Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway

References

• QiuJTraditional medicine: a culture in the balanceNature2007448715012612817625539
   PubMed Web of Science ®Google Scholar
• MehtaDHGardinerPMPhillipsRSMcCarthyEPHerbal and dietary supplement disclosure to health care providers by individuals with chronic conditionsJ Altern Complement Med200814101263126919032071
   PubMed Web of Science ®Google Scholar
• KennedyJHerb and supplement use in the US adult populationClin Ther200527111847185816368456
   PubMed Web of Science ®Google Scholar
• GuntherSPattersonREKristalARStrattonKLWhiteEDemographic and health-related correlates of herbal and specialty supplement useJ Am Diet Assoc20041041273414702580
   PubMedGoogle Scholar
• HeSMChanEZhouSFADME properties of herbal medicines in humans: evidence, challenges and strategiesCurr Pharm Des201117435740721385154
   PubMed Web of Science ®Google Scholar
• ChenXWSneedKBZhouSFPharmacokinetic profiles of anticancer herbal medicines in humans and the clinical implicationsCurr Med Chem201118213190321021671861
   PubMed Web of Science ®Google Scholar
• Hun LeeJShuLFuentesFSuZYKongTANCancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting Nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cellsJ Tradit Complement Med201331697924716158
   PubMedGoogle Scholar
• Fugh-BermanAHerb-drug interactionsLancet2000355919813413810675182
   PubMed Web of Science ®Google Scholar
• YangXXHuZPDuanWZhuYZZhouSFDrug-herb interactions: eliminating toxicity with hard drug designCurr Pharm Des200612354649466417168768
   PubMed Web of Science ®Google Scholar
• ZhouSFZhouZWLiCGIdentification of drugs that interact with herbs in drug developmentDrug Discov Today20071215–1666467317706549
   PubMed Web of Science ®Google Scholar
• DiYMLiCGXueCCZhouSFClinical drugs that interact with St John’s wort and implication in drug developmentCurr Pharm Des200814171723174218673195
   PubMed Web of Science ®Google Scholar
• YangAKHeSMLiuLLiuJPWeiMQZhouSFHerbal interactions with anticancer drugs: mechanistic and clinical considerationsCurr Med Chem201017161635167820345351
   PubMed Web of Science ®Google Scholar
• HeSMYangAKLiXTDuYMZhouSFEffects of herbal products on the metabolism and transport of anticancer agentsExpert Opin Drug Metab Toxicol20106101195121320701553
   PubMed Web of Science ®Google Scholar
• ZhouSGaoYJiangWHuangMXuAPaxtonJWInteractions of herbs with cytochrome P450Drug Metab Rev2003351359812635815
   PubMed Web of Science ®Google Scholar
• ZhouSLimLYChowbayBHerbal modulation of P-glycoproteinDrug Metab Rev20043615710415072439
   PubMed Web of Science ®Google Scholar
• TolsonAHWangHRegulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CARAdv Drug Deliv Rev201062131238124920727377
   PubMed Web of Science ®Google Scholar
• AleksunesLMKlaassenCDCoordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARa-, and Nrf2-null miceDrug Metab Dispos20124071366137922496397
   PubMed Web of Science ®Google Scholar
• WangYMOngSSChaiSCChenTRole of CAR and PXR in xenobiotic sensing and metabolismExpert Opin Drug Metab Toxicol20128780381722554043
   PubMed Web of Science ®Google Scholar
• UrquhartBLTironaRGKimRBNuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugsJ Clin Pharmacol200747556657817442683
   PubMed Web of Science ®Google Scholar
• MaQRole of Nrf2 in oxidative stress and toxicityAnnu Rev Pharmacol Toxicol20135340142623294312
   PubMed Web of Science ®Google Scholar
• KeumYSChoiBYMolecular and chemical regulation of the Keap1-Nrf2 signaling pathwayMolecules2014197100741008925014534
   PubMed Web of Science ®Google Scholar
• MaQHeXMolecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Pharmacol Rev20126441055108122966037
   PubMed Web of Science ®Google Scholar
• ShenGKongANNrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transportersBiopharm Drug Dispos200930734535519725016
   PubMed Web of Science ®Google Scholar
• StewartDKilleenENaquinRAlamSAlamJDegradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmiumJ Biol Chem200327842396240212441344
   PubMed Web of Science ®Google Scholar
• ItohKWakabayashiNKatohYIshiiTO’ConnorTYamamotoMKeap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophilesGenes Cells20038437939112653965
   PubMed Web of Science ®Google Scholar
• TakayaKSuzukiTMotohashiHValidation of the multiple sensor mechanism of the Keap1-Nrf2 systemFree Radic Biol Med201253481782722732183
   PubMed Web of Science ®Google Scholar
• BairdLLleresDSwiftSDinkova-KostovaATRegulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complexProc Natl Acad Sci U S A201311038152591526423986495
   PubMed Web of Science ®Google Scholar
• StewartJDHengstlerJGBoltHMControl of oxidative stress by the Keap1-Nrf2 pathwayArch Toxicol201185423921431330
   PubMed Web of Science ®Google Scholar
• IidaKItohKKumagaiYNrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesisCancer Res200464186424643115374950
   PubMed Web of Science ®Google Scholar
• BurtonNCKenslerTWGuilarteTRIn vivo modulation of the parkinsonian phenotype by Nrf2Neurotoxicology20062761094110016959318
   PubMed Web of Science ®Google Scholar
• KobayashiATsukideTMiyasakaTCentral nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunctionGenes Cells201116669270321554501
   PubMed Web of Science ®Google Scholar
• Aw YeangHXHamdamJMAl-HuseiniLMLoss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cellsJ Biol Chem201228713105561056422311972
   PubMed Web of Science ®Google Scholar
• WeerachayaphornJMennoneASorokaCJNuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestineAm J Physiol Gastrointest Liver Physiol20123029G925G93622345550
   PubMed Web of Science ®Google Scholar
• ChoHYvan HoutenBWangXTargeted deletion of Nrf2 impairs lung development and oxidant injury in neonatal miceAntioxid Redox Signal20121781066108222400915
   PubMed Web of Science ®Google Scholar
• VolonteDLiuZMusillePMInhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescenceMol Biol Cell201324121852186223637463
   PubMed Web of Science ®Google Scholar
• Al-HuseiniLMAw YeangHXSethuSNuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signalingJ Biol Chem201328831222812228823775080
   PubMed Web of Science ®Google Scholar
• MuramatsuHKatsuokaFToideKShimizuYFurusakoSYamamotoMNrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in miceGenes Cells2013181089990823890231
   PubMed Web of Science ®Google Scholar
• GuXManautouJERegulation of hepatic ABCC transporters by xenobiotics and in disease statesDrug Metab Rev201042348253820233023
   PubMed Web of Science ®Google Scholar
• WuTYKhorTOLeeJHPharmacogenetics, pharmacogenomics and epigenetics of Nrf2-regulated xenobiotic-metabolizing enzymes and transporters by dietary phytochemical and cancer chemopreventionCurr Drug Metab201314668869423869812
   PubMed Web of Science ®Google Scholar
• ChanSWPanax ginseng, Rhodiola rosea and Schisandra chinensisInt J Food Sci Nutr201263Suppl 1758122039930
   PubMed Web of Science ®Google Scholar
• WangMCLaiYCChangCLHigh throughput screening and antioxidant assay of dibenzo[a,c]cyclooctadiene lignans in modified-ultrasonic and supercritical fluid extracts of Schisandra chinensis Baill by liquid chromatography-mass spectrometry and a free radical-scavenging methodJ Sep Sci20083181322133218446887
   PubMed Web of Science ®Google Scholar
• LuYChenDFAnalysis of Schisandra chinensis and Schisandra sphenantheraJ Chromatogr A20091216111980199018849034
   PubMed Web of Science ®Google Scholar
• IpSPMakDHLiPCPoonMKKoKMEffect of a lignan-enriched extract of Schisandra chinensis on aflatoxin B1 and cadmium chloride-induced hepatotoxicity in ratsPharmacol Toxicol19967864134168829203
   PubMedGoogle Scholar
• ZhuMLinKFYeungRYLiRCEvaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication modelJ Ethnopharmacol1999671616810616961
   PubMed Web of Science ®Google Scholar
• IpSPYiuHYKoKMDifferential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated miceMol Cell Biochem20002051–211111410821428
   PubMed Web of Science ®Google Scholar
• ZhuMYeungRYLinKFLiRCImprovement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat modelPlanta Med200066652152510985077
   PubMed Web of Science ®Google Scholar
• ChiuPYMakDHPoonMKKoKMIn vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodinPlanta Med2002681195195612451481
   PubMed Web of Science ®Google Scholar
• ChangHFLinYHChuCCWuSJTsaiYHChaoJCProtective effects of Ginkgo biloba, Panax ginseng, and Schizandra chinensis extract on liver injury in ratsAm J Chin Med2007356995100918186586
   PubMed Web of Science ®Google Scholar
• ChenNChiuPYKoKMSchisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in ratsBiol Pharm Bull20083171387139118591780
   PubMed Web of Science ®Google Scholar
• YanFZhangQYJiaoLSynergistic hepatoprotective effect of Schisandrae lignans with Astragalus polysaccharides on chronic liver injury in ratsPhytomedicine200916980581319345075
   PubMed Web of Science ®Google Scholar
• StacchiottiALi VoltiGLavazzaARezzaniRRodellaLFSchisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chlorideFood Chem Toxicol200947112834284019747521
   PubMed Web of Science ®Google Scholar
• KimKJYoonKYHongHDLeeBYSchisandra chinensis prevents hepatic lipid peroxidation and oxidative stress in rats subjected to heat environmental stressPhytother Res201226111674168022389228
   PubMed Web of Science ®Google Scholar
• KangJWKimSJKimHYProtective effects of HV-P411 complex against D-galactosamine-induced hepatotoxicity in ratsAm J Chin Med201240346748022745064
   PubMed Web of Science ®Google Scholar
• PanSYYuQZhangYDietary Fructus Schisandrae extracts and fenofibrate regulate the serum/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicityLipids Health Dis20121112022989092
   PubMed Web of Science ®Google Scholar
• ChengNRenNGaoHLeiXZhengJCaoWAntioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in miceFood Chem Toxicol20135523424023201450
   PubMed Web of Science ®Google Scholar
• HwangISKimJELeeYJProtective effects of gomisin A isolated from Schisandra chinensis against CCl4-induced hepatic and renal injuryInt J Mol Med201331488889823381504
   PubMed Web of Science ®Google Scholar
• LiLZhangTZhouLSchisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in miceJ Gastroenterol Hepatol201429364064724219791
   PubMed Web of Science ®Google Scholar
• ParkHJLeeSJSongYSchisandra chinensis prevents alcohol-induced fatty liver disease in ratsJ Med Food201417110311024456360
   PubMed Web of Science ®Google Scholar
• WangKPBaiYWangJZhangJZInhibitory effects of Schisandra chinensis on acetaminophen-induced hepatotoxicityMol Med Rep2014951813181924604262
   PubMed Web of Science ®Google Scholar
• CheungKLYuSPanZMaJWuTYKongANtBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1Chem Res Toxicol201124567067621443188
   PubMed Web of Science ®Google Scholar
• ParkJSKimHSRegulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary butylhydroquinone-stimulated rat primary astrocytesBiochem Biophys Res Commun2014447467267724755082
   PubMed Web of Science ®Google Scholar
• KoncicMZTomczykMNew insights into dietary supplements used in sport: active substances, pharmacological and side effectsCurr Drug Targets20131491079109223574283
   PubMed Web of Science ®Google Scholar
• PanossianAWikmanGPharmacology of Schisandra chinensis Bail: an overview of Russian research and uses in medicineJ Ethnopharmacol2008118218321218515024
   PubMed Web of Science ®Google Scholar
• LiYJTakizawaHAzumaADisruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in miceClinical Immunology2008128336637318614404
   PubMed Web of Science ®Google Scholar
• IyanagiTMolecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxificationInt Rev Cytol20072603511217482904
   PubMed Web of Science ®Google Scholar
• ZhangQPiJWoodsCGAndersenMEPhase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responsesToxicol Appl Pharmacol2009237334535619371757
   PubMed Web of Science ®Google Scholar
• SiegelDYanCRossDNAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinonesBiochem Pharmacol20128381033104022209713
   PubMed Web of Science ®Google Scholar
• ZhuHLiYNAD(P)H:quinone oxidoreductase 1 and its potential protective role in cardiovascular diseases and related conditionsCardiovasc Toxicol2012121394521818552
   PubMed Web of Science ®Google Scholar
• WilksAHeinzlGHeme oxygenation and the widening paradigm of heme degradationArch Biochem Biophys2014544879524161941
   PubMed Web of Science ®Google Scholar
• ChenYShertzerHGSchneiderSNNebertDWDaltonTPGlutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levelsJ Biol Chem200528040337663377416081425
   PubMed Web of Science ®Google Scholar
• BoardPGMenonDGlutathione transferases, regulators of cellular metabolism and physiologyBiochim Biophys Acta2013183053267328823201197
   PubMed Web of Science ®Google Scholar
• WangZDouXLiSNuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in miceHepatology20145941381139224170703
   PubMed Web of Science ®Google Scholar
• LuSCRegulation of glutathione synthesisMol Aspects Med2009301–2425918601945
   PubMed Web of Science ®Google Scholar
• WongKMaJRothnieABigginPCKerrIDTowards understanding promiscuity in multidrug efflux pumpsTrends Biochem Sci201439181624316304
   PubMed Web of Science ®Google Scholar
• SahooSAurichMKJonssonJJThieleIMembrane transporters in a human genome-scale metabolic knowledgebase and their implications for diseaseFront Physiol201459124653705
   PubMed Web of Science ®Google Scholar
• ZhouSFStructure, function and regulation of P-glycoprotein and its clinical relevance in drug dispositionXenobiotica2008387–880283218668431
   PubMed Web of Science ®Google Scholar
• ZhouSFWangLLDiYMSubstrates and inhibitors of human multidrug resistance associated proteins and the implications in drug developmentCurr Med Chem200815201981203918691054
   PubMed Web of Science ®Google Scholar
• TeodoriEDeiSMartelliCScapecchiSGualtieriFThe functions and structure of ABC transporters: implications for the design of new inhibitors of P-gp and MRP1 to control multidrug resistance (MDR)Curr Drug Target200677893909
   Web of Science ®Google Scholar
• NiesATKepplerDThe apical conjugate efflux pump ABCC2 (MRP2)Pflugers Arch2007453564365916847695
   PubMed Web of Science ®Google Scholar
• RusselFGKoenderinkJBMasereeuwRMultidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling moleculesTrends Pharmacol Sci200829420020718353444
   PubMed Web of Science ®Google Scholar
• YooHHLeeMLeeMWLimSYShinJKimDHEffects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2Planta Med200773544445017566147
   PubMed Web of Science ®Google Scholar
• MadgulaVLAvulaBChoiYWTransport of Schisandra chinensis extract and its biologically-active constituents across Caco-2 cell monolayers – an in-vitro model of intestinal transportJ Pharm Pharmacol200860336337018284817
   PubMed Web of Science ®Google Scholar
• SunMXuXLuQPanQHuXSchisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1Cancer Lett20072461–230030716621244
   PubMed Web of Science ®Google Scholar
• QiangrongPWangTLuQHuXSchisandrin B – a novel inhibitor of P-glycoproteinBiochem Biophys Res Commun2005335240641116084496
   PubMed Web of Science ®Google Scholar
• SvobodaMRihaJWlcekKJaegerWThalhammerTOrganic anion transporting polypeptides (OATPs): regulation of expression and functionCurr Drug Metab201112213915321395542
   PubMed Web of Science ®Google Scholar
• ObaidatARothMHagenbuchBThe expression and function of organic anion transporting polypeptides in normal tissues and in cancerAnnu Rev Pharmacol Toxicol20125213515121854228
   PubMed Web of Science ®Google Scholar
• IusufDvan de SteegESchinkelAHFunctions of OATP1A and 1B transporters in vivo: insights from mouse modelsTrends Pharmacol Sci201233210010822130008
   PubMed Web of Science ®Google Scholar
• ShitaraYMaedaKIkejiriKYoshidaKHorieTSugiyamaYClinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorptionBiopharm Drug Dispos2013341457823115084
   PubMed Web of Science ®Google Scholar
• TamaiINakanishiTOATP transporter-mediated drug absorption and interactionCurr Opin Pharmacol201313685986324060700
   PubMed Web of Science ®Google Scholar
• LeeSBKimCYLeeHJYunJHNhoCWInduction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2Planta Med200975121314131819452436
   PubMed Web of Science ®Google Scholar
• ParkSYPark daJKimYHKimYChoiYWLeeSJSchisandra chinensis a-iso-cubebenol induces heme oxygenase-1 expression through PI3K/Akt and Nrf2 signaling and has anti-inflammatory activity in Porphyromonas gingivalis lipopolysaccharide-stimulated macrophagesInt Immunopharmacol201111111907191521840424
   PubMed Web of Science ®Google Scholar
• CheckerRPatwardhanRSSharmaDSchisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-kappaBFree Radic Biol Med20125371421143022917978
   PubMed Web of Science ®Google Scholar
• HongFSekharKRFreemanMLLieblerDCSpecific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activationJ Biol Chem200528036317683177515985429
   PubMed Web of Science ®Google Scholar
• NguyenTSherrattPJHuangHCYangCSPickettCBIncreased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasomeJ Biol Chem200327874536454112446695
   PubMed Web of Science ®Google Scholar