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Drug Design, Development and Therapy Volume 8, 2014 - Issue
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Original Research

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

Jun-ya Ueda1 Frontier Research Core for Life Sciences, Toyama, Japan;2 Institute of Natural Medicine, University of Toyama, Toyama, Japan
,
Sirivan Athikomkulchai3 Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, Thailand, Japan
,
Ryuta Miyatake4 Graduate School of Science and Engineering, University of Toyama, Toyama, Japan
,
Ikuo Saiki2 Institute of Natural Medicine, University of Toyama, Toyama, Japan
,
Hiroyasu Esumi5 Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan;6 National Cancer Center Hospital East, Chiba, Japan
&
Suresh Awale1 Frontier Research Core for Life Sciences, Toyama, Japan;2 Institute of Natural Medicine, University of Toyama, Toyama, JapanCorrespondence[email protected]
Pages 39-47 | Published online: 18 Dec 2013

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Kosuke Narise, Kensuke Okuda, Yukihiro Enomoto, Tasuku Hirayama & Hideko Nagasawa. (2014) Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Design, Development and Therapy 8, pages 701-717.
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Articles from other publishers (12)

Nguyen Duy Phan, Ashraf M. Omar, Ikue Takahashi, Hayato Baba, Tomoyuki Okumura, Johji Imura, Takuya Okada, Naoki Toyooka, Tsutomu Fujii & Suresh Awale. (2023) Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model. Journal of Natural Products.
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Juthamart Maneenet, Ashraf M. Omar, Sijia Sun, Min Jo Kim, Supawadee Daodee, Orawon Monthakantirat, Chantana Boonyarat, Yaowared Chulikhit & Suresh Awale. (2021) Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line . Zeitschrift für Naturforschung C 76:9-10, pages 401-406.
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Sijia Sun, Min Jo Kim, Dya Fita Dibwe, Ashraf M. Omar, Sirivan Athikomkulchai, Ampai Phrutivorapongkul, Takuya Okada, Kiyoshi Tsuge, Naoki Toyooka & Suresh Awale. (2021) Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of Kaempferia parviflora. Plants 10:2, pages 229.
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Ahmed M. Tawila, Sijia Sun, Min Jo Kim, Ashraf M. Omar, Dya Fita Dibwe, Jun-ya Ueda, Naoki Toyooka & Suresh Awale. (2020) Highly Potent Antiausterity Agents from Callistemon citrinus and Their Mechanism of Action against the PANC-1 Human Pancreatic Cancer Cell Line . Journal of Natural Products 83:7, pages 2221-2232.
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Dieudonné Tshitenge Tshitenge, Torsten Bruhn, Doris Feineis, David Schmidt, Virima Mudogo, Marcel Kaiser, Reto Brun, Frank Würthner, Suresh Awale & Gerhard Bringmann. (2019) Ealamines A–H, a Series of Naphthylisoquinolines with the Rare 7,8′-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis , Targeting Pancreatic Cancer Cells . Journal of Natural Products 82:11, pages 3150-3164.
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Emily A. Shimizu, Brett Cory, Johnson Hoang, Giovanni G. Castro, Michael E. Jung & David A. Vosburg. (2019) Aqueous Dearomatization/Diels–Alder Cascade to a Grandifloracin Precursor. Journal of Chemical Education 96:5, pages 998-1001.
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Suresh Awale, Dya Fita Dibwe, Chandrasekar Balachandran, Shaimaa Fayez, Doris Feineis, Blaise Kimbadi Lombe & Gerhard Bringmann. (2018) Ancistrolikokine E 3 , a 5,8′-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway . Journal of Natural Products 81:10, pages 2282-2291.
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Sijia Sun, Ampai Phrutivorapongkul, Dya Fita Dibwe, Chandrasekar Balachandran & Suresh Awale. (2018) Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line . Journal of Natural Products 81:8, pages 1877-1883.
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Ryoko Tomita, Kenichiro Todoroki, Tadashi Hayama, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi & Hitoshi Nohta. (2018) Assessment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-Depleted Conditions Using Intracellular and Extracellular Amino Acid Metabolomics. Biological and Pharmaceutical Bulletin 41:2, pages 220-228.
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Haruhiko Fuwa & Mizuho Sato. (2017) A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent against Starved Tumor Cells. Marine Drugs 15:10, pages 320.
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Nhan Trung Nguyen, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Dya Fita Dibwe, Hiroyasu Esumi & Suresh Awale. (2017) Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line . Journal of Natural Products 80:1, pages 141-148.
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Hai Xuan Nguyen, Truong Nhat Van Do, Tho Huu Le, Mai Thanh Thi Nguyen, Nhan Trung Nguyen, Hiroyasu Esumi & Suresh Awale. (2016) Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line . Journal of Natural Products 79:8, pages 2053-2059.
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