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International Journal of Nanomedicine Volume 11, 2016 - Issue
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Review

Recent insights into the biological activities and drug delivery systems of tanshinones

Yuee Cai1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China
,
Wenji Zhang2 Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People’s Republic of China
,
Zirong Chen3 Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, FL, USA
,
Zhi Shi1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China;2 Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence[email protected]
,
Chengwei He1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China
&
Meiwan Chen1 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of ChinaCorrespondence[email protected]
Pages 121-130 | Published online: 05 Jan 2016

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Luting Wang, Lin Xu, Junfeng Du, Xiao Zhao, Mei Liu, Jianfang Feng & Kaili Hu. (2021) Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury. Drug Delivery 28:1, pages 1363-1375.
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Yun-Peng Zhao, Fei Wang, Wei Jiang, Jinfeng Liu, Bao-Lin Liu, Lian-Wen Qi & Wen Zhou. (2019) A mitochondrion-targeting tanshinone IIA derivative attenuates myocardial hypoxia reoxygenation injury through a SDH-dependent antioxidant mechanism. Journal of Drug Targeting 27:8, pages 896-902.
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Yue Li, Yujuan Fan, Huizong Su, Qian Wang, Guo-Fu Li, Yiyang Hu, Jian Jiang, Bo Tan & Furong Qiu. (2019) Metabolic characteristics of Tanshinone I in human liver microsomes and S9 subcellular fractions. Xenobiotica 49:2, pages 152-160.
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Shouwen Zhang, Jingfang Li, Shunpeng Hu, Fangfang Wu & Xianzhao Zhang. (2018) Triphenylphosphonium and D-α-tocopheryl polyethylene glycol 1000 succinate-modified, tanshinone IIA-loaded lipid-polymeric nanocarriers for the targeted therapy of myocardial infarction. International Journal of Nanomedicine 13, pages 4045-4057.
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Junliang Zhang, Xue Zhang, Jianbin Zhang, Moying Li, Daijie Chen & Tong Wu. (2018) Minor compounds of the high purity salvianolic acid B freeze-dried powder from Salvia miltiorrhiza and antibacterial activity assessment. Natural Product Research 32:10, pages 1198-1202.
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Articles from other publishers (17)

Shalu VermaAlka SinghVikash Jakhmola. (2023) Ethosomes Loaded with Spiranolactone for Acne treatment through Topical Gel Formulation. Research Journal of Pharmacy and Technology, pages 1219-1224.
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Wenzheng Zhao, Bohao Ruan, Xiaoyi Sun & Zhenwei Yu. (2023) Preparation and optimization of surface stabilized cryptotanshinone nanocrystals with enhanced bioavailability. Frontiers in Pharmacology 14.
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Yunze Li, Yangjing Yao, Xinran Cao, Nan Yi, Anqi Chen, Jianjun Li & Minghua Wu. (2023) Clinical efficacy of Danshen preparation in the treatment of vascular cognitive impairment: A systematic review and meta-analysis. Frontiers in Aging Neuroscience 14.
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Wei Li, Tao Huang, Shenghan Xu, Bangwei Che, Ying Yu, Wenjun Zhang & Kaifa Tang. (2022) Molecular Mechanism of Tanshinone against Prostate Cancer. Molecules 27:17, pages 5594.
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Zi-Heng Li, Li Cheng, Chun Wen, Li Ding, Qiu-Yun You & Shun-Bo Zhang. (2022) Activation of CNR1/PI3K/AKT Pathway by Tanshinone IIA Protects Hippocampal Neurons and Ameliorates Sleep Deprivation-Induced Cognitive Dysfunction in Rats. Frontiers in Pharmacology 13.
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Cristina Estornut, Javier Milara, María Amparo Bayarri, Nada Belhadj & Julio Cortijo. (2022) Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis. Frontiers in Pharmacology 12.
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Baoguo Ye, Kong Qiao, Qiheng Zhao, Zhigang Jiang, Ningning Hu & Fei Wang. (2021) Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis. Molecular and Cellular Biochemistry 477:1, pages 1-13.
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Xiaojing Fu, Wenwen Zhao, Kangkang Li, Jingyi Zhou & Xuehong Chen. (2021) Cryptotanshinone Inhibits the Growth of HCT116 Colorectal Cancer Cells Through Endoplasmic Reticulum Stress-Mediated Autophagy. Frontiers in Pharmacology 12.
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Sophia Ogechi Ekeuku, Kok-Lun Pang & Kok-Yong Chin. (2021) The Skeletal Effects of Tanshinones: A Review. Molecules 26:8, pages 2319.
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Alexander Ou, Martina Ott, Dexing Fang & Amy Heimberger. (2021) The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma. Cancers 13:3, pages 437.
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Elisa Ceccherini, Antonella Cecchettini, Maria Aurora Morales & Silvia Rocchiccioli. (2020) The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From In Vitro to Clinical Studies. Frontiers in Pharmacology 11.
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Shuang Liang, Zijian Wang, Jiaqi Yuan, Jing Zhang, Xueling Dai, Fei Qin, Jiayu Zhang & Yaxuan Sun. (2019) Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-β1-42 Induced Alzherimer’s Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry. Molecules 24:14, pages 2584.
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Yuanliang Yan, Weiping Su, Shuangshuang Zeng, Long Qian, Xi Chen, Jie Wei, Na Chen, Zhicheng Gong & Zhijie Xu. (2018) Effect and Mechanism of Tanshinone I on the Radiosensitivity of Lung Cancer Cells. Molecular Pharmaceutics 15:11, pages 4843-4853.
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Jingjing Luo, Xiaofeng Meng, Jianyu Su, Hang Ma, Wen Wang, Liming Fang, Huade Zheng, Yexia Qin & Tianfeng Chen. (2018) Biotin-Modified Polylactic- co -Glycolic Acid Nanoparticles with Improved Antiproliferative Activity of 15,16-Dihydrotanshinone I in Human Cervical Cancer Cells . Journal of Agricultural and Food Chemistry 66:35, pages 9219-9230.
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Ching-Fen Wu & Thomas Efferth. 2017. Salvia Biotechnology. Salvia Biotechnology 179 207 .
Yu-Chiang Hung, Tai-Long Pan & Wen-Long Hu. (2016) Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge . Oxidative Medicine and Cellular Longevity 2016, pages 1-10.
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Cheng-Chieh Chang, Yu-Chun Chang, Wen-Long Hu & Yu-Chiang Hung. (2016) Oxidative Stress and Salvia miltiorrhiza in Aging-Associated Cardiovascular Diseases . Oxidative Medicine and Cellular Longevity 2016, pages 1-11.
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