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Journal of Hepatocellular Carcinoma Volume 7, 2020 - Issue
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Original Research

Cross-Linked Multimeric Pro-Peptides of Type III Collagen (PC3X) in Hepatocellular Carcinoma – A Biomarker That Provides Additional Prognostic Value in AFP Positive Patients

Christina Jensen1 Biomarkers & Research, Nordic Bioscience, Herlev, Denmark;2 Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3485-7307View further author information
ORCID Icon,
Signe Holm Nielsen1 Biomarkers & Research, Nordic Bioscience, Herlev, Denmark;3 Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, DenmarkView further author information
,
Mohammed Eslam4 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, AustraliaView further author information
,
Federica Genovese1 Biomarkers & Research, Nordic Bioscience, Herlev, DenmarkORCID Iconhttps://orcid.org/0000-0003-1984-1881View further author information
ORCID Icon,
Mette Juul Nielsen1 Biomarkers & Research, Nordic Bioscience, Herlev, DenmarkView further author information
,
Roslyn Vongsuvanh4 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, AustraliaView further author information
,
Raj Uchila4 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, AustraliaORCID Iconhttps://orcid.org/0000-0003-2013-1684View further author information
ORCID Icon,
David van der Poorten4 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, AustraliaView further author information
,
Jacob George4 Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, AustraliaView further author information
,
Morten Asser Karsdal1 Biomarkers & Research, Nordic Bioscience, Herlev, DenmarkORCID Iconhttps://orcid.org/0000-0001-5026-8740View further author information
ORCID Icon,
Diana Julie Leeming1 Biomarkers & Research, Nordic Bioscience, Herlev, DenmarkView further author information
&
Nicholas Willumsen1 Biomarkers & Research, Nordic Bioscience, Herlev, DenmarkView further author information
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Pages 301-313 | Published online: 09 Nov 2020

Citations (12)

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Martin Pehrsson, Joachim Høg Mortensen, Tina Manon-Jensen, Anne-Christine Bay-Jensen, Morten Asser Karsdal & Michael Jonathan Davies. (2021) Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment. Expert Review of Molecular Diagnostics 21:10, pages 1049-1064.
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Articles from other publishers (11)

Christina Jensen, Patryk Drobinski, Jeppe Thorlacius-Ussing, Morten A. Karsdal, Anne-Christine Bay-Jensen & Nicholas Willumsen. (2023) Autoreactivity against Denatured Type III Collagen Is Significantly Decreased in Serum from Patients with Cancer Compared to Healthy Controls. International Journal of Molecular Sciences 24:8, pages 7067.
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Elizabeth A. Brown, Anne Minnich, Arun J. Sanyal, Rohit Loomba, Shuyan Du, John Schwarz, Richard L. Ehman, Morten Karsdal, Diana J. Leeming, Giovanni Cizza & Edgar D. Charles. (2023) Effect of pegbelfermin on NASH and fibrosis-related biomarkers and correlation with histological response in the FALCON 1 trial. JHEP Reports 5:4, pages 100661.
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Neel I. Nissen, Astrid Z. Johansen, Inna M. Chen, Christina Jensen, Emilie A. Madsen, Carsten P. Hansen, Jeppe Thorlacius-Ussing, Morten Karsdal, Julia S. Johansen, Hadi M. H. Diab, Lars N. Jørgensen & Nicholas Willumsen. (2023) High serum levels of the C-propetide of type V collagen (PRO-C5) are prognostic for short overall survival in patients with pancreatic ductal adenocarcinoma. Frontiers in Molecular Biosciences 10.
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Troels D. Christensen, Christina Jensen, Ole Larsen, Bonna Leerhøy, Carsten P. Hansen, Kasper Madsen, Dan Høgdall, Morten A. Karsdal, Inna M. Chen, Dorte Nielsen, Julia S. Johansen & Nicholas Willumsen. (2022) Blood‐based tumor fibrosis markers as diagnostic and prognostic biomarkers in patients with biliary tract cancer. International Journal of Cancer 152:5, pages 1036-1049.
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Leona Dold, Mette J. Nielsen, Michael Praktiknjo, Carolynne Schwarze-Zander, Christoph Boesecke, Jan-Christian Wasmuth, Jenny Bischoff, Jürgen Kurt Rockstroh, Morten A. Karsdal, Ulrich Spengler, Jonel Trebicka, Christian P. Strassburg, Diana J. Leeming & Bettina Langhans. (2023) Circulating levels of endotrophin and cross-linked type III collagen reflect liver fibrosis in people with HIV. BMC Infectious Diseases 23:1.
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Ramón Lorenzo-Gómez, Alfonso Casero-Álvarez, Rebeca Miranda-Castro, Marcos García-Ocaña, Juan R. de los Toyos, Noemí de-los-Santos-Alvarez & M. Jesús Lobo-Castañón. (2022) A competitive assay for the detection of a 16-mer peptide from α1 chain of human collagen XI. Talanta 240, pages 123196.
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Nicholas Willumsen, Christina Jensen, George Green, Neel I. Nissen, Jaclyn Neely, David M. Nelson, Rasmus S. Pedersen, Peder Frederiksen, Inna M. Chen, Mogens K. Boisen, Astrid Z. Johansen, Daniel H. Madsen, Inge Marie Svane, Allan Lipton, Kim Leitzel, Suhail M. Ali, Janine T. Erler, Daan P. Hurkmans, Ron H. J. Mathijssen, Joachim Aerts, Mohammed Eslam, Jacob George, Claus Christiansen, Mina J. Bissel & Morten A. Karsdal. (2022) Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types. Cellular and Molecular Life Sciences 79:4.
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Neel I. Nissen, Astrid Z. Johansen, Inna Chen, Julia S. Johansen, Rasmus S. Pedersen, Carsten P. Hansen, Morten A. Karsdal & Nicholas Willumsen. (2022) Collagen Biomarkers Quantify Fibroblast Activity In Vitro and Predict Survival in Patients with Pancreatic Ductal Adenocarcinoma. Cancers 14:3, pages 819.
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Ramón Lorenzo-Gómez, Rebeca Miranda-Castro, Noemí de-los-Santos-Álvarez & María Jesús Lobo-Castañón. (2021) Bioanalytical methods for circulating extracellular matrix-related proteins: new opportunities in cancer diagnosis. Analytical and Bioanalytical Chemistry 414:1, pages 147-165.
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Christina Jensen, Neel I. Nissen, Claus S. Von Arenstorff, Morten A. Karsdal & Nicholas Willumsen. (2021) Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy. Journal of Experimental & Clinical Cancer Research 40:1.
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Diana Julie Leeming, Signe Holm Nielsen, Roslyn Vongsuvanh, Pruthviraj Uchila, Mette Juul Nielsen, Alexander L Reese-Petersen, David van der Poorten, Mohammed Eslam, Detlef Schuppan, Morten Asser Karsdal & Jacob George. (2021) Endotrophin, a pro-peptide of Type VI collagen, is a biomarker of survival in cirrhotic patients with hepatocellular carcinoma. Hepatic Oncology 8:2.
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