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International Journal of Nanomedicine Volume 11, 2016 - Issue
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Original Research

Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation

Man Yang1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Li Jing1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Ji Wang1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Yang Yu1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Lige Cao1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Lianshuang Zhang1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
,
Xianqing Zhou1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of China
&
Zhiwei Sun1 School of Public Health, Capital Medical University, Beijing, People’s Republic of China;2 Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 6217-6228 | Published online: 22 Nov 2016

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Yang Yu, Tingting Zhu, Yang Li, Li Jing, Man Yang, Yanbo Li, Junchao Duan & Zhiwei Sun. (2019) Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo. International Journal of Nanomedicine 14, pages 7237-7247.
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Jingjing Fu, Junwei Gao, Linji Gong, Yuanyuan Ma, Haiwei Xu, Zhanjun Gu, Jingci Zhu & Xiaotang Fan. (2018) Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life. International Journal of Nanomedicine 13, pages 3593-3608.
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Articles from other publishers (36)

Caixia Guo, Xinying Zhao, Ru Ma, Lingnan Zhu, Yueyue Chen, Zhu Yang, Zongwei Cai, Zhiwei Sun & Yanbo Li. (2023) Silica nanoparticles promoted pro-inflammatory macrophage and foam cell transformation via ROS/PPARγ/NF-κB signaling. Science of The Total Environment 881, pages 163430.
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Qingqing Liang, Mengqi Sun, Yuexiao Ma, Fenghong Wang, Zhiwei Sun & Junchao Duan. (2023) Adverse effects and underlying mechanism of amorphous silica nanoparticles in liver. Chemosphere 311, pages 136955.
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Patrick R. Suman, Lisiane S. Souza, Grasielle C. Kincheski, Helen M. Melo, Mariana N. Machado, Giovanna M. C. Carvalho, Fernanda G. De Felice, Walter A. Zin & Sergio T. Ferreira. (2022) Lung inflammation induced by silica particles triggers hippocampal inflammation, synapse damage and memory impairment in mice. Journal of Neuroinflammation 19:1.
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Eribe M. Jonathan, Ikhazuagbe H. Ifijen, Kate E. Mokobia, Emmanuel I. Okeke, Chiadika I. Omoruyi & Bala Anegbe. (2022) A Review on the Heightened Mechanical Features of Nanosilica-Based Concrete and the Response of Human Fibroblasts to Nanosilica. Biomedical Materials & Devices.
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Qingqing Liang, Yuexiao Ma, Fenghong Wang, Mengqi Sun, Lisen Lin, Tianyu Li, Zhiwei Sun & Junchao Duan. (2022) Silica nanoparticles induce hepatocyte ferroptosis and liver injury via ferritinophagy . Environmental Science: Nano 9:8, pages 3014-3029.
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Xueyan Li, Yan Li, Songqing Lv, Hailin Xu, Ru Ma, Zhiwei Sun, Yanbo Li & Caixia Guo. (2022) Long-term respiratory exposure to amorphous silica nanoparticles promoted systemic inflammation and progression of fibrosis in a susceptible mouse model. Chemosphere 300, pages 134633.
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Vanessa Marques Da Silva, Manon Benjdir, Pierrick Montagne, Jean-Claude Pairon, Sophie Lanone & Pascal Andujar. (2022) Pulmonary Toxicity of Silica Linked to Its Micro- or Nanometric Particle Size and Crystal Structure: A Review. Nanomaterials 12:14, pages 2392.
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Fumihiko Sasai, Keegan L. Rogers, David J. Orlicky, Arthur Stem, Joshua Schaeffer, Gabriela Garcia, Jacob Fox, Matthew S. Ray, Jaime Butler-Dawson, Marvin Gonzalez-Quiroz, Ricardo Leiva, Gangadhar Taduri, Sirirat Anutrakululchai, Vidhya Venugopal, Magdalena Madero, Jason Glaser, Julia Wijkstrom, Annika Wernerson, Jared M. Brown, Richard J. Johnson & Carlos A. Roncal-Jimenez. (2022) Inhaled silica nanoparticles cause chronic kidney disease in rats. American Journal of Physiology-Renal Physiology 323:1, pages F48-F58.
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Yanmei Huang, Peng Li, Ruikang Zhao, Laien Zhao, Jia Liu, Shengjun Peng, Xiaoxuan Fu, Xiaojie Wang, Rongrui Luo, Rong Wang & Zhuhong Zhang. (2022) Silica nanoparticles: Biomedical applications and toxicity. Biomedicine & Pharmacotherapy 151, pages 113053.
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Ning Li, Luyao Wang, Fan Shi, Pan Yang, Kun Sun, Jing Zhang, Xiaojing Yang, Xiaoming Li, Fuhai Shen, Heliang Liu, Yulan Jin & Sanqiao Yao. (2021) Silica nanoparticle induces pulmonary fibroblast transdifferentiation via macrophage route: Potential mechanism revealed by proteomic analysis. Toxicology in Vitro 76, pages 105220.
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Chun-Mei Gong, Yuan-Fei Xu, Xiong-Shun Liang, Jun-Luan Mo & Zhi-Xiong Zhuang. (2021) PARP-1 overexpression does not protect HaCaT cells from DNA damage induced by SiO2 nanoparticles. Toxicology Research 10:3, pages 399-408.
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Fátima Brandão, Carla Costa, Maria João Bessa, Elise Dumortier, Florence Debacq-Chainiaux, Roland Hubaux, Michel Salmon, Julie Laloy, Miruna S. Stan, Anca Hermenean, Sami Gharbia, Anca Dinischiotu, Anne Bannuscher, Bryan Hellack, Andrea Haase, Sónia Fraga & João Paulo Teixeira. (2021) Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NM). Nanomaterials 11:6, pages 1502.
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Caixia Guo, Yufan Liu & Yanbo Li. (2021) Adverse effects of amorphous silica nanoparticles: Focus on human cardiovascular health. Journal of Hazardous Materials 406, pages 124626.
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Jian Zou, Sheng-Peng Wang, Yi-Tao Wang & Jian-Bo Wan. (2021) Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury. Pharmacological Research 164, pages 105388.
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RaghdaA El-Sayed, FatmaM El-Demerdash & MohammedA El-Magd. (2021) Ginseng ameliorates pulmonary toxicity induced by silicon dioxide nanoparticles in rats. Asian Pacific Journal of Tropical Biomedicine 11:6, pages 254.
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Mingxiang Wang, Jin Li, Shunni Dong, Xiaobo Cai, Aili Simaiti, Xin Yang, Xinqiang Zhu, Jianhong Luo, Lin-Hua Jiang, Binyang Du, Peilin Yu & Wei Yang. (2020) Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Particle and Fibre Toxicology 17:1.
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Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof YakoubFrancine UwambayinemaPiero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, Dominique Lison & Bice Fubini. (2020) Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles. Proceedings of the National Academy of Sciences 117:45, pages 27836-27846.
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G. Yu. Yukina, I. V. Polovnikov, E. G. Sukhorukova, S. G. Zhuravskii & M. M. Galagudza. (2020) Morphological Analysis of the Respiratory Tract of Rats after Parenteral Administration of Silicon Dioxide Nanoparticles. Bulletin of Experimental Biology and Medicine 170:1, pages 93-97.
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Guo Ye, Fangyuan Bao, Xianzhu Zhang, Zhe Song, Youguo Liao, Yang Fei, Varitsara Bunpetch, Boon Chin Heng, Weiliang Shen, Hua Liu, Jing Zhou & Hongwei Ouyang. (2020) Nanomaterial-based scaffolds for bone tissue engineering and regeneration. Nanomedicine 15:20, pages 1995-2017.
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Maqusood Ahamed, Mohd Javed Akhtar & Hisham A. Alhadlaq. (2020) Influence of silica nanoparticles on cadmium‐induced cytotoxicity, oxidative stress, and apoptosis in human liver HepG2 cells. Environmental Toxicology 35:5, pages 599-608.
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Yang Li, Junchao Duan, Xiangyuan Chai, Man Yang, Ji Wang, Rui Chen & Zhiwei Sun. (2019) Microarray-assisted size-effect study of amorphous silica nanoparticles on human bronchial epithelial cells. Nanoscale 11:47, pages 22907-22923.
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Laura Rubio, Georgios Pyrgiotakis, Juan Beltran-Huarac, Yipei Zhang, Joshi Gaurav, Glen Deloid, Anastasia Spyrogianni, Kristopher A. Sarosiek, Dhimiter Bello & Philip Demokritou. (2019) Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity. Particle and Fibre Toxicology 16:1.
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Maqusood Ahamed, Mohd Javed Akhtar & Hisham A. Alhadlaq. (2019) Co-Exposure to SiO2 Nanoparticles and Arsenic Induced Augmentation of Oxidative Stress and Mitochondria-Dependent Apoptosis in Human Cells. International Journal of Environmental Research and Public Health 16:17, pages 3199.
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Jing Wu, Jie Zhang, Jihua Nie, Junchao Duan, Yanfeng Shi, Lin Feng, Xiaozhe Yang, Yan An & Zhiwei Sun. (2019) The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells. Toxicology Research 8:5, pages 731-740.
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Chong Guo, Ding-Yun You, Huan Li, Xiao-Yu Tuo & Zi-Jie Liu. (2019) Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1α (SDF-1α). Journal of International Medical Research 47:3, pages 1264-1278.
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YiXun Li, Huan Li, Yong Duan, XueMei Cai, DingYun You, Feng Zhou, ChuanQi Yang, XiaoYu Tuo & ZiJie Liu. (2019) Blockage of TGF- α Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells . BioMed Research International 2019, pages 1-10.
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Martin Wiemann, Antje Vennemann, Michael Stintz, Rodrigo Retamal Marín, Frank Babick, Gottlieb-Georg Lindner, Tobias Schuster, Ulrich Brinkmann & Nils Krueger. (2018) Effects of Ultrasonic Dispersion Energy on the Preparation of Amorphous SiO2 Nanomaterials for In Vitro Toxicity Testing. Nanomaterials 9:1, pages 11.
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Xiaozhe Yang, Lin Feng, Yannan Zhang, Hejing Hu, Yanfeng Shi, Shuang Liang, Tong Zhao, Lige Cao, Junchao Duan & Zhiwei Sun. (2018) Co-exposure of silica nanoparticles and methylmercury induced cardiac toxicity in vitro and in vivo. Science of The Total Environment 631-632, pages 811-821.
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Jianhui Liu, Man Yang, Li Jing, Lihua Ren, Jialiu Wei, Jin Zhang, Feng Zhang, Junchao Duan, Xianqing Zhou & Zhiwei Sun. (2017) Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice. Environmental Science and Pollution Research 25:4, pages 3423-3434.
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