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International Journal of Nanomedicine Volume 10, 2015 - Issue
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Original Research

Different patterns of nuclear and mitochondrial penetration by the G3 PAMAM dendrimer and its biotin–pyridoxal bioconjugate BC-PAMAM in normal and cancer cells in vitro

Łukasz Uram1 Bioorganic Chemistry Laboratory, Faculty of Chemistry, Rzeszow University of Technology, Rzeszow, PolandCorrespondence[email protected]
,
Magdalena Szuster1 Bioorganic Chemistry Laboratory, Faculty of Chemistry, Rzeszow University of Technology, Rzeszow, Poland
,
Aleksandra Filipowicz2 Cosmetology Department, University of Information Technology and Management in Rzeszow, Rzeszow, Poland
,
Krzysztof Gargasz3 Institute of Nursery and Health Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
,
Stanisław Wołowiec3 Institute of Nursery and Health Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
&
Elżbieta Wałajtys-Rode4 Department of Drug Technology and Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland
Pages 5647-5661 | Published online: 04 Sep 2015

Citations (16)

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Read on this site (3)

Barbara Ziemba, Maciej Borowiec & Ida Franiak-Pietryga. (2022) There and back again: a dendrimer’s tale. Drug and Chemical Toxicology 45:5, pages 2169-2184.
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Jianmeng Zhu, Zhilu Ye, Xiaoying Fan, Hongqin Wang, Zhen Wang & Bingyu Chen. (2019) A highly sensitive biosensor based on Au NPs/rGO-PAMAM-Fc nanomaterials for detection of cholesterol. International Journal of Nanomedicine 14, pages 835-849.
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Jaspreet Singh, Keerti Jain, Neelesh Kumar Mehra & N. K. Jain. (2016) Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers. Artificial Cells, Nanomedicine, and Biotechnology 44:7, pages 1626-1634.
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Articles from other publishers (13)

Konrad Wróbel, Anna Deręgowska, Gabriela Betlej, Małgorzata Walczak, Maciej Wnuk, Anna Lewińska & Stanisław Wołowiec. (2023) Cytarabine and dexamethasone-PAMAM dendrimer di-conjugate sensitizes human acute myeloid leukemia cells to apoptotic cell death. Journal of Drug Delivery Science and Technology 81, pages 104242.
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Jie Liu, Yuan Gao, Xiaodong Zhu, Yuerong Zhang, Hai Xu, Tianda Wang & Guangdong Zhang. (2021) Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells. Clinical Oral Investigations 26:2, pages 1737-1751.
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Rosario Planelló, Roberto Rosal, Mónica Aquilino & Óscar Herrero. (2021) Genotoxic effects and transcriptional deregulation of genetic biomarkers in Chironomus riparius larvae exposed to hydroxyl- and amine-terminated generation 3 (G3) polyamidoamine (PAMAM) dendrimers. Science of The Total Environment 774, pages 145828.
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Harish Padh, Snehal Shenoy, Shreya Thakkar & Manju Misra. 2021. Mitochondrial Dysfunction and Nanotherapeutics. Mitochondrial Dysfunction and Nanotherapeutics 263 289 .
Anna Czerniecka-Kubicka, Piotr Tutka, Marek Pyda, Małgorzata Walczak, Łukasz Uram, Maria Misiorek, Ewelina Chmiel & Stanisław Wołowiec. (2020) Stepwise Glucoheptoamidation of Poly(Amidoamine) Dendrimer G3 to Tune Physicochemical Properties of the Potential Drug Carrier: In Vitro Tests for Cytisine Conjugates. Pharmaceutics 12:5, pages 473.
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Zaręba, Sareło, Kopaczyńska, Białońska, Uram, Walczak, Aebisher & Wołowiec. (2019) Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells. International Journal of Molecular Sciences 20:20, pages 4998.
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Mohammad Yousefi, Parvin Orojzadeh & Seid Mahdi Jafari. 2019. Biopolymer Nanostructures for Food Encapsulation Purposes. Biopolymer Nanostructures for Food Encapsulation Purposes 607 625 .
Łukasz Uram, Aleksandra Filipowicz, Maria Misiorek, Natalia Pieńkowska, Joanna Markowicz, Elżbieta Wałajtys-Rode & Stanisław Wołowiec. (2018) Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines. European Journal of Pharmaceutical Sciences 124, pages 1-9.
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Magdalena Zaręba, Łukasz Uram, Agata Białońska, Monika Stompor & Stanisław Wołowiec. (2017) PAMAM Dendrimers Attached to Collagen via a Malondialdehyde Linker. ChemistrySelect 2:27, pages 8262-8269.
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Dandan Guo, Chaoyan Lou, Nani Wang, Meilan Chen, Peimin Zhang, Shuchao Wu & Yan Zhu. (2017) Poly (styrene-divinyl benzene-glycidylmethacrylate) stationary phase grafted with poly amidoamine (PAMAM) dendrimers for rapid determination of phenylene diamine isomers in HPLC. Talanta 168, pages 188-195.
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Łukasz Uram, Magdalena Szuster, Maria Misiorek, Aleksandra Filipowicz, Stanisław Wołowiec & Elżbieta Wałajtys-Rode. (2017) The effect of G3 PAMAM dendrimer conjugated with B-group vitamins on cell morphology, motility and ATP level in normal and cancer cells. European Journal of Pharmaceutical Sciences 102, pages 275-283.
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Łukasz Uram, Magdalena Szuster, Aleksandra Filipowicz, Magdalena Zaręba, Elżbieta Wałajtys-Rode & Stanisław Wołowiec. (2017) Cellular uptake of glucoheptoamidated poly(amidoamine) PAMAM G3 dendrimer with amide-conjugated biotin, a potential carrier of anticancer drugs. Bioorganic & Medicinal Chemistry 25:2, pages 706-713.
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Dandan Guo, Chaoyan Lou, Peimin Zhang, Jiajie Zhang, Nani Wang, Shuchao Wu & Yan Zhu. (2016) Polystyrene-divinylbenzene-glycidyl methacrylate stationary phase grafted with poly (amidoamine) dendrimers for ion chromatography. Journal of Chromatography A 1456, pages 113-122.
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