Curcumin on Artery Restenosis Following Carotid Endarterectomy and Its Associated Mechanism in vitro and in vivo
Dapeng Zhang, Yanhui Yang, Yuanchao Li, Guodong Zhang & Zhenguo Cheng
Pages: 855-866
Published online: 26 Feb 2020
AbstractforInhibitory Effect of Curcumin on Artery Restenosis Following Carotid Endarterectomy and Its Associated Mechanism in vitro and in vivo | Full Text | References | PDF (8.1 MB) | EPUB
  • 96 Views
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Article
Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop
Wenxiang Lin, Libei Zhao, Xuetao Huang, Qian Tan, Manqiang Peng, Muhammad Ahmad Khan & Ding Lin
Pages: 867-879
Published online: 26 Feb 2020
AbstractforComparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop | Full Text | References | PDF (6.9 MB) | EPUB
  • 102 Views
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Review

Review Article
Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent
Arthur G Mikaelian, Eric Traboulay, Xiaofei Michael Zhang, Emma Yeritsyan, Peter L Pedersen, Young Hee Ko & Khalid Z Matalka
Pages: 881-893
Published online: 27 Feb 2020
AbstractforPleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent | Full Text | References | PDF (1.9 MB) | EPUB
  • 601 Views
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Original Research

Article
miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats
Xiangwei Lv, Pan Lu, Yisen Hu & Tongtong Xu
Pages: 895-905
Published online: 27 Feb 2020
AbstractformiR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats | Full Text | References | PDF (4.6 MB) | EPUB
  • 89 Views
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Review

Review Article
Effect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages
Jing He, Peihao Yin & Ke Xu
Pages: 907-919
Published online: 28 Feb 2020
AbstractforEffect and Molecular Mechanisms of Traditional Chinese Medicine on Tumor Targeting Tumor-Associated Macrophages | Full Text | References | PDF (2.2 MB) | EPUB
  • 191 Views
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Original Research

Article
Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments
Huan Wang, Yifan Ding, Wei Zhang, Kang Wei, Yaping Pei, Chenming Zou, Chong Zhang, Jiahui Ding, Huang Fang & Songwei Tan
Pages: 921-931
Published online: 28 Feb 2020
AbstractforOxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments | Full Text | References | PDF (3.6 MB) | EPUB
  • 125 Views
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Article
The Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction
Yuanyuan Zhang, Yang Hu, Min Li, Jieman Wang, Gengshuo Guo, Fang Li, Boyang Yu & Junping Kou
Pages: 933-947
Published online: 28 Feb 2020
AbstractforThe Traditional Chinese Medicine Compound, GRS, Alleviates Blood–Brain Barrier Dysfunction | Full Text | References | PDF (6.6 MB) | EPUB
  • 141 Views
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Corrigendum

Correction
A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of LiuWei DiHuang Pill in Treating Type 2 Diabetes Mellitus [Corrigendum]
Page: 949
Published online: 02 Mar 2020
Citationfor A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of LiuWei DiHuang Pill in Treating Type 2 Diabetes Mellitus [Corrigendum] | Full Text | PDF (150 KB) | EPUB
  • 72 Views
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Review

Review Article
Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date
Wimolsiri Iamsumang, Kanchana Leerunyakul & Poonkiat Suchonwanit
Pages: 951-959
Published online: 02 Mar 2020
AbstractforFinasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date | Full Text | References | PDF (573.3 KB) | EPUB
  • 955 Views
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Original Research

Article
Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study
Catherine Leggett, Ei Mon Phyo Lwin, Usha Ritchie, Yunmei Song, Jacobus P Gerber, Sean Turner, William M Hague, Michael Stark, Richard Upton & Sanjay Garg
Pages: 961-967
Published online: 02 Mar 2020
AbstractforPerindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study | Full Text | References | PDF (513.6 KB) | EPUB
  • 175 Views
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Article
Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression
Wan Nuraini Wan Hasan, Kok-Yong Chin, Norzana Abd Ghafar & Ima Nirwana Soelaiman
Pages: 969-976
Published online: 03 Mar 2020
AbstractforAnnatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression | Full Text | References | PDF (3.7 MB) | EPUB
  • 148 Views
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Article
Study on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan
Pengshou Li, Yingying Peng, Qixiang Ma, Ziyong Li & Xiaohua Zhang
Pages: 977-992
Published online: 05 Mar 2020
AbstractforStudy on the Formation of Antihypertensive Twin Drugs by Caffeic Acid and Ferulic Acid with Telmisartan | Full Text | References | PDF (825.7 KB) | EPUB
  • 117 Views
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Article
Bisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination
Chengjiang Qiu, Kairui Liu, Sheng Zhang, Simin Gao, Weirun Chen, Dateng Li & Youxing Huang
Pages: 993-1001
Published online: 05 Mar 2020
AbstractforBisdemethoxycurcumin Inhibits Hepatocellular Carcinoma Proliferation Through Akt Inactivation via CYLD-Mediated Deubiquitination | Full Text | References | PDF (6.4 MB) | EPUB
  • 122 Views
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Article
Characterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds
Tekleab Teka & Haile Kassahun
Pages: 1003-1008
Published online: 05 Mar 2020
AbstractforCharacterization and Evaluation of Antioxidant Activity of Aloe schelpei Reynolds | Full Text | References | PDF (257.8 KB) | EPUB
  • 175 Views
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Review

Review Article
The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety
Joseph V Pergolizzi Jr, Paul J Christo, Jo Ann LeQuang & Peter Magnusson
Pages: 1009-1025
Published online: 11 Mar 2020
AbstractforThe Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety | Full Text | References | PDF (437 KB) | EPUB
  • 545 Views
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Original Research

Article
In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis
Katharigatta N Venugopala, Christophe Tratrat, Melendhran Pillay, Sandeep Chandrashekharappa, Omar Husham Ahmed Al-Attraqchi, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Anroop B Nair, Nagaraja Sreeharsha, Rashmi Venugopala, Mohamed A Morsy, Michelyne Haroun, Hezekiel M Kumalo, Bharti Odhav & Koleka Mlisana
Pages: 1027-1039
Published online: 09 Mar 2020
AbstractforIn silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis | Full Text | References | PDF (3.1 MB) | EPUB
  • 419 Views
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Article
KLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis
Fang Tian, Jinzhi Zhao, Shaochong Bu, He Teng, Jun Yang, Xiaomin Zhang, Xiaorong Li & Lijie Dong
Pages: 1041-1055
Published online: 09 Mar 2020
AbstractforKLF6 Induces Apoptosis in Human Lens Epithelial Cells Through the ATF4-ATF3-CHOP Axis | Full Text | References | PDF (9.1 MB) | EPUB
  • 150 Views
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Review

Review Article
Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors
Xiaohua Guo, Zhaowen Liu, Yizhou Zheng, Yamei Li, Linfu Li, Hai Liu, Zhixi Chen & Longhuo Wu
Pages: 1057-1081
Published online: 10 Mar 2020
AbstractforReview on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors | Full Text | References | PDF (2.3 MB) | EPUB
  • 190 Views
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Clinical Trial Report

Case Report
Impact of Intraoperative Infusion and Postoperative PCIA of Dexmedetomidine on Early Breastfeeding After Elective Cesarean Section: A Randomized Double-Blind Controlled Trial
Yu Wang, Xiang Fang, Chao Liu, Xiaotong Ma, Yutong Song & Ming Yan
Pages: 1083-1093
Published online: 11 Mar 2020
AbstractforImpact of Intraoperative Infusion and Postoperative PCIA of Dexmedetomidine on Early Breastfeeding After Elective Cesarean Section: A Randomized Double-Blind Controlled Trial | Full Text | References | PDF (800.2 KB) | EPUB
  • 199 Views
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Original Research

Article
Hyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer
Zhiyu Wang, Aimin Zang, Yaning Wei, Lin An, Dan Hong, Yan Shi, Jingnan Zhang, Shenyong Su & Guotao Fang
Pages: 1095-1105
Published online: 12 Mar 2020
AbstractforHyaluronic Acid Capped, Irinotecan and Gene Co-Loaded Lipid-Polymer Hybrid Nanocarrier-Based Combination Therapy Platform for Colorectal Cancer | Full Text | References | PDF (5.2 MB) | EPUB
  • 254 Views
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Article
PD98059 Protects Cerebral Cortex Mitochondrial Structure and Function at 48 h Post-Resuscitation in a Rat Model of Cardiac Arrest
Jun-Hui Zheng, Meng-Hua Chen, Zhao-Yin Fu, Nuo Li & Lu Xie
Pages: 1107-1115
Published online: 12 Mar 2020
AbstractforPD98059 Protects Cerebral Cortex Mitochondrial Structure and Function at 48 h Post-Resuscitation in a Rat Model of Cardiac Arrest | Full Text | References | PDF (3.1 MB) | EPUB
  • 98 Views
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Methodology

Article
Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study
Shuang-long Li, Yong-liang Zhu, Chun-yang Zhu, Shao-bin Li, Zi-heng Li & Xiang-jun Qiu
Pages: 1117-1125
Published online: 13 Mar 2020
AbstractforSimultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study | Full Text | References | PDF (3.5 MB) | EPUB
  • 122 Views
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Original Research

Article
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition
Lianjie Lin, Dongxu Wang, Suxuan Qu, Hong Zhao & Yan Lin
Pages: 1127-1141
Published online: 13 Mar 2020
AbstractformiR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition | Full Text | References | PDF (14 MB) | EPUB
  • 135 Views
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Corrigendum

Correction
Tetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling [Corrigendum]
Page: 1143
Published online: 13 Mar 2020
CitationforTetrandrine Suppresses Transient Receptor Potential Cation Channel Protein 6 Overexpression- Induced Podocyte Damage via Blockage of RhoA/ROCK1 Signaling [Corrigendum] | Full Text | PDF (708.1 KB) | EPUB
  • 70 Views
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Original Research

Article
Validation of the Key Active Ingredients and Anti-Inflammatory and Analgesic Effects of Shenjin Huoxue Mixture Against Osteoarthritis by Integrating Network Pharmacology Approach and Thin-Layer Chromatography Analysis
Mei-Xiang Yu, Xiao-Qin Ma, Xin Song, Yong-Mei Huang, Hui-Ting Jiang, Jing Wang & Wan-Hua Yang
Pages: 1145-1156
Published online: 16 Mar 2020
AbstractforValidation of the Key Active Ingredients and Anti-Inflammatory and Analgesic Effects of Shenjin Huoxue Mixture Against Osteoarthritis by Integrating Network Pharmacology Approach and Thin-Layer Chromatography Analysis | Full Text | References | PDF (7 MB) | EPUB
  • 185 Views
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Article
1,25(OH)2D3 Strengthens the Vasculogenesis of Multipotent Mesenchymal Stromal Cells from Rat Bone Marrow by Regulating the PI3K/AKT Pathway
Bozhi Ye, Yawen Weng, Shuang Lin, Jiahui Lin, Zhouqing Huang, Weijian Huang & Xueli Cai
Pages: 1157-1167
Published online: 16 Mar 2020
Abstractfor1,25(OH)2D3 Strengthens the Vasculogenesis of Multipotent Mesenchymal Stromal Cells from Rat Bone Marrow by Regulating the PI3K/AKT Pathway | Full Text | References | PDF (6.6 MB) | EPUB
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Article
Stability and Compatibility of Ramosetron with Midazolam in 0.9% Sodium Chloride Injection for Postoperative Nausea and Vomiting Administration
Jingsheng Xia & Peng Chen
Pages: 1169-1176
Published online: 17 Mar 2020
AbstractforStability and Compatibility of Ramosetron with Midazolam in 0.9% Sodium Chloride Injection for Postoperative Nausea and Vomiting Administration | Full Text | References | PDF (5.9 MB) | EPUB
  • 118 Views
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Article
A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia
Jason D Lickliter, Hui K Gan, Mark Voskoboynik, Surein Arulananda, Bo Gao, Adnan Nagrial, Peter Grimison, Michelle Harrison, Jianjun Zou, Lianshan Zhang, Stacey Luo, Michael Lahn, Howard Kallender, Andrea Mannucci, Catello Somma, Katherine Woods, Andreas Behren, Pablo Fernandez-Penas, Michael Millward & Tarek Meniawy
Pages: 1177-1189
Published online: 18 Mar 2020
AbstractforA First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia | Full Text | References | PDF (2.5 MB) | EPUB
  • 175 Views
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Article
Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition
Min Yu, Liyao Peng, Ping Liu, Mingxia Yang, Hong Zhou, Yirui Ding, Jingjing Wang, Wen Huang, Qi Tan, Yanli Wang, Weiping Xie, Hui Kong & Hong Wang
Pages: 1191-1202
Published online: 19 Mar 2020
AbstractforPaeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition | Full Text | References | PDF (8.1 MB) | EPUB
  • 113 Views
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Article
Effects of Cisatracurium, Rocuronium, and Mivacurium on Intraocular Pressure During Induction of General Anesthesia in Ophthalmic Surgery
Shuangshuang Li, Xiao Hu, Fang Tan & Wenxian Li
Pages: 1203-1208
Published online: 24 Mar 2020
AbstractforEffects of Cisatracurium, Rocuronium, and Mivacurium on Intraocular Pressure During Induction of General Anesthesia in Ophthalmic Surgery | Full Text | References | PDF (809.3 KB) | EPUB
  • 155 Views
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Article
Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells
Te-Fu Tsai, Po-Chun Chen, Yi-Chia Lin, Kuang-Yu Chou, Hung-En Chen, Chao-Yen Ho, Ji-Fan Lin & Thomas I-Sheng Hwang
Pages: 1209-1218
Published online: 24 Mar 2020
AbstractforMiconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells | Full Text | References | PDF (7.9 MB) | EPUB
  • 153 Views
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Article
Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects
Meng-Jie Yang, Hong-Rong Xu, Hui Li, Wei-Li Chen, Fei Yuan & Xue-Ning Li
Pages: 1219-1226
Published online: 24 Mar 2020
AbstractforComparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects | Full Text | References | PDF (314.5 KB) | EPUB
  • 151 Views
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Article
Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
Yewei Jia, Wei He, Hanxiao Zhang, Lei He, Yanben Wang, Tan Zhang, Jiaxuan Peng, Peng Sun & Yu Qian
Pages: 1227-1240
Published online: 26 Mar 2020
AbstractforMorusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway | Full Text | References | PDF (4.3 MB) | EPUB
  • 170 Views
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Review

Review Article
Growth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration
Wen-Bo Nie, Dan Zhang & Li-Sheng Wang
Pages: 1241-1256
Published online: 26 Mar 2020
AbstractforGrowth Factor Gene-Modified Mesenchymal Stem Cells in Tissue Regeneration | Full Text | References | PDF (1.7 MB) | EPUB
  • 242 Views
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Article
Safety and Feasibility of Low-Dose Apatinib Combined with S-1 as the Second-Line Therapy or Beyond in Chinese Patients with Pulmonary and Hepatic Metastasis of Nasopharyngeal Carcinoma
Liya Zhou, Jie Lin, Gang Wu, Jiawei Chen, Xiaopeng Huang & Shuai Zhang
Pages: 1257-1262
Published online: 30 Mar 2020
AbstractforSafety and Feasibility of Low-Dose Apatinib Combined with S-1 as the Second-Line Therapy or Beyond in Chinese Patients with Pulmonary and Hepatic Metastasis of Nasopharyngeal Carcinoma | Full Text | References | PDF (930.7 KB) | EPUB
  • 84 Views
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Article
Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases
Oscar Ekpenyong, Xiuqing Gao, Jing Ma, Candace Cooper, Linh Nguyen, Omonike A Olaleye, Dong Liang & Huan Xie
Pages: 1263-1277
Published online: 30 Mar 2020
AbstractforPre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases | Full Text | References | PDF (1.1 MB) | EPUB
  • 153 Views
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Article
Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways
Ting Wang, Shunjie Bai, Wei Wang, Zhi Chen, Jianjun Chen, Zihong Liang, Xunzhong Qi, Hailan Shen & Peng Xie
Pages: 1279-1294
Published online: 31 Mar 2020
AbstractforDiterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways | Full Text | References | PDF (10.1 MB) | EPUB
  • 111 Views
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Article
Alginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling
Ziqiang Xia, Li Ding, Juzeng Zheng, Yilun Xu, Wenyi Jin, Xiong Sheng & Jinming Wu
Pages: 1295-1305
Published online: 31 Mar 2020
AbstractforAlginate Suppresses Liver Fibrosis Through the Inhibition of Nuclear Factor-κB Signaling | Full Text | References | PDF (8 MB) | EPUB
  • 110 Views
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Article
Leishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture
Markos Tadele, Solomon M Abay, Eyasu Makonnen & Asrat Hailu
Pages: 1307-1317
Published online: 31 Mar 2020
AbstractforLeishmania donovani Growth Inhibitors from Pathogen Box Compounds of Medicine for Malaria Venture | Full Text | References | PDF (777.4 KB) | EPUB
  • 130 Views
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Article
Proniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits
Mahmoud Hasan Teaima, Mohamed Yasser, Mohamed Ahmed El-Nabarawi & Doaa Ahmed Helal
Pages: 1319-1331
Published online: 31 Mar 2020
AbstractforProniosomal Telmisartan Tablets: Formulation, in vitro Evaluation and in vivo Comparative Pharmacokinetic Study in Rabbits | Full Text | References | PDF (5.6 MB) | EPUB
  • 326 Views
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Article
The Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy After Acute Carbon Monoxide Poisoning
Jiefang Zhang, Yuewen Guo, Wenyao Li, Guangli Li & Yankun Chen
Pages: 1333-1339
Published online: 02 Apr 2020
AbstractforThe Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy After Acute Carbon Monoxide Poisoning | Full Text | References | PDF (356.5 KB) | EPUB
  • 154 Views
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Article
Long-Term Safety of a Novel Angiotensin Receptor Blocker, Fimasartan, According to the Absence or Presence of Underlying Liver Disease in Korean Hypertensive Patients: A Prospective, 12-Month, Observational Study
Gyu Chul Oh, Kwon Wook Joo, Myung-A Kim, Dong-Ju Choi, Yoon Jun Kim & Hae-Young Lee
Pages: 1341-1349
Published online: 03 Apr 2020
AbstractforLong-Term Safety of a Novel Angiotensin Receptor Blocker, Fimasartan, According to the Absence or Presence of Underlying Liver Disease in Korean Hypertensive Patients: A Prospective, 12-Month, Observational Study | Full Text | References | PDF (2.8 MB) | EPUB
  • 96 Views
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Article
Desflurane Preconditioning Protects Against Renal Ischemia–Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway
Yan Zheng, Hui Lu & Huiqiong Huang
Pages: 1351-1362
Published online: 03 Apr 2020
AbstractforDesflurane Preconditioning Protects Against Renal Ischemia–Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway | Full Text | References | PDF (6.5 MB) | EPUB
  • 118 Views
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Article
One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents
Abdelwahed R Sayed, Sobhi M Gomha, Eman A Taher, Zeinab A Muhammad, Hesham R El-Seedi, Hatem M Gaber & Mahgoub M Ahmed
Pages: 1363-1375
Published online: 03 Apr 2020
AbstractforOne-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents | Full Text | References | PDF (6 MB) | EPUB
  • 715 Views
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Article
MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway
Hua Fan, Damiao Li, Xinlei Guan, Yanhui Yang, Junqiang Yan, Jian Shi, Ranran Ma & Qing Shu
Pages: 1377-1389
Published online: 05 Apr 2020
AbstractforMsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway | Full Text | References | PDF (1.4 MB) | EPUB
  • 130 Views
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Review Article
Update on Eluxadoline for the Treatment of Irritable Bowel Syndrome with Diarrhea: Patient Selection and Perspectives
Rebecca Liu & Kyle Staller
Pages: 1391-1400
Published online: 09 Apr 2020
AbstractforUpdate on Eluxadoline for the Treatment of Irritable Bowel Syndrome with Diarrhea: Patient Selection and Perspectives | Full Text | References | PDF (1.5 MB) | EPUB
  • 189 Views
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Review Article
Metabolite Profiling in Anticancer Drug Development: A Systematic Review
Nadda Muhamad & Kesara Na-Bangchang
Pages: 1401-1444
Published online: 09 Apr 2020
AbstractforMetabolite Profiling in Anticancer Drug Development: A Systematic Review | Full Text | References | PDF (650 KB) | EPUB
  • 211 Views
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Article
Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats
Hui Gao, Lu Peng, Chao Li, Qinlong Ji & Ping Li
Pages: 1445-1454
Published online: 14 Apr 2020
AbstractforSalidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats | Full Text | References | PDF (7.3 MB) | EPUB
  • 129 Views
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Article
Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway
Yuan Liao, Rui-zhi Tan, Jian-chun Li, Tong-tong Liu, Xia Zhong, Ying Yan, Jie-ke Yang, Xiao Lin, Jun-ming Fan & Li Wang
Pages: 1455-1468
Published online: 14 Apr 2020
AbstractforIsoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway | Full Text | References | PDF (11.7 MB) | EPUB
  • 193 Views
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Article
The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling
Amira M Ghoneim & Suzan M Mansour
Pages: 1469-1479
Published online: 14 Apr 2020
AbstractforThe Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling | Full Text | References | PDF (647.2 KB) | EPUB
  • 270 Views
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Article
Formulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients”
Jiayi Zhu, Yanling Huang, Jiquan Zhang, Yi Feng & Lan Shen
Pages: 1481-1491
Published online: 16 Apr 2020
AbstractforFormulation, Preparation and Evaluation of Nanostructured Lipid Carrier Containing Naringin and Coix Seed Oil for Anti-Tumor Application Based on “Unification of Medicines and Excipients” | Full Text | References | PDF (1.4 MB) | EPUB
  • 247 Views
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Article
Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway
Linyuan Yu, Lihong Gong, Cheng Wang, Naihua Hu, Yunqiu Tang, Li Zheng, Xuyang Dai & Yunxia Li
Pages: 1493-1506
Published online: 15 Apr 2020
AbstractforRadix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway | Full Text | References | PDF (4.7 MB) | EPUB
  • 253 Views
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Article
Optimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso
Toussaint Rouamba, Paul Sondo, Karim Derra, Seydou Nakanabo-Diallo, Biebo Bihoun, Eli Rouamba, Zekiba Tarnagda, Adama Kazienga, Innocent Valea, Hermann Sorgho, Franco Pagnoni, Fati Samadoulougou-Kirakoya & Halidou Tinto
Pages: 1507-1521
Published online: 16 Apr 2020
AbstractforOptimal Approach and Strategies to Strengthen Pharmacovigilance in Sub-Saharan Africa: A Cohort Study of Patients Treated with First-Line Artemisinin-Based Combination Therapies in the Nanoro Health and Demographic Surveillance System, Burkina Faso | Full Text | References | PDF (2.3 MB) | EPUB
  • 145 Views
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Article
Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway
Qingbin Wu, Xiaochen Yuan, Bingwei Li, Ruiqin Han, Honggang Zhang & Ruijuan Xiu
Pages: 1523-1534
Published online: 16 Apr 2020
AbstractforSalvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway | Full Text | References | PDF (12.6 MB) | EPUB
  • 92 Views
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Article
Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells
Xiao-Xia Yu, Ke-Li Ge, Ning Liu, Jin-Yu Zhang, Mei-Lan Xue & Yin-Lin Ge
Pages: 1535-1545
Published online: 20 Apr 2020
AbstractforSelection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells | Full Text | References | PDF (6.5 MB) | EPUB
  • 119 Views
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Article
ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica
Shumin Li, Yaqian Li, Hong Xu, Zhongqiu Wei, Yi Yang, Fuyu Jin, Min Zhang, Chen Wang, Wenxiong Song, Jingchen Huo, Jingyuan Zhao, Xiuhong Yang & Fang Yang
Pages: 1547-1559
Published online: 21 Apr 2020
AbstractforACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica | Full Text | References | PDF (16.5 MB) | EPUB
  • 143 Views
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Article
Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1
Jianyun Ge, Yulin Huang, Yi Zhang, Lin Liu, Tianyu Gu, Xu Liu, Lei Yao, Mengmeng Cai, Jiafeng Sun & Jie Song
Pages: 1561-1569
Published online: 21 Apr 2020
AbstractforMetformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1 | Full Text | References | PDF (6.2 MB) | EPUB
  • 129 Views
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Article
Experimental Study on the Role of Apelin-13 in Alleviating Spinal Cord Ischemia Reperfusion Injury Through Suppressing Autophagy
Zhewei Xu & Zhiyue Li
Pages: 1571-1581
Published online: 22 Apr 2020
AbstractforExperimental Study on the Role of Apelin-13 in Alleviating Spinal Cord Ischemia Reperfusion Injury Through Suppressing Autophagy | Full Text | References | PDF (3 MB) | EPUB
  • 93 Views
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Article
Gallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex
Dong Wang & Burenbatu Bao
Pages: 1583-1592
Published online: 23 Apr 2020
AbstractforGallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex | Full Text | References | PDF (2.6 MB) | EPUB
  • 126 Views
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Article
In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds
Hamisi M Malebo, Sarah D’Alessandro, Yehenew A Ebstie, Harouna Sorè, Alain R Tenoh Guedoung, Shaaban J Katani, Silvia Parapini, Donatella Taramelli & Annette Habluetzel
Pages: 1593-1607
Published online: 28 Apr 2020
AbstractforIn vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds | Full Text | References | PDF (818.8 KB) | EPUB
  • 170 Views
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Article
Anisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation
Ping Li, Yu Liu & Qiang He
Pages: 1609-1620
Published online: 29 Apr 2020
AbstractforAnisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation | Full Text | References | PDF (9 MB) | EPUB
  • 114 Views
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Article
Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Improves Spinal Cord Function After Injury in Rats by Activating Autophagy
Jun Gu, Zheng Shuai Jin, Chun Ming Wang, Xue Fei Yan, Yuan Qing Mao & Sheng Chen
Pages: 1621-1631
Published online: 29 Apr 2020
AbstractforBone Marrow Mesenchymal Stem Cell-Derived Exosomes Improves Spinal Cord Function After Injury in Rats by Activating Autophagy | Full Text | References | PDF (8.1 MB) | EPUB
  • 222 Views
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Article
Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
ZhongHua Lei, Liu Ouyang, Yong Gong, ZhaoZhen Wang & Bo Yu
Pages: 1633-1639
Published online: 29 Apr 2020
AbstractforEffect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway | Full Text | References | PDF (2.8 MB) | EPUB
  • 119 Views
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Article
Arsenic Disulfide Promoted Hypomethylation by Increasing DNA Methyltransferases Expression in Myelodysplastic Syndrome
Qing-Bing Zhou, Zheng-Tang Liu, Hong-Zhi Wang, Xiao-Qing Guo, Yong-Gang Xu & Xiao-Mei Hu
Pages: 1641-1650
Published online: 30 Apr 2020
AbstractforArsenic Disulfide Promoted Hypomethylation by Increasing DNA Methyltransferases Expression in Myelodysplastic Syndrome | Full Text | References | PDF (2.3 MB) | EPUB
  • 94 Views
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Article
Astaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal
Ming Wang, Xiaolin Deng, Yangmei Xie & Yinghui Chen
Pages: 1651-1662
Published online: 30 Apr 2020
AbstractforAstaxanthin Attenuates Neuroinflammation in Status Epilepticus Rats by Regulating the ATP-P2X7R Signal | Full Text | References | PDF (3 MB) | EPUB
  • 147 Views
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Review Article
Pharmacokinetic-Based Drug–Drug Interactions with Anaplastic Lymphoma Kinase Inhibitors: A Review
Dehua Zhao, Jing Chen, Mingming Chu, Xiaoqing Long & Jisheng Wang
Pages: 1663-1681
Published online: 30 Apr 2020
AbstractforPharmacokinetic-Based Drug–Drug Interactions with Anaplastic Lymphoma Kinase Inhibitors: A Review | Full Text | References | PDF (458.1 KB) | EPUB
  • 364 Views
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Article
Laquinimod Protects Against TNF-α-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs) by Increasing the Expression of KLF2
Tiechao Jiang, Wenhao Zhang & Zhongyu Wang
Pages: 1683-1691
Published online: 30 Apr 2020
AbstractforLaquinimod Protects Against TNF-α-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs) by Increasing the Expression of KLF2 | Full Text | References | PDF (3.8 MB) | EPUB
  • 111 Views
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Review

Review Article
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development
Brooke Benner, Logan Good, Dionisia Quiroga, Thomas E Schultz, Mahmoud Kassem, William E Carson, Mathew A Cherian, Sagar Sardesai & Robert Wesolowski
Pages: 1693-1704
Published online: 04 May 2020
AbstractforPexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development | Full Text | References | PDF (1.3 MB) | EPUB
  • 496 Views
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Article
Chlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway
Lijuan Gao, Xiaoqiong Li, Shi Meng, Tengyun Ma, Lihong Wan & Shijun Xu
Pages: 1705-1716
Published online: 04 May 2020
AbstractforChlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway | Full Text | References | PDF (7.7 MB) | EPUB
  • 225 Views
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Article
High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma
Guo-feng Xie, Luo-dan Zhao, Qiang Chen, Dong-xiao Tang, Qiong-yu Chen, Hong-fei Lu, Jia-rong Cai & Zheng Chen
Pages: 1717-1727
Published online: 05 May 2020
AbstractforHigh ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma | Full Text | References | PDF (7.8 MB) | EPUB
  • 123 Views
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Article
Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers
Seok Kyu Yoon, Kyun-Seop Bae, Dong Hyun Hong, Seong Su Kim, Young Kweon Choi & Hyeong-Seok Lim
Pages: 1729-1737
Published online: 05 May 2020
AbstractforPharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers | Full Text | References | PDF (4.9 MB) | EPUB
  • 177 Views
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Article
Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo
Ying Wang, Qiu-geng Ou-yang, Wan-li Huang, Huan-le Huang, Xin-lei Zhuang, Qian-meng Lin & Da-li Zeng
Pages: 1739-1747
Published online: 06 May 2020
AbstractforInvestigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo | Full Text | References | PDF (3.7 MB) | EPUB
  • 121 Views
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Review

Review Article
The Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review
S R Mercuri, L Vollono & G Paolino
Pages: 1749-1755
Published online: 07 May 2020
AbstractforThe Usefulness of Platelet-Rich Plasma (PRP) for the Treatment of Vitiligo: State of the Art and Review | Full Text | References | PDF (471.4 KB) | EPUB
  • 474 Views
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Review Article
Dupilumab: Clinical Efficacy of Blocking IL-4/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps
Harsha H Kariyawasam, Louisa K James & Simon B Gane
Pages: 1757-1769
Published online: 08 May 2020
AbstractforDupilumab: Clinical Efficacy of Blocking IL-4/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps | Full Text | References | PDF (3.7 MB) | EPUB
  • 457 Views
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Original Research

Article
Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways
Shuang Feng, Hui Cong & Lei Ji
Pages: 1771-1778
Published online: 08 May 2020
AbstractforSalvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways | Full Text | References | PDF (1 MB) | EPUB
  • 145 Views
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Article
Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma
Ying-Qi Feng, Shuang-Xi Gu, Yong-Shou Chen, Xu-Dong Gao, Yi-Xin Ren, Jian-Chao Chen, Yin-Ying Lu, Heng Zhang & Shuang Cao
Pages: 1779-1798
Published online: 08 May 2020
AbstractforVirtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma | Full Text | References | PDF (9.3 MB) | EPUB
  • 146 Views
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Article
Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells
Inés Velázquez-Quesada, Angel J Ruiz-Moreno, Diana Casique-Aguirre, Charmina Aguirre-Alvarado, Fabiola Cortés-Mendoza, Marisol de la Fuente-Granada, Carlos García-Pérez, Sonia M Pérez-Tapia, Aliesha González-Arenas, Aldo Segura-Cabrera & Marco A Velasco-Velázquez
Pages: 1799-1811
Published online: 12 May 2020
AbstractforPranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells | Full Text | References | PDF (6.7 MB) | EPUB
  • 192 Views
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Article
Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling
Jian Liu, Peng Liu, Tiantian Xu, Zhiwei Chen, Huimin Kong, Weihong Chu, Yingchao Wang & Yufeng Liu
Pages: 1813-1823
Published online: 12 May 2020
AbstractforBerberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling | Full Text | References | PDF (8.2 MB) | EPUB
  • 167 Views
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Article
Cationic/Anionic Polyelectrolyte (PLL/PGA) Coated Vesicular Phospholipid Gels (VPGs) Loaded with Cytarabine for Sustained Release and Anti-glioma Effects
Na Qi, Yu Zhang, Xing Tang & Aimin Li
Pages: 1825-1836
Published online: 12 May 2020
AbstractforCationic/Anionic Polyelectrolyte (PLL/PGA) Coated Vesicular Phospholipid Gels (VPGs) Loaded with Cytarabine for Sustained Release and Anti-glioma Effects | Full Text | References | PDF (10.3 MB) | EPUB
  • 119 Views
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Article
Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS
Xiaofang Jiang, Lin Zhou, Lihua Zuo, Xiaohui Wang, Yingying Shi, Xiangyu Du, Jun Zhang, Liwei Liu, Zhuolun Li, Lianping Xue, Xin Liu & Zhi Sun
Pages: 1837-1850
Published online: 13 May 2020
AbstractforPharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS | Full Text | References | PDF (2.7 MB) | EPUB
  • 114 Views
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Open Access
Article
Applying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug
Usama Farghaly Aly, Hatem Abdel-monsef Sarhan, Taha F S Ali & Hosny Abd El-Bakey Sharkawy
Pages: 1851-1865
Published online: 14 May 2020
AbstractforApplying Different Techniques to Improve the Bioavailability of Candesartan Cilexetil Antihypertensive Drug | Full Text | References | PDF (7.5 MB) | EPUB
  • 394 Views
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Review

Review Article
Bacteriophages, a New Therapeutic Solution for Inhibiting Multidrug-Resistant Bacteria Causing Wound Infection: Lesson from Animal Models and Clinical Trials
Majid Taati Moghadam, Amin Khoshbayan, Zahra Chegini, Iman Farahani & Aref Shariati
Pages: 1867-1883
Published online: 15 May 2020
AbstractforBacteriophages, a New Therapeutic Solution for Inhibiting Multidrug-Resistant Bacteria Causing Wound Infection: Lesson from Animal Models and Clinical Trials | Full Text | References | PDF (1.4 MB) | EPUB
  • 1464 Views
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Original Research

Article
Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins
Min Lin, Chunyu Pan, Wenbin Xu, Jingwei Li & Xueqiong Zhu
Pages: 1885-1895
Published online: 15 May 2020
AbstractforLeonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins | Full Text | References | PDF (7.6 MB) | EPUB
  • 173 Views
  • 10 CrossRef citations
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Article
Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells
Li Cheng, Hao Wang, Zicheng Wang, Houbao Huang, Dong Zhuo & Jian Lin
Pages: 1897-1908
Published online: 18 May 2020
AbstractforLeflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells | Full Text | References | PDF (21 MB) | EPUB
  • 162 Views
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Open Access
Article
Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo
Yunfang Zhou, Ailian Hua, Quan Zhou, Peiwu Geng, Feifei Chen, Lianhe Yan, Shuanghu Wang & Congcong Wen
Pages: 1909-1919
Published online: 19 May 2020
AbstractforInhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo | Full Text | References | PDF (3.3 MB) | EPUB
  • 119 Views
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Open Access
Article
Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
Yanshuang Liu, Yingran Liang, Bin Zheng, Li Chu, Donglai Ma, Hongfang Wang, Xi Chu & Jianping Zhang
Pages: 1921-1931
Published online: 19 May 2020
AbstractforProtective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats | Full Text | References | PDF (4.1 MB) | EPUB
  • 182 Views
  • 20 CrossRef citations
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Article
Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity
Mozhdeh Roghani, Heibatullah Kalantari, Mohammad Javad Khodayar, Layasadat Khorsandi, Mojtaba Kalantar, Mehdi Goudarzi & Hadi Kalantar
Pages: 1933-1941
Published online: 20 May 2020
AbstractforAlleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity | Full Text | References | PDF (6.1 MB) | EPUB
  • 355 Views
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Open Access
Article
The NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages
Xiao-nan Zhao, Zhen-zi Bai, Cheng-hua Li, Chuan-lun Sheng & Hong-yan Li
Pages: 1943-1952
Published online: 20 May 2020
AbstractforThe NK-1R Antagonist Aprepitant Prevents LPS-Induced Oxidative Stress and Inflammation in RAW264.7 Macrophages | Full Text | References | PDF (4.7 MB) | EPUB
  • 176 Views
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Open Access
Article
Comparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets
Jun Gi Hwang, Kyung-Sang Yu & SeungHwan Lee
Pages: 1953-1961
Published online: 20 May 2020
AbstractforComparison of the Pharmacokinetics of Highly Variable Drugs in Healthy Subjects Using a Partial Replicated Crossover Study: A Fixed-Dose Combination of Fimasartan 120 mg and Atorvastatin 40 mg versus Separate Tablets | Full Text | References | PDF (565.6 KB) | EPUB
  • 186 Views
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Article
Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors
Yun-Ting Zhu, Zan Teng, Yi-Fan Zhang, Wei Li, Li-Xia Guo, Yun-Peng Liu, Xiu-Juan Qu, Quan-Ren Wang, Si-Yuan Mao, Xiao-Yan Chen & Da-Fang Zhong
Pages: 1963-1970
Published online: 20 May 2020
AbstractforEffects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors | Full Text | References | PDF (438 KB) | EPUB
  • 162 Views
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Open Access
Article
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling
Zhenming Gao, Jidong Sui, Rong Fan, Weikun Qu, Xuepeng Dong & Deguang Sun
Pages: 1971-1982
Published online: 21 May 2020
AbstractforEmodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling | Full Text | References | PDF (10.1 MB) | EPUB
  • 169 Views
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Article
Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats
Qin Yin, Yi-jin Wu, Shu Pan, Dan-dan Wang, Meng-qing Tao, Wei-ya Pei & Jian Zuo
Pages: 1983-1993
Published online: 22 May 2020
AbstractforActivation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats | Full Text | References | PDF (11.5 MB) | EPUB
  • 127 Views
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Article
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer
Manpreet Sambi, Vanessa Samuel, Bessi Qorri, Sabah Haq, Sergey V Burov, Elena Markvicheva, William Harless & Myron R Szewczuk
Pages: 1995-2019
Published online: 25 May 2020
AbstractforA Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer | Full Text | References | PDF (15.5 MB) | EPUB
  • 220 Views
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Article
Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway
Zhong-Jun Chen, Xu-Sheng Zhao, Tie-Ping Fan, Heng-Xu Qi & Di Li
Pages: 2021-2031
Published online: 25 May 2020
AbstractforGlycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway | Full Text | References | PDF (8.1 MB) | EPUB
  • 120 Views
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Open Access
Article
Improvement of Pain Relief of Fentanyl Citrate Drug Encapsulated in Nanostructured Lipid Carrier: Drug Formulation, Parameter Optimization, in vitro and in vivo Studies
Mohammad Amin Bahrami, Nafiseh Farhadian, Mohammad Karimi, Arash Forouzan & Kambiz Masoumi
Pages: 2033-2045
Published online: 25 May 2020
AbstractforImprovement of Pain Relief of Fentanyl Citrate Drug Encapsulated in Nanostructured Lipid Carrier: Drug Formulation, Parameter Optimization, in vitro and in vivo Studies | Full Text | References | PDF (9.5 MB) | EPUB
  • 168 Views
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Open Access
Article
Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells
Jinjing Wu, Yanli Yang, Yafen Gao, Zhaoqi Wang & Jun Ma
Pages: 2047-2060
Published online: 25 May 2020
AbstractforMelatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells | Full Text | References | PDF (7.8 MB) | EPUB
  • 177 Views
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Article
An LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study
Qiong Wang, Zhe Chen, Dingwen Chen & Xia-yan Ye
Pages: 2061-2067
Published online: 26 May 2020
AbstractforAn LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study | Full Text | References | PDF (3 MB) | EPUB
  • 123 Views
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Article
Synthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists
Yanli Wang, Yuan Yao, Jing Liu, Lili Wu, Tonghua Liu, Jian Cui & David Yue-Wei Lee
Pages: 2069-2078
Published online: 26 May 2020
AbstractforSynthesis and Biological Activity of Piperine Derivatives as Potential PPARγ Agonists | Full Text | References | PDF (4.5 MB) | EPUB
  • 201 Views
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Article
Resveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells
Xiaolei Xu, Xudan Liu, Yingchun Yang, Jianyi He, Mengqi Jiang, Yue Huang, Xiaotong Liu, Li Liu & Hailun Gu
Pages: 2079-2090
Published online: 26 May 2020
AbstractforResveratrol Exerts Anti-Osteoarthritic Effect by Inhibiting TLR4/NF-κB Signaling Pathway via the TLR4/Akt/FoxO1 Axis in IL-1β-Stimulated SW1353 Cells | Full Text | References | PDF (9.3 MB) | EPUB
  • 216 Views
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Article
Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis
Peng Gao, Shuo Shen, Xiaodong Li, Dandan Liu, Yuqing Meng, Yanqing Liu, Yongping Zhu, Junzhe Zhang, Piao Luo & Liwei Gu
Pages: 2091-2100
Published online: 27 May 2020
AbstractforDihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis | Full Text | References | PDF (7 MB) | EPUB
  • 144 Views
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Article
A Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers
Woo Youl Kang, Hae Won Lee, Mi-Ri Gwon, Seungil Cho, Wang-Seob Shim, Kyung-Tae Lee, Dong Heon Yang, Sook Jin Seong & Young-Ran Yoon
Pages: 2101-2111
Published online: 26 May 2020
AbstractforA Pharmacokinetic Drug Interaction Between Fimasartan and Linagliptin in Healthy Volunteers | Full Text | References | PDF (2.6 MB) | EPUB
  • 168 Views
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Article
Epigallocatechin-3-Gallate Protects H2O2-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation
Yixing Tian, Zhaohua Bao, Yiming Ji, Xin Mei & Huilin Yang
Pages: 2113-2122
Published online: 27 May 2020
AbstractforEpigallocatechin-3-Gallate Protects H2O2-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation | Full Text | References | PDF (5.2 MB) | EPUB
  • 266 Views
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Corrigendum

Correction
Effect of Lactoferrin Protein on Red Blood Cells and Macrophages: Mechanism of Parasite–Host Interaction [Corrigendum]
Pages: 2123-2124
Published online: 28 May 2020
CitationforEffect of Lactoferrin Protein on Red Blood Cells and Macrophages: Mechanism of Parasite–Host Interaction [Corrigendum] | Full Text | PDF (1.4 MB) | EPUB
  • 68 Views
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Correction
In situ Delivery of Thermosensitive Gel-Mediated 5-Fluorouracil Microemulsion for the Treatment of Colorectal Cancer [Corrigendum]
Pages: 2125-2126
Published online: 28 May 2020
CitationforIn situ Delivery of Thermosensitive Gel-Mediated 5-Fluorouracil Microemulsion for the Treatment of Colorectal Cancer [Corrigendum] | Full Text | PDF (1 MB) | EPUB
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Original Research

Article
A Comparison of Dexmedetomidine and Midazolam for the Prevention of Postoperative Nausea and Vomiting Caused by Hemabate in Cesarean Delivery: A Randomized Controlled Trial
Bailong Hu, Haiyan Zhou, Xiaohua Zou, Jing Shi, Xingyu Li & Li Tan
Pages: 2127-2133
Published online: 28 May 2020
AbstractforA Comparison of Dexmedetomidine and Midazolam for the Prevention of Postoperative Nausea and Vomiting Caused by Hemabate in Cesarean Delivery: A Randomized Controlled Trial | Full Text | References | PDF (1.4 MB) | EPUB
  • 136 Views
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Article
Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma
Wenli Mao, Heng Yin, Wenya Chen, Tingxiu Zhao, Shaofeng Wu, He Jin, Biaoyan Du, Yuhui Tan, Ren Zhang & Yanli He
Pages: 2135-2147
Published online: 28 May 2020
AbstractforNetwork Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma | Full Text | References | PDF (9.7 MB) | EPUB
  • 204 Views
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Article
Analysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age
Rossella Parini, Guillem Pintos-Morell, Julia B Hennermann, Ting-Rong Hsu, Nesrin Karabul, Vasiliki Kalampoki, Andrey Gurevich, Uma Ramaswami & On behalf of the FOS Study Group
Pages: 2149-2158
Published online: 03 Jun 2020
AbstractforAnalysis of Renal and Cardiac Outcomes in Male Participants in the Fabry Outcome Survey Starting Agalsidase Alfa Enzyme Replacement Therapy Before and After 18 Years of Age | Full Text | References | PDF (2 MB) | EPUB
  • 133 Views
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Review

Review Article
Characteristics of COVID-19 Clinical Trials in China Based on the Registration Data on ChiCTR and ClinicalTrials.gov
Jihan Huang, Yingchun He, Qianmin Su & Juan Yang
Pages: 2159-2164
Published online: 29 May 2020
AbstractforCharacteristics of COVID-19 Clinical Trials in China Based on the Registration Data on ChiCTR and ClinicalTrials.gov | Full Text | References | PDF (554.6 KB) | EPUB
  • 140 Views
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Open Access

Original Research

Article
Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives
Ashfaq Ahmad, Farhat Ullah, Abdul Sadiq, Muhammad Ayaz, Muhammad Saeed Jan, Muhammad Shahid, Abdul Wadood, Fawad Mahmood, Umer Rashid, Riaz Ullah, Muhammad Umar Khayam Sahibzada, Ali S Alqahtani & Hafiz Majid Mahmood
Pages: 2165-2178
Published online: 03 Jun 2020
AbstractforComparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives | Full Text | References | PDF (5.4 MB) | EPUB
  • 332 Views
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Article
Doublet vs Single-Agent Maintenance Therapy in the Treatment of Non-Small-Cell Lung Cancer: A Meta-Analysis
Jing Qi, Xiuzhi Guo & Aihua Li
Pages: 2179-2185
Published online: 03 Jun 2020
AbstractforDoublet vs Single-Agent Maintenance Therapy in the Treatment of Non-Small-Cell Lung Cancer: A Meta-Analysis | Full Text | References | PDF (964.6 KB) | EPUB
  • 72 Views
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Article
Development of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation
Guanyu Li, Tong Wang, Xiaoyi Zhang, Shurui Zhao, Yaonan Wang, Jianhui Wu, Shiqi Peng & Ming Zhao
Pages: 2187-2197
Published online: 03 Jun 2020
AbstractforDevelopment of 13-Cys-BBR as an Agent Having Dual Action of Anti-Thrombosis and Anti-Inflammation | Full Text | References | PDF (6.3 MB) | EPUB
  • 86 Views
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Article
Effects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats
Jiquan Shen, Bo Wang, Shuanghu Wang, Feifei Chen, Deru Meng, Hui Jiang, Yunfang Zhou, Peiwu Geng, Quan Zhou & Bin Liu
Pages: 2199-2206
Published online: 04 Jun 2020
AbstractforEffects of Voriconazole on the Pharmacokinetics of Vonoprazan in Rats | Full Text | References | PDF (2.1 MB) | EPUB
  • 284 Views
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Article
Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats
Danyan Li, Luqing Zhao, Yuxin Li, Xiuhong Kang & Shengsheng Zhang
Pages: 2207-2219
Published online: 09 Jun 2020
AbstractforGastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats | Full Text | References | PDF (11.6 MB) | EPUB
  • 120 Views
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Article
Treatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model
Xin Wang, Jin Deng, Chongxiang Xiong, Haishan Chen, Qin Zhou, Yue Xia, Xiaofei Shao & Hequn Zou
Pages: 2221-2233
Published online: 08 Jun 2020
AbstractforTreatment with a PPAR-γ Agonist Protects Against Hyperuricemic Nephropathy in a Rat Model | Full Text | References | PDF (11 MB) | EPUB
  • 143 Views
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Corrigendum

Correction
Activation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats [Corrigendum]
Pages: 2235-2236
Published online: 09 Jun 2020
CitationforActivation of Cholinergic Anti-Inflammatory Pathway in Peripheral Immune Cells Involved in Therapeutic Actions of α-Mangostin on Collagen-Induced Arthritis in Rats [Corrigendum] | Full Text | PDF (3.2 MB) | EPUB
  • 72 Views
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Original Research

Article
Parenteral Sustained Release Lipid Phase-Transition System of Ziprasidone: Fabrication and Evaluation for Schizophrenia Therapy
Urooj A Khan, Uzma Parveen, Nazeer Hasan, Mohammad Zubair Ahmed, Suma Saad, Farhan J Ahmad & Gaurav K Jain
Pages: 2237-2247
Published online: 09 Jun 2020
AbstractforParenteral Sustained Release Lipid Phase-Transition System of Ziprasidone: Fabrication and Evaluation for Schizophrenia Therapy | Full Text | References | PDF (3 MB) | EPUB
  • 227 Views
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Article
Combination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles
Ruifeng Wu, Zhiqiang Zhang, Baohua Wang, Ge Chen, Yaozhong Zhang, Haowen Deng, Zilong Tang, Junjie Mao & Lei Wang
Pages: 2249-2261
Published online: 09 Jun 2020
AbstractforCombination Chemotherapy of Lung Cancer – Co-Delivery of Docetaxel Prodrug and Cisplatin Using Aptamer-Decorated Lipid–Polymer Hybrid Nanoparticles | Full Text | References | PDF (8.4 MB) | EPUB
  • 411 Views
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Article
Combination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine
Yuan Hong, Shaomin Che, Beina Hui, Xiaoli Wang, Xiaozhi Zhang & Hailin Ma
Pages: 2263-2274
Published online: 09 Jun 2020
AbstractforCombination Therapy of Lung Cancer Using Layer-by-Layer Cisplatin Prodrug and Curcumin Co-Encapsulated Nanomedicine | Full Text | References | PDF (6.1 MB) | EPUB
  • 237 Views
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Review

Review Article
Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent
Jingjing Li, Chuanyong Guo & Jianye Wu
Pages: 2275-2285
Published online: 09 Jun 2020
AbstractforAstaxanthin in Liver Health and Disease: A Potential Therapeutic Agent | Full Text | References | PDF (1.9 MB) | EPUB
  • 719 Views
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Review Article
The Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults
Omer Khan & Nauman Chaudary
Pages: 2287-2294
Published online: 10 Jun 2020
AbstractforThe Use of Amikacin Liposome Inhalation Suspension (Arikayce) in the Treatment of Refractory Nontuberculous Mycobacterial Lung Disease in Adults | Full Text | References | PDF (388.4 KB) | EPUB
  • 500 Views
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Original Research

Article
Nimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis
Jun-Wei Li, Shao-Hua Ren, Jin-Rui Ren, Zi-Gang Zhen, Li-Rong Li, Xu-Dong Hao & Hong-Ming Ji
Pages: 2295-2306
Published online: 10 Jun 2020
AbstractforNimodipine Improves Cognitive Impairment After Subarachnoid Hemorrhage in Rats Through IncRNA NEAT1/miR-27a/MAPT Axis | Full Text | References | PDF (8.8 MB) | EPUB
  • 147 Views
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Article
Scalable in silico Simulation of Transdermal Drug Permeability: Application of BIOiSIM Platform
Neha Maharao, Victor Antontsev, Hypatia Hou, Jason Walsh & Jyotika Varshney
Pages: 2307-2317
Published online: 11 Jun 2020
AbstractforScalable in silico Simulation of Transdermal Drug Permeability: Application of BIOiSIM Platform | Full Text | References | PDF (3.2 MB) | EPUB
  • 271 Views
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Article
In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines
Hasaya Dokduang, Wassana Jamnongkarn, Bundit Promraksa, Manida Suksawat, Sureerat Padthaisong, Malinee Thanee, Jutarop Phetcharaburanin, Nisana Namwat, Sakkarn Sangkhamanon, Attapol Titapun, Narong Khuntikeo, Poramate Klanrit & Watcharin Loilome
Pages: 2319-2334
Published online: 11 Jun 2020
AbstractforIn vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines | Full Text | References | PDF (12 MB) | EPUB
  • 156 Views
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Article
Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study
Hanan M Hassan, Lamya H Al-Wahaibi, Mohammed A Elmorsy & Yasmen F Mahran
Pages: 2335-2353
Published online: 11 Jun 2020
AbstractforSuppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by Ganoderma lucidum: Theoretical and Experimental Study | Full Text | References | PDF (24.8 MB) | EPUB
  • 264 Views
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Article
A Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity
Yufan Jian, Meina Zhao, Jinyi Cao, Tingting Fan, Wei Bu, Yang Yang, Weiwei Li, Wei Zhang, Yi Qiao, Jingwen Wang & Aidong Wen
Pages: 2355-2370
Published online: 12 Jun 2020
AbstractforA Gastric Cancer Peptide GX1-Modified Nano-Lipid Carriers Encapsulating Paclitaxel: Design and Evaluation of Anti-Tumor Activity | Full Text | References | PDF (7.6 MB) | EPUB
  • 140 Views
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Article
Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes
Jiaxiang Gu, Hongsheng Lin, Yiyuan Zhang, Tao Xu, Tianliang Wang, Xiawei Xue, Wenzhong Zhang & Hongjun Liu
Pages: 2371-2379
Published online: 15 Jun 2020
AbstractforActivation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes | Full Text | References | PDF (4.1 MB) | EPUB
  • 90 Views
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Article
RETRACTED ARTICLE: Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo
Gao-Fei Ren, Li-Li Xiao, Xiao-Jun Ma, Yu-Shan Yan & Peng-Fei Jiao
Pages: 2381-2392
Published online: 17 Jun 2020
AbstractforRETRACTED ARTICLE: Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo | PDF (7.4 MB)
  • 45 Views
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Article
Sinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo
Hui Chen, Yao Wang, Fang-Zhou Jiao, Fan Yang, Xun Li & Lu-Wen Wang
Pages: 2393-2403
Published online: 17 Jun 2020
AbstractforSinomenine Attenuates Acetaminophen-Induced Acute Liver Injury by Decreasing Oxidative Stress and Inflammatory Response via Regulating TGF-β/Smad Pathway in vitro and in vivo | Full Text | References | PDF (8.5 MB) | EPUB
  • 187 Views
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Article
Sugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection
Saeed Moayedi, Abbas Yadegar, Saeed Balalaie, Mahdiyeh Yarmohammadi, Mohammad Reza Zali, Hidekazu Suzuki, Gert Fricker & Ismaeil Haririan
Pages: 2405-2412
Published online: 17 Jun 2020
AbstractforSugar Codes Conjugated Alginate: An Innovative Platform to Make a Strategic Breakthrough in Simultaneous Prophylaxis of GERD and Helicobacter pylori Infection | Full Text | References | PDF (2.6 MB) | EPUB
  • 148 Views
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Article
Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo
Hongzhang Wu, Xurui Cheng, Feiyan Huang, Gang Shao, Yueming Meng, Lingfei Wang, Tao Wang, Xiaoyuan Jia, Tianxin Yang, Xi Wang & Caiyun Fu
Pages: 2413-2422
Published online: 18 Jun 2020
AbstractforAprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo | Full Text | References | PDF (8.8 MB) | EPUB
  • 132 Views
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Review

Review Article
Evaluation of the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer
Huan Wang & Xiaoyun Mao
Pages: 2423-2433
Published online: 18 Jun 2020
AbstractforEvaluation of the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer | Full Text | References | PDF (318 KB) | EPUB
  • 1960 Views
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Original Research

Article
Artificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet
Asad Majeed Khan, Muhammad Hanif, Nadeem Irfan Bukhari, Rahat Shamim, Fatima Rasool, Sumaira Rasul & Sana Shafique
Pages: 2435-2448
Published online: 22 Jun 2020
AbstractforArtificial Neural Network (ANN) Approach to Predict an Optimized pH-Dependent Mesalamine Matrix Tablet | Full Text | References | PDF (5.8 MB) | EPUB
  • 275 Views
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Article
Berberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy
Xiao Ke, Yiteng Huang, Liang Li, Fuya Xin, Luhua Xu, Yuangui Zhang, Zhicong Zeng, Fengxia Lin & Yinzhi Song
Pages: 2449-2460
Published online: 23 Jun 2020
AbstractforBerberine Attenuates Arterial Plaque Formation in Atherosclerotic Rats with Damp-Heat Syndrome via Regulating Autophagy | Full Text | References | PDF (8.5 MB) | EPUB
  • 184 Views
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Article
Lycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway
Ran Wang, Xinxing Lu & Riyue Yu
Pages: 2461-2471
Published online: 24 Jun 2020
AbstractforLycopene Inhibits Epithelial–Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway | Full Text | References | PDF (8.6 MB) | EPUB
  • 228 Views
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Article
Are Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes
David A Brott, Michael J Goodman, Richard P Hermann, Isobel Anderson & Alexandre Kiazand
Pages: 2473-2486
Published online: 24 Jun 2020
AbstractforAre Laboratory Parameter (Biomarker) Values Similar to the Healthy Volunteer Reference Range in Individuals with Diabetes | Full Text | References | PDF (1.6 MB) | EPUB
  • 93 Views
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Review

Review Article
Remogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy
Viswanathan Mohan, Ambrish Mithal, Shashank R Joshi, S R Aravind & Subhankar Chowdhury
Pages: 2487-2501
Published online: 24 Jun 2020
AbstractforRemogliflozin Etabonate in the Treatment of Type 2 Diabetes: Design, Development, and Place in Therapy | Full Text | References | PDF (3.7 MB) | EPUB
  • 455 Views
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Review Article
Management of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab
Marla Guzman & Joyce S Hui-Yuen
Pages: 2503-2513
Published online: 25 Jun 2020
AbstractforManagement of Pediatric Systemic Lupus Erythematosus: Focus on Belimumab | Full Text | References | PDF (322.3 KB) | EPUB
  • 454 Views
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Corrigendum

Correction
Attenuation of Myocardial Fibrosis with Curcumin Is Mediated by Modulating Expression of Angiotensin II AT1/AT2 Receptors and ACE2 in Rats [Corrigendum]
Page: 2515
Published online: 26 Jun 2020
CitationforAttenuation of Myocardial Fibrosis with Curcumin Is Mediated by Modulating Expression of Angiotensin II AT1/AT2 Receptors and ACE2 in Rats [Corrigendum] | Full Text | PDF (542.9 KB) | EPUB
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Original Research

Article
Synthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent
Zhenli Min, Yue Zhu, Xing Hong, Zhijun Yu, Min Ye, Qiong Yuan & Xiamin Hu
Pages: 2517-2534
Published online: 29 Jun 2020
AbstractforSynthesis and Biological Evaluations of Monocarbonyl Curcumin Inspired Pyrazole Analogues as Potential Anti-Colon Cancer Agent | Full Text | References | PDF (9.4 MB) | EPUB
  • 169 Views
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Article
Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway
Qiongyao Zeng, Yuncheng Che, Yu Zhang, Mei Chen, Qiang Guo & Wenjing Zhang
Pages: 2535-2547
Published online: 01 Jul 2020
AbstractforThymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway | Full Text | References | PDF (8.8 MB) | EPUB
  • 434 Views
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Article
Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition
Jan Hansen, Jacob Johnsen, Jan Møller Nielsen, Charlotte Brandt Sørensen, Casper Carlsen Elkjær, Nichlas Riise Jespersen & Hans Erik Bøtker
Pages: 2549-2560
Published online: 02 Jul 2020
AbstractforImpact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition | Full Text | References | PDF (1.1 MB) | EPUB
  • 75 Views
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Article
Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats
Kok-Yong Chin, Benjamin Ka Seng Thong, Rhivaldy Faahim Kamalulloh, Nur Vaizura Mohamad, Sok Kuan Wong, Azlan Mohd Arlamsyah, Rahma Triliana & Ima Nirwana Soelaiman
Pages: 2561-2572
Published online: 02 Jul 2020
AbstractforEffects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats | Full Text | References | PDF (7 MB) | EPUB
  • 220 Views
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Article
Melatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats
Feng Liang, Jianli Wang, Xiangyu Zhu, Zhen Wang, Jingwei Zheng, Zeyu Sun, Shenbin Xu, Jianmin Zhang, Jingyi Zhou & Ligen Shi
Pages: 2573-2584
Published online: 02 Jul 2020
AbstractforMelatonin Alleviates Neuronal Damage After Intracerebral Hemorrhage in Hyperglycemic Rats | Full Text | References | PDF (8.6 MB) | EPUB
  • 84 Views
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Article
Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor
Zaibing Li, Jingyu Li, Liyan Liu, Wenyi Deng, Qingrong Liu, Ruofan Liu, Wen Zhang, Zaiqing He, Lei Fan, Yingzhuo Yang, Yun Duan, Huifang Hou, Xinyuan Wang, Zhimei Yang, Xiaoying Wang, Shanze Chen, Yi Wang, Ning Huang & Junli Chen
Pages: 2585-2594
Published online: 03 Jul 2020
AbstractforStructural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor | Full Text | References | PDF (4.8 MB) | EPUB
  • 83 Views
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Article
Effects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS
Wei Zhou, Shuang-long Li, Ti Zhao, Le Li, Wen-bin Xing, Xiang-jun Qiu & Wei Zhang
Pages: 2595-2605
Published online: 03 Jul 2020
AbstractforEffects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS | Full Text | References | PDF (4.4 MB) | EPUB
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Hypothesis

Discussion
Plasmapheresis, Anti-ACE2 and Anti-FcγRII Monoclonal Antibodies: A Possible Treatment for Severe Cases of COVID-19
Amin Sedokani & Sadegh Feizollahzadeh
Pages: 2607-2611
Published online: 06 Jul 2020
AbstractforPlasmapheresis, Anti-ACE2 and Anti-FcγRII Monoclonal Antibodies: A Possible Treatment for Severe Cases of COVID-19 | Full Text | References | PDF (2.1 MB) | EPUB
  • 128 Views
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Original Research

Article
The Expression and Therapeutic Potential of Checkpoint Kinase 2 in Laryngeal Squamous Cell Carcinoma
Ying Tian, Yan Wang, Shan Xu, Chao Guan, Qingfu Zhang & Wei Li
Pages: 2613-2622
Published online: 06 Jul 2020
AbstractforThe Expression and Therapeutic Potential of Checkpoint Kinase 2 in Laryngeal Squamous Cell Carcinoma | Full Text | References | PDF (3.6 MB) | EPUB
  • 101 Views
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Review

Review Article
Volanesorsen in the Treatment of Familial Chylomicronemia Syndrome or Hypertriglyceridaemia: Design, Development and Place in Therapy
Oluwayemisi Esan & Anthony S Wierzbicki
Pages: 2623-2636
Published online: 06 Jul 2020
AbstractforVolanesorsen in the Treatment of Familial Chylomicronemia Syndrome or Hypertriglyceridaemia: Design, Development and Place in Therapy | Full Text | References | PDF (1 MB) | EPUB
  • 258 Views
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Clinical Trial Report

Case Report
Evaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects
Gehang Ju, Keyu Yan, Youwei Xu, Shilin Chen, Zhonghui Zheng & Wen Qiu
Pages: 2637-2644
Published online: 06 Jul 2020
AbstractforEvaluation of Bioequivalency and Pharmacokinetic Parameters for Two Formulations of Glimepiride 1-mg in Chinese Subjects | Full Text | References | PDF (1.3 MB) | EPUB
  • 237 Views
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Original Research

Article
Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis
Zhi Li, Jiangqi Cheng & Jiuxiang Liu
Pages: 2645-2655
Published online: 07 Jul 2020
AbstractforBaicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis | Full Text | References | PDF (14.2 MB) | EPUB
  • 147 Views
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Article
N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis
Huining Wang, Wenwen Yu, Hongyan Li, Yi Zheng, Zhen Chen, Hongbing Lin & Yuqin Shen
Pages: 2657-2665
Published online: 07 Jul 2020
AbstractforN-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis | Full Text | References | PDF (5.3 MB) | EPUB
  • 123 Views
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Article
Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway
Xing Zhou, Xingchun Wu, Luhui Qin, Shunyu Lu, Hongliang Zhang, Jinbin Wei, Lixiu Chen, Luhui Jiang, Yani Wu, Chunxia Chen & Renbin Huang
Pages: 2667-2684
Published online: 07 Jul 2020
AbstractforAnti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway | Full Text | References | PDF (15.4 MB) | EPUB
  • 125 Views
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Article
Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure
Xia Yuan, Hongjun Liu, Yufeng Li, Wen Li, Huiqian Yu & Xia Shen
Pages: 2685-2693
Published online: 08 Jul 2020
AbstractforRibbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure | Full Text | References | PDF (5.4 MB) | EPUB
  • 84 Views
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Article
Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression
Jincheng Zhang, Yingqi Zhang, Lei Chen, Zhitao Rao & Yeqing Sun
Pages: 2695-2705
Published online: 09 Jul 2020
AbstractforUlinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression | Full Text | References | PDF (4.4 MB) | EPUB
  • 110 Views
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Article
Clostridium histolyticum (AA4500) for the Treatment of Adhesive Capsulitis of the Shoulder: A Randomised Double-Blind, Placebo-Controlled Study for the Safety and Efficacy of Collagenase – Single Site Report
Jane Fitzpatrick, Christen Richardson, Ianiv Klaber & Martin D Richardson
Pages: 2707-2713
Published online: 10 Jul 2020
AbstractforClostridium histolyticum (AA4500) for the Treatment of Adhesive Capsulitis of the Shoulder: A Randomised Double-Blind, Placebo-Controlled Study for the Safety and Efficacy of Collagenase – Single Site Report | Full Text | References | PDF (552.6 KB) | EPUB
  • 132 Views
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Article
The Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage
Ting Ye, Hua-Wu Gao, Wei-Ting Xuan, Shu Ye, Peng Zhou, Xin-Quan Li, Yan Wang, Hang Song, Yan-Yan Liu & Biao Cai
Pages: 2715-2723
Published online: 13 Jul 2020
AbstractforThe Regulating Mechanism of Chrysophanol on Protein Level of CaM-CaMKIV to Protect PC12 Cells Against Aβ25-35-Induced Damage | Full Text | References | PDF (4 MB) | EPUB
  • 72 Views
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Article
Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer
Siqi Huang, Zheyu Zhang, Wenqun Li, Fanhua Kong, Pengji Yi, Jianhua Huang, Dan Mao, Weijun Peng & Sifang Zhang
Pages: 2725-2740
Published online: 14 Jul 2020
AbstractforNetwork Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer | Full Text | References | PDF (19.1 MB) | EPUB
  • 515 Views
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Article
Promising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers
Mahmoud Teaima, Magdi M. Abdel Hamid, Nabil A. Shoman, Bhaskara R. Jasti & Mohamed A. El-Nabarawi
Pages: 2741-2757
Published online: 14 Jul 2020
AbstractforPromising Swellable Floating Bupropion Tablets: Formulation, in vitro/in vivo Evaluation and Comparative Pharmacokinetic Study in Human Volunteers | Full Text | References | PDF (8.5 MB) | EPUB
  • 270 Views
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Review

Review Article
Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy
Miao Miao, Xixi Jing, Erik De Clercq & Guangdi Li
Pages: 2759-2774
Published online: 14 Jul 2020
AbstractforDanoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy | Full Text | References | PDF (5.5 MB) | EPUB
  • 183 Views
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Original Research

Article
Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling
Jing Wang, Guangxiao Ni, Yanming Liu, Ying Han, Lin Jia & Yali Wang
Pages: 2775-2787
Published online: 15 Jul 2020
AbstractforTanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling | Full Text | References | PDF (9.5 MB) | EPUB
  • 122 Views
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Article
Does an Earlier or Late Intravenous Injection of Ondansetron Affect the Dose of Phenylephrine Needed to Prevent Spinal-Anesthesia Induced Hypotension in Cesarean Sections?
Jing Qian, Lin Liu, Xiufeng Zheng & Fei Xiao
Pages: 2789-2795
Published online: 16 Jul 2020
AbstractforDoes an Earlier or Late Intravenous Injection of Ondansetron Affect the Dose of Phenylephrine Needed to Prevent Spinal-Anesthesia Induced Hypotension in Cesarean Sections? | Full Text | References | PDF (344.6 KB) | EPUB
  • 162 Views
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Article
A Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection
Neda Moazzezy, Mohammad Reza Asadi Karam, Sima Rafati, Saeid Bouzari & Mana Oloomi
Pages: 2797-2807
Published online: 17 Jul 2020
AbstractforA Synthetic Peptide 2Abz23S29 Reduces Bacterial Titer and Induces Pro-Inflammatory Cytokines in a Murine Model of Urinary Tract Infection | Full Text | References | PDF (2 MB) | EPUB
  • 101 Views
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Article
RETRACTED ARTICLE: Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy
Xiao-Mei Tao, Peng-Fei Liu, Hong-Yan Gu, Dong-Bo Lian, Lei Gao, Wei-Wei Tao, Dan Yan & Bin Zhao
Pages: 2809-2817
Published online: 17 Jul 2020
AbstractforRETRACTED ARTICLE: Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy | PDF (6.9 MB)
  • 36 Views
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Article
Lentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes
Zhaozhen Zhang, Zhuqing Zha, Zhiwei Zhao, Wenjing Liu & Wuyin Li
Pages: 2819-2829
Published online: 17 Jul 2020
AbstractforLentinan Inhibits AGE-Induced Inflammation and the Expression of Matrix-Degrading Enzymes in Human Chondrocytes | Full Text | References | PDF (4.8 MB) | EPUB
  • 129 Views
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Review

Review Article
A critical review of the United States regulatory pathways for determining the equivalence of efficacy between CT-P13 and original infliximab (Remicade®)
Soohyun Kim, Siun Kim & Howard Lee
Pages: 2831-2840
Published online: 17 Jul 2020
AbstractforA critical review of the United States regulatory pathways for determining the equivalence of efficacy between CT-P13 and original infliximab (Remicade®) | Full Text | References | PDF (2.1 MB) | EPUB
  • 75 Views
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Original Research

Article
The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation
Tavga Ahmed Aziz, Ahmed Azad Kareem, Hemn Hassan Othman & Zheen Aorahman Ahmed
Pages: 2841-2851
Published online: 20 Jul 2020
AbstractforThe Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation | Full Text | References | PDF (4.9 MB) | EPUB
  • 199 Views
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Article
Tanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis
Hong Xu, Haiqing Li, Pengxiong Zhu, Yun Liu, Mi Zhou & Anqing Chen
Pages: 2853-2863
Published online: 20 Jul 2020
AbstractforTanshinone IIA Ameliorates Progression of CAD Through Regulating Cardiac H9c2 Cells Proliferation and Apoptosis by miR-133a-3p/EGFR Axis | Full Text | References | PDF (8.1 MB) | EPUB
  • 85 Views
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Article
Neuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation
Min Han, Ying Cao, Hao Xue, Xili Chu, Tingting Li, Danqing Xin, Lin Yuan, Hongfei Ke, Gang Li & Zhen Wang
Pages: 2865-2876
Published online: 20 Jul 2020
AbstractforNeuroprotective Effect of Mesenchymal Stromal Cell-Derived Extracellular Vesicles Against Cerebral Ischemia-Reperfusion-Induced Neural Functional Injury: A Pivotal Role for AMPK and JAK2/STAT3/NF-κB Signaling Pathway Modulation | Full Text | References | PDF (5.8 MB) | EPUB
  • 196 Views
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Methodology

Article
Pharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS
Hao-Zhen Zheng, Xiao Shen, Ying-Ying He, Xiang-Li Yan, Sheng-Xin Wang, Ai-Ming Yu & Li-Sheng Wang
Pages: 2877-2888
Published online: 21 Jul 2020
AbstractforPharmacokinetic Analysis of Huangqi Guizhi Wuwu Decoction on Blood and Brain Tissue in Rats with Normal and Cerebral Ischemia-Reperfusion Injury by Microdialysis with HPLC-MS/MS | Full Text | References | PDF (5.8 MB) | EPUB
  • 122 Views
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Clinical Trial Report

Case Report
The Safety and Efficacy of Ultrasound-Guided Bilateral Dual Transversus Abdominis Plane (BD-TAP) Block in ERAS Program of Laparoscopic Hepatectomy: A Prospective, Randomized, Controlled, Blinded, Clinical Study
Jun Zhang, Tieshuai Liu, Haiyan Zhou, Yue Fei & Xin Yu
Pages: 2889-2898
Published online: 21 Jul 2020
AbstractforThe Safety and Efficacy of Ultrasound-Guided Bilateral Dual Transversus Abdominis Plane (BD-TAP) Block in ERAS Program of Laparoscopic Hepatectomy: A Prospective, Randomized, Controlled, Blinded, Clinical Study | Full Text | References | PDF (2.3 MB) | EPUB
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Original Research

Article
Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes
Feng Gao & Shanyong Zhang
Pages: 2899-2908
Published online: 21 Jul 2020
AbstractforLoratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes | Full Text | References | PDF (5.4 MB) | EPUB
  • 187 Views
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Review

Review Article
Film-Forming Sprays for Topical Drug Delivery
Abd Kakhar Umar, Maria Butarbutar, Sriwidodo Sriwidodo & Nasrul Wathoni
Pages: 2909-2925
Published online: 22 Jul 2020
AbstractforFilm-Forming Sprays for Topical Drug Delivery | Full Text | References | PDF (2.5 MB) | EPUB
  • 2665 Views
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Original Research

Article
Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p
Qi He, Bo Zhang, Feng Hu, Jianwen Long, Quan Shi, Xianming Pi, Hongxiang Chen & Jiawen Li
Pages: 2927-2935
Published online: 22 Jul 2020
AbstractforTriptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p | Full Text | References | PDF (4 MB) | EPUB
  • 133 Views
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Article
The Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma
Seyfi Kartal, Gülay Kip, Ayşegül Küçük, Seyhan Sümeyra Aşçı, Özlem Erdem, Mustafa Arslan & Mustafa Kavutçu
Pages: 2937-2943
Published online: 23 Jul 2020
AbstractforThe Effects of Dexmedetomidine and Ketamine on Oxidative Injuries and Histological Changes Following Blunt Chest Trauma | Full Text | References | PDF (971.5 KB) | EPUB
  • 105 Views
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Article
Enhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer
Yang Chen, Li Wang, Shi Luo, Jun Hu, Xing Huang, Pei-Wen Li, Yi Zhang, Chao Wu & Bo-Le Tian
Pages: 2945-2957
Published online: 23 Jul 2020
AbstractforEnhancement of Antitumor Efficacy of Paclitaxel-Loaded PEGylated Liposomes by N,N-Dimethyl Tertiary Amino Moiety in Pancreatic Cancer | Full Text | References | PDF (6.5 MB) | EPUB
  • 115 Views
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Article
Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability
Pei Liu, Jian-yu Zhou, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Chun-shi Li, Jian Wang & Cui-zhe Liu
Pages: 2959-2975
Published online: 27 Jul 2020
AbstractforSoluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability | Full Text | References | PDF (24.8 MB) | EPUB
  • 386 Views
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Article
Potential Allylpyrocatechol Derivatives as Antibacterial Agent Against Oral Pathogen of S. sanguinis ATCC 10,556 and as Inhibitor of MurA Enzymes: in vitro and in silico Study
Dikdik Kurnia, Geofanny Sarah Hutabarat, Devi Windaryanti, Tati Herlina, Yetty Herdiyati & Mieke Hemiawati Satari
Pages: 2977-2985
Published online: 27 Jul 2020
AbstractforPotential Allylpyrocatechol Derivatives as Antibacterial Agent Against Oral Pathogen of S. sanguinis ATCC 10,556 and as Inhibitor of MurA Enzymes: in vitro and in silico Study | Full Text | References | PDF (14.8 MB) | EPUB
  • 232 Views
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Article
Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis
Chia-Yih Wang, Shih-Wei Tsai, Han-Hsiang Chien, Ting-Yu Chen, Shi-Yuan Sheu, Edmund Cheung So & Bu-Miin Huang
Pages: 2987-3000
Published online: 27 Jul 2020
AbstractforCordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis | Full Text | References | PDF (11.1 MB) | EPUB
  • 145 Views
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Review

Review Article
Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients
Lu Li, Xiaojuan Wang, Rongrong Wang, Yunzhen Hu, Saiping Jiang & Xiaoyang Lu
Pages: 3001-3013
Published online: 28 Jul 2020
AbstractforAntiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients | Full Text | References | PDF (541.2 KB) | EPUB
  • 167 Views
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Original Research

Article
Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats
Taiyang Liao, Liang Ding, Peng Wu, Li Zhang, Xiaochen Li, Bo Xu, Haosheng Zhang, Zhenyuan Ma, Yancheng Xiao & Peimin Wang
Pages: 3015-3027
Published online: 28 Jul 2020
AbstractforChrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats | Full Text | References | PDF (31.3 MB) | EPUB
  • 293 Views
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Article
Botulinum Toxin Type A Possibly Affects Cav3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity
Kening Ma, Dan Zhu, Chunguo Zhang & Lijie Lv
Pages: 3029-3041
Published online: 28 Jul 2020
AbstractforBotulinum Toxin Type A Possibly Affects Cav3.2 Calcium Channel Subunit in Rats with Spinal Cord Injury-Induced Muscle Spasticity | Full Text | References | PDF (7.8 MB) | EPUB
  • 150 Views
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Expert Opinion

Article Commentary
The Climate is Changing for Metered-Dose Inhalers and Action is Needed
John N Pritchard
Pages: 3043-3055
Published online: 29 Jul 2020
AbstractforThe Climate is Changing for Metered-Dose Inhalers and Action is Needed | Full Text | References | PDF (3.4 MB) | EPUB
  • 789 Views
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Original Research

Article
Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers
He Bao, Nanbo Zheng, Zhuanting Li & Yuan Zhi
Pages: 3057-3068
Published online: 29 Jul 2020
AbstractforSynergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers | Full Text | References | PDF (4.7 MB) | EPUB
  • 268 Views
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Article
In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether
Kan Chen, Yuqi Fan, Jun Gu, Zhihua Han, Huasu Zeng, Chengyu Mao & Changqian Wang
Pages: 3069-3078
Published online: 30 Jul 2020
AbstractforIn vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether | Full Text | References | PDF (3.1 MB) | EPUB
  • 151 Views
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Article
Antibacterial of Dibenzo-p-Dioxi-2,8-Dicarboxylic Acid Against Pathogenic Oral Bacteria E. faecalis ATCC 29212 Peptide Pheromones: Quorum Sensing of in vitro and in silico Study
Dikdik Kurnia, Putri Rachmawati & Mieke H Satari
Pages: 3079-3086
Published online: 30 Jul 2020
AbstractforAntibacterial of Dibenzo-p-Dioxi-2,8-Dicarboxylic Acid Against Pathogenic Oral Bacteria E. faecalis ATCC 29212 Peptide Pheromones: Quorum Sensing of in vitro and in silico Study | Full Text | References | PDF (4.2 MB) | EPUB
  • 153 Views
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Article
Nano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines
Vida Mirzaie, Mehdi Ansari, Seyed Noureddin Nematollahi-Mahani, Mahshid Moballegh Nasery, Behzad Karimi, Touba Eslaminejad & Yaghoub Pourshojaei
Pages: 3087-3097
Published online: 30 Jul 2020
AbstractforNano-Graphene Oxide-supported APTES-Spermine, as Gene Delivery System, for Transfection of pEGFP-p53 into Breast Cancer Cell Lines | Full Text | References | PDF (7.5 MB) | EPUB
  • 227 Views
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Article
The PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells
Zhenyu Wang, Wenhao Shen, Xugang Li, Yang Feng, Kun Qian, Gaoren Wang, Yiying Gao, Xiaohui Xu, Shuyu Zhang, Ling Yue & Jianping Cao
Pages: 3099-3110
Published online: 31 Jul 2020
AbstractforThe PPARγ Agonist Rosiglitazone Enhances the Radiosensitivity of Human Pancreatic Cancer Cells | Full Text | References | PDF (47.1 MB) | EPUB
  • 118 Views
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Article
Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity
Ahmed A E Mourad, Mai A E Mourad & Peter G Jones
Pages: 3111-3130
Published online: 03 Aug 2020
AbstractforNovel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity | Full Text | References | PDF (12.3 MB) | EPUB
  • 257 Views
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Clinical Trial Report

Case Report
Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
You Zhai, Lihua Wu, Yunliang Zheng, Minglan Wu, Yujie Huang, Qian Huang, Jianzhong Shentu, Qingwei Zhao & Jian Liu
Pages: 3131-3142
Published online: 04 Aug 2020
AbstractforBioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions | Full Text | References | PDF (1.7 MB) | EPUB
  • 203 Views
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Original Research

Article
Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization
Shurong Duan, Fei Wang, Jingwei Cao & Chunyan Wang
Pages: 3143-3158
Published online: 05 Aug 2020
AbstractforExosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization | Full Text | References | PDF (70.9 MB) | EPUB
  • 201 Views
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Article
Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin
Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Hayder Shabeeb Abd Ali & Masoud Najafi
Pages: 3159-3163
Published online: 05 Aug 2020
AbstractforCurcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin | Full Text | References | PDF (3.3 MB) | EPUB
  • 195 Views
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Article
The Protective Effects of Juglanin in Cerebral Ischemia Reduce Blood–Brain Barrier Permeability via Inhibition of VEGF/VEGFR2 Signaling
Jia Liu, Lei Chen, Xin Zhang, Lixiao Pan & Lili Jiang
Pages: 3165-3175
Published online: 05 Aug 2020
AbstractforThe Protective Effects of Juglanin in Cerebral Ischemia Reduce Blood–Brain Barrier Permeability via Inhibition of VEGF/VEGFR2 Signaling | Full Text | References | PDF (24.1 MB) | EPUB
  • 178 Views
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Article
Melatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury
Bo Yang, Li-E Zang, Jing-Wen Cui, Ming-Yuan Zhang, Xue Ma & Lin-Lin Wei
Pages: 3177-3188
Published online: 06 Aug 2020
AbstractforMelatonin Plays a Protective Role by Regulating miR-26a-5p-NRSF and JAK2-STAT3 Pathway to Improve Autophagy, Inflammation and Oxidative Stress of Cerebral Ischemia-Reperfusion Injury | Full Text | References | PDF (8.4 MB) | EPUB
  • 123 Views
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Clinical Trial Report

Case Report
First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP‐ribose) Polymerase‐1 Inhibitor, JPI-289, in Healthy Volunteers
Sungpil Han, Yo Han Kim, Hee Youn Choi, Dong-Jun Soh, Jeongmin Kim, Joonwoo Nam, Jong-Woo Kim, Kyun-Seop Bae & Hyeong-Seok Lim
Pages: 3189-3199
Published online: 05 Aug 2020
AbstractforFirst-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of a Neuroprotective Poly (ADP‐ribose) Polymerase‐1 Inhibitor, JPI-289, in Healthy Volunteers | Full Text | References | PDF (538.3 KB) | EPUB
  • 130 Views
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Original Research

Article
Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody
Lei Huang, Kun Xie, Hongwen Li, Ruiqin Wang, Xiaoqing Xu, Kaiming Chen, Hua Gu & Jianmin Fang
Pages: 3201-3214
Published online: 07 Aug 2020
AbstractforSuppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody | Full Text | References | PDF (43.7 MB) | EPUB
  • 181 Views
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Review

Review Article
A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19
Seyed MohammadReza Hashemian, Tayebeh Farhadi & Ali Akbar Velayati
Pages: 3215-3222
Published online: 06 Aug 2020
AbstractforA Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19 | Full Text | References | PDF (5.1 MB) | EPUB
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Original Research

Article
Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway
Jiarui Han, Xinxin Pang, Yage Zhang, Zining Peng, Xiujie Shi & Yufeng Xing
Pages: 3223-3234
Published online: 07 Aug 2020
AbstractforHirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway | Full Text | References | PDF (56.6 MB) | EPUB
  • 228 Views
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Review

Review Article
Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases
Xolani H Makhoba, Claudio Viegas Jr, Rebamang A Mosa, Flávia P D Viegas & Ofentse J Pooe
Pages: 3235-3249
Published online: 11 Aug 2020
AbstractforPotential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases | Full Text | References | PDF (3.4 MB) | EPUB
  • 1165 Views
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Original Research

Article
Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil
Marion Ortner, Marion Stange, Heike Schneider, Charlotte Schröder, Katharina Buerger, Claudia Müller, Felix Müller-Sarnowski, Janine Diehl-Schmid, Hans Förstl, Timo Grimmer & Werner Steimer
Pages: 3251-3262
Published online: 11 Aug 2020
AbstractforTherapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil | Full Text | References | PDF (630.7 KB) | EPUB
  • 178 Views
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Clinical Trial Report

Case Report
Effect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial
Dongyue Wang, Min Wang, Hui Zhang, He Zhu, Na Zhang & Jindong Liu
Pages: 3263-3270
Published online: 11 Aug 2020
AbstractforEffect of Intravenous Injection of Vitamin C on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Double-Blind, Randomized Trial | Full Text | References | PDF (2.7 MB) | EPUB
  • 198 Views
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Review

Review Article
Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages
Parisa Ghasemiyeh & Soliman Mohammadi-Samani
Pages: 3271-3289
Published online: 12 Aug 2020
AbstractforPotential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages | Full Text | References | PDF (2.8 MB) | EPUB
  • 2204 Views
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Original Research

Article
Atorvastatin Combined with Low-Dose Dexamethasone Treatment Protects Endothelial Function Impaired by Chronic Subdural Hematoma via the Transcription Factor KLF-2
Yueshan Fan, Dong Wang, Chenxu Rao, Ying Li, Hongtao Rong, Zengguang Wang & Jianning Zhang
Pages: 3291-3299
Published online: 12 Aug 2020
AbstractforAtorvastatin Combined with Low-Dose Dexamethasone Treatment Protects Endothelial Function Impaired by Chronic Subdural Hematoma via the Transcription Factor KLF-2 | Full Text | References | PDF (3.3 MB) | EPUB
  • 113 Views
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Article
Dual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer
Yihan Sun, Guofeng Li, Qi Zhou, Danyue Shao, Jingwei Lv & Jianhua Zhou
Pages: 3301-3313
Published online: 12 Aug 2020
AbstractforDual Targeting of Cell Growth and Phagocytosis by Erianin for Human Colorectal Cancer | Full Text | References | PDF (8 MB) | EPUB
  • 142 Views
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Article
Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study
Hadi Zare-Zardini, Ashraf Alemi, Asghar Taheri-Kafrani, Seyed Ahmad Hosseini, Hossein Soltaninejad, Amir Ali Hamidieh, Mojtaba Haghi Karamallah, Majid Farrokhifar & Mohammad Farrokhifar
Pages: 3315-3324
Published online: 13 Aug 2020
AbstractforAssessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study | Full Text | References | PDF (4 MB) | EPUB
  • 230 Views
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Article
Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model
Rong-zi Li, Xiao-Wen Ding, Thangiah Geetha, Layla Al-Nakkash, Tom L Broderick & Jeganathan Ramesh Babu
Pages: 3325-3336
Published online: 17 Aug 2020
AbstractforBeneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model | Full Text | References | PDF (5.4 MB) | EPUB
  • 285 Views
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Article
New Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis
Gizele Cabral Costa, Tadeu Lima Montagnoli, Jaqueline Soares Da Silva, Allan Kardec Nogueira de Alencar, Luis Eduardo Reina Gamba, Bryelle Eccard Oliveira Alves, Marina Moraes Carvalho da Silva, Margarete Manhães Trachez, José Hamilton M do Nascimento, Pedro Moreno Pimentel-Coelho, Rosália Mendez-Otero, Lidia Moreira Lima, Eliezer J Barreiro, Roberto Takashi Sudo & Gisele Zapata-Sudo
Pages: 3337-3350
Published online: 17 Aug 2020
AbstractforNew Benzofuran N-Acylhydrazone Reduces Cardiovascular Dysfunction in Obese Rats by Blocking TNF-Alpha Synthesis | Full Text | References | PDF (3 MB) | EPUB
  • 100 Views
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Article
Cannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model
Elham Rouhollahi, Bernard A MacLeod, Alasdair M Barr & Ernest Puil
Pages: 3351-3361
Published online: 17 Aug 2020
AbstractforCannabis Extract CT-921 Has a High Efficacy–Adverse Effect Profile in a Neuropathic Pain Model | Full Text | References | PDF (2.3 MB) | EPUB
  • 114 Views
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Article
Cinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4
Jie Mei, Jing Ma, Yuwei Xu, Yuanyuan Wang, Minghua Hu, Fangli Ma, Zhihai Qin, Rui Xue & Ning Tao
Pages: 3363-3372
Published online: 18 Aug 2020
AbstractforCinnamaldehyde Treatment of Prostate Cancer-Associated Fibroblasts Prevents Their Inhibitory Effect on T Cells Through Toll-Like Receptor 4 | Full Text | References | PDF (5.4 MB) | EPUB
  • 147 Views
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Article
Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study
Hui Chen, Jing-Qiu Wei, Yi-Wen Wang, Kun-Peng Zhou, Ying He, He Liu & Yue-Ying Zhang
Pages: 3373-3384
Published online: 18 Aug 2020
AbstractforProtective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study | Full Text | References | PDF (2.3 MB) | EPUB
  • 121 Views
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Article
Cyanidin-3-O-Glucoside Improves Colonic Motility During Severe Acute Pancreatitis by Inhibiting the H2S-Regulated AMPK/mTOR Pathway
Wei Lian & Wensheng Chen
Pages: 3385-3391
Published online: 19 Aug 2020
AbstractforCyanidin-3-O-Glucoside Improves Colonic Motility During Severe Acute Pancreatitis by Inhibiting the H2S-Regulated AMPK/mTOR Pathway | Full Text | References | PDF (2.2 MB) | EPUB
  • 90 Views
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Article
Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy
Xinxu Zhang, Yuanyuan Deng, Juan Xiang, Huixia Liu, Jiani Zhang, Jie Liao, Ke Chen, Bo Liu, Jun Liu & Ying Pu
Pages: 3393-3405
Published online: 19 Aug 2020
AbstractforGalangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy | Full Text | References | PDF (10.5 MB) | EPUB
  • 131 Views
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Article
Efficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation
Libei Zhao, Manqiang Peng, Wenxiang Lin, Qian Tan, Muhammad Ahmad Khan & Ding Lin
Pages: 3407-3416
Published online: 20 Aug 2020
AbstractforEfficacy of Sub-Tenon Micro-Perfusion of Cyclophosphamide in Rabbits with Severe Ocular Inflammation | Full Text | References | PDF (4.2 MB) | EPUB
  • 81 Views
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Article
Carboplatin Inhibits the Progression of Retinoblastoma Through IncRNA XIST/miR-200a-3p/NRP1 Axis
Hong Zhao, Jingjing Wan & Yu Zhu
Pages: 3417-3427
Published online: 21 Aug 2020
AbstractforCarboplatin Inhibits the Progression of Retinoblastoma Through IncRNA XIST/miR-200a-3p/NRP1 Axis | Full Text | References | PDF (6.1 MB) | EPUB
  • 86 Views
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Hypothesis

Discussion
A Single Large Dose of Vitamin D Could be Used as a Means of Coronavirus Disease 2019 Prevention and Treatment
Guoqiang Liu, Tianpei Hong & Jin Yang
Pages: 3429-3434
Published online: 21 Aug 2020
AbstractforA Single Large Dose of Vitamin D Could be Used as a Means of Coronavirus Disease 2019 Prevention and Treatment | Full Text | References | PDF (1.2 MB) | EPUB
  • 197 Views
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Original Research

Article
Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo
Jiaxuan Peng, Kangxian Zhao, Jiling Zhu, Yanben Wang, Peng Sun, Qichang Yang, Tan Zhang, Weiqi Han, Wenjun Hu, Wanlei Yang, Jianwei Ruan & Yu Qian
Pages: 3435-3447
Published online: 24 Aug 2020
AbstractforSarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo | Full Text | References | PDF (8.9 MB) | EPUB
  • 100 Views
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Article
Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway
Na Liang, Wenfeng Zhang, Hongjiang Wang, Wei Shi, Li Wang & Lijuan Ma
Pages: 3449-3460
Published online: 24 Aug 2020
AbstractforLevonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway | Full Text | References | PDF (6.4 MB) | EPUB
  • 78 Views
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Article
Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma
Kai-Cai Liu, Ying-Hong Hao, Wei-Fu Lv, Wei-Dong Jia, Chu-Shu Ji, Chun-Ze Zhou, De-Lei Cheng, Shao-Bao Xu, Zong-Gen Gao, Ming-Xue Su & Chang-Sheng Shi
Pages: 3461-3468
Published online: 25 Aug 2020
AbstractforTransarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma | Full Text | References | PDF (2.4 MB) | EPUB
  • 99 Views
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Article
Analysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin
Yahdiana Harahap, Puspitasari Ardiningsih, Agatha Corintias Winarti & Denni Joko Purwanto
Pages: 3469-3475
Published online: 25 Aug 2020
AbstractforAnalysis of the Doxorubicin and Doxorubicinol in the Plasma of Breast Cancer Patients for Monitoring the Toxicity of Doxorubicin | Full Text | References | PDF (2.7 MB) | EPUB
  • 671 Views
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Article
Video Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial
Ziqi Ye, Jie Chen, Yanfang Zhang, Xi Hu, Zixue Xuan, Si Yang, Xiaohong Mao & Yuefeng Rao
Pages: 3477-3483
Published online: 25 Aug 2020
AbstractforVideo Education Reduces Pain and Anxiety Levels in Cancer Patients Who First Use Fentanyl Transdermal Patch: A Randomized Controlled Trial | Full Text | References | PDF (790.2 KB) | EPUB
  • 179 Views
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Article
Effectiveness of Metoprolol in Improving Cardiac and Motor Functions in Patients with Chronic Heart Failure: A Prospective Study
XiaoLiang Cheng, Min Zhu, Qing Liu, Zhenxia Feng & Yong Meng
Pages: 3485-3494
Published online: 25 Aug 2020
AbstractforEffectiveness of Metoprolol in Improving Cardiac and Motor Functions in Patients with Chronic Heart Failure: A Prospective Study | Full Text | References | PDF (323.4 KB) | EPUB
  • 195 Views
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Article
Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo
Ling Zuo, Hongyu Tao, Huanli Xu, Cong Li, Gan Qiao, Mingyue Guo, Shousong Cao, Minghua Liu & Xiukun Lin
Pages: 3495-3507
Published online: 25 Aug 2020
AbstractforExosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo | Full Text | References | PDF (10.6 MB) | EPUB
  • 181 Views
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Article
Application of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study
Xiaoxiao Li, Xueli Lv, Zhenfei Jiang, Xinrui Nie, Xinghe Wang, Tong Li, Lianyi Zhang & Su Liu
Pages: 3509-3518
Published online: 27 Aug 2020
AbstractforApplication of Intravenous Lidocaine in Obese Patients Undergoing Painless Colonoscopy: A Prospective, Randomized, Double-Blind, Controlled Study | Full Text | References | PDF (1.1 MB) | EPUB
  • 196 Views
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Article
Bone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification
Limin Zhou, Haojun Wu, Xiang Gao, Xiaoyan Zheng, Hang Chen, Hailong Li, Jun Peng, Weichong Liang, Wenxing Wang, Zuocheng Qiu, Anjaneyulu Udduttula, Kefeng Wu, Lin Li, Yuyu Liu & Yanzhi Liu
Pages: 3519-3533
Published online: 26 Aug 2020
AbstractforBone-Targeting Liposome-Encapsulated Salvianic Acid A Improves Nonunion Healing Through the Regulation of HDAC3-Mediated Endochondral Ossification | Full Text | References | PDF (6.7 MB) | EPUB
  • 126 Views
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Article
Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer
Ying Liu, Ning Zhang, Hanwen Zhang, Lijuan Wang, Yi Duan, Xiaolong Wang, Tong Chen, Yiran Liang, Yaming Li, Xiaojin Song, Chen Li, Dianwen Han, Bing Chen, Wenjing Zhao & Qifeng Yang
Pages: 3535-3545
Published online: 26 Aug 2020
AbstractforFatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer | Full Text | References | PDF (6.2 MB) | EPUB
  • 160 Views
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Article
LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway
Lu Cao, Peng Qin, Jianjiang Zhang, Huiju Qiao, Peipei Shi & Huali Huo
Pages: 3547-3557
Published online: 26 Aug 2020
AbstractforLncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-β Signaling Pathway | Full Text | References | PDF (4.2 MB) | EPUB
  • 143 Views
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Clinical Trial Report

Case Report
Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial
Bin Qian, Wenting Zheng, Jiawei Shi, Zihan Chen, Yanhua Guo & Yusheng Yao
Pages: 3559-3565
Published online: 26 Aug 2020
AbstractforKetamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial | Full Text | References | PDF (1.4 MB) | EPUB
  • 242 Views
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Original Research

Article
Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway
Fan Yang, Lu Deng, JinPeng Li, MuHu Chen, Ying Liu, YingChun Hu & Wu Zhong
Pages: 3567-3575
Published online: 03 Sep 2020
AbstractforEmodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway | Full Text | References | PDF (2.5 MB) | EPUB
  • 147 Views
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Article
Pinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway
Ze-Chun Kang, Hai-Gang Wang, Yu-Lin Yang, Xiao-Yue Zhao, Qi-Meng Zhou, Ying-Lin Yang, Jing-Yu Yang & Guan-Hua Du
Pages: 3577-3587
Published online: 04 Sep 2020
AbstractforPinocembrin Ameliorates Cognitive Impairment Induced by Vascular Dementia: Contribution of Reelin-dab1 Signaling Pathway | Full Text | References | PDF (7 MB) | EPUB
  • 118 Views
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Article
Enhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine
Vida Mirzaie, Touba Eslaminejad, Homayoon Babaei & Seyed Noureddin Nematollahi-Mahani
Pages: 3589-3599
Published online: 04 Sep 2020
AbstractforEnhancing the Butyrylcholinesterase Activity in HEK-293 Cell Line by Dual-Promoter Vector Decorated on Lipofectamine | Full Text | References | PDF (4.2 MB) | EPUB
  • 155 Views
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Article
Computational and Pharmacological Investigation of (E)-2-(4-Methoxybenzylidene)Cyclopentanone for Therapeutic Potential in Neurological Disorders
Sabah Farooq, Arif-ullah Khan & Muhammad Shahid Iqbal
Pages: 3601-3614
Published online: 07 Sep 2020
AbstractforComputational and Pharmacological Investigation of (E)-2-(4-Methoxybenzylidene)Cyclopentanone for Therapeutic Potential in Neurological Disorders | Full Text | References | PDF (2.1 MB) | EPUB
  • 98 Views
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Article
Investigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation
Youqiang Liu, Yanlin Ma, Zheng Li, Yang Yang, Bin Yu, Zhenya Zhang & Guiying Wang
Pages: 3615-3623
Published online: 07 Sep 2020
AbstractforInvestigation of Inhibition Effect of Gossypol-Acetic Acid on Gastric Cancer Cells Based on a Network Pharmacology Approach and Experimental Validation | Full Text | References | PDF (9.5 MB) | EPUB
  • 116 Views
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Review

Review Article
Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy
Leilei Ai, Jian Chen, Hao Yan, Qiaojun He, Peihua Luo, Zhifei Xu & Xiaochun Yang
Pages: 3625-3649
Published online: 08 Sep 2020
AbstractforResearch Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy | Full Text | References | PDF (7.3 MB) | EPUB
  • 695 Views
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Original Research

Article
Knockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p
Kui Chi, Jinwen Zhang, Huanhuan Sun, Yang Liu, Ye Li, Tao Yuan & Feng Zhang
Pages: 3651-3662
Published online: 09 Sep 2020
AbstractforKnockdown of lncRNA HOXA-AS3 Suppresses the Progression of Atherosclerosis via Sponging miR-455-5p | Full Text | References | PDF (5.7 MB) | EPUB
  • 88 Views
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Article
Emodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway
Qiaomei Zheng, Jinhua Wang, Wenwen Li, Xiaoyun Chen, Shaozhan Chen & Lihong Chen
Pages: 3663-3672
Published online: 10 Sep 2020
AbstractforEmodin Reverses the Epithelial–Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway | Full Text | References | PDF (9.8 MB) | EPUB
  • 90 Views
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Article
Comparison of GnRH-a Prolonged Protocol and Short GnRH-a Long Protocol in Patients with Thin Endometrium for Assisted Reproduction: A Retrospective Cohort Study
Jianyuan Song, Cuicui Duan, Wangyu Cai, Wei Wu, Houyi Lv & Jian Xu
Pages: 3673-3682
Published online: 11 Sep 2020
AbstractforComparison of GnRH-a Prolonged Protocol and Short GnRH-a Long Protocol in Patients with Thin Endometrium for Assisted Reproduction: A Retrospective Cohort Study | Full Text | References | PDF (2.4 MB) | EPUB
  • 133 Views
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Article
LncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury
Shuo Zhang, Wen-chong Sun, Zuo-di Liang, Xiu-ru Yin, Zhen-rong Ji, Xiao-huan Chen, Min-jie Wei & Ling Pei
Pages: 3683-3695
Published online: 11 Sep 2020
AbstractforLncRNA SNHG4 Attenuates Inflammatory Responses by Sponging miR-449c-5p and Up-Regulating STAT6 in Microglial During Cerebral Ischemia-Reperfusion Injury | Full Text | References | PDF (6.3 MB) | EPUB
  • 95 Views
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Article
Formulation of Nanospanlastics as a Promising Approach for ‎Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-‎Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro ‎Characterization, and ex vivo Permeation Study
Farid Badria & Eman Mazyed
Pages: 3697-3721
Published online: 15 Sep 2020
AbstractforFormulation of Nanospanlastics as a Promising Approach for ‎Improving the Topical Delivery of a Natural Leukotriene Inhibitor (3-‎Acetyl-11-Keto-β-Boswellic Acid): Statistical Optimization, in vitro ‎Characterization, and ex vivo Permeation Study | Full Text | References | PDF (8.2 MB) | EPUB
  • 499 Views
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Article
Synthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent
A-Long Cui, Wen-Fang Sun, Zhao-Jin Zhong, Jie Jin, Si-Tu Xue, Shuo Wu, Yu-Huan Li & Zhuo-Rong Li
Pages: 3723-3729
Published online: 15 Sep 2020
AbstractforSynthesis and Bioactivity of N-(4-Chlorophenyl)-4-Methoxy-3-(Methylamino) Benzamide as a Potential Anti-HBV Agent | Full Text | References | PDF (1.3 MB) | EPUB
  • 81 Views
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Review

Review Article
Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases
Yu-Qing Tan, Heng-Wen Chen & Jun Li
Pages: 3731-3746
Published online: 15 Sep 2020
AbstractforAstragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases | Full Text | References | PDF (1.5 MB) | EPUB
  • 421 Views
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Review Article
Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection
Amanda L Blackmon & Lauren Pinter-Brown
Pages: 3747-3754
Published online: 16 Sep 2020
AbstractforSpotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection | Full Text | References | PDF (272.1 KB) | EPUB
  • 111 Views
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Original Research

Article
The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats
Shuai Miao, Yu Yang, Ruiling Li, Li Yin, Kai Zhang, Lijun Cheng, Xiaona Xu, Weiding Wang, Zhiqiang Zhao & Guangping Li
Pages: 3755-3764
Published online: 16 Sep 2020
AbstractforThe Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats | Full Text | References | PDF (6.2 MB) | EPUB
  • 75 Views
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Article
Exosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis
Jiayou Tang, Lu Jin, Yang Liu, Lanlan Li, Yanyan Ma, Linhe Lu, Jipeng Ma, Peng Ding, Xiuling Yang, Jincheng Liu & Jian Yang
Pages: 3765-3775
Published online: 16 Sep 2020
AbstractforExosomes Derived from Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis | Full Text | References | PDF (7.4 MB) | EPUB
  • 150 Views
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Article
Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels
Naeem Ur Rehman, Muzaffar Abbas, Mariya al-Rashida, Ahmed Tokhi, Muhammad Awais Arshid, Muhammad Sona Khan, Izhar Ahmad & Khalid Rauf
Pages: 3777-3786
Published online: 17 Sep 2020
AbstractforEffect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels | Full Text | References | PDF (4.1 MB) | EPUB
  • 121 Views
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Review

Review Article
Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review)
Anahita Jenab, Rasoul Roghanian & Giti Emtiazi
Pages: 3787-3801
Published online: 18 Sep 2020
AbstractforBacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review) | Full Text | References | PDF (5.7 MB) | EPUB
  • 753 Views
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Review Article
Study Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19
Weilong Zhang, Yinghua Lv, Juan Yang, Yunhui Chen, Yingchun He & Jihan Huang
Pages: 3803-3813
Published online: 18 Sep 2020
AbstractforStudy Design Characteristics and Pharmacological Mechanisms in International Clinical Trials Registry Platform: Registered Clinical Trials on Antiviral Drugs for COVID-19 | Full Text | References | PDF (2.4 MB) | EPUB
  • 131 Views
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Original Research

Article
Quercetin Inhibits Adenomyosis by Attenuating Cell Proliferation, Migration and Invasion of Ectopic Endometrial Stromal Cells
Wenbin Xu, Yizuo Song, Kehan Li, Biyun Zhang & Xueqiong Zhu
Pages: 3815-3826
Published online: 21 Sep 2020
AbstractforQuercetin Inhibits Adenomyosis by Attenuating Cell Proliferation, Migration and Invasion of Ectopic Endometrial Stromal Cells | Full Text | References | PDF (6.9 MB) | EPUB
  • 224 Views
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Article
Hydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway
Hongfei Ke, Dexiang Liu, Tingting Li, Xili Chu, Danqing Xin, Min Han, Shuanglian Wang & Zhen Wang
Pages: 3827-3839
Published online: 21 Sep 2020
AbstractforHydrogen-Rich Saline Regulates Microglial Phagocytosis and Restores Behavioral Deficits Following Hypoxia-Ischemia Injury in Neonatal Mice via the Akt Pathway | Full Text | References | PDF (10 MB) | EPUB
  • 87 Views
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Article
Synergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding
Sadia Sarwar, Jun Qing Yu, Humaira Nadeem & Fazlul Huq
Pages: 3841-3852
Published online: 22 Sep 2020
AbstractforSynergistic Cytotoxic Effect from Combination of Wedelolactone and Cisplatin in HeLa Cell Line: A Novel Finding | Full Text | References | PDF (6.4 MB) | EPUB
  • 150 Views
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Article
Protective Effect of Pravastatin on Myocardial Ischemia Reperfusion Injury by Regulation of the miR-93/Nrf2/ARE Signal Pathway
Zhiqiang Liu, Fucheng Zhang, Lipei Zhao, Xueping Zhang, Yibo Li & Lingling Liu
Pages: 3853-3864
Published online: 22 Sep 2020
AbstractforProtective Effect of Pravastatin on Myocardial Ischemia Reperfusion Injury by Regulation of the miR-93/Nrf2/ARE Signal Pathway | Full Text | References | PDF (6.5 MB) | EPUB
  • 80 Views
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Article
Phoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice
Fan Yang, Ping Huang, Liandong Shi, Feng Liu, Aimei Tang & Shaohui Xu
Pages: 3865-3874
Published online: 22 Sep 2020
AbstractforPhoenixin 14 Inhibits High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Experimental Mice | Full Text | References | PDF (3.8 MB) | EPUB
  • 176 Views
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Review

Review Article
Recent Progress in the Development of New Antimalarial Drugs with Novel Targets
Tafere Mulaw Belete
Pages: 3875-3889
Published online: 22 Sep 2020
AbstractforRecent Progress in the Development of New Antimalarial Drugs with Novel Targets | Full Text | References | PDF (1.9 MB) | EPUB
  • 1585 Views
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Original Research

Article
Effects of High-Dose Rosuvastatin on Ventricular Remodelling and Cardiac Function in ST-Segment Elevation Myocardial Infarction
Rong Luo, Xiaochen Sun, Feiyan Shen, Bin Hong & Zilong Wang
Pages: 3891-3898
Published online: 23 Sep 2020
AbstractforEffects of High-Dose Rosuvastatin on Ventricular Remodelling and Cardiac Function in ST-Segment Elevation Myocardial Infarction | Full Text | References | PDF (294.8 KB) | EPUB
  • 139 Views
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Article
Integrating Unified Medical Language System and Kleinberg’s Burst Detection Algorithm into Research Topics of Medications for Post-Traumatic Stress Disorder
Shuang Xu, Dan Xu, Liang Wen, Chen Zhu, Ying Yang, Shuang Han & Peng Guan
Pages: 3899-3913
Published online: 24 Sep 2020
AbstractforIntegrating Unified Medical Language System and Kleinberg’s Burst Detection Algorithm into Research Topics of Medications for Post-Traumatic Stress Disorder | Full Text | References | PDF (5.5 MB) | EPUB
  • 114 Views
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Article
Antiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
Karin Melanie Cabanillas Stanchi, Semjon Willier, Julia Vek, Patrick Schlegel, Manon Queudeville, Nora Rieflin, Veronika Klaus, Melanie Gansel, Joachim Vincent Rupprecht, Tim Flaadt, Vera Binder, Tobias Feuchtinger, Peter Lang, Rupert Handgretinger & Michaela Döring
Pages: 3915-3927
Published online: 25 Sep 2020
AbstractforAntiemetic Prophylaxis with Fosaprepitant and 5-HT3-Receptor Antagonists in Pediatric Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation | Full Text | References | PDF (2.5 MB) | EPUB
  • 136 Views
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Article
DPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation
Haoran Wang, Yue Li, Xiaoliang Zhang, Zhonglin Xu, Jianzhong Zhou & Wei Shang
Pages: 3929-3940
Published online: 25 Sep 2020
AbstractforDPP-4 Inhibitor Linagliptin Ameliorates Oxidized LDL-Induced THP-1 Macrophage Foam Cell Formation and Inflammation | Full Text | References | PDF (4.5 MB) | EPUB
  • 183 Views
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Article
The Activity and Safety of Anlotinib for Patients with Extremity Desmoid Fibromatosis: A Retrospective Study in a Single Institution
Chuanxi Zheng, Yong Zhou, Yitian Wang, Yi Luo, Chongqi Tu & Li Min
Pages: 3941-3950
Published online: 25 Sep 2020
AbstractforThe Activity and Safety of Anlotinib for Patients with Extremity Desmoid Fibromatosis: A Retrospective Study in a Single Institution | Full Text | References | PDF (1.6 MB) | EPUB
  • 72 Views
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Article
Knockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Itchy E3 Ubiquitin Protein Ligase
Daliang Kong, Rui Gu, Chengtao Zhang & Ruofeng Yin
Pages: 3951-3963
Published online: 25 Sep 2020
AbstractforKnockdown of hsa_circ_0059955 Induces Apoptosis and Cell Cycle Arrest in Nucleus Pulposus Cells via Inhibiting Itchy E3 Ubiquitin Protein Ligase | Full Text | References | PDF (6.6 MB) | EPUB
  • 92 Views
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Article
Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells
Zhongyan Tang, Lihua Lu & Zhengxiang Xia
Pages: 3965-3976
Published online: 25 Sep 2020
AbstractforAnti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells | Full Text | References | PDF (5.6 MB) | EPUB
  • 210 Views
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Review

Review Article
Acquired Hypothyroidism in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors
Jialu Wu & Hui Huang
Pages: 3977-3982
Published online: 28 Sep 2020
AbstractforAcquired Hypothyroidism in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors | Full Text | References | PDF (264.9 KB) | EPUB
  • 79 Views
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Original Research

Article
Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma
Ruosi Yao, Yu Xie, Xiaoyang Sun, Menghui Zhang, Jian Zhou, Linlin Liu, Jian Gao & Kailin Xu
Pages: 3983-3993
Published online: 28 Sep 2020
AbstractforIdentification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma | Full Text | References | PDF (5.8 MB) | EPUB
  • 141 Views
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Commentary

Article Commentary
Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19
Chenghai Li, Hua Zhao & Bin Wang
Pages: 3995-4001
Published online: 29 Sep 2020
AbstractforChallenges for Mesenchymal Stem Cell-Based Therapy for COVID-19 | Full Text | References | PDF (930.6 KB) | EPUB
  • 164 Views
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Original Research

Article
RETRACTED ARTICLE: Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling
Mohammed F Alotaibi, Fakhria Al-Joufi, Howida S Abou Seif, Mohammed A Alzoghaibi, Laiche Djouhri, Ahmad F Ahmeda & Ayman M Mahmoud
Pages: 4003-4019
Published online: 29 Sep 2020
AbstractforRETRACTED ARTICLE: Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling | PDF (11.3 MB)
  • 118 Views
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Hypothesis

Discussion
Multifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets
Xue Bai, Qilin Pei, Chunyi Pu, Yi Chen, Sirong He & Bin Wang
Pages: 4021-4027
Published online: 29 Sep 2020
AbstractforMultifunctional Islet Transplantation Hydrogel Encapsulating A20 High-Expressing Islets | Full Text | References | PDF (3.3 MB) | EPUB
  • 132 Views
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Review

Review Article
A Review on the Role of Denosumab in Fracture Prevention
Kok-Lun Pang, Nie Yen Low & Kok-Yong Chin
Pages: 4029-4051
Published online: 01 Oct 2020
AbstractforA Review on the Role of Denosumab in Fracture Prevention | Full Text | References | PDF (2 MB) | EPUB
  • 447 Views
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Original Research

Article
Integrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of Abelmoschus manihot (L.) Medik. on Renal Fibrosis
Lifei Gu, Fang Hong, Kaikai Fan, Lei Zhao, Chunlei Zhang, Boyang Yu & Chengzhi Chai
Pages: 4053-4067
Published online: 01 Oct 2020
AbstractforIntegrated Network Pharmacology Analysis and Pharmacological Evaluation to Explore the Active Components and Mechanism of Abelmoschus manihot (L.) Medik. on Renal Fibrosis | Full Text | References | PDF (11.4 MB) | EPUB
  • 163 Views
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Article
Integrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of Moringa oleifera Seeds
Qiong Huang, Rong Liu, Jing Liu, Qi Huang, Shao Liu & Yueping Jiang
Pages: 4069-4084
Published online: 02 Oct 2020
AbstractforIntegrated Network Pharmacology Analysis and Experimental Validation to Reveal the Mechanism of Anti-Insulin Resistance Effects of Moringa oleifera Seeds | Full Text | References | PDF (8.8 MB) | EPUB
  • 377 Views
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Article
[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats
Qianqian Cheng, Xiaodi Feng, Qi Meng, Yaqi Li, Siqi Chen, Guoen Wang & Ke Nie
Pages: 4085-4099
Published online: 02 Oct 2020
Abstractfor[6]-Gingerol Ameliorates Cisplatin-Induced Pica by Regulating the TPH/MAO-A/SERT/5-HT/5-HT3 Receptor System in Rats | Full Text | References | PDF (14.1 MB) | EPUB
  • 226 Views
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Article
Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats
Qi-Shan Wang, Bing-Xin Xu, Kai-Jian Fan, Yun-Wu Li, Jing Wu & Ting-Yu Wang
Pages: 4101-4113
Published online: 05 Oct 2020
AbstractforDexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats | Full Text | References | PDF (7.1 MB) | EPUB
  • 318 Views
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Article
Charge Transfer Complex of Neostigmine with 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone: Synthesis, Spectroscopic Characterization, Antimicrobial Activity, and Theoretical Study
Tarek A Yousef, Essam Ezzeldin, Hatem A Abdel-Aziz, Mohamed H Al-Agamy & Gamal A E Mostafa
Pages: 4115-4129
Published online: 06 Oct 2020
AbstractforCharge Transfer Complex of Neostigmine with 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone: Synthesis, Spectroscopic Characterization, Antimicrobial Activity, and Theoretical Study | Full Text | References | PDF (7.4 MB) | EPUB
  • 165 Views
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Retraction

Retraction
Ginkgolide B Ameliorates Myocardial Ischemia Reperfusion Injury in Rats via Inhibiting Endoplasmic Reticulum Stress [Retraction]
Page: 4131
Published online: 07 Oct 2020
CitationforGinkgolide B Ameliorates Myocardial Ischemia Reperfusion Injury in Rats via Inhibiting Endoplasmic Reticulum Stress [Retraction] | Full Text | PDF (166.7 KB) | EPUB
  • 63 Views
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Retraction
Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy [Retraction]
Page: 4133
Published online: 07 Oct 2020
CitationforCordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy [Retraction] | Full Text | PDF (185.5 KB) | EPUB
  • 65 Views
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Original Research

Article
Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy
Zhi-chao Zheng, Wei Zhu, Lei Lei, Xue-qi Liu & Yong-gui Wu
Pages: 4135-4148
Published online: 08 Oct 2020
AbstractforWogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy | Full Text | References | PDF (11.7 MB) | EPUB
  • 165 Views
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Article
Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells
Bessi Qorri, William Harless & Myron R Szewczuk
Pages: 4149-4167
Published online: 08 Oct 2020
AbstractforNovel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells | Full Text | References | PDF (9 MB) | EPUB
  • 234 Views
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Article
The Impact of Icariside II on Human Prostate Cancer Cell Proliferation, Mobility, and Autophagy via PI3K-AKT-mTOR Signaling Pathway
Shuang Li, Yunlu Zhan, Yingwei Xie, Yonghui Wang & Yuexin Liu
Pages: 4169-4178
Published online: 08 Oct 2020
AbstractforThe Impact of Icariside II on Human Prostate Cancer Cell Proliferation, Mobility, and Autophagy via PI3K-AKT-mTOR Signaling Pathway | Full Text | References | PDF (5.2 MB) | EPUB
  • 135 Views
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Article
Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration
Peng Chen, Fuchao Chen, Jiexin Lei & Benhong Zhou
Pages: 4179-4187
Published online: 09 Oct 2020
AbstractforPhysical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration | Full Text | References | PDF (5.4 MB) | EPUB
  • 262 Views
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Article
Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo
Peng Sun, Qichang Yang, Yanben Wang, Jiaxuan Peng, Kangxian Zhao, Yewei Jia, Tan Zhang, Xuanyuan Lu, Weiqi Han & Yu Qian
Pages: 4189-4203
Published online: 09 Oct 2020
AbstractforPristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo | Full Text | References | PDF (12.6 MB) | EPUB
  • 102 Views
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Article
Effect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells
Fan Zhang, Lei Liu, Han Zhang & Zhe-Li Liu
Pages: 4205-4214
Published online: 12 Oct 2020
AbstractforEffect of Platelet-Activating Factor on Barrier Function of ARPE-19 Cells | Full Text | References | PDF (7.8 MB) | EPUB
  • 100 Views
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Article
Clinical Outcome of Systemic Treatment for Advanced Soft Tissue Sarcoma: Real-Life Perspective in Japan
Tomoki Nakamura, Kunihiro Asanuma, Tomohito Hagi & Akihiro Sudo
Pages: 4215-4220
Published online: 12 Oct 2020
AbstractforClinical Outcome of Systemic Treatment for Advanced Soft Tissue Sarcoma: Real-Life Perspective in Japan | Full Text | References | PDF (573.1 KB) | EPUB
  • 98 Views
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Article
Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized, Single Dose, 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions
Qingqing Wu, Xiaodong Wang, Qian Chen, Yang Zou, Xiaoyan Xu, Tingting Li, Chen Yu, Fu Zhu, Kanyin E Zhang, Jingying Jia & Yanmei Liu
Pages: 4221-4230
Published online: 12 Oct 2020
AbstractforPharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized, Single Dose, 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions | Full Text | References | PDF (1.7 MB) | EPUB
  • 410 Views
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Article
Dexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress
Zhipeng Zhu, Xiaoyan Ling, Hongmei Zhou, Caijun Zhang & Weiwei Yan
Pages: 4231-4243
Published online: 12 Oct 2020
AbstractforDexmedetomidine Attenuates Cellular Injury and Apoptosis in H9c2 Cardiomyocytes by Regulating p-38MAPK and Endoplasmic Reticulum Stress | Full Text | References | PDF (6.5 MB) | EPUB
  • 86 Views
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Review

Review Article
The Potential Roles of Epigallocatechin-3-Gallate in the Treatment of Ovarian Cancer: Current State of Knowledge
Sabrina Bimonte & Marco Cascella
Pages: 4245-4250
Published online: 12 Oct 2020
AbstractforThe Potential Roles of Epigallocatechin-3-Gallate in the Treatment of Ovarian Cancer: Current State of Knowledge | Full Text | References | PDF (263.5 KB) | EPUB
  • 132 Views
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Original Research

Article
EGCG Upregulates UCP3 Levels to Protect MIN6 Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis
Xu Jia, Ziren Luo, Ying Gao, Hua Liu, Xinghai Liu, Wenli Mai, Hong Liu & Qian Zheng
Pages: 4251-4261
Published online: 13 Oct 2020
AbstractforEGCG Upregulates UCP3 Levels to Protect MIN6 Pancreatic Islet Cells from Interleukin-1β-Induced Apoptosis | Full Text | References | PDF (2.7 MB) | EPUB
  • 109 Views
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Article
Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs
Yunlu Liu, Lin Wang, Feng Wan & Na Yang
Pages: 4263-4276
Published online: 13 Oct 2020
AbstractforEffects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs | Full Text | References | PDF (7.8 MB) | EPUB
  • 101 Views
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Article
Bucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation
Soad A Mohamad, Hesham Salem, Heba A Yassin & Heba F Mansour
Pages: 4277-4289
Published online: 15 Oct 2020
AbstractforBucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation | Full Text | References | PDF (3.8 MB) | EPUB
  • 324 Views
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Article
HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition
Huachen Song, Xiaonan Tang, Xiang Li, Yufei Wang, Anjun Deng, Wenjie Wang, Haijing Zhang, Hailin Qin & LianQiu Wu
Pages: 4291-4302
Published online: 15 Oct 2020
AbstractforHLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial–Mesenchymal Transition | Full Text | References | PDF (6.9 MB) | EPUB
  • 92 Views
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Article
Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile
Fahad Mehmood Khan, Mahmood Ahmad & Hafiz Arfat Idrees
Pages: 4303-4313
Published online: 19 Oct 2020
AbstractforSimvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile | Full Text | References | PDF (6.3 MB) | EPUB
  • 194 Views
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Article
Synthesis and Identification of a Novel Peptide, Ac-SDK (Biotin) Proline, That Can Elicit Anti-Fibrosis Effects in Rats Suffering from Silicosis
Jin Wang, Ye Qian, Xuemin Gao, Na Mao, Yucong Geng, Gaojie Lin, Guibin Zhang, Han Li, Fang Yang & Hong Xu
Pages: 4315-4326
Published online: 19 Oct 2020
AbstractforSynthesis and Identification of a Novel Peptide, Ac-SDK (Biotin) Proline, That Can Elicit Anti-Fibrosis Effects in Rats Suffering from Silicosis | Full Text | References | PDF (9.2 MB) | EPUB
  • 91 Views
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Review

Review Article
Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer
Yu Cao, Huajian Zhu, Ruoyu He, Limin Kong, Jiaan Shao, Rangxiao Zhuang, Jianjun Xi & Jiankang Zhang
Pages: 4327-4342
Published online: 19 Oct 2020
AbstractforProteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer | Full Text | References | PDF (8 MB) | EPUB
  • 193 Views
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Original Research

Article
Development, Characterization, and in-vivo Pharmacokinetic Study of Lamotrigine Solid Self-Nanoemulsifying Drug Delivery System
Rehab Abdelmonem, Marian Sobhy Azer, Amna Makky, Abdelazim Zaghloul, Mohamed El-Nabarawi & Aly Nada
Pages: 4343-4362
Published online: 19 Oct 2020
AbstractforDevelopment, Characterization, and in-vivo Pharmacokinetic Study of Lamotrigine Solid Self-Nanoemulsifying Drug Delivery System | Full Text | References | PDF (8.5 MB) | EPUB
  • 445 Views
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Article
ISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro
Lei Song, Yi Luo, Shaoling Li, Ming Hong, Qi Wang, Xiaoling Chi & Cong Yang
Pages: 4363-4376
Published online: 20 Oct 2020
AbstractforISL Induces Apoptosis and Autophagy in Hepatocellular Carcinoma via Downregulation of PI3K/AKT/mTOR Pathway in vivo and in vitro | Full Text | References | PDF (12.6 MB) | EPUB
  • 143 Views
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Article
Validated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study
Mohamed Hefnawy, Mona Al-Shehri, Sara Al-Rashood, Sherif Hammad, Mohammed Alanazi, Nawaf Alsaif, Mostafa Mohammed, Ahmad Obaidullah & Manal El-Gendy
Pages: 4377-4385
Published online: 20 Oct 2020
AbstractforValidated Microwell-Based Spectrofluorimetric Method for Quantification of Ravidasvir (New Anti-Chronic Hepatitis C Virus-GT4) in Rat Plasma and Its Application to Pharmacokinetic Study | Full Text | References | PDF (2.2 MB) | EPUB
  • 102 Views
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Review

Review Article
Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System
Nasrul Wathoni, An Ny Nguyen, Agus Rusdin, Abd Kakhar Umar, Ahmed Fouad Abdelwahab Mohammed, Keiichi Motoyama, I Made Joni & Muchtaridi Muchtaridi
Pages: 4387-4405
Published online: 21 Oct 2020
AbstractforEnteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System | Full Text | References | PDF (2.3 MB) | EPUB
  • 675 Views
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Original Research

Article
Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition
Zhenbai Qin, Binghui Kong, Jing Zheng, Xiantao Wang & Lang Li
Pages: 4407-4422
Published online: 22 Oct 2020
AbstractforAlprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition | Full Text | References | PDF (6.1 MB) | EPUB
  • 97 Views
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Article
Metabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity
Kai Wang, Jinqiu Rao, Tingting Zhang, Qing Gao, Jichao Zhang, Chenxi Guang, Liqin Ding & Feng Qiu
Pages: 4423-4438
Published online: 22 Oct 2020
AbstractforMetabolic Activation and Covalent Protein Binding of Berberrubine: Insight into the Underlying Mechanism Related to Its Hepatotoxicity | Full Text | References | PDF (4.9 MB) | EPUB
  • 123 Views
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Article
LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay
Mohamed W Attwa, Ali S Abdelhameed, Nasser S Al-Shakliah & Adnan A Kadi
Pages: 4439-4449
Published online: 23 Oct 2020
AbstractforLC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay | Full Text | References | PDF (3.4 MB) | EPUB
  • 187 Views
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Article
Resveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase
Liang Wang, Qiushi Li, Haibo Yan, Guangjun Jiao, Hongliang Wang, Hai Chi, Hongming Zhou, Lu Chen, Yu Shan & Yunzhen Chen
Pages: 4451-4463
Published online: 23 Oct 2020
AbstractforResveratrol Protects Osteoblasts Against Dexamethasone-Induced Cytotoxicity Through Activation of AMP-Activated Protein Kinase | Full Text | References | PDF (5.4 MB) | EPUB
  • 165 Views
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Article
Enhancement of Pancreatic Cancer Therapy Efficacy by Type-1 Matrix Metalloproteinase-Functionalized Nanoparticles for the Selective Delivery of Gemcitabine and Erlotinib
Na Yin, Hui Yu, Xiaodi Zhang & Xiaodan Lv
Pages: 4465-4475
Published online: 23 Oct 2020
AbstractforEnhancement of Pancreatic Cancer Therapy Efficacy by Type-1 Matrix Metalloproteinase-Functionalized Nanoparticles for the Selective Delivery of Gemcitabine and Erlotinib | Full Text | References | PDF (3.9 MB) | EPUB
  • 127 Views
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Article
Synthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials
Ashraf Atef Hatamleh, Dunia Al Farraj, Sarah Salah Al-Saif, SathishKumar Chidambaram, Surendrakumar Radhakrishnan & Idhayadhulla Akbar
Pages: 4477-4492
Published online: 23 Oct 2020
AbstractforSynthesis, Cytotoxic Analysis, and Molecular Docking Studies of Tetrazole Derivatives via N-Mannich Base Condensation as Potential Antimicrobials | Full Text | References | PDF (7.9 MB) | EPUB
  • 254 Views
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Article
Pharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects
Inyoung Hwang, Yun Kim, Hyounggyoon Yoo, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 4493-4502
Published online: 23 Oct 2020
AbstractforPharmacokinetic/Pharmacodynamic Interaction Between Evogliptin and Pioglitazone in Healthy Male Subjects | Full Text | References | PDF (3.4 MB) | EPUB
  • 196 Views
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Article
Co-Delivery Anticancer Drug Nanoparticles for Synergistic Therapy Against Lung Cancer Cells
Yuzhou Shen & Jicheng TanTai
Pages: 4503-4510
Published online: 23 Oct 2020
AbstractforCo-Delivery Anticancer Drug Nanoparticles for Synergistic Therapy Against Lung Cancer Cells | Full Text | References | PDF (2.4 MB) | EPUB
  • 217 Views
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Article
Analgesic and Antiallodynic Effects of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain
Naeem Ur Rehman, Mariya al-Rashida, Ahmed Tokhi, Zainab Ahmed, Fazal Subhan, Muzaffar Abbas, Muhammad Awais Arshid & Khalid Rauf
Pages: 4511-4518
Published online: 27 Oct 2020
AbstractforAnalgesic and Antiallodynic Effects of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain | Full Text | References | PDF (3.4 MB) | EPUB
  • 130 Views
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Article
Lung Cancer Combination Treatment: Evaluation of the Synergistic Effect of Cisplatin Prodrug, Vinorelbine and Retinoic Acid When Co-Encapsulated in a Multi-Layered Nano-Platform
Zhen Liang, Juan Li & Budong Zhu
Pages: 4519-4531
Published online: 27 Oct 2020
AbstractforLung Cancer Combination Treatment: Evaluation of the Synergistic Effect of Cisplatin Prodrug, Vinorelbine and Retinoic Acid When Co-Encapsulated in a Multi-Layered Nano-Platform | Full Text | References | PDF (5.3 MB) | EPUB
  • 144 Views
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Article
S-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway
Guang Yang, Shui Sun, Jian Wang, Wei Li, Xianquan Wang, Lin Yuan & Siying Li
Pages: 4533-4546
Published online: 28 Oct 2020
AbstractforS-Allylmercaptocysteine Targets Nrf2 in Osteoarthritis Treatment Through NOX4/NF-κB Pathway | Full Text | References | PDF (11.1 MB) | EPUB
  • 139 Views
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Methodology

Article
Novel Fast and Reliable Method for Nano-Erythrosome Production Using Shear Force
Simona Capossela, Vikas Mathew, Manuela Boos, Alessandro Bertolo, Olga Krupkova & Jivko V Stoyanov
Pages: 4547-4560
Published online: 28 Oct 2020
AbstractforNovel Fast and Reliable Method for Nano-Erythrosome Production Using Shear Force | Full Text | References | PDF (4.6 MB) | EPUB
  • 151 Views
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Original Research

Article
Pseudolaric Acid B Inhibits Proliferation, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma Through Regulating CD147
Zhe Yin, Huarong Cai, Zhiqiang Wang & Yuequan Jiang
Pages: 4561-4573
Published online: 28 Oct 2020
AbstractforPseudolaric Acid B Inhibits Proliferation, Invasion, and Angiogenesis in Esophageal Squamous Cell Carcinoma Through Regulating CD147 | Full Text | References | PDF (14.2 MB) | EPUB
  • 104 Views
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Corrigendum

Correction
Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway [Corrigendum]
Pages: 4575-4577
Published online: 28 Oct 2020
First Page PreviewforAnti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway [Corrigendum] | Full Text | PDF (3.6 MB) | EPUB
  • 57 Views
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Original Research

Article
Osteogenic Effect of tsRNA-10277-Loaded Exosome Derived from Bone Mesenchymal Stem Cells on Steroid-Induced Osteonecrosis of the Femoral Head
Shanhong Fang, Tianmin He, Jiarun Jiang, Yongfeng Li & Peng Chen
Pages: 4579-4591
Published online: 28 Oct 2020
AbstractforOsteogenic Effect of tsRNA-10277-Loaded Exosome Derived from Bone Mesenchymal Stem Cells on Steroid-Induced Osteonecrosis of the Femoral Head | Full Text | References | PDF (6.7 MB) | EPUB
  • 140 Views
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Article
Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway
Motoyasu Kato, Fumiyuki Takahashi, Tadashi Sato, Yoichiro Mitsuishi, Ken Tajima, Hiroaki Ihara, Fariz Nurwidya, Hario Baskoro, Akiko Murakami, Isao Kobayashi, Moulid Hidayat, Naoko Shimada, Shinichi Sasaki, Reiko Mineki, Tsutomu Fujimura, Toshio Kumasaka, Shin-ichiro Niwa & Kazuhisa Takahashi
Pages: 4593-4603
Published online: 29 Oct 2020
AbstractforTranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway | Full Text | References | PDF (6.3 MB) | EPUB
  • 169 Views
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Article
The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice
Liang-Jian Hong, Ai-Jun Chen, Feng-Zeng Li, Ke-Jun Chen & Sheng Fang
Pages: 4605-4612
Published online: 29 Oct 2020
AbstractforThe HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice | Full Text | References | PDF (3.9 MB) | EPUB
  • 91 Views
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Review

Review Article
A Comprehensive Review on Pharmaceutical Film Coating: Past, Present, and Future
Abdel Naser Zaid
Pages: 4613-4623
Published online: 29 Oct 2020
AbstractforA Comprehensive Review on Pharmaceutical Film Coating: Past, Present, and Future | Full Text | References | PDF (1.4 MB) | EPUB
  • 1344 Views
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Original Research

Article
RETRACTED ARTICLE: Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways
Yanran Huang, Jin Chen, Shengdong Yang, Tao Tan, Nan Wang, Yuping Wang, Lulu Zhang, Chunmei Yang, Huakun Huang, Jinyong Luo & Xiaoji Luo
Pages: 4625-4637
Published online: 30 Oct 2020
AbstractforRETRACTED ARTICLE: Cinnamaldehyde Inhibits the Function of Osteosarcoma by Suppressing the Wnt/β-Catenin and PI3K/Akt Signaling Pathways | PDF (15.7 MB)
  • 118 Views
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Article
Stoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells
Jamal Moideen Muthu Mohamed, Ali Alqahtani, Fazil Ahmad, V Krishnaraju & K Kalpana
Pages: 4639-4658
Published online: 02 Nov 2020
AbstractforStoichiometrically Governed Curcumin Solid Dispersion and Its Cytotoxic Evaluation on Colorectal Adenocarcinoma Cells | Full Text | References | PDF (7.2 MB) | EPUB
  • 152 Views
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Article
Pristimerin Suppresses Trophoblast Cell Epithelial–Mesenchymal Transition via miR-542-5p/EGFR Axis
Chang Shu, Xiaowei Yu, Shihuan Cheng, Jili Jing, Cong Hu & Bo Pang
Pages: 4659-4670
Published online: 02 Nov 2020
AbstractforPristimerin Suppresses Trophoblast Cell Epithelial–Mesenchymal Transition via miR-542-5p/EGFR Axis | Full Text | References | PDF (6.3 MB) | EPUB
  • 94 Views
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Article
The Effects of Short-Chain Fatty Acids on Rat Colonic Hypermotility Induced by Water Avoidance Stress
FangTing Yuan, Wei Tan, HaiXia Ren, Lin Yan, Ying Wang & HeSheng Luo
Pages: 4671-4684
Published online: 02 Nov 2020
AbstractforThe Effects of Short-Chain Fatty Acids on Rat Colonic Hypermotility Induced by Water Avoidance Stress | Full Text | References | PDF (8.3 MB) | EPUB
  • 157 Views
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Article
In vitro and in vivo Effects of Artesunate on Echinococcus granulosus Protoscoleces and Metacestodes
Limei Wen, Guodong Lv, Jun Zhao, Shuai Lu, Yuehong Gong, Yafen Li, Haiya Zheng, Bei Chen, Huijing Gao, Chunyan Tian & Jianhua Wang
Pages: 4685-4694
Published online: 02 Nov 2020
AbstractforIn vitro and in vivo Effects of Artesunate on Echinococcus granulosus Protoscoleces and Metacestodes | Full Text | References | PDF (3.9 MB) | EPUB
  • 108 Views
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Article
Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study
He Zhu, Aolin Ren, Kang Zhou, Qiuchong Chen, Mengjun Zhang & Jindong Liu
Pages: 4695-4701
Published online: 02 Nov 2020
AbstractforImpact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study | Full Text | References | PDF (1.3 MB) | EPUB
  • 120 Views
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Article
Cerebral Oxygen Changes in Neonates During Immediate Transition After Birth and Early Life: An Observational Study
Hang Xue, Ziyi Wu, Jiaxin Yao, Anqi Zhao, Lanlan Zheng, Xiao Yin, Fang Wang & Ping Zhao
Pages: 4703-4715
Published online: 02 Nov 2020
AbstractforCerebral Oxygen Changes in Neonates During Immediate Transition After Birth and Early Life: An Observational Study | Full Text | References | PDF (1.3 MB) | EPUB
  • 87 Views
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Clinical Trial Report

Case Report
Interaction of Analgesic Effects of Dezocine and Sufentanil for Relief of Postoperative Pain: A Pilot Study
He Zhu, Yaobing Chen, Shaoqiang Huang & Xingfeng Sun
Pages: 4717-4724
Published online: 03 Nov 2020
AbstractforInteraction of Analgesic Effects of Dezocine and Sufentanil for Relief of Postoperative Pain: A Pilot Study | Full Text | References | PDF (2.5 MB) | EPUB
  • 106 Views
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Original Research

Article
Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model
Chao Yu, Ping Li, Yan-Xiu Wang, Kai-Gang Zhang, Zun-Cheng Zheng & Li-Shuang Liang
Pages: 4725-4733
Published online: 04 Nov 2020
AbstractforSanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model | Full Text | References | PDF (9.4 MB) | EPUB
  • 137 Views
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Review

Review Article
Pharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases
Rui Guo, Lan Li, Jing Su, Sheng Li, Sophia Esi Duncan, Zhihao Liu & Guanwei Fan
Pages: 4735-4748
Published online: 05 Nov 2020
AbstractforPharmacological Activity and Mechanism of Tanshinone IIA in Related Diseases | Full Text | References | PDF (1.5 MB) | EPUB
  • 613 Views
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Original Research

Article
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy
Yanyu Zhang, Ning Huang, Jie Xu, Wei Zheng & Xing Cui
Pages: 4749-4763
Published online: 05 Nov 2020
AbstractforHomoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy | Full Text | References | PDF (8.4 MB) | EPUB
  • 85 Views
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Article
Effects of Snake-Derived Phospholipase A2 Inhibitors on Acute Pancreatitis: In vitro and in vivo Characterization
Yanping Wu, Gen-You Liao, Hua-Jing Ke & Pi Liu
Pages: 4765-4774
Published online: 06 Nov 2020
AbstractforEffects of Snake-Derived Phospholipase A2 Inhibitors on Acute Pancreatitis: In vitro and in vivo Characterization | Full Text | References | PDF (8.5 MB) | EPUB
  • 95 Views
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Review

Review Article
SGLT2 Inhibitors: A Novel Player in the Treatment and Prevention of Diabetic Cardiomyopathy
Na Li & Hong Zhou
Pages: 4775-4788
Published online: 06 Nov 2020
AbstractforSGLT2 Inhibitors: A Novel Player in the Treatment and Prevention of Diabetic Cardiomyopathy | Full Text | References | PDF (2.5 MB) | EPUB
  • 393 Views
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Original Research

Article
LncRNA KCNQ1OT1 Sponges miR-206 to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF
Yao Yao, Xuesong Wang & Jin Gao
Pages: 4789-4800
Published online: 09 Nov 2020
AbstractforLncRNA KCNQ1OT1 Sponges miR-206 to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF | Full Text | References | PDF (5.2 MB) | EPUB
  • 108 Views
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Article
Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo
Hao Wang, Zengxin Jiang, Zhiying Pang, Tianyao Zhou & Yutong Gu
Pages: 4801-4813
Published online: 10 Nov 2020
AbstractforAcacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo | Full Text | References | PDF (7.6 MB) | EPUB
  • 162 Views
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Article
In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine
Feifei Chen, Hui Jiang, Jia Xu, Shuanghu Wang, Deru Meng, Peiwu Geng, Dapeng Dai, Quan Zhou & Yunfang Zhou
Pages: 4815-4824
Published online: 10 Nov 2020
AbstractforIn Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine | Full Text | References | PDF (2.5 MB) | EPUB
  • 295 Views
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Article
Intermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats
Yanhong Wang, Yang Mi, Jihua Tian, Xi Qiao, Xiaole Su, Jing Kang, Zhijing Wu, Guiqing Wang, Xiaoshuang Zhou, Yun Zhou & Rongshan Li
Pages: 4825-4834
Published online: 10 Nov 2020
AbstractforIntermedin Alleviates Renal Ischemia-Reperfusion Injury and Enhances Neovascularization in Wistar Rats | Full Text | References | PDF (10.6 MB) | EPUB
  • 92 Views
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Article
Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia
Le-jing Lian, Bin Lin, Xiao Cui, Jie He, Zhe Wang, Xiao-dong Lin, Wei-jian Ye, Rui-jie Chen & Wei Sun
Pages: 4835-4843
Published online: 10 Nov 2020
AbstractforDevelopment and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia | Full Text | References | PDF (2.1 MB) | EPUB
  • 143 Views
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Article
Downregulation of miR-200a Protects Mouse Leydig Cells Against Triptolide by Triggering Autophagy
Hui Miao, Congxiu Miao, Jing Han & Na Li
Pages: 4845-4854
Published online: 10 Nov 2020
AbstractforDownregulation of miR-200a Protects Mouse Leydig Cells Against Triptolide by Triggering Autophagy | Full Text | References | PDF (5.3 MB) | EPUB
  • 94 Views
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Review

Review Article
Indole: The After Next Scaffold of Antiplasmodial Agents?
Abdrrahman Shemsu Surur, Solomon Assefa Huluka, Melese Legesse Mitku & Kaleab Asres
Pages: 4855-4867
Published online: 11 Nov 2020
AbstractforIndole: The After Next Scaffold of Antiplasmodial Agents? | Full Text | References | PDF (2.1 MB) | EPUB
  • 184 Views
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Original Research

Article
Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation
Ekaterina Vladimirovna Silina, Natalia Evgenievna Manturova, Petr Frantsevich Litvitskiy & Victor Aleksandrovich Stupin
Pages: 4869-4883
Published online: 12 Nov 2020
AbstractforComparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation | Full Text | References | PDF (6.5 MB) | EPUB
  • 105 Views
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Article
iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment
Yi Jiang, Yingxue Bian, Naqi Lian, Yaoqi Wang, Keliang Xie, Chao Qin & Yonghao Yu
Pages: 4885-4900
Published online: 12 Nov 2020
AbstractforiTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment | Full Text | References | PDF (11.5 MB) | EPUB
  • 109 Views
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Article
Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway
Cancan Huang, Chaotao Zhang, Panpan Yang, Rui Chao, Ziqi Yue, Congshan Li, Jie Guo & Minqi Li
Pages: 4901-4913
Published online: 13 Nov 2020
AbstractforEldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway | Full Text | References | PDF (6.6 MB) | EPUB
  • 205 Views
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Review

Review Article
HIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases
Ruo-Lan Li, Li-Ying He, Qing Zhang, Jia Liu, Feng Lu, Hu-Xin-Yue Duan, Lin-Hong Fan, Wei Peng, Yong-Liang Huang & Chun-Jie Wu
Pages: 4915-4949
Published online: 16 Nov 2020
AbstractforHIF-1α is a Potential Molecular Target for Herbal Medicine to Treat Diseases | Full Text | References | PDF (7 MB) | EPUB
  • 214 Views
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Original Research

Article
Chrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway
Chuan Guo, Yarong Wang, Yuanlin Piao, Xiangrong Rao & Dehai Yin
Pages: 4951-4962
Published online: 16 Nov 2020
AbstractforChrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway | Full Text | References | PDF (7.3 MB) | EPUB
  • 101 Views
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Review

Review Article
Palmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review
Sophia Ogechi Ekeuku, Kok-Lun Pang & Kok-Yong Chin
Pages: 4963-4974
Published online: 17 Nov 2020
AbstractforPalmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review | Full Text | References | PDF (1.6 MB) | EPUB
  • 233 Views
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Original Research

Article
Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology
Lingyun Gao, Yang Zhang, Huangfang Xu, Fangui Zhao & Wenjun Wang
Pages: 4975-4992
Published online: 17 Nov 2020
AbstractforTherapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology | Full Text | References | PDF (13.5 MB) | EPUB
  • 125 Views
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Article
Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates
Jing-Fang Shi, Ping Wu, Xiao-Li Cheng, Xiao-Yi Wei & Zi-Hua Jiang
Pages: 4993-5004
Published online: 17 Nov 2020
AbstractforSynthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates | Full Text | References | PDF (2.4 MB) | EPUB
  • 115 Views
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Article
Efficacy and Safety of Nebivolol and Rosuvastatin Combination Treatment in Patients with Concomitant Hypertension and Hyperlipidemia
Moo-Yong Rhee, Cheol Ho Kim, Youngkeun Ahn, Joon-Han Shin, Seung Hwan Han, Hyun-Jae Kang, Soon Jun Hong & Hae-Young Kim
Pages: 5005-5017
Published online: 17 Nov 2020
AbstractforEfficacy and Safety of Nebivolol and Rosuvastatin Combination Treatment in Patients with Concomitant Hypertension and Hyperlipidemia | Full Text | References | PDF (1.8 MB) | EPUB
  • 271 Views
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Article
Casticin Improves Respiratory Dysfunction and Attenuates Oxidative Stress and Inflammation via Inhibition of NF-ĸB in a Chronic Obstructive Pulmonary Disease Model of Chronic Cigarette Smoke-Exposed Rats
Jie Li, Chen Qiu, Peng Xu, Yongzhen Lu & Rongchang Chen
Pages: 5019-5027
Published online: 17 Nov 2020
AbstractforCasticin Improves Respiratory Dysfunction and Attenuates Oxidative Stress and Inflammation via Inhibition of NF-ĸB in a Chronic Obstructive Pulmonary Disease Model of Chronic Cigarette Smoke-Exposed Rats | Full Text | References | PDF (2.5 MB) | EPUB
  • 147 Views
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Article
Efficacy and Safety of Supplemental Transarterial Chemoembolization Through Extrahepatic Collateral Arteries with Drug-eluting Beads: Treatment for Unresectable Hepatocellular Carcinoma
Sung-Hua Chiu, Ping-Ying Chang, Yu-Lueng Shih, Wen-Yen Huang, Kai-Hsiung Ko, Wei-Chou Chang & Guo-Shu Huang
Pages: 5029-5041
Published online: 17 Nov 2020
AbstractforEfficacy and Safety of Supplemental Transarterial Chemoembolization Through Extrahepatic Collateral Arteries with Drug-eluting Beads: Treatment for Unresectable Hepatocellular Carcinoma | Full Text | References | PDF (5 MB) | EPUB
  • 87 Views
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Corrigendum

Correction
Paeoniflorin Improves Cardiac Function and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Rat Model of Acute Myocardial Infarction [Corrigendum]
Page: 5043
Published online: 18 Nov 2020
CitationforPaeoniflorin Improves Cardiac Function and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Rat Model of Acute Myocardial Infarction [Corrigendum] | Full Text | PDF (591.1 KB) | EPUB
  • 66 Views
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Review

Review Article
Repurposing Anti-Cancer Drugs for COVID-19 Treatment
Nicholas Borcherding, Yogesh Jethava & Praveen Vikas
Pages: 5045-5058
Published online: 18 Nov 2020
AbstractforRepurposing Anti-Cancer Drugs for COVID-19 Treatment | Full Text | References | PDF (1.3 MB) | EPUB
  • 257 Views
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Original Research

Article
QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia
Anita Kovács, Nikolett Kis, Mária Budai-Szűcs, Attila Gácsi, Erzsébet Csányi, Ildikó Csóka & Szilvia Berkó
Pages: 5059-5076
Published online: 18 Nov 2020
AbstractforQbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia | Full Text | References | PDF (6 MB) | EPUB
  • 249 Views
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Article
Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation
Shubin Wang, Binhui Lin, Wei Liu, Guojun Wei, Zongguang Li, Naichun Yu, Xiang Xue & Guangrong Ji
Pages: 5077-5085
Published online: 18 Nov 2020
AbstractforAcacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation | Full Text | References | PDF (3.2 MB) | EPUB
  • 148 Views
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Article
Loxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs)
Chuanzhao Ji, Yang Yu, Min Zhang, Wenyan Yu & Shuo Dong
Pages: 5087-5096
Published online: 18 Nov 2020
AbstractforLoxoprofen Sodium Alleviates Oxidative Stress and Apoptosis Induced by Angiotensin II in Human Umbilical Vein Endothelial Cells (HUVECs) | Full Text | References | PDF (4 MB) | EPUB
  • 150 Views
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Article
COVID-19 Clinical Trials Registered Worldwide for Drug Intervention: An Overview and Characteristic Analysis
Bin Wang, Junkai Lai, Xiaoyan Yan, Feifei Jin, Bin Yi, Caixia An, Yuanxiao Li & Chen Yao
Pages: 5097-5108
Published online: 19 Nov 2020
AbstractforCOVID-19 Clinical Trials Registered Worldwide for Drug Intervention: An Overview and Characteristic Analysis | Full Text | References | PDF (2 MB) | EPUB
  • 175 Views
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Article
Research on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology
Yanxia Huang, Jiatong Lin, Weimin Yi, Qinghua Liu, Linhui Cao, Yongcong Yan, Anqi Fu, Tingxuan Huang, Yingcheng Lyu, Qihui Huang & Jie Wang
Pages: 5109-5118
Published online: 23 Nov 2020
AbstractforResearch on the Potential Mechanism of Gentiopicroside Against Gastric Cancer Based on Network Pharmacology | Full Text | References | PDF (5.9 MB) | EPUB
  • 170 Views
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Article
In vitro Comparative Quality Assessment of Different Brands of Furosemide Tablets Marketed in Northwest Ethiopia
Simachew Abebe, Gebremariam Ketema & Haile Kassahun
Pages: 5119-5128
Published online: 24 Nov 2020
AbstractforIn vitro Comparative Quality Assessment of Different Brands of Furosemide Tablets Marketed in Northwest Ethiopia | Full Text | References | PDF (499.1 KB) | EPUB
  • 680 Views
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Article
Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism
Peng-fei Tang, Xiang Zheng, Xiao-xia Hu, Cheng-cheng Yang, Zhe Chen, Jian-chang Qian, Jian-ping Cai & Guo-xin Hu
Pages: 5129-5141
Published online: 24 Nov 2020
AbstractforFunctional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism | Full Text | References | PDF (3.2 MB) | EPUB
  • 212 Views
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Article
Agonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B)
Chengkuan Sun, Yulin Li, Xianglan Li & Jing Sun
Pages: 5143-5153
Published online: 24 Nov 2020
AbstractforAgonism of Gpr40 Protects the Capacities of Epidermal Stem Cells (ESCs) Against Ultraviolet-B (UV-B) | Full Text | References | PDF (4.7 MB) | EPUB
  • 112 Views
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Article
Activation of PI3K/Akt/HIF-1α Signaling is Involved in Lung Protection of Dexmedetomidine in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Pilot Study
Linjia Zhu, Yang Zhang, Zhenfeng Zhang, Xiahao Ding, Chanjuan Gong & Yanning Qian
Pages: 5155-5166
Published online: 24 Nov 2020
AbstractforActivation of PI3K/Akt/HIF-1α Signaling is Involved in Lung Protection of Dexmedetomidine in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Pilot Study | Full Text | References | PDF (4.8 MB) | EPUB
  • 80 Views
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Article
Comparison of Bioavailability and Bioequivalence of Generic and Brand Name Formulations of Escitalopram Oxalate Tablets in Healthy Chinese Population Under Fasting and Fed Conditions
Qiuying Li, Hua Huo, Wenli Hu, Yin Sui & Yunbiao Tang
Pages: 5167-5177
Published online: 24 Nov 2020
AbstractforComparison of Bioavailability and Bioequivalence of Generic and Brand Name Formulations of Escitalopram Oxalate Tablets in Healthy Chinese Population Under Fasting and Fed Conditions | Full Text | References | PDF (1,003.6 KB) | EPUB
  • 351 Views
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Article
Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects
Hyounggyoon Yoo, Yun Kim, In-Jin Jang, Kyung-Sang Yu & SeungHwan Lee
Pages: 5179-5187
Published online: 24 Nov 2020
AbstractforPharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects | Full Text | References | PDF (2.5 MB) | EPUB
  • 158 Views
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Article
In Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin
Charlaine A Aventurado, Junie B Billones, Ross D Vasquez & Agnes L Castillo
Pages: 5189-5204
Published online: 25 Nov 2020
AbstractforIn Ovo and In Silico Evaluation of the Anti-Angiogenic Potential of Syringin | Full Text | References | PDF (5.7 MB) | EPUB
  • 255 Views
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Article
Synergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and pH Sensitive Nanocarriers
Yonglong Jin, Yi Wang, Xiguang Liu, Jing Zhou, Xintong Wang, Hui Feng & Hong Liu
Pages: 5205-5215
Published online: 25 Nov 2020
AbstractforSynergistic Combination Chemotherapy of Lung Cancer: Cisplatin and Doxorubicin Conjugated Prodrug Loaded, Glutathione and pH Sensitive Nanocarriers | Full Text | References | PDF (3.4 MB) | EPUB
  • 216 Views
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Article
Quality by Design (QbD)-Based Numerical and Graphical Optimization Technique for the Development of Osmotic Pump Controlled-Release Metoclopramide HCl Tablets
Sadaf Farooqi, Rabia Ismail Yousuf, Muhammad Harris Shoaib, Kamran Ahmed, Sabah Ansar & Tazeen Husain
Pages: 5217-5234
Published online: 26 Nov 2020
AbstractforQuality by Design (QbD)-Based Numerical and Graphical Optimization Technique for the Development of Osmotic Pump Controlled-Release Metoclopramide HCl Tablets | Full Text | References | PDF (7.1 MB) | EPUB
  • 391 Views
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Article
Prediction of Targets of Curculigoside A in Osteoporosis and Rheumatoid Arthritis Using Network Pharmacology and Experimental Verification
Jiawen Han, Minjie Wan, Zhanchuan Ma, Cong Hu & Huanfa Yi
Pages: 5235-5250
Published online: 26 Nov 2020
AbstractforPrediction of Targets of Curculigoside A in Osteoporosis and Rheumatoid Arthritis Using Network Pharmacology and Experimental Verification | Full Text | References | PDF (7.7 MB) | EPUB
  • 289 Views
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Article
Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells
Hongfang Li, Yunyan Tang, Yang Wang, Weipeng Wei, Chengchen Yin & Fushang Tang
Pages: 5251-5258
Published online: 26 Nov 2020
AbstractforEffects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells | Full Text | References | PDF (2.3 MB) | EPUB
  • 121 Views
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Article
Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach
Ali S Abdelhameed, Mohamed W Attwa & Adnan A Kadi
Pages: 5259-5273
Published online: 30 Nov 2020
AbstractforCharacterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach | Full Text | References | PDF (9.6 MB) | EPUB
  • 141 Views
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Article
Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats
Emad H M Hassanein, Omnia A M Abd El-Ghafar, Marwa A Ahmed, Ahmed M Sayed, Wail M Gad-Elrab, Jamaan S Ajarem, Ahmed A Allam & Ayman M Mahmoud
Pages: 5275-5288
Published online: 30 Nov 2020
AbstractforEdaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats | Full Text | References | PDF (11.4 MB) | EPUB
  • 383 Views
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Article
Adjuvant Vaginal Use of Sildenafil Citrate in a Hormone Replacement Cycle Improved Live Birth Rates Among 10,069 Women During First Frozen Embryo Transfers
Yu Tao & Ningling Wang
Pages: 5289-5297
Published online: 01 Dec 2020
AbstractforAdjuvant Vaginal Use of Sildenafil Citrate in a Hormone Replacement Cycle Improved Live Birth Rates Among 10,069 Women During First Frozen Embryo Transfers | Full Text | References | PDF (302.2 KB) | EPUB
  • 189 Views
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Article
Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF
Karem H Alzoubi, Laila Abdel-Hafiz, Omar F Khabour, Tamam El-Elimat, Mohammad A Alzubi & Feras Q Alali
Pages: 5299-5314
Published online: 01 Dec 2020
AbstractforEvaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF | Full Text | References | PDF (5 MB) | EPUB
  • 198 Views
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Article
Cytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition
Kaiqiang Li, Lingling Wu, Yili Chen, Yuanyuan Li, Qianni Wang, Min Li, Ke Hao, Wei Zhang, Shanshan Jiang & Zhen Wang
Pages: 5315-5324
Published online: 01 Dec 2020
AbstractforCytotoxic and Antiproliferative Effects of β-Mangostin on Rat C6 Glioma Cells Depend on Oxidative Stress Induction via PI3K/AKT/mTOR Pathway Inhibition | Full Text | References | PDF (6.3 MB) | EPUB
  • 146 Views
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Article
Modulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation
Afrasim Moin, Hosahalli V Gangadharappa, Mohd Adnan, Syed M Rizvi, Syed A Ashraf, Mitesh Patel, Amr S Abu Lila & Ahmed N Allam
Pages: 5325-5336
Published online: 01 Dec 2020
AbstractforModulation of Drug Release from Natural Polymer Matrices by Response Surface Methodology: in vitro and in vivo Evaluation | Full Text | References | PDF (4.8 MB) | EPUB
  • 160 Views
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Article
Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling
Qicen Yao, Qingchao Wu, Xiayu Xu, Yixi Xing, Jin Liang, Qianqi Lin, Meiqiong Huang, Yiling Chen, Bo Lin & Weifei Chen
Pages: 5337-5348
Published online: 02 Dec 2020
AbstractforResveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling | Full Text | References | PDF (8.3 MB) | EPUB
  • 179 Views
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Article
The Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes
Guang Wang, Bing Wu, Wenzhou Xu, Xuefei Jin, Kun Wang & Heyuan Wang
Pages: 5349-5357
Published online: 02 Dec 2020
AbstractforThe Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes | Full Text | References | PDF (4.2 MB) | EPUB
  • 190 Views
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Article
The Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced by Helicobacter pylori Infection
Sophia Ogechi Ekeuku, Benjamin Ka Seng Thong, Adam Quraisiah, Fazalda Annuar, Alfizah Hanafiah, Mohd Fahami Nur Azlina & Kok-Yong Chin
Pages: 5359-5366
Published online: 03 Dec 2020
AbstractforThe Skeletal Effects of Short-Term Triple Therapy in a Rat Model of Gastric Ulcer Induced by Helicobacter pylori Infection | Full Text | References | PDF (4.4 MB) | EPUB
  • 107 Views
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Article
Safety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention
Giuseppe Derosa, Angela D’Angelo, Paola Preti & Pamela Maffioli
Pages: 5367-5374
Published online: 03 Dec 2020
AbstractforSafety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention | Full Text | References | PDF (282.9 KB) | EPUB
  • 326 Views
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Review

Review Article
Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives
Sang Yeul Lee, Chul Young Kim & Tae-Gyu Nam
Pages: 5375-5392
Published online: 03 Dec 2020
AbstractforRuthenium Complexes as Anticancer Agents: A Brief History and Perspectives | Full Text | References | PDF (6.7 MB) | EPUB
  • 2403 Views
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Original Research

Article
Design and Development of a Behaviorally Active Recombinant Neurotrophic Factor
Nicholas J Pekas, Jason L Petersen, Monica Sathyanesan & Samuel S Newton
Pages: 5393-5403
Published online: 04 Dec 2020
AbstractforDesign and Development of a Behaviorally Active Recombinant Neurotrophic Factor | Full Text | References | PDF (6.8 MB) | EPUB
  • 97 Views
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Article
Mini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study
Dalia A Gaber, Hessah S Alhawas, Fatimah A Alfadhel, Siham A Abdoun, Amal M Alsubaiyel & Rehab M Alsawi
Pages: 5405-5418
Published online: 07 Dec 2020
AbstractforMini-Tablets versus Nanoparticles for Controlling the Release of Amoxicillin: In vitro/In vivo Study | Full Text | References | PDF (2.7 MB) | EPUB
  • 194 Views
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Article
Neohesperidin Ameliorates Steroid-Induced Osteonecrosis of the Femoral Head by Inhibiting the Histone Modification of lncRNA HOTAIR
Shuai Yuan, Chuanxin Zhang, Yunli Zhu & Bo Wang
Pages: 5419-5430
Published online: 07 Dec 2020
AbstractforNeohesperidin Ameliorates Steroid-Induced Osteonecrosis of the Femoral Head by Inhibiting the Histone Modification of lncRNA HOTAIR | Full Text | References | PDF (6 MB) | EPUB
  • 107 Views
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Article
Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway
Chuanhao Jiang, Ning Xie, Taoli Sun, Wanjun Ma, Bikui Zhang & Wenqun Li
Pages: 5431-5439
Published online: 07 Dec 2020
AbstractforXanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway | Full Text | References | PDF (3.9 MB) | EPUB
  • 95 Views
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Clinical Trial Report

Case Report
Budesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus As-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in pAtients without Optimally Controlled asThma (REACT) Study
Shih-Lung Cheng, Ming-Lin Ho, Yun-Fa Lai, Hao-Chien Wang, Jeng-Yuan Hsu, Shih-Feng Liu, Ming-Shyang Huang, Cheng-Hung Lee, Ching-Hsiung Lin, Liang-Wen Hang, Yu-Chih Liu, Kuang-Yao Yang & Jia-Horng Wang
Pages: 5441-5450
Published online: 08 Dec 2020
AbstractforBudesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus As-Needed, Short-Acting β2 Agonist: Real-World Effectiveness in pAtients without Optimally Controlled asThma (REACT) Study | Full Text | References | PDF (319.4 KB) | EPUB
  • 313 Views
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Original Research

Article
The Median Effective Dose of Oxytocin Needed to Prevent Uterine Atony During Cesarean Delivery in Elderly Parturients
Chang Na Wei, Jia Li Deng, Jin Hua Dong, Ze Peng Ping & Xin Zhong Chen
Pages: 5451-5458
Published online: 08 Dec 2020
AbstractforThe Median Effective Dose of Oxytocin Needed to Prevent Uterine Atony During Cesarean Delivery in Elderly Parturients | Full Text | References | PDF (312.1 KB) | EPUB
  • 210 Views
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Article
Live-Birth Outcomes and Congenital Malformations After Progestin-Primed Ovarian Stimulation in Maternal Endometriosis
Zhou Liang, Yun Wang & Yanping Kuang
Pages: 5459-5467
Published online: 10 Dec 2020
AbstractforLive-Birth Outcomes and Congenital Malformations After Progestin-Primed Ovarian Stimulation in Maternal Endometriosis | Full Text | References | PDF (1.5 MB) | EPUB
  • 180 Views
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Article
Naringenin Prevents Propofol Induced Neurodegeneration in Neonatal Mice Brain and Long-Term Neurocognitive Impacts on Adults
Lili Zou, Mingliang Ning, Wenjuan Wang, Yuemei Zheng, Liping Ma & Jing Lv
Pages: 5469-5482
Published online: 10 Dec 2020
AbstractforNaringenin Prevents Propofol Induced Neurodegeneration in Neonatal Mice Brain and Long-Term Neurocognitive Impacts on Adults | Full Text | References | PDF (3.8 MB) | EPUB
  • 115 Views
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Review

Review Article
Chronic Rhinosinusitis with Nasal Polyps: Targeting IgE with Anti-IgE Omalizumab Therapy
Harsha H Kariyawasam & Louisa K James
Pages: 5483-5494
Published online: 10 Dec 2020
AbstractforChronic Rhinosinusitis with Nasal Polyps: Targeting IgE with Anti-IgE Omalizumab Therapy | Full Text | References | PDF (2.9 MB) | EPUB
  • 345 Views
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Review Article
A Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes
Meilin Zhang, Ying Du, Shujun Wang & Baoan Chen
Pages: 5495-5503
Published online: 14 Dec 2020
AbstractforA Review of Biomimetic Nanoparticle Drug Delivery Systems Based on Cell Membranes | Full Text | References | PDF (1.8 MB) | EPUB
  • 471 Views
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Original Research

Article
Ulinastatin Inhibits the Proliferation, Invasion and Phenotypic Switching of PDGF-BB-Induced VSMCs via Akt/eNOS/NO/cGMP Signaling Pathway
Cheng Huang, Weihui Huang, Rui Wang & Yongli He
Pages: 5505-5514
Published online: 14 Dec 2020
AbstractforUlinastatin Inhibits the Proliferation, Invasion and Phenotypic Switching of PDGF-BB-Induced VSMCs via Akt/eNOS/NO/cGMP Signaling Pathway | Full Text | References | PDF (10.4 MB) | EPUB
  • 92 Views
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Article
The Effect of Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) on Liver Enzymes, Glucose, and Lipid Profile
Nicola Squillace, Elena Ricci, Barbara Menzaghi, Giuseppe Vittorio De Socio, Simone Passerini, Canio Martinelli, Maria Sabrina Mameli, Paolo Maggi, Katia Falasca, Laura Cordier, Benedetto Maurizio Celesia, Elena Salomoni, Antonio Di Biagio, Giovanni Francesco Pellicanò, Paolo Bonfanti & On behalf of the CISAI Study Group
Pages: 5515-5520
Published online: 15 Dec 2020
AbstractforThe Effect of Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) on Liver Enzymes, Glucose, and Lipid Profile | Full Text | References | PDF (288 KB) | EPUB
  • 240 Views
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Article
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis
Jinsong Kong, Jiacheng Wang, Xiaokang Gong, Xin Zheng & Tao Chen
Pages: 5521-5533
Published online: 15 Dec 2020
AbstractforPunicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis | Full Text | References | PDF (7.6 MB) | EPUB
  • 135 Views
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Article
Super Activated Platelet Lysate, a Novel Autologous Platelet Lysate, Regulates the Expression of Inflammasome and Cytokine in the Experimental Periodontitis in Rats
Yi Zhang, Deshu Zhuang, Yi Zhang, Huiying Lu, Haijiao Zhang, Tingting Li & Liangjia Bi
Pages: 5535-5543
Published online: 15 Dec 2020
AbstractforSuper Activated Platelet Lysate, a Novel Autologous Platelet Lysate, Regulates the Expression of Inflammasome and Cytokine in the Experimental Periodontitis in Rats | Full Text | References | PDF (3.3 MB) | EPUB
  • 114 Views
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Corrigendum

Correction
The Drug Efficacy and Adverse Reactions in a Mouse Model of Oral Squamous Cell Carcinoma Treated with Oxaliplatin at Different Time Points During a Day [Corrigendum]
Page: 5545
Published online: 16 Dec 2020
CitationforThe Drug Efficacy and Adverse Reactions in a Mouse Model of Oral Squamous Cell Carcinoma Treated with Oxaliplatin at Different Time Points During a Day [Corrigendum] | Full Text | PDF (412.1 KB) | EPUB
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Original Research

Article
4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation
Yang Li, Xing Chen, Hua Zhang, Jie Xiao, Chuanlei Yang, Weiqiang Chen, Zhanjie Wei, Xinzhong Chen & Jinping Liu
Pages: 5547-5558
Published online: 17 Dec 2020
Abstractfor4-Octyl Itaconate Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting Oxidative Stress and Inflammation | Full Text | References | PDF (8.9 MB) | EPUB
  • 257 Views
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Review

Review Article
Brexpiprazole for the Treatment of Schizophrenia in Adults: An Overview of Its Clinical Efficacy and Safety and a Psychiatrist’s Perspective
Yoshinori Watanabe, Sakiko Yamada, Tempei Otsubo & Toshiaki Kikuchi
Pages: 5559-5574
Published online: 18 Dec 2020
AbstractforBrexpiprazole for the Treatment of Schizophrenia in Adults: An Overview of Its Clinical Efficacy and Safety and a Psychiatrist’s Perspective | Full Text | References | PDF (2.1 MB) | EPUB
  • 481 Views
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Original Research

Article
Beneficial Effects of Echinacoside on Diabetic Cardiomyopathy in Diabetic Db/Db Mice
Xiang Zhang & Yarong Hao
Pages: 5575-5587
Published online: 18 Dec 2020
AbstractforBeneficial Effects of Echinacoside on Diabetic Cardiomyopathy in Diabetic Db/Db Mice | Full Text | References | PDF (5.5 MB) | EPUB
  • 114 Views
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Article
Agomelatine Attenuates Isoflurane-Induced Inflammation and Damage in Brain Endothelial Cells
Fang Cheng, Huanxian Chang, Fengfeng Yan, Aixing Yang, Jing Liu & Yuliang Liu
Pages: 5589-5598
Published online: 18 Dec 2020
AbstractforAgomelatine Attenuates Isoflurane-Induced Inflammation and Damage in Brain Endothelial Cells | Full Text | References | PDF (4.5 MB) | EPUB
  • 119 Views
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Article
Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157
Hailu Wu, Ming Wei, Nan Li, Qin Lu, Sachin Mulmi Shrestha, Jiacheng Tan, Zhenyu Zhang, Guoqiu Wu & Ruihua Shi
Pages: 5599-5610
Published online: 21 Dec 2020
AbstractforClopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157 | Full Text | References | PDF (7.7 MB) | EPUB
  • 143 Views
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Article
Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice
Dong Liu, Yanjun Chen, Fang Li, Cunwu Chen, Peipei Wei, Deli Xiao & Bangxin Han
Pages: 5611-5622
Published online: 22 Dec 2020
AbstractforSinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice | Full Text | References | PDF (6.7 MB) | EPUB
  • 101 Views
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Article
Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine
Xuan Zou, Yang Wang, Yuheng Wang, Junting Yang, Huishu Guo & Zhengxu Cai
Pages: 5623-5632
Published online: 22 Dec 2020
AbstractforPaeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine | Full Text | References | PDF (5.6 MB) | EPUB
  • 144 Views
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Article
Magnesium Isoglycyrrhizinate Induces an Inhibitory Effect on Progression and Epithelial–Mesenchymal Transition of Laryngeal Cancer via the NF-κB/Twist Signaling
Jiarui Zhang, Rui Zhao, Dongliang Xing, Jing Cao, Yan Guo, Liang Li, Yanan Sun, Linli Tian & Ming Liu
Pages: 5633-5644
Published online: 22 Dec 2020
AbstractforMagnesium Isoglycyrrhizinate Induces an Inhibitory Effect on Progression and Epithelial–Mesenchymal Transition of Laryngeal Cancer via the NF-κB/Twist Signaling | Full Text | References | PDF (5.6 MB) | EPUB
  • 101 Views
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Article
Preventive Effect of Lactobacillus acidophilus XY27 on DSS-Induced Ulcerative Colitis in Mice
Tiantian Hu, Hongxia Wang, Chengzheng Xiang, Jianfei Mu & Xin Zhao
Pages: 5645-5657
Published online: 22 Dec 2020
AbstractforPreventive Effect of Lactobacillus acidophilus XY27 on DSS-Induced Ulcerative Colitis in Mice | Full Text | References | PDF (7.7 MB) | EPUB
  • 353 Views
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Article
Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia
Yuzhao Sun & Rui Hua
Pages: 5659-5665
Published online: 22 Dec 2020
AbstractforLong-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia | Full Text | References | PDF (762.1 KB) | EPUB
  • 108 Views
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Article
Curcumin- and Cyclopamine-Loaded Liposomes to Enhance Therapeutic Efficacy Against Hepatic Fibrosis
Ting Zhang, Yanping Li, Yi Song, Xiaoshuang Chen, Jing Li, Qiang Peng, Jinhan He & Xiaofan Fei
Pages: 5667-5678
Published online: 23 Dec 2020
AbstractforCurcumin- and Cyclopamine-Loaded Liposomes to Enhance Therapeutic Efficacy Against Hepatic Fibrosis | Full Text | References | PDF (5.7 MB) | EPUB
  • 107 Views
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Article
Intravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with Urosepsis
Hyeok Jun Goh, Ki Soo Lee, Tae Hyo Kim, Kyu Nam Kim, Hyun Jin Lim, Kyu Shik Kim, Won Jae Yang & Jung Ki Jo
Pages: 5679-5687
Published online: 23 Dec 2020
AbstractforIntravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with Urosepsis | Full Text | References | PDF (1.7 MB) | EPUB
  • 119 Views
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Article
Simultaneous Quantitative Analysis of Six Proton-Pump Inhibitors with a Single Marker and Evaluation of Stability of Investigated Drugs in Polypropylene Syringes for Continuous Infusion Use
Fuchao Chen, Xudong He, Baoxia Fang & Sicen Wang
Pages: 5689-5698
Published online: 24 Dec 2020
AbstractforSimultaneous Quantitative Analysis of Six Proton-Pump Inhibitors with a Single Marker and Evaluation of Stability of Investigated Drugs in Polypropylene Syringes for Continuous Infusion Use | Full Text | References | PDF (3.5 MB) | EPUB
  • 165 Views
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Article
Silencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p
Xiaohan Xu, Junhong Wang & Xiaowei Wang
Pages: 5699-5710
Published online: 29 Dec 2020
AbstractforSilencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p | Full Text | References | PDF (6 MB) | EPUB
  • 123 Views
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Article
Effective Tacrolimus Treatment for Patients with Non-Severe Aplastic Anemia That is Refractory/Intolerant to Cyclosporine A: A Retrospective Study
Yali Du, Yuzhou Huang, Wenzhe Zhou, Xinjian Liu, Fangfei Chen, Chen Yang, Miao Chen, Jing Ruan & Bing Han
Pages: 5711-5719
Published online: 30 Dec 2020
AbstractforEffective Tacrolimus Treatment for Patients with Non-Severe Aplastic Anemia That is Refractory/Intolerant to Cyclosporine A: A Retrospective Study | Full Text | References | PDF (839 KB) | EPUB
  • 143 Views
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Article
Pretreatment with Lactobacillus fermentum XY18 Relieves Gastric Injury Induced by HCl/Ethanol in Mice via Antioxidant and Anti-Inflammatory Mechanisms
Ranran Wang, Kexiang Zhou, Rongrong Xiong, Yi Yang, Ruokun Yi, Jing Hu, Wei Liao & Xin Zhao
Pages: 5721-5734
Published online: 30 Dec 2020
AbstractforPretreatment with Lactobacillus fermentum XY18 Relieves Gastric Injury Induced by HCl/Ethanol in Mice via Antioxidant and Anti-Inflammatory Mechanisms | Full Text | References | PDF (2.5 MB) | EPUB
  • 113 Views
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Article
Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study
Soon Jun Hong, Ki-Chul Sung, Sang-Wook Lim, Seok-Yeon Kim, Weon Kim, Jinho Shin, Sungha Park, Hae-Young Kim, Moo-Yong Rhee & On behalf of HM_APOLLO Investigators
Pages: 5735-5746
Published online: 31 Dec 2020
AbstractforLow-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study | Full Text | References | PDF (3.9 MB) | EPUB
  • 321 Views
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Article
RGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy
Qifang Long, Weipei Zhu, Liangsheng Guo & Li Pu
Pages: 5747-5756
Published online: 30 Dec 2020
AbstractforRGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy | Full Text | References | PDF (4.2 MB) | EPUB
  • 186 Views
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Review

Review Article
Volumetric Absorptive Microsampling as a Sampling Alternative in Clinical Trials and Therapeutic Drug Monitoring During the COVID-19 Pandemic: A Review
Yahdiana Harahap, Rasmina Diptasaadya & Denni Joko Purwanto
Pages: 5757-5771
Published online: 31 Dec 2020
AbstractforVolumetric Absorptive Microsampling as a Sampling Alternative in Clinical Trials and Therapeutic Drug Monitoring During the COVID-19 Pandemic: A Review | Full Text | References | PDF (465.1 KB) | EPUB
  • 182 Views
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Original Research

Article
Tanshinone IIA Ameliorates Streptozotocin-Induced Diabetic Nephropathy, Partly by Attenuating PERK Pathway-Induced Fibrosis
Shujuan Xu, Lianjun He, Keke Ding, Lingling Zhang, Xinhui Xu, Sheng Wang & Xueyi Qian
Pages: 5773-5782
Published online: 31 Dec 2020
AbstractforTanshinone IIA Ameliorates Streptozotocin-Induced Diabetic Nephropathy, Partly by Attenuating PERK Pathway-Induced Fibrosis | Full Text | References | PDF (5.7 MB) | EPUB
  • 114 Views
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