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OncoTargets and Therapy Volume 13, 2020 - Issue
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Original Research

Inhibition of EGFR Signaling and Activation of Mitochondrial Apoptosis Contribute to Tanshinone IIA-Mediated Tumor Suppression in Non-Small Cell Lung Cancer Cells

Feng Gao1 Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;2 Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan410013, People’s Republic of China
,
Ming Li1 Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan410013, People’s Republic of China;3 School of Stomatology, Hunan University of Chinese Medicine, Changsha, Hunan410208, People’s Republic of China;4 Changsha Stomatological Hospital, Hunan University of Chinese Medicine, Changsha, Hunan, 410004, People’s Republic of China
,
Wenbin Liu5 Department of Pathology, The Affiliated Hunan Cancer Hospital of Central South University, Changsha, Hunan410013, People’s Republic of China
&
Wei Li2 Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan410013, People’s Republic of China;6 Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan410013, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7267-6494
ORCID Icon
Pages 2757-2769 | Published online: 02 Apr 2020

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Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang & Zhiyong Yuan. (2021) Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation. Pharmaceutical Biology 59:1, pages 87-94.
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Rutuja Damare, Kritika Engle & Gautam Kumar. (2024) Targeting epidermal growth factor receptor and its downstream signaling pathways by natural products: A mechanistic insight. Phytotherapy Research.
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Yaoquan Cao, Haibo Tang, Guohui Wang, Pengzhou Li, Zhi Song, Weizheng Li, Xulong Sun, Xiaoxiao Zhong, Qianqian Yu, Shaihong Zhu & Liyong Zhu. (2023) Targeting survivin with Tanshinone IIA inhibits tumor growth and overcomes chemoresistance in colorectal cancer. Cell Death Discovery 9:1.
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Fatma Fouad Hagar, Samar H. Abbas, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Ahmed M. Sayed, Dalia Abdelhamid & Mohamed Abdel-Aziz. (2023) Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV600E. BMC Chemistry 17:1.
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Fei Sun, Xiaoli Yang, Wei Song, Nan Yu & Qingyi Lin. (2022) Tanshinone IIA (TSIIA) represses the progression of non-small cell lung cancer by the circ_0020123/miR-1299/HMGB3 pathway. Molecular and Cellular Biochemistry 478:9, pages 1973-1986.
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Zhicheng Wei, Jing Chen, Fang Zuo, Julie Guo, Xiaodong Sun, Deming Liu & Conghai Liu. (2023) Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review. Journal of Ethnopharmacology 300, pages 115748.
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Hongkui Chen, Min Zheng, Wenhui Zhang, Yuan Long, Yu Xu & Man Yuan. (2022) Research Status of Mouse Models for Non-Small-Cell Lung Cancer (NSCLC) and Antitumor Therapy of Traditional Chinese Medicine (TCM) in Mouse Models. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-13.
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Meng Lu, Xintian Lan, Xi Wu, Xiaoxue Fang, Yegang Zhang, Haoming Luo, Wenyi Gao & Donglu Wu. (2022) Salvia miltiorrhiza in cancer: Potential role in regulating MicroRNAs and epigenetic enzymes. Frontiers in Pharmacology 13.
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Reem N El-Naga. (2022) Forskolin alleviates cisplatin-induced acute renal toxicity in rats. Journal of Pharmacy and Pharmacology 74:7, pages 1051-1060.
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Hailiang Qi, Zhengyi Chen, Yuhuan Qin, Xianlei Wang, Zhihua Zhang & Yazhai Li. (2022) Tanshinone IIA inhibits cell growth by suppressing SIX1‑induced aerobic glycolysis in non‑small cell lung cancer cells. Oncology Letters 23:6.
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Shuangze Han, Xiaoying Li, Yu Gan & Wei Li. (2022) Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance. BioMed Research International 2022, pages 1-12.
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Syed Sahajada Mahafujul Alam, Faizan Uddin, Farheen Badrealam Khan, Mohammad Amjad Kamal & Mehboob Hoque. (2022) Therapeutic and pharmacological potential of Tanshinones against lung cancer: A systematic review. Phytomedicine Plus 2:1, pages 100202.
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Wenfeng Zhang, Cun Liu, Jie Li, Yiping Lu, Huayao Li, Jing Zhuang, Xin Ren, Mengmeng Wang & Changgang Sun. (2022) Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine. The American Journal of Chinese Medicine 50:01, pages 209-239.
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Teng Wang, Jun Zou, Qiong Wu, Rui Wang, Chan-Ling Yuan, Jing Shu, Bing-Bing Zhai, Xiao-Ting Huang, Ning-Zhi Liu, Feng-Yang Hua, Xi-Cheng Wang & Wen-Jie Mei. (2021) Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway. European Journal of Pharmacology 912, pages 174586.
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Chenhui Zhong, Zuan Lin, Liyuan Ke, Peiying Shi, Shaoguang Li, Liying Huang, Xinhua Lin & Hong Yao. (2021) Recent Research Progress (2015–2021) and Perspectives on the Pharmacological Effects and Mechanisms of Tanshinone IIA. Frontiers in Pharmacology 12.
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Xianglian Zhou, Yuting Pan, Yue Wang, Bojun Wang, Yu Yan, Yi Qu & Xisong Ke. (2021) Tanshinones induce tumor cell apoptosis via directly targeting FHIT. Scientific Reports 11:1.
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Qi-Xing Yan, Yun Pan, Hai-Li Huang & Hui Zhao. (2021) Therapeutic Potential of Natural Products in Lung Cancer. International Journal of Pharmacology 17:5, pages 251-261.
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Tingting Wen, Lei Song & Shucheng Hua. (2021) Perspectives and controversies regarding the use of natural products for the treatment of lung cancer. Cancer Medicine 10:7, pages 2396-2422.
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Zhiyuan Sun, Jinxiang Dong, Lijie Song, Fuqiang Li, Xue Wu, Zhidong Qiu & Donglu Wu. (2021) Network Pharmacology Validation of Therapeutic Mechanisms of Tanshinone IIA in Colorectal Cancer. Natural Product Communications 16:3, pages 1934578X2110042.
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