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Original Research

Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway

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Pages 127-146 | Published online: 17 Dec 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Chi Thanh Nguyen, Jong-Man Han, Van Huong Tran, Hun Jeong & Eun Sook Kim. (2021) A Study on the Fabrication of an Effective Natural Substance Based on Schisandra chinensis Extracted Fermentation. Clinical, Cosmetic and Investigational Dermatology 14, pages 1603-1612.
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Wang Cuiqiong, Xu Chao, Fu Xinling & Jiang Yinyan. (2020) Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway. Artificial Cells, Nanomedicine, and Biotechnology 48:1, pages 473-478.
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Qingshan Chen, Hai Zhang, Yan Cao, Ying Li, Sen Sun, Junping Zhang & Guoqing Zhang. (2017) Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways. Drug Design, Development and Therapy 11, pages 2179-2191.
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Qiao Lai, Jiabao Wei, Mohammed Mahmoodurrahman, Chenxue Zhang, Shijian Quan, Tongming Li & Yang Yu. (2015) Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime. Drug Design, Development and Therapy 9, pages 4997-5018.
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Articles from other publishers (7)

Erika Ramos-Tovar & Pablo Muriel. 2023. Antioxidants. Antioxidants 271 292 .
Yongfeng Zhou, Junnan Wang, Dingkun Zhang, Jiaxin Liu, Qinghua Wu, Jiang Chen, Peng Tan, Boyu Xing, Yanzhong Han, Ping Zhang, Xiaohe Xiao & Jin Pei. (2021) Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs. Chinese Medicine 16:1.
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Yongfang Gong & Yan Yang. (2020) Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis — A review. Life Sciences 256, pages 117909.
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Ling Cheng, Zhizhou Yang, Zhaorui Sun, Wei Zhang, Yi Ren, Mengmeng Wang, Xiaoqin Han, Libo Fei, Yang Zhao, Hui Pan, Ji Xie & Shinan Nie. (2020) Schizandrin B Mitigates Rifampicin-Induced Liver Injury by Inhibiting Endoplasmic Reticulum Stress. Biological and Pharmaceutical Bulletin 43:1, pages 145-152.
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Xiaopei Liu, Lin Chen, Mingyi Liu, Hong Zhang, Shibo Huang, Yuqing Xiong & Chunhua Xia. (2018) Ginsenoside Rb1 and Rd Remarkably Inhibited the Hepatic Uptake of Ophiopogonin D in Shenmai Injection Mediated by OATPs/oatps. Frontiers in Pharmacology 9.
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Eun-Jeong Kim, Minhee Jang, Min Jung Lee, Jong Hee Choi, Sung Joong Lee, Sun Kwang Kim, Dae Sik Jang & Ik-Hyun Cho. (2017) Schisandra chinensis Stem Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity via Activation of the Nrf2 Pathway and Inhibition of the MAPKs and NF-κB Pathways. Frontiers in Pharmacology 8.
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Ming Yang, Jialei Chen, Xiufeng Shi, Liwen Xu, Zhijun Xi, Lisha You, Rui An & Xinhong Wang. (2015) Development of in Silico Models for Predicting P-Glycoprotein Inhibitors Based on a Two-Step Approach for Feature Selection and Its Application to Chinese Herbal Medicine Screening. Molecular Pharmaceutics 12:10, pages 3691-3713.
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