Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

Fahad Mehmood Khan1 Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Punjab 63100, Pakistan

Mahmood Ahmad2 Faculty of Pharmacy, University of Central Punjab, Punjab 54000, PakistanCorrespondence[email protected]

https://orcid.org/0000-0002-8361-2875

Hafiz Arfat Idrees1 Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Punjab 63100, Pakistan

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Hongge Wang, Peixu Zhao, Ruilong Ma, Jirun Jia & Qiang Fu. (2024) Drug–drug co-amorphous systems: An emerging formulation strategy for poorly water-soluble drugs. Drug Discovery Today 29:2, pages 103883.
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Paul B. Rodriques & Bhupendra G. Prajapati. (2023) DESIGN AND DEVELOPMENT OF DOLUTEGRAVIR SODIUM CO-CRYSTALS LOADED ORODISPERSIBLE TABLET WITH IMPROVED DISSOLUTION BEHAVIOUR. Indian Drugs 60:03, pages 30-39.
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Prerana D. Navti, Gasper Fernandes, Soji Soman, Ajinkya N. Nikam, Sanjay Kulkarni, Sumit R Birangal, Namdev Dhas, Gautham G. Shenoy, Vinay Rao, Kunnatur Balasundara Koteshwara & Srinivas Mutalik. (2024) Co-rotating twin screw process for continuous manufacturing of solid crystal suspension: A promising strategy to enhance the solubility, permeation and oral bioavailability of Carvedilol. F1000Research 12, pages 1438.
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Prerana D. Navti, Gasper Fernandes, Soji Soman, Ajinkya N. Nikam, Sanjay Kulkarni, Sumit R Birangal, Namdev Dhas, Gautham G. Shenoy, Vinay Rao, Kunnatur Balasundara Koteshwara & Srinivas Mutalik. (2023) Co-rotating twin screw process for continuous manufacturing of solid crystal suspension: A promising strategy to enhance the solubility, permeation and oral bioavailability of Carvedilol. F1000Research 12, pages 1438.
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Man Wang, Rong Xu, Xiaoli Liu, Ling Zhang, Siyan Qiu, Yuting Lu, Peng Zhang, Ming Yan & Jing Zhu. (2022) A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ. Communications Biology 5:1.
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Suryanarayana Polaka, Nimeet Desai, Bhavesh Kshirsagar, Kuldeep Rajpoot & Rakesh Kumar Tekade. 2021. Biopharmaceutics and Pharmacokinetics Considerations. Biopharmaceutics and Pharmacokinetics Considerations 387 413 .

Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

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Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

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