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International Journal of Nanomedicine Volume 11, 2016 - Issue
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Original Research

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

Caixia Guo1 Department of Occupational and Environmental Health, School of Public Health;2 Beijing Key Laboratory of Environmental Toxicology
,
Man Yang2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Li Jing2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Ji Wang2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Yang Yu2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Yang Li2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Junchao Duan2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Xianqing Zhou2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of China
,
Yanbo Li2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Zhiwei Sun2 Beijing Key Laboratory of Environmental Toxicology;3 Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 5257-5276 | Published online: 11 Oct 2016

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Samia A. Abd El-Baset, Nehad F. Mazen, Rehab S. Abdul-Maksoud & Asmaa A. A. Kattaia. (2023) The therapeutic prospect of zinc oxide nanoparticles in experimentally induced diabetic nephropathy. Tissue Barriers 11:1.
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Yan Li, Yawen Zhu, Bosen Zhao, Qing Yao, Hailin Xu, Songqing Lv, Ji Wang, Zhiwei Sun, Yanbo Li & Caixia Guo. (2022) Amorphous silica nanoparticles caused lung injury through the induction of epithelial apoptosis via ROS/Ca2+/DRP1-mediated mitochondrial fission signaling. Nanotoxicology 16:6-8, pages 713-732.
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Se-Eun Lee, Chiyeon Lim & Suin Cho. (2021) Angelica gigas root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways. Pharmaceutical Biology 59:1, pages 660-669.
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Shuang Liang, Junchao Duan, Hejing Hu, Jingyi Zhang, Shan Gao, Haiming Jing, Guojun Li & Zhiwei Sun. (2020) Comprehensive Analysis of SiNPs on the Genome-Wide Transcriptional Changes in Caenorhabditis elegans. International Journal of Nanomedicine 15, pages 5227-5237.
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Reza Mohammadinejad, Mohammad Amin Moosavi, Shima Tavakol, Deniz Özkan Vardar, Asieh Hosseini, Marveh Rahmati, Luciana Dini, Salik Hussain, Ali Mandegary & Daniel J. Klionsky. (2019) Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles. Autophagy 15:1, pages 4-33.
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Magdalena Kusaczuk, Rafał Krętowski, Monika Naumowicz, Anna Stypułkowska & Marzanna Cechowska-Pasko. (2018) Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells. International Journal of Nanomedicine 13, pages 2279-2294.
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Yan Wang & Meng Tang. (2018) Dysfunction of various organelles provokes multiple cell death after quantum dot exposure. International Journal of Nanomedicine 13, pages 2729-2742.
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Yongming Liu, Huan Yu, Xihui Zhang, Yong Wang, Zhentao Song, Jian Zhao, Haibin Shi, Ruibin Li, Yangyun Wang & Leshuai W. Zhang. (2018) The protective role of autophagy in nephrotoxicity induced by bismuth nanoparticles through AMPK/mTOR pathway. Nanotoxicology 12:6, pages 586-601.
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Caixia Guo, Ji Wang, Man Yang, Yang Li, Shuxiang Cui, Xianqing Zhou, Yanbo Li & Zhiwei Sun. (2017) Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells via P53 signaling. Nanotoxicology 11:9-10, pages 1176-1194.
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